肾上腺素/盐酸利多卡因(Epinephrine/Lidocaine Hydrochloride) - 药物靶点：SCNA x adrenergic receptor_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

EPINEPHRINE BITARTRATE/LIDOCAINE HYDROCHLORIDE、Iontocaine、Lidocaton

+ [3]

靶点

SCNA x adrenergic receptor

作用机制

SCNA阻滞剂(钠通道α亚基家族阻滞剂)、adrenergic receptor激动剂(肾上腺素能受体家族激动剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

Fresenius Kabi USA LLCHakusui Trading Co. Ltd.

非在研机构

Vyteris, Inc.

Dentsply Sirona, Inc.

Empi, Inc.

最高研发阶段批准上市

首次获批日期

美国 (1948-11-19),

麻醉

最高研发阶段(中国)-

特殊审评-

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结构

分子式C14H23ClN2O

InChIKeyIYBQHJMYDGVZRY-UHFFFAOYSA-N

CAS号73-78-9

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关联

3

项与肾上腺素/盐酸利多卡因相关的临床试验

NCT05804630 / Enrolling by invitationN/AIIT

Efficacy and Safety of Articaine and Lidocaine in Extraction of Wisdom Teeth of Upper and Lower Jaws

Local anesthesia drugs and anesthesia technique play an imperative role in dental treatment. The purpose of this study was to compare the efficacy and safety of different dental local anesthetics drugs and brands in clinical use for the extraction of wisdom teeth.

开始日期2023-03-15

申办/合作机构

National Taiwan University Hospital

NCT03119181 / Completed临床2期

A Prospective, Multicenter Study to Evaluate Effectiveness and Safety of Tymbion Iontophoresis and Tympanostomy Tube Placement Using the Tula Iontophoresis and Tube Delivery Systems for Adults in an Office Setting

A prospective, multicenter study to determine if active Tymbion iontophoresis is superior to sham Tymbion iontophoresis in providing anesthesia to the tympanic membrane (TM). The study will use the Tula iontophoresis systems for healthy adult volunteers in an office setting, called Group A of Protocol CPR007003.
The protocol CPR007003 also includes a Group B study described in a separate Registration (NCT03197558).

开始日期2017-04-27

申办/合作机构

Tusker Medical, Inc.初创企业

NCT01602692 / Completed临床4期

A Comparison of Tumescence in Breast Reduction Surgery

The investigators' main hypothesis is that in breast reduction surgery, the use of tumescent solution containing both dilute lidocaine and epinephrine will lead to better control of postoperative pain, nausea, vomiting, shorter time through postoperative phases of care, quicker discharge from the hospital and lower numbers of hospital readmissions than the use of tumescent solution containing only dilute epinephrine.

开始日期2012-08-01

申办/合作机构

University of Wisconsin Madison

100 项与肾上腺素/盐酸利多卡因相关的临床结果

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100 项与肾上腺素/盐酸利多卡因相关的转化医学

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100 项与肾上腺素/盐酸利多卡因相关的专利（医药）

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9

项与肾上腺素/盐酸利多卡因相关的文献（医药）

1981-10-01·Biochemical and Biophysical Research Communications3区 · 生物学

Effect of catecholamines on ornithin decarboxylase activity in the testis of immature rat

3区 · 生物学

Article

作者: P.R.K. Reddy ; R. Madhubala

Intratesticular injection of epinephrine bitartrate (I bitartrate) [51-42-3] and norepinephrine bitartrate [51-40-1] stimulated of ornithine decarboxylase (ODC) [9024-60-6] activity in the testes of immature rats.The effect of I was time and dose dependant.The minimal ED for I was 100 pg and optimal stimulation was observed with 500 ng I.Maximal stimulation of ODC occurred at 2 h after the treatment and was reduced at 4 h reaching control levels at 6 h.Simultaneous injection of I with dibutyryl cAMP [362-74-3], LH [9002-67-9], FSH [9002-68-0] or PGE₂ [363-24-6] addnl. stimulated the enzyme.Injection of I to norepinephrine-treated animals caused an addnl. effect.Both I and norepinephrine stimulated the enzyme activity in Leydig cell and seminiferous tubule fractions.Apparently, catecholamines are also involved in the regulation of ODC activity in the testis of rat.

1981-06-01·Biochimica et Biophysica Acta (BBA) - General Subjects

Catecholamine-induced phosphorylation of cardiac muscle proteins

Article

作者: James G. Dobson

Addition of 10^-5M l-isoproterenol chloride (I chloride) [5984-95-2] to rat ventricular muscle slice preparations for 10 min increased ³²P incorporation into 100,000g particulate and 100,000g supernatant (soluble) fractions but not into homogenates or 1000 and 29,000g particulate fractions prepared from the slices.I also produced a 93% increase in ³²P incorporation and a 27% increase in inorganic phosphate in TCA-insoluble protein that was obtained from ventricular slice homogenates.An increase in the incorporation of ³²P occurred in the 100,000g particulate and supernatant fractions and the acid-insoluble protein within 2 and 1 min, resp.While the β-adrenergic blocking agent propranolol had no effect by itself on ³²P incorporation, it prevented the I-induced incorporation of ³²P into the 100,000g particulate and supernatant fractions and the acid-insoluble protein.Removal of I from the bathing medium eliminated the differences in ³²P incorporation, indicating that the effects of the catecholamine were reversible.l-Norepinephrine bitartrate [51-40-1] and l-epinephrine bitartrate [51-42-3] at 10^-5M caused phosphorylation effects similar to that of I.When the slices were bathed under anoxic conditions, I failed to enhance the incorporation of ³²P into proteins of the 100,000g particulate and supernatant fractions or acid-insoluble protein.SDS gel electrophoresis of ventricular slice homogenates revealed that I enhanced the ³²P incorporation into several myocardial proteins having mol. weights of 155, 94 (glycogen phosphorylase), 79, 68-77, and 54-59 · 10³ and decreased the incorporation into a 30 · 10³ dalton protein(s).These results are consistent with the notion that catecholamines may increase the phosphorylation of myocardial proteins in the intact myocardium which in turn may play a role in catecholamine-induced glycogenolysis and augmentation of contractility.

1980-04-01·Archives of Biochemistry and Biophysics3区 · 生物学

The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production

3区 · 生物学

Article

作者: Robert C. Haynes ; Michael A. Titheradge

Isolated hepatocytes incubated with 2 mM ornithine-10 mM glutamine as substrates and challenged with either glucagon [9007-92-5], epinephrine bitartrate (I bitartrate) [51-42-3] or phenylephrine-HCl [61-76-7] exhibited stimulated rates of urea [57-13-6] production, and mitochondria isolated from these cells displayed an increased rate of energy-dependent citrulline [372-75-8] formation.There was no change in the total carbamyl phosphate synthetase (EC 2.7.2.5) [9026-23-7] I activity, nor mitochondrial content of the pos. effector N-acetyl glutamate [1188-37-0] after acute hormonal treatment.The time of onset of ureogenesis and its sensitivity to glucagon were compared with stimulation of glucose [50-99-7] production from lactate-pyruvate.No apparent differences in time of onset or sensitivity of the responses were observed indicating both pathways may be stimulated by a common mechanism.Mitochondria prepared from cells treated with catecholamines exhibited increased rates of State 3 respiration and increased uncoupler-dependent ATPase [9000-83-3] activity, in addition to the increased rates of citrulline formation.There was also an elevated intramitochondrial content of ATP [56-65-5] and an increased ATP/ADP [58-64-0] ratio.The catecholamine-induced stimulation of ureogenesis was mediated by an α-adrenergic cyclic AMP [60-92-4] independent mechanism.The addition of the α-adrenergic antagonist, dihydroergotamine, blocked both the I-induced stimulation of ureogenesis and also the stimulated functions in the isolated mitochondria.dl-Propranolol, a β-antagonist, inhibited the rise in cyclic AMP due to I, but had no effect on any of the other reactions measured.The effects of catecholamines on citrulline formation and urea production are correlated with the increased capacity of the mitochondria to generate ATP.Apparently, both glucagon and catecholamines, acting via independent mechanisms, stimulate electron transport and the activity of the ATP-forming enzyme complex.The consequent elevated intramitochondrial ATP levels and ATP/ADP ratio enhance the rate of citrulline formation and hence ureogenesis.

100 项与肾上腺素/盐酸利多卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	肾上腺素/盐酸利多卡因	N01BB52 S01EA51	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	美国	Fresenius Kabi USA LLC	1948-11-19

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01602692 (CTgov)	临床4期	术后恶心呕吐 \| 术后疼痛	40	Tumescent Solution with dilute epinephrine (Tumescent Solution With Dilute Epinephrine)	鏇鹹築鬱積獵鬱蓋窪淵(願糧餘壓糧觸製壓選積) = 選觸網淵鏇願築窪廠蓋繭鏇構鹹繭範選糧壓繭 (繭窪遞遞齋餘膚壓積顧, 觸餘鏇鹹繭鏇廠構蓋鹹 ~ 鹹糧襯淵積積範簾鏇獵) 更多	-	2020-10-05
				Tumescent solution with dilute lidocaine and epinephrine (Tumescent Solution With Dilute Lidocaine and Epinephrine)	鏇鹹築鬱積獵鬱蓋窪淵(願糧餘壓糧觸製壓選積) = 淵積鑰製簾窪鹹淵蓋艱繭鏇構鹹繭範選糧壓繭 (繭窪遞遞齋餘膚壓積顧, 壓壓艱獵積膚築網醖窪 ~ 糧顧廠餘襯選鑰憲夢積) 更多
NCT03119181 (ADEPT, CTgov)	临床2期	-	40	Iontophoresis System+lidocaine/epinephrine solution (Active Tymbion Iontophoresis)	製鏇夢繭構製積選窪築(蓋獵築膚選顧願壓顧簾) = 網遞蓋構淵憲齋簾築壓夢襯繭鹹餘積窪觸鑰網 (簾廠鹽範積艱憲鑰夢鏇, 衊淵淵艱淵窪構網範蓋 ~ 淵製糧壓壓窪衊網積獵) 更多	-	2020-01-06
				Tymbion Lidocaine/epinephrine solution (Sham Tymbion Iontophoresis)	製鏇夢繭構製積選窪築(蓋獵築膚選顧願壓顧簾) = 壓鏇壓糧窪齋顧糧獵繭夢襯繭鹹餘積窪觸鑰網 (簾廠鹽範積艱憲鑰夢鏇, 獵蓋艱鑰構醖繭窪遞構 ~ 淵鹹廠憲窪簾蓋餘簾鑰) 更多