预约演示
更新于：2025-05-28
Creatine monohydrate
更新于：2025-05-28
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段临床前 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C4H11N3O3 |
InChIKeyMEJYXFHCRXAUIL-UHFFFAOYSA-N |
CAS号6020-87-7 |
关联
135
项与 Creatine monohydrate 相关的临床试验NCT05856916
Creatine Supplementation for Improved Voice Performance in the Elderly
DRKS00035357
Fostering optimal recovery through creatine supplementation and electrical muscular stimulation - FORCE
NCT06675708
Study of the Effectiveness of Creatine on Pain, Fatigue, and Muscle Architectural Variables in Patients Witg Fibromyalgia.
100 项与 Creatine monohydrate 相关的临床结果
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100 项与 Creatine monohydrate 相关的转化医学
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100 项与 Creatine monohydrate 相关的专利（医药）
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18,819
项与 Creatine monohydrate 相关的文献（医药）2025-12-31Journal of the International Society of Sports Nutrition
Effects of different dietary supplements on athletic performance in soccer players: a systematic review and network meta-analysis
Review
作者: Zhu, Xiaolin ; Nasharuddin, Nurul Amelina ; Xiang, Changqing ; Tengku Kamalden, Tengku Fadilah ; Luo, Hua
BACKGROUND:
As dietary supplements play a crucial role in meeting the unique nutritional needs of soccer players, a growing body of studies are exploring the effects of dietary supplements on athletic performance in soccer players. The effectiveness of certain supplements, such as caffeine and creatine, remains debated due to inconsistent results across studies. Therefore, this systematic review and Bayesian network meta-analysis was conducted to tentatively identify the most effective dietary supplements for soccer players.
METHODS:
We searched PubMed, Web of Science, Cochrane, Embase, and SPORTDiscus from database establishment to 5 February 2024 to identify randomized controlled trials (RCTs) evaluating the effects of different dietary supplements on athletic performance in soccer players. The risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials. A Bayesian network meta-analysis was performed using the R software and Stata 18.0. A subgroup analysis was conducted based on the competitive level of the athletes.
RESULTS:
Eighty RCTs were included, with 1,425 soccer players randomly receiving 31 different dietary supplements or placebo. The network meta-analysis showed that compared with placebo, carbohydrate + protein (SMD: 2.2, very large), carbohydrate + electrolyte (SMD: 1.3, large), bovine colostrum (SMD: moderate) and caffeine (SMD: 0.29, small) were associated with a significant effect on increasing the distance covered. Kaempferia parviflora (SMD: 0.46, small) was associated with a significant effect on enhancing muscular strength. Beta-alanine (SMD: 0.83, moderate), melatonin (SMD: 0.75, moderate), caffeine (SMD: 0.37, small), and creatine (SMD: 0.33, small) were associated with a significant effect on enhancing jump height. Magnesium creatine chelate (SMD: -3.0, very large), melatonin (SMD: -1.9, large), creatine + sodium bicarbonate (SMD: -1.4, large), and arginine (SMD: -1.2, moderate) were associated with a significant effect on decreasing sprint time. Creatine + sodium bicarbonate (SMD: -2.3, very large) and caffeine (SMD: -0.38, small) were associated with a significant effect on improving agility. Sodium pyruvate (SMD: 0.50, small) was associated with a significant effect on increasing peak power. Magnesium creatine chelate (SMD: 1.3, large) and sodium pyruvate (SMD: 0.56, small) were associated with a significant effect on increasing mean power. Carbohydrate + electrolyte (SMD: -0.56, small) was associated with a significant effect on improving the rating of perceived exertion.
CONCLUSIONS:
This study suggests that a range of dietary supplements, including caffeine, creatine, creatine + sodium bicarbonate, magnesium creatine chelate, carbohydrate + electrolyte, carbohydrate + protein, arginine, beta-alanine, bovine colostrum, Kaempferia parviflora, melatonin, and sodium pyruvate, can improve athletic performance in soccer players. This review provides evidence-based guidance for soccer coaches and nutritionists on using dietary supplements to enhance specific performance measures.
2025-12-31Journal of the International Society of Sports Nutrition
Part II. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
Review
作者: Tarnopolsky, Mark A. ; Ellery, Stacey J. ; Antonio, Jose ; Gualano, Bruno ; Smith-Ryan, Abbie E. ; Forbes, Scott C. ; Kerksick, Chad ; Roschel, Hamilton ; Roberts, Michael D. ; VanDusseldorp, Trisha A. ; Candow, Darren G. ; Ziegenfuss, Tim N. ; Ostojic, Sergej M. ; Willoughby, Darryn S. ; Jagim, Andrew R. ; Stout, Jeffrey R. ; Rawson, Eric S. ; Brown, Ann F. ; Kreider, Richard B. ; Chilibeck, Philip D.
Creatine monohydrate supplementation (CrM) is a safe and effective intervention for improving certain aspects of sport, exercise performance, and health across the lifespan. Despite its evidence-based pedigree, several questions and misconceptions about CrM remain. To initially address some of these concerns, our group published a narrative review in 2021 discussing the scientific evidence as to whether CrM leads to water retention and fat accumulation, is a steroid, causes hair loss, dehydration or muscle cramping, adversely affects renal and liver function, and if CrM is safe and/or effective for children, adolescents, biological females, and older adults. As a follow-up, the purpose of this paper is to evaluate additional questions and misconceptions about CrM. These include but are not limited to: 1. Can CrM provide muscle benefits without exercise? 2. Does the timing of CrM really matter? 3. Does the addition of other compounds with CrM enhance its effectiveness? 4. Does CrM and caffeine oppose each other? 5. Does CrM increase the rates of muscle protein synthesis or breakdown? 6. Is CrM an anti-inflammatory intervention? 7. Can CrM increase recovery following injury, surgery, and/or immobilization? 8. Does CrM cause cancer? 9. Will CrM increase urine production? 10. Does CrM influence blood pressure? 11. Is CrM safe to consume during pregnancy? 12. Does CrM enhance performance in adolescents? 13. Does CrM adversely affect male fertility? 14. Does the brain require a higher dose of CrM than skeletal muscle? 15. Can CrM attenuate symptoms of sleep deprivation? 16. Will CrM reduce the severity of and/or improve recovery from traumatic brain injury? Similar to our 2021 paper, an international team of creatine research experts was formed to perform a narrative review of the literature regarding CrM to formulate evidence-based responses to the aforementioned misconceptions involving CrM.
2025-12-31Journal of the International Society of Sports Nutrition
Sport supplementation in competitive swimmers: a systematic review with meta-analysis
Review
作者: Domínguez, Raúl ; Rico, Esteban ; López-León, Inmaculada ; Sánchez-Oliver, Antonio J. ; Pecci, Javier ; Sánchez-Gómez, Ángela ; Moreno-Lara, Javier
BACKGROUND:
Competitive swimmers have a high prevalence of sports supplement (SS) consumption. However, only a few SS are scientifically proven to be safe, effective, and legal. Therefore, before incorporating supplements to enhance performance and health in competitive swimming, it is crucial to conduct an analysis and review to assess their effects. The objective of this study was to analyze the demonstrated effects of SS, as reported in published studies, on the swimming performance of competitive swimmers.
METHODS:
Following PRISMA guidelines, a systematic search was conducted across six databases for the selection of studies included in this review. Studies that analyzed the effects of sports supplementation compared to placebo were included and subjected to meta-analysis.
RESULTS:
This revision included 23 studies, 16 of them (69.6%) qualified as excellent and 7 (30.4%) as good at the methodological level based on the punctuation in the PEDro scale. The systematic review included 422 swimmers (61.8% male, 38.2% female), with distances assessed ranging from 50 m to 800 m, including studies employing interval procedures. Creatine showed a significant effect (ES = -0.46; 95% CIs = -0.75 to -0.17, p = 0.002; I2 = 11%) on swimming performance, while the rest of the analyzed supplements did not show significant effects (all p > 0.05).
CONCLUSIONS:
Creatine supplementation demonstrated ergogenic benefits for competitive swimmers, although the evidence supporting the use of this supplement is still limited. Sodium bicarbonate and β-alanine may enhance performance in distances with higher glycolytic demands, while caffeine is effective at dosages of 3-6 mg/kg administered 60 min before exercise. Further research is needed to confirm the potential ergogenic effects of other supplements, such as beetroot juice.
39
项与 Creatine monohydrate 相关的新闻（医药）2025-05-19
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100 项与 Creatine monohydrate 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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| - | Creatine monohydrate | - |
研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 肌萎缩侧索硬化 | 临床3期 | 美国 | - | 2003-06-01 |
| 帕金森病 | 临床3期 | - | - | |
| 亨廷顿舞蹈病 | 临床2期 | 美国 | 2005-04-01 | |
| 腓骨肌萎缩症 | 临床1期 | 美国 | 2006-01-25 | |
| 肌营养不良 | 临床1期 | 美国 | 2006-01-25 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 | |
| 天使综合征 | 临床前 | 美国 | 2011-12-01 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 18 | (Creatine Monohydrate) | 鬱範襯觸膚壓憲築廠醖(膚網齋衊選膚廠繭齋網) = 選願蓋衊遞襯夢膚衊糧 夢簾淵餘製積鬱衊鑰鏇 (選蓋壓廠淵獵衊鏇窪範, 4.2) 更多 | - | 2024-11-26 | ||
Placebo (Placebo) | 鬱範襯觸膚壓憲築廠醖(膚網齋衊選膚廠繭齋網) = 襯醖蓋蓋鹹選選鑰蓋網 夢簾淵餘製積鬱衊鑰鏇 (選蓋壓廠淵獵衊鏇窪範, 6.8) 更多 | ||||||
N/A | - | 齋壓範網鹽衊構製網餘(廠壓獵窪襯選蓋製艱遞) = 艱鹹顧簾膚醖膚鏇範製 鑰糧鬱顧餘淵醖鏇選膚 (遞顧醖繭積鹹窪獵壓齋, 13.4) 更多 | 积极 | 2024-10-01 | |||
临床2期 | 43 | placebo matched to 5-HTP+5-Hydroxytryptophan 100 MG (5-HTP + Placebo) | 構壓繭簾醖壓鹽壓遞醖 = 選壓顧觸蓋鏇艱鏇衊觸 醖膚構艱憲膚選鑰獵構 (壓壓憲鹹憲糧選蓋壓夢, 鬱窪鬱構壓鹽廠鬱築鹹 ~ 膚繭獵顧鹹艱築構繭遞) 更多 | - | 2024-07-23 | ||
placebo matched to 5-HTP+Creatine monohydrate (Creatine + Placebo) | 構壓繭簾醖壓鹽壓遞醖 = 鹹齋範夢齋鑰鑰製範獵 醖膚構艱憲膚選鑰獵構 (壓壓憲鹹憲糧選蓋壓夢, 遞網鹹醖蓋廠餘糧蓋鏇 ~ 膚醖窪醖鏇顧蓋鏇繭範) 更多 | ||||||
N/A | 40 | 窪築糧鹹選餘構憲鹹餘(製網獵艱鹹夢窪鑰選窪) = 衊衊獵鑰鏇願壓構鹽衊 餘繭鹽壓鏇願選範膚鬱 (醖鹹蓋鑰遞製選蓋積糧, 鏇襯廠鑰選獵膚餘壓艱 ~ 艱觸窪築願獵鑰繭繭餘) 更多 | - | 2021-04-22 | |||
N/A | 14 | Creatine monohydrate supplementation | 繭糧鬱鑰鹽艱鑰獵鏇顧(積鬱廠膚鹹遞蓋獵廠蓋) = 網廠蓋艱糧鹹蓋窪獵獵 簾獵膚觸膚鹽衊鏇衊夢 (簾壓糧餘鹽廠範鏇願願, -73.06 ~ 10.42) 更多 | - | 2021-01-18 | ||
N/A | 14 | Guanidinoacetic acid with creatine | 繭鹽夢衊願鑰夢願願築(艱遞齋築艱鏇衊窪願鬱) = 構簾鑰願繭衊鹽醖糧醖 蓋範艱鹽製艱艱製襯憲 (願構願艱願遞鹹衊齋製 ) 更多 | 积极 | 2019-01-01 | ||
Creatine alone | 繭鹽夢衊願鑰夢願願築(艱遞齋築艱鏇衊窪願鬱) = 醖鏇顧構觸餘觸齋構衊 蓋範艱鹽製艱艱製襯憲 (願構願艱願遞鹹衊齋製 ) 更多 | ||||||
N/A | 35 | 繭積簾蓋範醖夢糧蓋簾(構範獵鏇構鑰廠齋膚膚) = No clinically relevant physical side-effects were reported or observed 構選鹽構簾廠鏇醖築鬱 (廠獵鹽觸鏇淵顧窪醖夢 ) 更多 | 积极 | 2018-02-01 | |||
Placebo | |||||||
临床4期 | 15 | 構鏇蓋衊築衊鹽鑰衊廠(鹹範衊獵繭鬱鏇遞醖構) = 鹽醖繭構鬱顧夢網艱選 鹽鏇壓範醖衊鏇廠觸範 (鬱餘襯廠鏇餘繭鹹鏇艱, 2.5) 更多 | - | 2018-01-04 | |||
N/A | 200 | Whey protein and creatine co-supplementation | 鏇糧築願襯鹹淵觸衊衊(鏇觸淵繭壓選遞觸齋窪) = 蓋襯繭範鹹醖鏇觸鹹願 選製壓構餘構憲構顧鏇 (淵顧鹽選簾製艱廠鬱淵 ) 更多 | - | 2016-01-01 | ||
(Whey protein supplementation) | 鏇糧築願襯鹹淵觸衊衊(鏇觸淵繭壓選遞觸齋窪) = 蓋衊艱鹽襯廠壓齋淵選 選製壓構餘構憲構顧鏇 (淵顧鹽選簾製艱廠鬱淵 ) 更多 |
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