PatSnap Synapse, a novel, AI Powered Drug Competitive Intelligence database. Access to drugs, clinical trials, patents, literature and news in one search
Nykode Therapeutics, a biopharmaceutical company based in Oslo, Norway, has announced positive final results from its Phase 2 clinical trial evaluating the safety and efficacy of VB10.16 in combination with the PD-L1 inhibitor, atezolizumab, for the treatment of advanced or recurrent, non-resectable HPV16-positive cervical cancer.
The trial involved 52 patients with advanced cervical cancer who had previously received chemotherapy. The study aimed to evaluate the safety and efficacy of VB10.16, a therapeutic vaccine that works by stimulating the immune system to target cancer cells, in combination with atezolizumab, a checkpoint inhibitor that blocks PD-L1 to enhance immune responses against cancer.
The results showed that the combination of VB10.16 and atezolizumab was well-tolerated and demonstrated promising clinical activity in patients with advanced cervical cancer. The overall response rate was 40% and DCR 80% with a median progression free survival of 16.9 months and median overall survival more than 25 months (not reached).