预约演示
更新于：2025-02-07
Dexketoprofen Trometamol
右酮洛芬氨丁三醇
更新于：2025-02-07
概要
基本信息
原研机构 |
在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H14O3 |
InChIKeyDKYWVDODHFEZIM-NSHDSACASA-N |
CAS号22161-81-5 |
关联
74
项与 右酮洛芬氨丁三醇 相关的临床试验CTR20244396
一项评估右酮洛芬氨丁三醇注射液在健康成年受试者中单、多次静脉滴注的药代动力学特征及安全性、耐受性的I期临床研究
NCT05176158
Efficacy of Dexketoprofen Prescribed According to the Circadian Rhythms
ChiCTR2400087079
Effect of sufentanil combined with dexketoprofen tromethamine in postoperative patient-controlled intravenous analgesia in patients undergoing thoracoscopic surgery
100 项与 右酮洛芬氨丁三醇 相关的临床结果
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100 项与 右酮洛芬氨丁三醇 相关的转化医学
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100 项与 右酮洛芬氨丁三醇 相关的专利（医药）
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1,280
项与 右酮洛芬氨丁三醇 相关的文献（医药）2025-01-01JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Optimizing analgesia for endometrial biopsy: A prospective, randomized comparative study
Article
作者: Coskun, Enes Serhat ; Bacak, Havva Betul ; Salman, Suleyman ; Yeniocak, Ali Selcuk
Abstract:
Aim:
This prospective, randomized, observational study aimed to compare the efficacy of intrauterine lidocaine, oral dexketoprofen, cervical lidocaine spray, and paracervical block with prilocaine for pain management during outpatient endometrial biopsy (EMB).
Methods:
One hundred ninety‐seven women aged 18–75 undergoing EMB were randomly assigned to one of four groups: intrauterine lidocaine (n = 49), oral dexketoprofen (n = 48), cervical lidocaine spray (n = 50), or paracervical block with prilocaine (n = 50). Pain intensity was assessed using a visual analog scale (VAS) immediately post‐procedure and at 30 min, with additional analgesia needs recorded at 60 min. Statistical analyses included Kruskal–Wallis, chi‐square tests, and post hoc analysis.
Results:
The intrauterine lidocaine group had the lowest pain scores, while oral dexketoprofen had the highest (p < 0.001). Intrauterine lidocaine and paracervical block scores were significantly lower than those in the lidocaine spray and dexketoprofen groups (p < 0.001). Additional analgesia was needed in 30% of the lidocaine spray group, with none required in other groups. Severe pain (VAS ≥5.8) was more frequent in the dexketoprofen group compared to others (p < 0.001).
Conclusion:
Intrauterine lidocaine and paracervical block are more effective than lidocaine spray and oral dexketoprofen in reducing procedural pain during EMB, highlighting the importance of appropriate analgesic selection to enhance patient comfort in office‐based gynecological procedures.
2024-12-01TALANTA
Facile synthesis of a new chiral polyimine macrocycle and its application for enantioseparation in high-performance liquid chromatography
Article
作者: Yuan, Li-Ming ; Xie, Sheng-Ming ; Wang, Bang-Jin ; Zhang, You-Ping ; Zhang, Jun-Hui ; Yu, Li-Qin ; Chen, Juan
Macrocyclic compounds such as crown ethers and cyclodextrins play an important role in the field of chromatography and show excellent separation performance. The design of simple and convenient methods for the efficient synthesis of novel chiral macrocycles for chromatographic separation is of great significance. In this work, a novel chiral polyimine macrocycle (PIMC) was designed and synthesized by the simply one-step reaction of 2,6-diformyl-4-tert-butylphenol with (S)-(-)-1,2-propanediamine. Then, it was bonded onto silica by the thiol-ene click reaction to construct a new chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC). The chiral separation performance of the proposed CSP was examined by separating various racemates in the normal-phase (NP) and reversed-phase (RP) HPLC. In total, twelve and nine racemates, including ethers, esters, amines, alcohols, organic acids, ketones, and epoxides, were separated to varying degrees via NP-HPLC and RP-HPLC, respectively, Moreover, the CSP offered good chiral separation complementarity to Chiralcel OD-H and Chiralpak AD-H columns for resolution of these test racemates, and it can separate several racemic compounds that either cannot be separated or cannot be separated well be separated by the two commercially available columns. After the column was used for hundreds of injections, the relative standard deviations of the retention time and resolution were below 0.56 % and 0.45 %, respectively, showing the good reproducibility and stability of the CSP. This study provides a simple and convenient approach to synthesize a novel chiral macrocycle and CSP and also indicates the broad application prospects of such chiral PIMCs in HPLC chiral separation.
2024-12-01BIOMEDICAL CHROMATOGRAPHY
LC enantioseparation of active pharmaceutical ingredients using rationally synthesized CDRs and chiral molecules with high molar absorptivity
Review
作者: Bhushan, Ravi ; Sethi, Sonika
Abstract:
The synthesis of optically active compounds requires determination of ee, er, and enantiomeric purity. The aim of the present paper is to review the synthesis of several chiral derivatizing reagents (CDRs) in a rational manner, which were successful for the separation and isolation of enantiomers of a variety of active pharmaceutical ingredients and other important and useful racemates. Besides, the application of (i) certain enantiomerically pure amines, either directly or by incorporating each of them as chiral auxiliary in difluorodinitrobenzene or cyanuric chloride moieties to construct the CDR, (ii) (S)‐ketoprofen and (S)‐levofloxacin as chiral platforms, and (iii) a few isothiocyanates, have been suitably included. Attention is drawn to the use of water micellar mobile phase as the “green” RP‐HPLC method and the use of simple achiral derivatization with ninhydrin, particularly. Synthesis of CDRs and their application for enantioseparation of racemates and detagging of certain chromophoric reagent components for obtaining native enantiomers are other interesting features included herein. The methods can be easily used to determine and control enantiomeric purity with advantages over a variety of commercial chiral phases. This comprehensive review not only highlights innovative methodologies for enantioseparation but also underscores their practical applications in controlling and ensuring the enantiomeric purity of pharmaceutical compounds.
100 项与 右酮洛芬氨丁三醇 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 术后疼痛 | 中国 | 2023-05-29 | |
| 偏头痛 | 中国 | 2006-10-27 | |
| 疼痛 | 中国 | 2006-10-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性疼痛 | 临床3期 | 中国 | 2023-11-02 | |
| 绞痛 | 临床3期 | 中国 | 2018-12-27 | |
| 腰痛 | 临床3期 | 中国 | 2018-12-27 | |
| 镇痛 | 临床3期 | 中国 | 2015-10-16 | |
| 中度疼痛 | 临床3期 | 中国 | 2015-10-16 | |
| 重度疼痛 | 临床3期 | 中国 | 2015-10-16 | |
| 背痛 | 临床3期 | 中国 | 2015-07-15 | |
| 肾绞痛 | 临床3期 | 中国 | 2015-07-15 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | - | - | Dexketoprofen 25 mg/Vitamin B (Thiamine 100 mg, Pyridoxine 50 mg, Cyanocobalamin 0.50 mg) FDC | 蓋鹽窪夢鹹簾鹽廠膚廠(憲鹹製窪積顧膚糧糧鹹) = 廠選襯衊構構遞簾願窪 醖鏇壓構獵襯膚繭製築 (製廠鬱鹽衊蓋願淵夢壓, 2.5 ~ 10.5) | 积极 | 2024-06-01 | |
蓋鹽窪夢鹹簾鹽廠膚廠(憲鹹製窪積顧膚糧糧鹹) = 範憲願蓋構鹽遞廠糧鬱 醖鏇壓構獵襯膚繭製築 (製廠鬱鹽衊蓋願淵夢壓, 5.0 ~ 13.8) | |||||||
N/A | 1,038 | Arylpropionic acids | 艱鹹夢構襯顧窪遞鬱憲(願壓艱壓襯壓鑰淵淵鬱) = 淵願築糧鬱觸廠糧選鹽 夢願廠繭窪糧醖膚獵鬱 (衊鬱壓艱蓋鏇廠簾襯鏇 ) | - | 2018-02-01 | ||
临床3期 | 641 | 簾夢選積壓鹽齋簾憲淵(獵築鹽襯願憲齋淵鏇選): P-Value = 0.019 | 积极 | 2016-02-01 | |||
临床4期 | 224 | (Dexketoprofen) | 膚遞淵糧繭窪廠鹽構鹽(齋襯繭膚構齋構鬱餘廠) = 鹽繭積製構廠憲衊網艱 範築蓋壓選遞觸廠鑰襯 (網鏇廠餘製構餘糧襯蓋, 膚構醖夢遞製鹹遞觸遞 ~ 鏇夢窪醖鬱鹽鑰範襯膚) 更多 | - | 2015-07-23 | ||
(Normal Slaline) | 膚遞淵糧繭窪廠鹽構鹽(齋襯繭膚構齋構鬱餘廠) = 網淵製醖繭網築廠範襯 範築蓋壓選遞觸廠鑰襯 (網鏇廠餘製構餘糧襯蓋, 鬱觸構夢鬱壓顧襯鬱蓋 ~ 膚網壓網憲選廠鹹窪構) 更多 | ||||||
临床1期 | 26 | (Enantyum® Oral Solution) | 製選範膚憲夢廠鑰衊獵(餘醖廠鹽艱遞遞鹹鬱衊) = 夢遞鑰築構製築鏇淵顧 餘鑰繭襯襯願壓範蓋獵 (構壓壓鹽淵壓艱憲觸鹽, 顧壓鑰願獵壓獵壓鬱憲 ~ 衊構齋鹽憲膚艱糧獵鑰) 更多 | - | 2015-07-09 | ||
(Keral® Tablet) | 製選範膚憲夢廠鑰衊獵(餘醖廠鹽艱遞遞鹹鬱衊) = 範醖夢觸糧鏇鹹鏇網膚 餘鑰繭襯襯願壓範蓋獵 (構壓壓鹽淵壓艱憲觸鹽, 鹽糧鏇選顧鑰壓積鹽積 ~ 選網鏇鏇憲築網鏇築築) 更多 |
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