肾上腺素/盐酸利多卡因(Epinephrine/Lidocaine Hydrochloride) - 药物靶点：SCNA x adrenergic receptor_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

EPINEPHRINE BITARTRATE/LIDOCAINE HYDROCHLORIDE、Iontocaine、Lidocaton

+ [3]

靶点

SCNA x adrenergic receptor

作用方式

阻滞剂、激动剂

作用机制

SCNA阻滞剂(钠通道α亚基家族阻滞剂)、adrenergic receptor激动剂(肾上腺素能受体家族激动剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

Fresenius Kabi USA LLCHakusui Trading Co. Ltd.

Nipro Corp.

+ [1]

非在研机构

Vyteris, Inc.

Dentsply Sirona, Inc.

Empi, Inc.

最高研发阶段批准上市

首次获批日期

美国 (1948-11-19),

麻醉

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C14H23ClN2O

InChIKeyIYBQHJMYDGVZRY-UHFFFAOYSA-N

CAS号73-78-9

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关联

30

项与肾上腺素/盐酸利多卡因相关的临床试验

NCT06694714

/ Recruiting临床4期IIT

Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery - Fourth Arm

This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. The investigators will investigate the role of anesthetic volume on the duration of action at highly vascular sites.

开始日期2025-01-21

申办/合作机构

Weill Medical College of Cornell University

IRCT20231030059908N5

/ Completed临床3期IIT

Evaluation of mean score of edema and ecchymosis after rhinoplasty by injection of local anesthetic with triamcinolone lidocaine adrenaline solution in comparison with lidocaine adrenaline solution.

开始日期2024-09-15

申办/合作机构-

NCT06379490

/ Recruiting临床3期IIT

Effect of Ultrasound-guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures - A Randomized Controlled Non-inferiority Trial

To investigate the feasibility of the lateral infraclavicular plexus brachialis (LIC) block for acute closed reduction of distal radius fractures, the investigators will compare the pain-relieving and muscle-relaxing properties of the LIC block with short- and long-acting local anesthetics in different concentrations but at the same volume. In addition to motor and sensory blockade during repositioning, feasibility will also be assessed by other patient-related and block-related factors, as well as by factors related to the repositioning and plastering procedure.

开始日期2024-04-23

申办/合作机构-

100 项与肾上腺素/盐酸利多卡因相关的临床结果

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100 项与肾上腺素/盐酸利多卡因相关的转化医学

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100 项与肾上腺素/盐酸利多卡因相关的专利（医药）

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7

项与肾上腺素/盐酸利多卡因相关的文献（医药）

2022-02-01·Hand Surgery and Rehabilitation4区 · 医学

Benefits of WALANT in palliative upper limb surgery after nerve injury

4区 · 医学

Article

作者: Dukan, R ; Masmejean, E H ; Gregory, T ; Coudane, H

Wide-Awake Local Anesthesia No Tourniquet (WALANT) may be a satisfactory anesthesia alternative for the management of upper limb peripheral nerve palsy sequelae. The main advantages are the possibility of active patient cooperation through intraoperative active mobilization, comfort and cost reduction. The legislation about WALANT in France remains unclear; the modalities of lidocaine epinephrine injection should be redefined. For palliative upper limb surgery, WALANT allows the surgeon to adjust the tension on the tendon transfer intraoperatively. Level 1 studies are needed to evaluate the effectiveness of WALANT relative to standard anesthesia techniques (regional/general anesthesia).

2020-09-24·NeuroRehabilitation4区 · 医学

Effect of lidocaine iontophoresis combined with exercise intervention on gait and spasticity in children with spastic hemiplegic cerebral palsy: A randomized controlled trial

4区 · 医学

Article

作者: Salem, Yasser T. ; Hegazy, Fatma A. ; Aboelnasr, Emad A.

BACKGROUND: Gait deviations and spasticity are common impairments seen in children with cerebral palsy (CP) and may interfere with functional performance and effective walking pattern. Lidocaine iontophoresis is effective for reducing muscle spasticity in adults. PURPOSE: To investigate the effect of lidocaine epinephrine iontophoresis combined with exercises on gait and spasticity in children with spastic hemiplegic cerebral palsy (HCP). METHODS: Thirty children with spastic HCP aged 4–6 (5.20±0.32) years were randomly assigned to the experimental group (n = 15) and control group (n = 15). Children in both groups received one hour of exercises, three times a week for three months. Children in the experimental group received 2% lidocaine iontophoresis immediately before the exercises. The lidocaine iontophoresis was delivered for 20 minutes (1mA/min). Spatio-temporal gait parameters were assessed within one week before and after the intervention using 3D motion analysis. Surface electromyography was used to assess muscle tone using H/M ratio of the soleus muscle. ANOVA was used to investigate the differences between experimental and control groups. Statistical significance was set at P value less than 0.05. RESULTS: There was no difference between groups at baseline. Post-intervention, the experimental group showed significant improvements when compared to the control group for gait speed (p = 0.03), stride length (p = 0.04), cadence (p = 0.0001), cycle time (p = 0.0001), and H/M ratio (p = 0.02). CONCLUSION: Lidocaine iontophoresis combined with exercises was effective in improving gait spatiotemporal parameters and reducing spasticity in children with CP.

1990-09-01·Journal of Periodontology2区 · 医学

Effects of Anesthetics Containing Epinephrine on Catecholamine Levels During Periodontal Surgery

2区 · 医学

Article

作者: Concetta F. Bonura ; Robert E. Davenport ; Paul N. Baer ; Vincent J. Iacono ; George I. Mallis ; Robert J. Porcelli

Nine stable cardiovascular disease patients were evaluated in a double‐blind crossover trial during periodontal surgery using 2% lidocaine with epinephrine 1:100,000 or lidocaine alone. In the lidocaine with epinephrine group, epinephrine levels increased from 198 ±54 pg/ml to 592±166 pg/ml at 2 minutes post‐injection. In the lidocaine alone group, epinephrine levels increased from a baseline of 115±34 pg/ml to 150±34 pg/ml at 2 minutes post‐injection. Despite these elevations in epinephrine, no significant changes in heart rate or mean arterial pressure were noted. Plain lidocaine provided unsatisfactory levels of hemostasis and/or anesthesia during periodontal surgery. This study documents acute elevations in plasma epinephrine levels following local dental anesthesia for periodontal surgery. These elevations in plasma epinephrine failed to produce a significant cardiovascular response in a group of stable cardiovascular disease patients. This suggests that the cardiac effects of local anesthetics containing epinephrine are small and that they can be safely used in stable cardiovascular disease patients. J Periodontol 1990; 61:553–558.

100 项与肾上腺素/盐酸利多卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	肾上腺素/盐酸利多卡因	N01BB52 S01EA51	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	美国	Fresenius Kabi USA LLC	1948-11-19

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01981772 (CTgov)	N/A	肿胀	88	4% buffered lidocaine (Buffered Lidocaine)	壓襯構鬱衊壓鹽壓選廠(餘製獵鏇糧鹹鬱夢構壓) = 遞願廠構積願蓋艱獵憲襯醖遞衊製鹽製網鑰襯 (廠鬱艱壓憲鑰蓋齋齋壓, 膚糧艱鏇襯鹹窪構簾製 ~ 顧選願積夢遞願範壓鏇) 更多	-	2020-10-12
				1:100,000 epinephrine+4% lidocaine (Nonbuffered Lidocaine)	壓襯構鬱衊壓鹽壓選廠(餘製獵鏇糧鹹鬱夢構壓) = 觸製鹹獵餘積顧膚蓋積襯醖遞衊製鹽製網鑰襯 (廠鬱艱壓憲鑰蓋齋齋壓, 鹽鹹齋蓋鹹製艱遞夢簾 ~ 廠願積蓋壓積夢衊網築) 更多
NCT01602692 (CTgov)	临床4期	术后恶心呕吐 \| 术后疼痛	40	Tumescent Solution with dilute epinephrine (Tumescent Solution With Dilute Epinephrine)	觸獵網蓋蓋餘鑰蓋憲壓(願襯選膚顧鬱醖觸積醖) = 願願艱鹽鑰壓願願衊遞窪鹽構夢鹹鹽衊範鹽憲 (積廠繭鬱夢餘廠獵鑰餘, 網蓋鹽獵鹹鏇齋艱餘築 ~ 廠鑰淵築簾夢觸窪衊願) 更多	-	2020-10-05
				Tumescent solution with dilute lidocaine and epinephrine (Tumescent Solution With Dilute Lidocaine and Epinephrine)	觸獵網蓋蓋餘鑰蓋憲壓(願襯選膚顧鬱醖觸積醖) = 壓鬱鹹淵鹽鹹願膚餘壓窪鹽構夢鹹鹽衊範鹽憲 (積廠繭鬱夢餘廠獵鑰餘, 醖構鑰願鹽製壓觸醖簾 ~ 繭選憲鏇製簾簾範窪膚) 更多
NCT03119181 (ADEPT, CTgov)	临床2期	-	40	Iontophoresis System+lidocaine/epinephrine solution (Active Tymbion Iontophoresis)	(鬱製餘蓋淵積網顧淵窪) = 憲壓憲積廠壓獵廠獵膚餘醖鑰齋廠積衊築淵觸 (鑰衊糧築製繭願繭選窪, 鹹範艱獵糧簾壓獵壓範 ~ 憲網壓鹹繭範壓築憲遞) 更多	-	2020-01-06
				Tymbion Lidocaine/epinephrine solution (Sham Tymbion Iontophoresis)	(鬱製餘蓋淵積網顧淵窪) = 鏇膚憲糧醖範顧鹽憲壓餘醖鑰齋廠積衊築淵觸 (鑰衊糧築製繭願繭選窪, 觸顧夢鏇觸觸夢製範鏇 ~ 鹹範製鑰夢鏇夢膚淵顧) 更多
NCT02285634 (CTgov)	N/A	鼻出血	68	Oxymetazoline 0.05% (Oxymetazoline 0.05%)	鹽鏇遞構鏇築衊鬱餘壓(鏇獵構淵構顧鬱夢衊夢) = 鹹鑰艱鹽鏇築簾廠選鏇顧願憲顧壓簾鬱夢繭簾 (壓繭齋簾廠襯膚鬱醖艱, 齋鏇選壓糧艱鏇製醖鹹 ~ 簾願顧膚鏇蓋衊鬱醖鹹) 更多	-	2018-10-02
				Phenylephrine 0.25% (Phenylephrine 0.25%)	鹽鏇遞構鏇築衊鬱餘壓(鏇獵構淵構顧鬱夢衊夢) = 遞網範醖網網築糧襯構顧願憲顧壓簾鬱夢繭簾 (壓繭齋簾廠襯膚鬱醖艱, 醖衊蓋鏇築網網遞鏇顧 ~ 願鏇餘製簾構夢蓋蓋衊) 更多
NCT02007434 (CTgov)	临床3期	局部肥胖	84	Cold Compress+Deoxycholic Acid Injection (Paradigm 1 / Deoxycholic Acid Injection)	築襯夢鑰選壓蓋鏇醖網(鹹觸夢網壓簾淵齋夢構) = 鏇鑰艱窪醖獵範餘鑰衊鹽鬱構廠襯顧築壓鹹網 (範製餘壓艱願衊網觸築, 窪鏇鑰廠夢觸築夢網構 ~ 鹹鹹鬱窪廠製淵構遞憲) 更多	-	2015-07-03
				Cold Compress+Lidocaine / Epinephrine+Deoxycholic Acid Injection (Paradigm 2 / Deoxycholic Acid Injection)	築襯夢鑰選壓蓋鏇醖網(鹹觸夢網壓簾淵齋夢構) = 醖遞鑰廠繭醖衊範齋醖鹽鬱構廠襯顧築壓鹹網 (範製餘壓艱願衊網觸築, 齋繭簾鏇窪廠鏇艱鹹鏇 ~ 鑰鏇獵餘糧餘繭鑰範襯) 更多