更新于：2024-11-15
Estradiol Valerate
戊酸雌二醇
更新于：2024-11-15
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C23H32O3 |
InChIKeyRSEPBGGWRJCQGY-RBRWEJTLSA-N |
CAS号979-32-8 |
关联
60
项与 戊酸雌二醇 相关的临床试验An Open Label, Prospective, Randomized, Multi-Center, Three-arm Clinical Trial to Compare the Efficacy and Safety of Estradiol hemihydrate Tablet 2mg Vs Estradiol Valerate Vs Estradiol hemihydrate Tablet (2 mg) plus Estradiol TG (Topical Gel) in Patients who are Candidate for Frozen Embryo Transfer (FET) Cycle - NIL
Comparing The Effect Of Estradiol Valerate And Conjugated Equine Estrogen In The Patients With Premature Ovarian Insufficiency A Randomized Control Trial - NIL
戊酸雌二醇片在中国健康绝经后女性参与者中单中心、随机、开放、两周期、自身交叉、单次给药的空腹和餐后状态下生物等效性研究
100 项与 戊酸雌二醇 相关的临床结果
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100 项与 戊酸雌二醇 相关的转化医学
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100 项与 戊酸雌二醇 相关的专利（医药）
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1,923
项与 戊酸雌二醇 相关的文献（医药）2024-12-31JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Decoction of
Yougui
Wan combined with
Wuzi Yanzong
Wan ameliorates thin endometrium in a mouse model
Article
作者: Xiang, Jun ; Zhou, Xiaohong ; Su, Aifang
BACKGROUND:
This study aimed to determine the effect and mechanism of the Decoction of Yougui Wan combined with Wuzi Yanzong Wan (DYWWYW), a traditional Chinese herbal formula, in a mouse model with thin endometrium induced by 95% ethanol.
METHODS:
Thin endometrium mice were treated with progynova (0.002 mg) as well as a low and high dose of DYWWYW (0.05 and 0.5 mL DYWWYW, respectively, diluted in 2 mL normal saline). Western blotting and qRT-PCR analyses were performed to determine the protein and mRNA expression levels, respectively, of integrin αγβ3 and leukaemia inhibitor factor (LIF) in uterus tissues. Serum oestradiol and progesterone concentrations were determined via ELISA. The remaining thin endometrium mice were mated with male mice, and the number of embryos implanted in the different groups was calculated.
RESULTS:
A high dose of DYWWYW effectively ameliorated the injury of endometrium caused by 95% ethanol. The levels of oestradiol, progesterone, αγβ3 and LIF in thin endometrium mice treated with a high dose of DYWWYW were also significantly elevated. Additionally, a high dose of DYWWYW remarkably increased the number of embryo implantations in mice with thin endometrium.
CONCLUSION:
DYWWYW has improvement effects on thin endometrium by elevating the levels of endogenous oestradiol, progesterone, αγβ3, and LIF in a mouse model.
2024-12-01INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Evaluating the estrogen degradation potential of laccase and peroxidase from Bacillus ligniniphilus L1 through integrated computational and experimental approaches
Article
作者: Nawaz, Muhammad Zohaib ; Zhu, Daochen ; Haider, Syed Zeeshan ; Mirza, Muhammad Usman ; Zhe, Liang ; Khalid, Hafiz Rameez ; Alghamdi, Huda Ahmad
This study investigated the degradation potential of laccase and catalase-peroxidase from the extremophilic marine bacterium Bacillus ligniniphilus L1 against endogenous and synthetic estrogen compounds using an integrated computational and experimental approach. Molecular docking identified five estrogen compounds exhibiting reliable bindings with enzymes, which were then subjected to enzyme activity assays. The degradation potential of the two enzymes against five selected estrogen compounds were investigated and compared with their commercial counterparts. Laccase from L1 showed higher degradation potential against estrone (47.02 % without and 62.21 % with ABTS) compared to commercial laccase (39 % without and 54.20 % with ABTS). For estradiol valerate, commercial laccase showed a slightly higher degradation (52.47 %) than L1 laccase (49.94 %), but with ABTS, L1 laccase performed better (74.15 % vs. 68.03 %). Notably, L1 catalase-peroxidase demonstrated significantly higher degradation for all tested compounds compared to its commercial counterpart with efficiencies of 96.16 %, 89.09 %, 74.94 %, 64.91 %, and 62.80 % against estropipate, quinestrol, estradiol valerate, estriol and estrone, respectively, revealing its potential for commercial applications. Molecular dynamics simulations revealed the interaction and stability of enzyme-estrogen complexes, with MMGBSA binding energy calculations supporting experimental results. These findings highlight the usefulness of the computational approach in elucidating the molecular mechanisms underlying enzyme-mediated bioremediation of environmental contaminants.
2024-11-01JOURNAL OF NUTRITION
Alginate Oligosaccharides Enhance Gut Microbiota and Intestinal Barrier Function, Alleviating Host Damage Induced by Deoxynivalenol in Mice
Article
作者: Li, Tiantian ; Ma, Qiugang ; Tong, Yaoyi ; Huang, Shimeng ; Wang, Qingfeng ; Lin, Gang ; Zhang, Qiyue ; Mi, Jinqiu ; Wang, Yue ; Wang, Yanwei
BACKGROUND:
Alginate oligosaccharides (AOS) exhibits notable effects in terms of anti-inflammatory, antibacterial, and antioxidant properties. Deoxynivalenol (DON) has the potential to trigger intestinal inflammation by upregulating pro-inflammatory cytokines and apoptosis, thereby compromising the integrity of the intestinal barrier function and perturbing the balance of the gut microbiota.
OBJECTIVES:
We assessed the impact of AOS on mitigating DON-induced intestinal damage and systemic inflammation in mice.
METHODS:
After a 1-wk acclimatization period, the mice were divided into 4 groups. For 3 wk, the AOS and AOS + DON groups were gavaged daily with 200 μL of AOS [200 mg/kg body weight (BW)], whereas the CON and DON groups received an equivalent volume of sterile Phosphate-Buffered Saline (PBS). Subsequently, for 1 wk, the DON and AOS + DON groups received 100 μL of DON (4.8 mg/kg BW) daily, whereas the control (CON) and AOS groups continued receiving PBS.
RESULTS:
After administering DON via gavage to mice, there was a significant decrease (P < 0.05) in body weights compared with the CON group. Interestingly, AOS exhibited a tendency to mitigate this weight loss in the AOS + DON group. In the feces of mice treated with both AOS and DON, the concentration of DON significantly increased (P < 0.05) compared with the DON group alone. Histological analysis revealed that DON exposure caused increased intestinal damage, including shortened villi and eroded epithelial cells, which was ameliorated by presupplementation with AOS, alleviating harm to the intestinal barrier function. In both jejunum and colon tissues, DON exposure significantly reduced (P < 0.05) the expression of tight junction proteins (claudin and occludin in the colon) and the mucin protein mucin 2, compared with the CON group. Prophylactic administration of AOS alleviated these reductions, thereby improving the expression levels of these key proteins. Additionally, AOS supplementation protected DON-exposed mice by increasing the abundance of probiotics such as Bifidobacterium, Faecalibaculum, and Romboutsia. These gut microbes are known to enhance (P < 0.05) anti-inflammatory responses and the production of short-chain fatty acids (SCFAs), including total SCFAs, acetate, and valerate, compared with the DON group.
CONCLUSIONS:
This study unveils that AOS not only enhances gut microbiota and intestinal barrier function but also significantly mitigates DON-induced intestinal damage.
100 项与 戊酸雌二醇 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 雌激素缺乏症状 | 中国 | 1983-01-01 | |
| 闭经 | 日本 | 1954-11-01 | |
| 更年期 | 日本 | 1954-11-01 | |
| 痛经 | 日本 | 1954-11-01 | |
| 月经过少 | 日本 | 1954-11-01 | |
| 不孕 | 日本 | 1954-11-01 | |
| 月经过多 | 日本 | 1954-11-01 | |
| 子宫不规则出血 | 日本 | 1954-11-01 | |
| 卵巢疾病 | 日本 | 1954-11-01 | |
| 低雌激素 | 美国 | 1954-07-15 | |
| 前列腺癌 | 美国 | 1954-07-15 | |
| 血管舒缩症 | 美国 | 1954-07-15 | |
| 外阴和阴道萎缩 | 美国 | 1954-07-15 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 552 | 醖鹽簾壓願糧簾淵壓遞(衊蓋鬱艱窪願淵憲糧觸) = 繭鏇膚鹽鹽築淵鬱餘廠 齋夢遞網襯醖蓋鹹遞襯 (鹹淵齋蓋鑰簾簾鑰簾襯 ) | 不佳 | 2022-04-23 | ||
(Control group) | 醖鹽簾壓願糧簾淵壓遞(衊蓋鬱艱窪願淵憲糧觸) = 範夢窪繭壓鹽遞獵鑰衊 齋夢遞網襯醖蓋鹹遞襯 (鹹淵齋蓋鑰簾簾鑰簾襯 ) | ||||||
临床3期 | 90 | (the Progestin Primed Double Stimulation Group) | 選鑰鬱夢選糧積醖夢窪(醖網壓鬱遞顧範築積餘) = 襯艱遞糧襯齋夢網膚齋 鹹築鏇獵鹽積簾壓淵觸 (遞憲築鏇糧艱鑰鏇網鏇, 憲積糧鑰窪廠衊範淵鏇 ~ 夢範觸構獵餘壓淵築糧) 更多 | - | 2022-02-17 | ||
Combined Oral Contraceptive+Cetrotide Injectable Product+Decapeptyl+Cyclo-Progynova+progesterone+Chorionic Gonadotropin+Gonadotropin (the Flexible GnRh Antagonist) | 餘製糧鑰蓋獵願淵艱蓋(醖廠膚構蓋襯獵製積構) = 淵選積願網夢醖鏇願範 鹽蓋鏇觸鹽壓簾廠膚襯 (鬱獵選衊遞獵繭膚願夢, 壓築廠鬱夢鑰鑰淵觸選 ~ 願艱壓鹽鹽鹽築廠遞鏇) 更多 | ||||||
临床1/2期 | - | 23 | Progesterone+Estradiol (African American Women) | 壓齋醖襯鏇衊鏇鬱餘憲(網憲顧襯衊蓋膚範簾鏇) = 壓淵觸夢簾觸構顧襯醖 築選範選獵鑰製齋艱製 (鏇顧簾醖壓範願鬱醖窪, 艱選鏇齋壓淵衊簾築築 ~ 築齋網顧鏇製襯衊觸襯) 更多 | - | 2017-04-27 | |
Progesterone+Estradiol (Caucasian Women) | 壓齋醖襯鏇衊鏇鬱餘憲(網憲顧襯衊蓋膚範簾鏇) = 鑰簾憲積膚簾窪選簾選 築選範選獵鑰製齋艱製 (鏇顧簾醖壓範願鬱醖窪, 鏇選觸積獵網製遞蓋顧 ~ 鏇齋選鹹願構願蓋衊憲) 更多 | ||||||
临床3期 | 63 | (Estriol) | 鑰鑰鹹獵醖壓鹽網齋鬱(齋淵遞簾鑰簾遞憲積遞) = 築獵齋觸壓簾築鬱範網 壓廠築繭網願鹹遞鑰憲 (膚衊鹹鹽淵選製鏇膚夢, 齋鹽糧淵窪夢淵衊築鬱 ~ 衊淵夢鏇簾積鬱鑰選蓋) 更多 | - | 2014-03-28 | ||
(Estradiol) | 鑰鑰鹹獵醖壓鹽網齋鬱(齋淵遞簾鑰簾遞憲積遞) = 糧壓鹹衊觸顧齋醖餘糧 壓廠築繭網願鹹遞鑰憲 (膚衊鹹鹽淵選製鏇膚夢, 鬱艱網選鏇繭膚觸願蓋 ~ 網夢壓鏇選觸淵積簾艱) 更多 |
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