预约演示
更新于：2025-08-12
Phytonadione
维生素K1
更新于：2025-08-12
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1955-09-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C31H46O2 |
InChIKeyMBWXNTAXLNYFJB-NKFFZRIASA-N |
CAS号84-80-0 |
关联
169
项与 维生素K1 相关的临床试验CTR20252350
维生素K1注射液人体生物等效性研究（口服给药）
CTR20251738
健康成年参与者空腹状态下口服维生素K1注射液的单中心、随机、开放、单剂量、两周期、两序列、交叉生物等效性试验
NCT06385275
The Role of Vitamin K on Knee Osteoarthritis Outcomes
100 项与 维生素K1 相关的临床结果
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100 项与 维生素K1 相关的转化医学
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100 项与 维生素K1 相关的专利（医药）
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10,571
项与 维生素K1 相关的文献（医药）2025-12-31ANNALS OF MEDICINE
The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review
Review
作者: Cao, Wenhai ; Zhu, Yue ; Li, Hongyang ; Tao, Lin
PURPOSE:
The purpose of this review is to discuss the role of fat-soluble vitamins in bone metabolism and explore whether there is a relationship between each fat-soluble vitamins in the occurrence and development of osteoporosis.
METHODS:
We selected several databases, including PubMed, PubMed Central (PMC), Embase, and Web of Science, as the primary sources for the search. Keywords closely related to the subject of this study, such as 'osteoporosis', 'vitamin A', 'vitamin D', 'vitamin E', 'Vitamin K', 'ferroptosis', 'osteoblast' and 'osteoclast', were used in the search. The search deadline is April 20, 2025. All included clinical studies were graded for critical analysis GRADE.
RESULTS:
Among 573 reviewed articles, 182 were included (52 met GRADE criteria: A=10, B=26, C=11, D=5; 130 N/A). Vitamins D and K enhance osteoblast differentiation via RUNX2/ALP upregulation. Vitamin A's bone effects remain debated, potentially interacting with vitamin D. Vitamins E and K may jointly regulate bone metabolism as ferroptosis inhibitors.
CONCLUSION:
i Fat-soluble vitamins (D, K, E) may positively impact bone mineral density (BMD), while vitamin A's effects remain controversial, potentially harming BMD at high doses. Current single-vitamin studies have limitations; future research should explore combined vitamin interactions to advance osteoporosis diagnosis and treatment.
2025-12-31Gut Microbes
Exclusive breastfeeding is associated with the gut microbiome maturation in infants according to delivery mode
Article
作者: Polanczyk, Guilherme V. ; Fujita, André ; Pereira-Santos, Davi ; Passos-Bueno, Maria Rita ; Campos, Alline C. ; Carvalho, André C. P. L. F. ; Klepac-Ceraj, Vanja ; Valim, Tamires Amabili ; Schüroff, Paulo A. ; Bonham, Kevin S. ; Naspolini, Nathalia F. ; Vanzele, Pedro A. R. ; Beltrão-Braga, Patricia C. B. ; Taddei, Carla R.
Exclusive breastfeeding (EBF) plays a crucial role in infant gut microbiome assembly and development. However, few studies have investigated the effects of EBF in restoring a perturbed microbiome. In this study, we applied whole metagenomic sequencing to assess the gut microbiome assembly in 525 Brazilian infants from 3 to 9 months of age of the Germina Cohort, demonstrating the early determinants of microbial taxonomy and function modulation. Our analysis shows that EBF alters the relative abundance of genes related to the microbiome taxonomy and function, with effects varying by delivery mode. EBF alters the pattern of carbohydrates, lipid metabolism, and cell structure pathways depending on the delivery mode. The microbiome age is closer to chronological infant age in EBF than in non-EBF infants, meaning a lower microbiome maturation index (MMI). Using a complementary machine learning approach, we show that Escherichia coli, Ruminococcus gnavus, and Clostridium neonatale, as well as vitamin K and o-antigen pathways contribute strongly to EBF prediction. Moreover, EBF influences the microbiome maturation in early life, toward a microbiome age more similar to the chronological infant's age.
2025-12-31Toxicology communications
Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum
Article
作者: Ahmad, Intakhar ; Feferman, Leonid ; Rayala, Ramanjaneyulu ; van Breemen, Richard B. ; Lindeblad, Matthew ; Naqib, Ankur ; Rocha, Jackie ; McDonald, Zachary ; Feinstein, Douglas L. ; Rubinstein, Israel ; Chen, Hui ; Chlipala, George E. ; Kalinin, Sergey ; Green, Stefan J. ; Tandon, Ankit
Long-acting anti-coagulant rodenticides (LAARs) are well characterized with respect to inhibition of vitamin K1 synthesis and effects on blood coagulation. However, the effects of LAARs on the microbiome have not been explored. We administered brodifacoum (BDF), one of the more potent LAARs, to adult male New Zealand White rabbits, and carried out 16S RNA sequencing on cecal samples collected after different times. Samples were also obtained from rabbits treated with the bile sequestrant cholestyramine (CSA) which accelerates BDF clearance from the body, and from CSA-only treated rabbits. Changes at both the phylum and genus levels in relative abundance were observed after 2- and 3-days exposure to BDF. The majority of those microbiota changes were prevented by co-treatment with CSA. Identification of metabolic pathways potentially altered by BDF using Picrust2 identified several L-arginine-related pathways. Exposure to BDF caused increases in plasma L-arginine concentration as well as nitrites, suggesting increased activity of nitric oxide synthase. We also observed increases due to BDF in plasma concentrations of L-arginine-related molecules including L-citrulline, L-ornithine, and methylated L-arginines. These results demonstrate that LAAR poisoning can induce microbiome dysbiosis and influence metabolic pathways and metabolites involved in inflammation and vasodilation.
100 项与 维生素K1 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 维生素K缺乏症 | 日本 | 1962-03-31 | |
| 低凝血酶原血症 | 美国 | 1955-09-30 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 凝血障碍 | 申请上市 | 加拿大 | 2021-06-17 | |
| 骨质疏松症 | 临床3期 | 美国 | 2000-09-01 | |
| 维生素K缺乏性出血 | 临床1期 | 中国 | 2023-07-28 | |
| 皮疹 | 临床前 | 意大利 | 2011-05-20 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 59 | 窪糧積簾廠繭醖衊糧鹽(淵鹽網範獵憲壓範壓觸) = 夢蓋鏇簾觸遞願鏇鑰獵 鹹醖蓋鹽醖獵壓製遞願 (鬱製製鹹夢鹽糧願鹹蓋, 0.6) 更多 | - | 2016-05-30 | |||
N/A | - | Vitamin K1 supplement | 廠築積選窪糧製廠膚鹹(糧構積衊醖選衊夢蓋遞) = 製膚繭廠範醖淵願積膚 衊齋餘鏇網鑰蓋製製構 (鬱膚積繭範繭壓齋餘範 ) 更多 | - | 2015-08-01 | ||
(Placebo) | 廠築積選窪糧製廠膚鹹(糧構積衊醖選衊夢蓋遞) = 獵遞觸夢築糧獵願願襯 衊齋餘鏇網鑰蓋製製構 (鬱膚積繭範繭壓齋餘範 ) 更多 | ||||||
N/A | 16 | 鑰艱壓顧鹹積繭鏇膚艱(鹹艱醖顧鏇蓋襯鑰鬱餘) = 選遞壓觸夢齋蓋範廠齋 顧壓觸遞簾糧糧鹽廠淵 (糧範鏇齋鏇糧獵襯願獵, 0.68) 更多 | - | 2012-12-04 | |||
临床3期 | - | 鬱鏇顧襯憲構醖壓醖壓(餘淵觸廠範構簾廠衊遞) = 鏇艱鹽膚構鑰製鏇衊築 構夢製鬱齋壓遞構製鏇 (範鑰糧網鹽餘簾範餘顧 ) | - | 2010-12-01 | |||
Placebo | 鬱鏇顧襯憲構醖壓醖壓(餘淵觸廠範構簾廠衊遞) = 觸襯願鹹製鏇製餘鬱遞 構夢製鬱齋壓遞構製鏇 (範鑰糧網鹽餘簾範餘顧 ) | ||||||
N/A | 120 | 襯壓製構齋簾膚窪遞願(艱網壓襯網鏇醖夢窪憲) = 艱築範繭衊糧選鹽積顧 繭鹹網築構顧憲鏇築艱 (鹽選選選糧選鏇憲糧獵 ) | - | 2010-05-20 |
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