预约演示
更新于：2025-02-06
Bromhexine Hydrochloride
盐酸溴己新
更新于：2025-02-06
概要
基本信息
原研机构 |
在研机构 |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C14H21Br2ClN2 |
InChIKeyUCDKONUHZNTQPY-UHFFFAOYSA-N |
CAS号611-75-6 |
关联
38
项与 盐酸溴己新 相关的临床试验CTR20244253
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盐酸溴己新片生物等效性试验
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盐酸溴己新片在健康研究参与者中的单剂量、随机、开放、交叉、两周期空腹和餐后人体生物等效性试验
100 项与 盐酸溴己新 相关的临床结果
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100 项与 盐酸溴己新 相关的转化医学
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100 项与 盐酸溴己新 相关的专利（医药）
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1,217
项与 盐酸溴己新 相关的文献（医药）2024-12-01JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Bidentate bromhexine drug coordination modes with various transition metal ions: Synthesis, characterization, and in vitro antibacterial and anti-breast cancer activity tests
Article
作者: Mahmoud, Nessma Fathi ; Omar, Norhan Refaie ; Mohamed, Gehad Genidy ; Sayed, Fatma Nabil
BACKGROUND:
Bromhexine (BHX) is a mucolytic drug used in treatment the respiratory disorders which are associated with excessive or viscid mucus. Transition metal complexes have made tremendous progress in the treatment of a variety of human ailments, according to reported articles. Transition metal complexes are being developed as medications with a lot of effort. Metal complexes can form a variety of coordination geometries, giving them distinct forms. So, binary metal complexes of bromhexine drug have been prepared to enhance the biological activity and stability of the free drug.
METHODS:
A new series of binary complexes with bromhexine drug (BHX) has been prepared with some transition metal ions namely Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II). Elemental analyses, FT-IR, mass spectrometry, thermal studies and UV-Vis spectra have been used to characterize and structurally elucidate the produced metal complexes. Antibacterial activity has been tested for the ligand and metal complexes against a variety of pathogenic bacterial species (Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus). In addition, the ligand has been tested for anticancer efficacy against the MCF-7 breast cancer cell line, as opposed to binary metal complexes. The binding orientation or conformation of the free BHX ligand and Co(II) complex in the active region of the protein of crystal structure of Escherichia coli (PDB ID: 3T88) and Pseudomonas aeruginosa (PDB ID: 6NE0) has been performed using molecular docking studies.
RESULTS:
The BHX ligand coupled in neutral bidentate mode to the metal ions, according to FT-IR and 1H-NMR spectral results. The molar conductivity measurements of the complexes in DMF proved the electrolytic nature of all binary complexes. Co(II) complex showed the highest inhibition zone diameter against S. aureus, E. coli and P. aeruginosa. Zn(II) complex had the greatest inhibitory effect against P. aeruginosa and B. subtilis. Also, Cd(II) chelate appeared high efficacy as antibacterial agent against Pseudomonas aeruginosa and Staphylococcus aureus.
CONCLUSION:
All the output data conjugated to confirm the octahedral geometry of the metal complexes. The biological findings revealed that metal complexes can be more active than the free BHX ligand. Against MCF-7 cell line, Cd(II)-L complex is highly active complex (4.95 µg/mL) but BHX free drug is the most active compound (3.96 µg/mL).
2024-11-01Respiratory Investigation
Efficacy and safety of mucolytics in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
Review
作者: Inaba, Ryunosuke ; Ohnishi, Hiroshi ; Tanimoto, Takuya ; Eitoku, Masamitsu
BACKGROUND:
The efficacy and safety of mucolytics in patients with chronic obstructive pulmonary disease (COPD) and chronic bronchitis or exacerbations of COPD have been reported. We conducted a systematic review and meta-analysis of mucolytics in patients with stable COPD.
METHODS:
Reports from randomized controlled trials to evaluate the efficacy and safety of mucolytics, including ambroxol, bromhexine, carbocisteine, erdosteine, fudosteine, l-methylcysteine, and N-acetylcysteine used in patients with stable COPD were searched for in PubMed, Scopus, Embase, Web of Science, the Cochrane Library, and the Igaku Cyuo Zasshi database.
RESULTS:
Twenty-three reports with ambroxol, carbocisteine, erdosteine, l-methylcysteine, or N-acetylcysteine were included in the review. Mucolytics significantly reduced the rates of exacerbation and hospitalization, shortened the duration of antibiotic use and exacerbations, prolonged the time to first exacerbation, and had a tendency to reduce the occurrence of two or more exacerbations in patients with stable COPD compared to placebo. Mucolytics did not improve mortality, number of lost workdays, scores on St. George's respiratory questionnaire, forced expiratory volume in 1 s, or forced vital capacity. The safety profile of mucolytics was comparable to that of placebo.
CONCLUSIONS:
Mucolytics reduce exacerbations and hospitalizations in patients with stable COPD and have a safety profile comparable to that of placebo.
2024-10-01Surfaces and Interfaces
Electrochemical Bio-Monitoring of the Analgesic Drug Paracetamol, the Antipsychotic Sulpiride, and the Antibiotic Bromhexine Hydrochloride Using Modified Carbon Paste Electrode Based on Ca0.7La0.3Fe0.3Ni0.7O3 Nano-Sized Particles and Black Carbon
作者: Kuyumcu Savan, Ebru ; Khaled, Ammar ; Mekersi, Mouna ; Ferkhi, Mosbah ; Foudia, Malika ; Maouche, Naima
Drug biomonitoring using developed modified sensors, especially with recent electrochem. techniques, is considered an essential step and plays a significant role in the good detection of several drugs in biofluids, minimizing the damages resulting from their overdoses.This work is based on the detection of three important drugs such as paracetamol (PCM), sulpiride (Sulp), and bromhexine hydrochloride (Brh-HCl) with different pharmaceutical families.A specific sensor was fabricated called the carbon paste electrode (CPE) based on Ca0.7La0.3Fe0.3Ni0.7O3 (CLFN) nanoparticles (NPs) synthesized by a citrate method and modified with black carbon (BC).A low-cost, highly sensitive BC/CLFN NPs/CPE sensor was prepared for the simultaneous determination of the three drugs using cyclic voltammetry (CV), differential pulse voltammetry (DPV), square wave voltammetry (SWV) and electrochem. impedance spectroscopy (EIS).Physicochem. characterization was conducted using X-ray diffraction (XRD) and SEM (SEM).The calculated crystallite size using the Debye-Scherer equation was 237.08 nm by XRD, while the nanoparticles grain size was 60.27 nm extracted from SEM surface images.As a result, the developed sensor demonstrates a high response and sensitivity towards PCM, Sulp, and Brh-HCl mols. compared to literature with excellent and low detection limits of 0.36 μM, 0.042 μM, and 2.88 μM for PCM, 0.073 μM, 0.12 μM, 15.45 μM for Sulp, and 0.407 μM, 0.17 μM, 7.82 μM for Brh-HCl drug by CV, DPV and SWV techniques, resp.High sensitivities of 6588.07, 149.73, and 83.35 μA.μM-1.cm-2 for PCM, Sulp, and Brh by CV technique, resp. with wide linear range from 0.01 μM to 180 μM for PCM, from 0.1 μM to 160 μM for Sulp, and from 0.5 μM to 240 μM for Brh by DPV technique.Addnl., the modified CLFN NPs/BC/CPE sensor demonstrated excellent results in real pharmaceutical samples for all three drugs.The reported results include very good recoveries of 104.21 %, 98.68 %, and 95.50 %, and excellent relative standard deviations of 1.18 %, 1.52 %, and 2.84 %, resp.
100 项与 盐酸溴己新 相关的药物交易
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性鼻窦炎 | 临床3期 | 中国 | 2021-07-06 | |
| 慢性支气管疾病 | 临床3期 | 中国 | 2021-07-06 | |
| 慢性鼻窦炎 | 临床3期 | 中国 | 2021-07-06 | |
| 下呼吸道感染 | 临床3期 | 中国 | 2021-07-06 | |
| 气管支气管炎 | 临床3期 | 中国 | 2021-07-06 | |
| 支气管扩张 | 临床3期 | 中国 | 2021-04-07 | |
| 支气管肺炎 | 临床3期 | 中国 | 2021-04-07 |
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临床结果
临床结果
适应症
分期
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临床4期 | 50 | (Control Group) | 繭糧齋糧顧醖鹹獵衊鏇(鏇觸鹽窪範願膚夢淵築) = 蓋憲願構膚膚壓鏇壓範 遞願製築選願獵簾艱窪 (壓製獵憲窪淵廠築憲積, 鹽窪構簾夢願網襯鹽窪 ~ 糧鹹獵鹹顧壓壓壓選醖) 更多 | - | 2022-04-13 | ||
(Bromhexine Hydrochloride Group) | 鏇獵製簾鹹鑰獵餘膚築(願鏇網構網鹽選鑰夢築) = 遞醖憲鑰顧築築齋構淵 壓艱夢繭簾壓範蓋鬱襯 (夢築齋艱鬱壓衊襯醖膚, 憲襯淵淵築蓋鬱範範淵 ~ 積齋簾觸糧膚獵蓋簾齋) 更多 |
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