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更新于：2025-03-20

Erythrityl Tetranitrate

丁四硝酯

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

(2R*,3S)-rel-1,2,3,4-butanetetroltetranitrate、1,2,3,4-Butanetetralyl tetranitrate、ETN

+ [11]

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病心血管疾病

在研适应症

心绞痛冠心病

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C4H6N4O12

InChIKeySNFOERUNNSHUGP-ZXZARUISSA-N

CAS号7297-25-8

关联

项与丁四硝酯相关的临床试验

EUCTR2006-004454-25-DE

/ Not yet recruitingN/A

A multicenter double blind, placebo-controlled randomized pilot study evaluating efficacy and safety of ETN in patients with moderate to severe plaque psoriasis after cessation of ciclosporin therapy

开始日期2007-09-13

申办/合作机构-

100 项与丁四硝酯相关的临床结果

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100 项与丁四硝酯相关的转化医学

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100 项与丁四硝酯相关的专利（医药）

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642

项与丁四硝酯相关的文献（医药）

2025-02-01·Food Chemistry

Season-dependent variation in the contents of glucosinolates and S-methyl-l-cysteine sulfoxide and their hydrolysis in Brassica oleracea

Article

作者: Rohn, Sascha ; Hanschen, Franziska Sabine ; Witzel, Katja ; Púčiková, Vanda

Brassica vegetables contain glucosinolates and S-methyl-l-cysteine sulfoxide, which can be enzymatically hydrolyzed to form bioactive compounds. Glucosinolate hydrolysis can result in formation of health-promoting isothiocyanates, however, often less desirable nitriles and epithionitriles are formed due to presence of specifier proteins. Also, S-methyl-l-cysteine sulfoxide yields beneficial volatile organosulfur compounds (VOSC), such as S-methyl methanethiosulfinate. To optimize the nutritional value of Brassica oleracea vegetables, the outcome of these hydrolysis pathways was monitored over the harvest seasons of different cultivars in three consecutive years. Strong seasonal shifts in glucosinolate hydrolysis were observed only in red cabbages. They formed up to 40-fold more isothiocyanates in summer than in autumn, when nitriles and epithionitriles increased due to the induction of epithiospecifier proteins. Further, higher VOSC levels were found in autumn red cabbage. By elucidating the impact of abiotic growth factors on the regulation of the hydrolyses, the health value of Brassica vegetables can be improved.

2025-02-01·Pancreatology

Outcomes of percutaneous endoscopic versus endoscopic transmural necrosectomy for necrotizing pancreatitis: A propensity score-matched study

Article

作者: Zhu, Yong ; Zhu, Yin ; Ding, Ling ; Liu, Pi ; Li, Lei ; Xiong, Huifang ; Xia, Liang ; Hu, Yang ; Rao, Jingwen ; Chen, Youxiang ; He, Wenhua ; Lu, Nonghua ; Shu, Xu ; Huang, Xin ; Luo, Lingyu ; Ke, Huajing ; Liu, Zhijian ; Lei, Yupeng ; Wu, Yao

BACKGROUNDFew published studies exist that compare the outcomes of different endoscopic necrosectomy methods for necrotizing pancreatitis (NP). We compared the safety and efficacy of percutaneous versus transmural endoscopic necrosectomy for NP patients.METHODSIn this retrospective cohort study, we analyzed adult NP patients who underwent either percutaneous endoscopic necrosectomy (PEN) or endoscopic transmural necrosectomy (ETN), and compared safety and efficacy between the two groups. Propensity score-matched analysis and multivariable logistic regression analysis were conducted.RESULTSA total of 280 patients were enrolled, among which 142 underwent PEN and 138 underwent ETN. There were differences in baseline characteristics between the two groups, including body mass index, C-reactive protein, systemic inflammatory response syndrome score. The incidences of sepsis, respiratory failure, and intensive care unit stay were higher among patients who underwent PEN than those who underwent ETN (all P < 0.01). Ninety-one pairs were matched with comparable baseline characteristics and severity. The incidence of postoperative complications, open surgery, clinical success, radiological success, collection recurrence, and reintervention were not significantly different between the ETN group and PEN group (all P > 0.05). Multivariate analysis also showed that the approaches (PEN vs ETN) was not associated with postoperative complications or mortality.CONCLUSIONSIn real world setting, sicker patients tend to be more effectively managed through PEN compared to ETN. PEN demonstrates comparable efficacy and safety to ETN in the treatment of NP patients.

2025-01-01·Propellants, Explosives, Pyrotechnics

Combined Solid‐Phase Extraction of Organic, Organic Peroxide, and Inorganic Explosives for Post‐Blast Residue Analysis

作者: Thomas, Jennifer L. ; Tipple, Christopher A. ; Fowble, Kristen L. ; Cruse, Courtney A. ; Miller, Jason V. ; Sipe, Sarah N. ; Borchers, Amara E. ; Armas, Stephanie ; Pavone, David C. ; Miller, Mark L. ; Mulder, Haley A.

ABSTRACTPost‐blast explosives residue may contain organic and/or inorganic explosives. Current methods employed involve splitting the sample swab in two for syringe extraction for each explosive type (acetone for organics, water for inorganics). A comprehensive solid‐phase extraction (SPE) trace sample clean‐up procedure for the combined recovery of 12 organic, 2 organic peroxide, and 15 inorganic analytes from explosives residue on cotton swabs is demonstrated and validated. By keeping the sample whole and using a single extraction process, the proposed method saves time, provides a more representative sample, and increases the possibility of detecting explosives that might be present on collection swabs. Thus, recoveries are improved for one class of explosives without sacrificing recoveries of another analyte or explosives class in the process. Extractions were demonstrated by syringe filtration and SPE from cotton balls (CBs) and cotton‐tipped applicators (CAs). For SPE of both matrices, organic explosives (nitramines, nitrate esters, nitroalkanes, and nitroaromatics) had a limit of detection (LOD) of 500 ppb or lower, organic peroxides had higher LODs at 5 ppm or lower, and most inorganic anions and cations had LODs at 1 ppm or lower. Application to 32 post‐blast samples, 9 burned powders simulating post‐blast, and 1 pre‐blast sample successfully demonstrated the SPE method with both cotton matrices in a comparison study of the two extraction procedures. SPE resulted in a lower false screen rate (number of compounds that met the screening criteria, but not confirmed present) when compared to syringe extraction.

100 项与丁四硝酯相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04051	丁四硝酯	C01DA13	DB01613

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心绞痛	-	-	-
冠心病	-	-	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


equira study (EULAR2018)	临床3期	类风湿关节炎	-	GP2015	(鑰積餘築顧窪廠獵遞鏇) = 齋蓋夢衊憲醖鑰選範膚蓋構鏇製鬱壓鏇膚鬱淵 (鹹餘餘襯顧鹽夢廠遞廠 ) 更多	-	2018-06-13
				ETN	(鑰積餘築顧窪廠獵遞鏇) = 鬱顧範獵糧鹽醖窪積鏇蓋構鏇製鬱壓鏇膚鬱淵 (鹹餘餘襯顧鹽夢廠遞廠 ) 更多
EULAR2017	临床3期	类风湿关节炎 anti-drug antibody (ADA) \| injection site reaction (ISR)	-	SB4	(選遞窪網選醖襯齋鬱範) = 鑰糧齋築構壓糧糧餘觸製醖餘顧壓鹽顧顧醖觸 (壓範鹹淵鬱繭鑰繭衊糧 ) 更多	积极	2017-06-14
				ETN	(選遞窪網選醖襯齋鬱範) = 鏇糧衊簾願繭鹽鹹艱膚製醖餘顧壓鹽顧顧醖觸 (壓範鹹淵鬱繭鑰繭衊糧 ) 更多
EULAR2016	N/A	-	-	TNF + ADA	遞構鹽蓋構鹽鬱構鏇簾(範衊衊夢製膚襯餘艱遞) = 糧齋淵製淵遞夢憲繭繭鹹製淵願艱構憲範齋憲 (餘蓋範繭糧夢遞構廠鬱 )	-	2016-06-08
				TNF + ETN	遞構鹽蓋構鹽鬱構鏇簾(範衊衊夢製膚襯餘艱遞) = 獵願窪夢積願蓋齋壓願鹹製淵願艱構憲範齋憲 (餘蓋範繭糧夢遞構廠鬱 )
EULAR2015	临床3期	类风湿关节炎	596	SB4	(夢衊餘積範製窪衊衊鹹) = 廠齋憲艱鏇網齋夢鬱範艱願淵網蓋淵願鏇鹽鹽 (襯艱壓選憲膚選遞窪積 ) 更多	积极	2015-06-10
				ETN	(夢衊餘積範製窪衊衊鹹) = 製觸選鹹範窪膚範壓築艱願淵網蓋淵願鏇鹽鹽 (襯艱壓選憲膚選遞窪積 ) 更多
PRIZE study (EULAR2014)	临床1期	类风湿关节炎	306	ETN+MTX combination therapy	齋艱繭鹹範願範夢醖艱(獵範艱網遞鏇憲鹹鹽網) = 鹽鏇築鬱鬱夢壓壓積築願鹹鏇膚鏇顧簾鑰願鬱 (觸鹽蓋範繭鬱構鹽糧製, 66.1 ~ 92.7) 更多	积极	2014-06-11
EULAR2014	N/A	类风湿关节炎	-	ETN+MTX combination therapy	範製艱憲積積觸壓鏇獵(遞選鹽遞醖憲蓋選膚網) = 淵鬱築夢簾簾簾襯衊鹽鬱蓋積鹽鹹製壓簾鏇壓 (製憲積壓鏇蓋鬱膚鏇廠 ) 更多	-	2014-06-11
				Triple therapy (MTX+HCQ+SLZ)	範製艱憲積積觸壓鏇獵(遞選鹽遞醖憲蓋選膚網) = 膚夢壓觸鹽願構膚選淵鬱蓋積鹽鹹製壓簾鏇壓 (製憲積壓鏇蓋鬱膚鏇廠 ) 更多
EULAR2009	N/A	类风湿关节炎 \| 肺孢子菌肺炎	-	ETN	淵構鏇醖艱壓憲鹹衊獵(構繭構餘衊膚鹽觸鬱餘) = 積遞蓋選積鹽願蓋鬱網艱壓鏇壓築夢艱製顧鏇 (糧憲鬱襯築廠鬱鏇膚蓋 )	积极	2009-06-10
EULAR2008	N/A	类风湿关节炎	-	MTX	(齋獵廠鹹餘窪窪鹹顧鬱) = 鹽鹹齋糧夢窪齋膚壓窪窪鹽艱繭鏇醖構願構鑰 (憲簾築選齋蓋膚鏇膚醖 ) 更多	-	2008-06-11
				ETN	積構衊鏇鏇獵膚鑰築膚(選糧齋鏇憲製選繭衊製) = 鏇衊憲衊範範艱糧網醖鏇蓋鏇顧積廠製壓願構 (製鏇廠醖壓窪齋獵鹹繭 ) 更多
EULAR2006	临床3期	-	-	ETN plus NSAIDs	憲鹽鹹遞遞觸淵願壓鏇(鹹構齋簾鬱網壓鏇廠網) = 構襯鏇鏇鑰餘選襯夢壓憲遞簾糧遞顧壓淵醖糧 (鹹艱築築夢顧鏇淵鏇憲 )	-	2006-06-21
EULAR2005	N/A	类风湿关节炎	-	Methotrexate (MTX)	(觸襯壓簾繭憲顧範衊範) = 顧簾鑰醖鹽鑰觸遞鑰醖憲衊鹽鏇築鏇選鹹齋積 (範齋憲窪艱構夢鑰獵夢 ) 更多	-	2005-06-08
				Etanercept (ETN)	(觸襯壓簾繭憲顧範衊範) = 齋膚構艱膚鬱網選積醖憲衊鹽鏇築鏇選鹹齋積 (範齋憲窪艱構夢鑰獵夢 ) 更多