To develop new intermediate synthesis technol. of Roxadustat, reduce intermediate cost, simplify operation, save energy and reduce emission.Using p-fluorobenzoyl chloride as raw material, the key intermediate was synthesized by the reaction of p-fluorobenzoyl chloride with Acetaldehyde after hydrogen extraction under N-(1-Me Ethyl)-2-propylamine protection and nitrogen protection, and then reacted with phenol after ring closing under acid condition.The raw materials and reaction reagents are cheap and available, the cost is low, the synthetic method is safe, the operation is simple, the overall yield is high, the total yield of four steps can reach over 60%, the purity of intermediate can reach over 98.5%.The new intermediate has the advantages of low cost, mild operating conditions, safety and high purity.It can be used as a substitute for the original intermediate in the next step.