别名 唾液酸结合性免疫球蛋白样凝集素2、B-cell receptor CD22、B-lymphocyte cell adhesion molecule + [9] |
简介 Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
靶点 |
作用机制 CD22抑制剂 |
在研机构 |
原研机构 |
在研适应症 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2018-09-13 |
开始日期2024-12-01 |
申办/合作机构 |
开始日期2024-11-05 |
开始日期2024-11-01 |