1区 · 综合性期刊
ArticleOA
作者: Wang, Shuang ; Peng, Yun ; Wang, Rongjuan ; Jiao, Shasha ; Wang, Min ; Huang, Weijin ; Shan, Chao ; Jiang, Wen ; Li, Zepeng ; Gu, Chunying ; Chen, Ben ; Hu, Xue ; Yao, Yanfeng ; Min, Juan ; Zhang, Huajun ; Chen, Ying ; Gao, Ge ; Tang, Peipei ; Li, Gang ; Wang, An ; Wang, Lan ; Zhang, Jinchao ; Chen, Shuo ; Gui, Xun ; Yuan, Zhiming ; Liu, Datao
Efficacious interventions are urgently needed for the treatment of COVID-19. Here, we report a monoclonal antibody (mAb), MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor. Crosslinking of Fc with FcγRIIB mediates antibody-dependent enhancement (ADE) activity by MW05. This activity is eliminated by introducing the LALA mutation to the Fc region (MW05/LALA). Potent prophylactic and therapeutic effects against SARS-CoV-2 are observed in rhesus monkeys. A single dose of MW05/LALA blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in a therapeutic treatment setting. These results pave the way for the development of MW05/LALA as an antiviral strategy for COVID-19.