In the Emergency Department, there is no standard of care for pain medication distribution for children with an acute musculoskeletal injury when there is no fracture present. Currently, ibuprofen is a favorable choice for the treatment, but studies have shown concern for delayed healing activity associated with NSAIDs like Ibuprofen. Homeopathic Arnica Montana is a well-established complimentary medicine and may provide a good alternative for managing acute pain from musculoskeletal injuries, especially in children, given the palatability and rarity of side effects. This study aims to compare usual care vs. usual care plus Arnica 1M* (oral) or the placebo for management of pain in acute musculoskeletal extremity injuries without fracture by utilizing a double-blind clinical trial design. The primary outcome is to determine if subjects use less ibuprofen when given Arnica 1M.

开始日期2021-07-15

申办/合作机构-

NCT04677712 / Completed临床4期

MOBI: A Phase 4, Open-Label Study to Assess Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite in Adult Females

This study will investigate treatments that may mitigate bruising after QWO™ (Collagenase clostridium histolyticum [CCH]-aaes) treatment of cellulite in the buttocks.

开始日期2020-12-28

申办/合作机构

Endo Pharmaceuticals, Inc.

[+4]

NCT04534426 / Completed临床4期IIT

Influence of Different Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus After Extraction of Impacted Third Molar

The present study was to evaluate the effect of topical Arnica and MPSP application with respect to visual analogue scale (VAS) scores, maximal interincisal opening (MIO) and edema values after mandibular impacted third molar removal on days 1, 3, 5 and 10 postoperatively. The following null hypotheses of the present research were determined as follows: usage of topical agents would not influence i) VAS scores, ii) MIO values, and iii) edema values on 1st, 3rd, 5th, and 10th days after the mandibular impacted third molar surgery

开始日期2018-12-01

申办/合作机构

Abant Izzet Baysal University

100 项与山金车提取物相关的临床结果

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100 项与山金车提取物相关的转化医学

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100 项与山金车提取物相关的专利（医药）

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项与山金车提取物相关的文献（医药）

2024-01-01·Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Can Topical Agents (Arnica and Mucopolysaccharide Polysulfate) Reduce Postoperative Pain, Edema and Trismus Following Mandibular Third Molar Surgery?

Article

作者: Akay, Neşet ; Şanal, Koray Onur

BACKGROUND:

Postoperative supplemental maintenance following mandibular third molar surgery remains an area of interest.

PURPOSE:

Topical agents can modulate inflammatory processes. The aim of the present study was to determine if topical application of arnica or mucopolysaccharide polysulfate (MPSP) reduces pain, trismus, and edema following the removal of impacted mandibular third molars.

MATERIALS AND METHODS:

A single center randomized controlled clinical trial was conducted. The patients were randomized into three groups: the control group (standard therapy [ST]: antibiotic + nonsteroidal anti-inflammatory drugs twice a day), the arnica group (arnica + ST), and the MPSP group (MPSP + ST). The patients' pain, trismus, and edema values were measured preoperatively and on postoperative days 1, 3, 5, and 10. Sex, age, and operation time were also included. Analyses included descriptive statistics, analysis of variance, post hoc tests, and determinations of intraclass correlation coefficients. Statistical significance was set at P < .05.

RESULTS:

Sixty patients with a mean age of 26.98 ± 10.88 years were included in the study; 55% were females and 45% were males. The mean operation time was 23.8 ± 3.27 minutes. According to the visual analogue scale scores (in centimeter units), the arnica and MPSP groups felt less pain than the control group until day 5 (0.6 ± 0.88, 3.75 ± 1.16, 4.75 ± 1.29, and 1.05 ± 1.10, respectively, for the arnica group; 0.35 ± 0.59, 3.25 ± 1.62, 5.0 ± 1.65, and 1.50 ± 1.32 for the MPSP group; and 1.30 ± 1.17, 5.75 ± 1.37, 7.05 ± 1.10, and 3.15 ± 1.53 for the control group; P < .05). The trismus was lower on days 1, 3, and 5 in the arnica group (-8.05 ± 2.82, -12.15 ± 3.1, and -2.15 ± 1.81, respectively) than in the control group (-12 ± 3.82, -15.65 ± 4.81, and -4±2.81, respectively) (P < .05). The edema was lower on days 1 and 3 in the MPSP group (0.95 ± 2.2 and 1.75 ± 3.7, respectively) than in the control group (2.45 ± 0.9 and 3.6 ± 0.8, respectively) (P < .05). Arnica and MPSP had similar pain-relieving action, but arnica was more effective at reducing trismus, while MPSP was more effective at reducing edema.

CONCLUSIONS:

Topical application of arnica or MPSP may have a beneficial effect on relieving pain 5 days after surgery, but arnica was also effective at reducing trismus, while MPSP was also effective at reducing edema. Both arnica and MPSP reduced postoperative sequelae.

2023-04-01·Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Cellulite: Clinical Challenges and Future Perspectives.

Review

作者: Khalifian, Saami ; Bass, Lawrence S ; Moradi, Amir ; Shridharani, Sachin M ; Petraki, Chrysi ; LaTowsky, Brenda

BACKGROUND:

Existing cellulite interventions pose various clinical challenges related mostly to ecchymosis and recovery time.

OBJECTIVE:

To discuss the current treatment options for minimizing recovery time, efficacy of these options, and investigations into possible future approaches.

METHODS:

A roundtable meeting was convened to discuss and share views on the clinical challenges seen in the present practice of cellulite treatments along with future approaches and mitigation strategies. The participants' views helped guide a narrative review on this topic.

RESULTS:

Cosmetic clinicians have a range of new interventions to choose from for cellulite improvement, each with different benefits and safety aspects. Bruising is a typical side effect that is seen with treatments targeting the fibrous septa, such as subcision and injectable treatments, and in some cases may produce long-lasting hyperpigmentation from postinflammatory hyperpigmentation or hemosiderin staining. Various strategies that could potentially mitigate bruising and other adverse effects of cellulite treatment are under clinical investigation, including, but not limited to, different injection techniques and dilutions, compression garments, cold packs, arnica gel, pulsed dye laser treatment, intralesional epinephrine, and tranexamic acid.

CONCLUSION:

Clinical challenges including varying treatment outcomes and certain treatment sequelae remain, and further research is needed to prevent side effects and improve treatment outcomes.

2022-06-30·International journal of clinical pediatric dentistry

Comparison of the Efficacy of Homeopathic Drug Arnica and Ibuprofen on Postextraction Pain in Children: A Triple-blind Randomized Controlled Trial

Article

作者: Thakur, Jagruti H ; Katre, Amar N

Aim:

To compare the homeopathic drug Arnica with ibuprofen as an analgesic for postextraction pain control in children.

Materials and methods:

Forty-four healthy children between 8 and 12 years of age requiring two clinical sessions of tooth extraction in two different quadrants of the oral cavity were selected for the study. All the children received both the drugs in this crossover trial with a washout of 10 days. Patient-rated and operator-assessed pain was compared to a 10-point validated Visual Analog Scale at baseline, 24, 48, and 72 hours using the paired t-test. Acceptance to taste and frequency of dosing was recorded at the end of three days using a five-point Likert scale and were compared using the Chi-squared test. Kappa statistics were performed to assess intraoperator variability.

Results:

Pain reduction by Ibuprofen was significantly more than Arnica only at 48 hours with respect to both patient-reported and operator-assessed pain [(t = 3.567, p < 0.05), (t = 2.834, p < 0.05)]. As the age of the child increased, patient-reported pain significantly decreased. Children preferred the taste of Arnica over that of Ibuprofen (x ² = 56.76, p < 0.0001).

Conclusion:

There was no difference between Arnica and Ibuprofen in the postextraction pain management in 8-12-year-old children.

Clinical significance:

The results of this study suggest that Arnica may be considered as an alternative to ibuprofen in managing postextraction pain in 8-12-year-old children, especially those with asthma, COPD, or known allergy to ibuprofen.

How to cite this article:

Thakur JH, Katre AN. Comparison of the Efficacy of Homeopathic Drug Arnica and Ibuprofen on Postextraction Pain in Children: A Triple-blind Randomized Controlled Trial. Int J Clin Pediatr Dent 2022;15(3):332-337.

项与山金车提取物相关的新闻（医药）

2022-07-18

·PRNewswire

Taking 'Everybody Deserves A Massage Week' to the Next Level

River Organics, the USDA Certified Organic CBD Company Celebrates National Wellness Week– GLOUCESTER, Va., July 18, 2022 /PRNewswire/ -- River Organics knows better than anyone about the benefits that relief and relaxation can have on the body. This year, River Organics is spreading the word by encouraging everyone to take part in "Everybody Deserves A Massage Week". Continue Reading River Organics, USDA Certified Organic CBD Company, Celebrate National Wellness Week The observed week takes place July 17th through July 23rd and spreads awareness of the many health benefits of massage therapy, including stress relief, sleep improvement, muscle relaxation, pain reduction and more. River Organics strives to educate and motivate massage enthusiasts to receive top-of-the-line experiences, and that's why they have developed a high-quality collection of CBD massage oils. River Organics' massage oils feature hand-seeded and harvested, full-spectrum CBD. Their original massage oil is available in two sizes: a 2oz 600 mg bottle or a 4oz 1,200 mg bottle. In addition to their massage oil, River Organics has introduced their "magic oil" - Extra Strength Pain Relief Oil with Arnica (ESPRO). ESPRO contains a whopping 1500 mg of CBD per ounce, alongside Arnica, an herb also known to decrease inflammation and pain. Adrianne Ryder-Cook Joseph, Founder, and CEO of River Organics says, "CBD is a powerful holistic remedy offering a host of benefits to boost health and wellness. Having a massage with our CBD massage oil and using our ESPRO on those hard-to-release trigger points takes the massage experience to another level. You will float off the table." To celebrate the week, River Organics is offering 30% off their massage and pain relief oils on riverorganics.com. To learn more about River Organics and the benefits of CBD massage oils, visit riverorganics.com/blog/news. Start your CBD journey by following River Organics on Instagram at @riverorganics_. Media contact: Kayla Perez [email protected] 212.777.2220 SOURCE River Organics

100 项与山金车提取物相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
疼痛	临床3期	美国	Children's Health Care	2021-07-15

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04677712 (CTgov)	临床4期	皮肤疾病 \| 挫伤 \| 脂肪团	48	CCH-aaes (Cohort 1: CCH-aaes)	築糧艱餘構積積蓋鏇醖(襯繭鹽糧膚壓繭範憲壓) = 憲構顧顧網顧衊衊範顧窪膚簾餘積衊廠窪憲顧 (範壓選壓廠鹽壓鏇鹹遞, 觸獵製壓遞製糧範鏇選 ~ 艱憲鑰獵艱憲願襯積網) 更多	-	2023-08-21
NCT04677712 (CTgov)	临床4期	皮肤疾病 \| 挫伤 \| 脂肪团	48	Compression (Cohort 2: CCH-aaes + Compression Garment)	築糧艱餘構積積蓋鏇醖(襯繭鹽糧膚壓繭範憲壓) = 鹹憲夢淵築構齋齋觸鑰窪膚簾餘積衊廠窪憲顧 (範壓選壓廠鹽壓鏇鹹遞, 餘遞網繭夢糧繭簾壓鹹 ~ 艱繭窪選窪壓積獵簾鏇) 更多	-	2023-08-21
NCT00363038 (CTgov)	N/A	挫伤 \| 瘀斑	16	vitamin K+arnica	膚醖膚鏇願憲遞膚壓糧(鹽積窪壓蓋構襯鏇醖範) = 顧艱夢鏇網醖繭淵製遞鹹範襯鏇憲鏇製獵顧鏇 (鏇鏇築糧鑰餘遞顧網遞, 憲網製夢襯衊構獵壓廠 ~ 繭齋網壓範餘鏇鏇膚築) 更多	-	2012-12-04