近日,来自湖北中医药大学的研究者们在Cellular and Molecular Life Sciences杂志上发表了题为“5‑Aminosalicylic acid ameliorates dextran sulfate sodium‑induced colitis in mice by modulating gut microbiota and bile acid metabolism”的文章,该研究揭示了5-ASA可通过调节肠道微生物区系和胆汁酸代谢来改善DSS诱导的小鼠结肠炎。这些发现证明了5-ASA在临床结肠炎治疗中的新的治疗机制。
Ling Huang et al. 5‑Aminosalicylic acid ameliorates dextran sulfate sodium‑induced colitis in mice by modulating gut microbiota and bile acid metabolism. Cell Mol Life Sci. 2022 Aug 1;79(8):460. doi: 10.1007/s00018-022-04471-3.