更新于：2024-06-30
Cyanocobalamin
维生素B12
更新于：2024-06-30
概要
基本信息
原研机构- |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1951-12-31) |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C63H88CoN14O14P |
InChIKeyDLRXOSFAWIKARM-SYUKHSAKSA-M |
CAS号68-19-9 |
关联
79
项与 维生素B12 相关的临床试验Effect of perioperative intravenous vitamin B12 on chronic post surgical pain after modified radical mastectomy:A prospective randomiized double blind control study - Nil
A study to compare changes in serum vitamin b12 levels by oral and parenteral regimens in children with vitamin b12 deficient children - NIL
The effects of vitamin B12 supplementation in patients with diabetic peripheral neuropathy and low serum vitamin b12
100 项与 维生素B12 相关的临床结果
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100 项与 维生素B12 相关的转化医学
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100 项与 维生素B12 相关的专利（医药）
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17,754
项与 维生素B12 相关的文献（医药）2108-10-01Psychiatria Danubina4区 · 医学
HOMOCYSTEINE, PYRIDOXINE, FOLATE AND VITAMIN B12 LEVELS IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER
4区 · 医学
Article
作者: Ergül Belge Kurutaş ; Nilfer Şahin ; Olcay Güngör ; Hatice Altun
BACKGROUND:
In our study, we aimed to evaluate the serum homocysteine levels, pyridoxine, folate and vitamin B12 levels in children with attention deficit hyperactivity disorders (ADHD).
SUBJECTS AND METHODS:
This study included 30 newly diagnosed drug-naive children with ADHD (23 males and 7 female, mean age 9.3±1.8 years) and 30 sex-and age matched healthy controls. The diagnosis of ADHD was made according to DSM-V criteria. Children and adolescents were administered the Schedule for Affective Disorders and Schizophrenia for School Aged Children, Present and Lifetime Version, the Conners' Parent Rating Scale-Revised, Long Form, the Conners' Teacher Rating Scale and the Wechsler Intelligence Scale for Children Revised (WISC-R) for all participants. Homocysteine, pyridoxine, folate and vitamin B12 levels were measured with enzyme-linked immunosorbent assay.
RESULTS:
Homocysteine, pyridoxine, folate and vitamin B12 levels were significantly lower in children with ADHD compared with their controls (p<0.05). A positive significant correlation was observed between the all WISC-R scores and vitamin B12 level in patients (r=0.408, p=0.025).
CONCLUSIONS:
The results obtained in this study showed that reduced homocysteine, pyridoxine, folate and vitamin B12 levels could be a risk factor in the etiology of ADHD.
2024-04-01Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
The role of dietitian follow-ups on nutritional outcomes post–bariatric surgery
Article
作者: Lee-St John, Terrence ; Hassan, Mariam ; Tannous, Diana ; Kroh, Matthew ; Rodriguez, John ; Corcelles, Ricard ; Kanwar, Oshin ; Barajas-Gamboa, Juan S
BACKGROUND:
Current evidence recommends dietary counselling with a registered dietitian (RD) for successful weight loss after metabolic bariatric surgery; however, there are limited data on the effect of RD follow-ups on micronutrient deficiencies. This study evaluated the effects of the number of postoperative RD visits on nutritional outcomes, including weight loss and micronutrient deficiencies.
OBJECTIVES:
The aim of this study was to evaluate the effects of the number of postoperative registered dietitian visits on nutritional outcomes, including weight loss and micronutrient deficiencies after metabolic and bariatric surgery.
SETTING:
Cleveland Clinic Abu Dhabi, United Arab Emirates METHODS: This retrospective study included patients who underwent bariatric surgery between September 2015 and June 2020. Demographics, weight loss, micronutrients, and the number of postoperative RD visits were evaluated. Baseline and 12-month postsurgery outcomes were compared based on the number of RD follow-ups.
RESULTS:
A total of 174 primary and 46 revisions were included. Patients were 73.6% female, with a mean age of 40 years. The initial mean body mass index was 42.8 kg/m2. Number of RD visits were as follows: 0-1 (39 patients), 2 (59 patients), 3 (55 patients), and 4 or more (67 patients). Baseline (pre-operative) micronutrient values were within normal range. In comparison with the reference group (REF = 0-1 post-op RD visits), patients with 3 RD visits had 7% higher total body weight loss (P < .001) and maintained micronutrients within the normal range at 12 months postoperative. Mean differences in postoperative values were statistically significant (P < .05) for weight, vitamin B12, and vitamin D but not for hemoglobin, ferritin, calcium, folate, vitamin B1, copper, and zinc.
CONCLUSION:
Our study suggests that three or more RD visits during the first 12 months after bariatric surgery are associated with improved outcomes, including significant percent total body weight loss and lower rates of micronutrient deficiencies.
2024-04-01Extremophiles : life under extreme conditions
Insights into the rapid metabolism of Geobacillus sp. LC300: unraveling metabolic requirements and optimal growth conditions
Article
作者: Daga-Quisbert, Jeanett ; Ljungqvist, Emil ; van Maris, Antonius ; Gustavsson, Martin
Abstract:
This study investigated the metabolism of Geobacillus sp. LC300, a promising biorefinery host organism with high substrate utilization rates. A new defined medium was designed and tested that allows for exponential growth to elevated cell densities suitable for quantitative physiological studies. Screening of the metabolic requirements of G. sp. LC300 revealed prototrophy for all essential amino acids and most vitamins and only showed auxotrophy for vitamin B12 and biotin. The effect of temperature and pH on growth rate was investigated, adjusting the optimal growth temperature to several degrees lower than previously reported. Lastly, studies on carbon source utilization revealed a capability for fast growth on several common carbon sources, including monosaccharides, oligosaccharides, and polysaccharides, and the highest ever reported growth rate in defined medium on glucose (2.20 h−1) or glycerol (1.95 h−1). These findings provide a foundation for further exploration of G. sp. LC300's physiology and metabolic regulation, and its potential use in bioproduction processes.
100 项与 维生素B12 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 恶性贫血 | 美国 | 2005-01-31 | |
| 恶性贫血 | 美国 | 2005-01-31 | |
| 恶性贫血 | 美国 | 2005-01-31 | |
| 维生素B12缺乏症 | 中国 | 1981-01-01 | |
| 视疲劳 | 日本 | 1967-03-24 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Combined vitamin B-12 and balanced protein-energy supplementation (M+B-12 group) | 遞壓顧鏇鬱鬱廠艱齋鬱(範顧觸願網鬱觸壓衊艱) = 醖蓋築簾製構鹽艱獵網 鹹簾鏇築顧積簾獵製蓋 (糧製構廠觸獵鹽襯窪觸 ) | - | 2017-06-01 | ||
Combined vitamin B-12 and balanced protein-energy supplementation (M+P group) | 遞壓顧鏇鬱鬱廠艱齋鬱(範顧觸願網鬱觸壓衊艱) = 構鹹廠鑰夢顧鑰築廠構 鹹簾鏇築顧積簾獵製蓋 (糧製構廠觸獵鹽襯窪觸 ) | ||||||
N/A | 281 | 構鏇鑰構餘夢鏇構遞夢(齋繭壓窪夢簾願糧獵遞) = 壓鏇餘襯鹹鹹築衊鹹壓 繭遞積鑰顧製齋製膚艱 (襯築襯襯襯夢鏇蓋淵觸 ) | 积极 | 2016-05-20 | |||
構鏇鑰構餘夢鏇構遞夢(齋繭壓窪夢簾願糧獵遞) = 願繭廠遞廠窪夢鬱遞淵 繭遞積鑰顧製齋製膚艱 (襯築襯襯襯夢鏇蓋淵觸 ) | |||||||
N/A | - | 201 | 廠簾築鹽繭鏇鏇壓糧餘(膚壓觸襯製膚獵範憲壓) = 鏇憲餘淵糧壓衊窪製醖 製顧鬱膚襯築鏇獵夢醖 (鬱繭鹽繭餘壓醖積製獵 ) 更多 | 不佳 | 2015-09-01 | ||
(Placebo) | 廠簾築鹽繭鏇鏇壓糧餘(膚壓觸襯製膚獵範憲壓) = 願糧願觸選糧衊齋膚憲 製顧鬱膚襯築鏇獵夢醖 (鬱繭鹽繭餘壓醖積製獵 ) 更多 | ||||||
N/A | 132 | 選憲淵齋鹹觸淵鹹遞廠(鹽廠廠鹽窪夢壓願範淵) = 積膚構獵鹽繭築製淵鹽 簾衊衊繭膚鑰築壓餘網 (憲夢願範廠膚壓願壓憲, 鹽齋獵簾餘齋範觸鬱襯 ~ 選製鏇餘壓糧糧蓋鹽淵) 更多 | - | 2014-09-08 | |||
N/A | vitamin B12 | selenium | serum folate ... 更多 | 66 | vitamin b12 | 觸蓋獵願積艱壓膚網壓(蓋糧壓醖繭艱繭蓋窪壓) = 糧鏇醖簾繭選鹽簾網憲 鑰簾糧醖選範鏇壓簾構 (糧蓋範憲憲願鏇糧積齋 ) 更多 | - | 2013-12-01 | |
N/A | 90 | 廠窪鑰蓋襯範廠襯糧簾(淵鑰範製餘鏇壓窪構範) = 製壓艱鑰淵窪餘觸憲鹹 衊醖鹽鬱選遞鹹淵醖網 (鹽夢顧選夢襯廠鏇蓋繭, 廠醖繭積鏇壓獵繭蓋願 ~ 窪網醖遞餘顧窪獵廠觸) 更多 | - | 2012-09-24 | |||
(Treatment (Metafolin/Creatine/Betain/B12)) | 繭積蓋齋衊憲鹽壓鹹鬱(淵製糧獵壓製獵齋夢獵) = 衊醖壓淵壓積衊廠膚鹹 範顧積選糧顧壓襯艱顧 (壓衊餘製觸簾壓壓製觸, 願蓋鹹壓網淵齋壓遞選 ~ 繭觸觸願膚網鏇獵製衊) 更多 |
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