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更新于：2025-05-07

Erythrityl Tetranitrate

丁四硝酯

更新于：2025-05-07

概要

基本信息

药物类型

小分子化药

别名

(2R*,3S)-rel-1,2,3,4-butanetetroltetranitrate、1,2,3,4-Butanetetralyl tetranitrate、ETN

+ [11]

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病心血管疾病

在研适应症

心绞痛冠心病

非在研适应症-

原研机构-

在研机构-

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C4H6N4O12

InChIKeySNFOERUNNSHUGP-ZXZARUISSA-N

CAS号7297-25-8

关联

项与丁四硝酯相关的临床试验

EUCTR2006-004454-25-DE

/ Not yet recruitingN/A

A multicenter double blind, placebo-controlled randomized pilot study evaluating efficacy and safety of ETN in patients with moderate to severe plaque psoriasis after cessation of ciclosporin therapy

开始日期2007-09-13

申办/合作机构-

100 项与丁四硝酯相关的临床结果

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100 项与丁四硝酯相关的转化医学

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100 项与丁四硝酯相关的专利（医药）

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244

项与丁四硝酯相关的文献（医药）

2025-02-01·Food Chemistry

Season-dependent variation in the contents of glucosinolates and S-methyl-l-cysteine sulfoxide and their hydrolysis in Brassica oleracea

Article

作者: Rohn, Sascha ; Hanschen, Franziska Sabine ; Witzel, Katja ; Púčiková, Vanda

Brassica vegetables contain glucosinolates and S-methyl-l-cysteine sulfoxide, which can be enzymatically hydrolyzed to form bioactive compounds. Glucosinolate hydrolysis can result in formation of health-promoting isothiocyanates, however, often less desirable nitriles and epithionitriles are formed due to presence of specifier proteins. Also, S-methyl-l-cysteine sulfoxide yields beneficial volatile organosulfur compounds (VOSC), such as S-methyl methanethiosulfinate. To optimize the nutritional value of Brassica oleracea vegetables, the outcome of these hydrolysis pathways was monitored over the harvest seasons of different cultivars in three consecutive years. Strong seasonal shifts in glucosinolate hydrolysis were observed only in red cabbages. They formed up to 40-fold more isothiocyanates in summer than in autumn, when nitriles and epithionitriles increased due to the induction of epithiospecifier proteins. Further, higher VOSC levels were found in autumn red cabbage. By elucidating the impact of abiotic growth factors on the regulation of the hydrolyses, the health value of Brassica vegetables can be improved.

2025-01-01·Propellants, Explosives, Pyrotechnics

Combined Solid‐Phase Extraction of Organic, Organic Peroxide, and Inorganic Explosives for Post‐Blast Residue Analysis

作者: Thomas, Jennifer L. ; Cruse, Courtney A. ; Fowble, Kristen L. ; Tipple, Christopher A. ; Miller, Jason V. ; Sipe, Sarah N. ; Borchers, Amara E. ; Pavone, David C. ; Armas, Stephanie ; Miller, Mark L. ; Mulder, Haley A.

ABSTRACTPost‐blast explosives residue may contain organic and/or inorganic explosives. Current methods employed involve splitting the sample swab in two for syringe extraction for each explosive type (acetone for organics, water for inorganics). A comprehensive solid‐phase extraction (SPE) trace sample clean‐up procedure for the combined recovery of 12 organic, 2 organic peroxide, and 15 inorganic analytes from explosives residue on cotton swabs is demonstrated and validated. By keeping the sample whole and using a single extraction process, the proposed method saves time, provides a more representative sample, and increases the possibility of detecting explosives that might be present on collection swabs. Thus, recoveries are improved for one class of explosives without sacrificing recoveries of another analyte or explosives class in the process. Extractions were demonstrated by syringe filtration and SPE from cotton balls (CBs) and cotton‐tipped applicators (CAs). For SPE of both matrices, organic explosives (nitramines, nitrate esters, nitroalkanes, and nitroaromatics) had a limit of detection (LOD) of 500 ppb or lower, organic peroxides had higher LODs at 5 ppm or lower, and most inorganic anions and cations had LODs at 1 ppm or lower. Application to 32 post‐blast samples, 9 burned powders simulating post‐blast, and 1 pre‐blast sample successfully demonstrated the SPE method with both cotton matrices in a comparison study of the two extraction procedures. SPE resulted in a lower false screen rate (number of compounds that met the screening criteria, but not confirmed present) when compared to syringe extraction.

2025-01-01·Propellants, Explosives, Pyrotechnics

Confirmation of Solid Phase Extracted Post‐Blast Explosives Residues Analyzed Using Pulsed Split Injection GC/MS

作者: Cruse, Courtney A. ; Miller, Mark L. ; Tipple, Christopher A.

AbstractA pulsed split injection method was developed for the improved detection of explosives using gas chromatography with mass spectrometric detection (GC/MS) with negative chemical ionization for 12 organic explosives (nitramines, nitrate esters, nitroalkanes, nitroaromatics) and electron ionization with selected ion monitoring for triacetone triperoxide (TATP). An order of magnitude increase in signal (average factor of 13) was observed for all organic explosives with the utilization of the pulsed split injection for samples processed by solid phase extraction (SPE). The method was successfully applied to post‐blast explosives residue processed by SPE and syringe filtration as a confirmatory technique following gas chromatography with electron capture detection (GC/ECD) screening. Compared to current methodologies previously reported, a decrease in the false screen rate (the number of compounds that passed the screening criteria, but not confirmed present) was achieved when employing this method. Processing of post‐blast explosives samples using SPE decreased the false screen rate from 60% to 34%, while using syringe filtration decreased the false screen rate from 73% to 51%.

100 项与丁四硝酯相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D04051	丁四硝酯	C01DA13	DB01613

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心绞痛	-	-	-
冠心病	-	-	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


equira study (EULAR2018)	临床3期	类风湿关节炎	-	GP2015	(餘鏇願壓淵繭襯艱醖壓) = 範顧淵淵簾繭積艱醖膚鏇選餘鏇衊衊選顧餘淵 (糧窪齋淵艱網鑰憲網憲 ) 更多	-	2018-06-13
				ETN	(餘鏇願壓淵繭襯艱醖壓) = 築壓獵醖簾壓鬱餘齋壓鏇選餘鏇衊衊選顧餘淵 (糧窪齋淵艱網鑰憲網憲 ) 更多
EULAR2017	临床3期	类风湿关节炎 anti-drug antibody (ADA) \| injection site reaction (ISR)	-	SB4	(醖簾觸獵選醖齋簾衊簾) = 夢壓衊衊襯簾鹹獵蓋築鹽觸網願齋遞構選鹹積 (願齋繭醖醖齋壓醖憲構 ) 更多	积极	2017-06-14
				ETN	(醖簾觸獵選醖齋簾衊簾) = 選夢糧鹽憲夢範襯糧構鹽觸網願齋遞構選鹹積 (願齋繭醖醖齋壓醖憲構 ) 更多
EULAR2016	N/A	-	-	TNF + ADA	衊鹹醖簾顧餘繭憲觸憲(鬱獵顧夢顧壓願築衊遞) = 繭鹽鑰網糧鑰遞鏇夢鏇願壓壓廠齋餘糧選鑰積 (鬱餘製獵襯襯構鬱壓衊 )	-	2016-06-08
				TNF + ETN	衊鹹醖簾顧餘繭憲觸憲(鬱獵顧夢顧壓願築衊遞) = 鑰醖餘壓鑰艱顧範衊衊願壓壓廠齋餘糧選鑰積 (鬱餘製獵襯襯構鬱壓衊 )
EULAR2015	临床3期	类风湿关节炎	596	SB4	(鹹選餘膚願鑰簾窪襯蓋) = 鑰觸蓋範選願積築鹹積艱壓觸壓窪壓鹹憲鏇積 (醖觸窪觸廠壓獵觸夢積 ) 更多	积极	2015-06-10
				ETN	(鹹選餘膚願鑰簾窪襯蓋) = 膚膚顧衊積醖艱選鹽範艱壓觸壓窪壓鹹憲鏇積 (醖觸窪觸廠壓獵觸夢積 ) 更多
PRIZE study (EULAR2014)	临床1期	类风湿关节炎	306	ETN+MTX combination therapy	顧廠餘製顧鹽齋願鬱願(窪糧淵範願糧艱築廠選) = 遞鹹憲繭觸廠壓艱築膚繭繭憲廠簾觸願遞齋餘 (襯積糧範鹽糧憲憲糧蓋, 66.1 ~ 92.7) 更多	积极	2014-06-11
EULAR2014	N/A	类风湿关节炎	-	ETN+MTX combination therapy	淵願選襯範蓋襯襯齋鏇(膚糧夢簾構蓋淵鏇夢衊) = 淵餘願蓋積憲壓積壓構憲構顧壓壓餘選鏇獵網 (憲觸壓願獵齋鑰夢遞選 ) 更多	-	2014-06-11
				Triple therapy (MTX+HCQ+SLZ)	淵願選襯範蓋襯襯齋鏇(膚糧夢簾構蓋淵鏇夢衊) = 觸糧遞膚觸餘網獵網鏇憲構顧壓壓餘選鏇獵網 (憲觸壓願獵齋鑰夢遞選 ) 更多
EULAR2009	N/A	类风湿关节炎 \| 肺孢子菌肺炎	-	ETN	壓襯選遞鬱淵簾窪積積(衊壓衊蓋鏇願膚顧網選) = 窪襯憲醖觸壓糧範顧壓糧憲繭製願廠齋築簾醖 (築鑰遞鏇網齋積鏇構蓋 )	积极	2009-06-10
EULAR2008	N/A	类风湿关节炎	-	MTX	(簾簾鹽餘淵齋簾積蓋構) = 鑰艱壓襯蓋壓淵範鬱獵窪製繭選憲醖餘製廠憲 (糧遞願積餘衊顧獵築範 ) 更多	-	2008-06-11
				ETN	構積鑰窪製鬱鏇網夢鹹(衊製餘襯選鑰遞醖選糧) = 獵齋鬱製鏇餘鹹齋窪網淵獵淵構構繭淵廠積糧 (觸築膚範範願廠製鑰鬱 ) 更多
EULAR2006	临床3期	-	-	ETN plus NSAIDs	繭淵觸鑰遞艱窪構膚鏇(鬱鹽餘繭齋鑰製廠窪觸) = 襯憲鏇遞網顧艱醖壓膚醖糧鬱淵簾繭選窪壓艱 (範衊構醖鹽鬱糧積簾顧 )	-	2006-06-21
EULAR2005	N/A	类风湿关节炎	-	Methotrexate (MTX)	(觸獵願簾夢襯獵壓鏇鑰) = 範蓋艱憲夢鏇鹹襯願艱觸醖構構餘遞鬱願鹽壓 (衊壓襯醖淵壓顧廠廠淵 ) 更多	-	2005-06-08
				Etanercept (ETN)	(觸獵願簾夢襯獵壓鏇鑰) = 製製築選憲餘蓋襯夢鑰觸醖構構餘遞鬱願鹽壓 (衊壓襯醖淵壓顧廠廠淵 ) 更多