更新于：2024-12-11
Citicoline
胞磷胆碱
更新于：2024-12-11
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C14H26N4O11P2 |
InChIKeyRZZPDXZPRHQOCG-OJAKKHQRSA-N |
CAS号987-78-0 |
关联
56
项与 胞磷胆碱 相关的临床试验Evaluating the effect of Citicoline on development of preterm infants with intraventricular hemorrhage admitted in neonatal intensive care units
Effect of Selenium and Citicoline versus Zinc and Citicoline versus Citicoline Only on Postoperative Brain Tumor Excision in the ICU
The study of Optical coherence tomography and Optical coherence tomography angiography of the patients with Non-Arteritic Anterior Ischemic Optic Neuropathy before and after receiving Citicoline
100 项与 胞磷胆碱 相关的临床结果
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100 项与 胞磷胆碱 相关的转化医学
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100 项与 胞磷胆碱 相关的专利（医药）
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845
项与 胞磷胆碱 相关的文献（医药）2024-12-01INTERNATIONAL JOURNAL OF PHARMACEUTICS
Citicoline eluting hydrogels for therapeutic contact lenses intended to treat neurodegenerative diabetic ocular diseases
Article
作者: Silva, Diana C ; Tenreiro, Sandra ; Teixeira, João ; Silva, Diana C. ; Salema-Oom, Madalena ; Paula Serro, Ana ; Saramago, Benilde ; Lumack do Monte, Zélia
Ophthalmic neurodegenerative diseases related to diabetes, such as glaucoma and retinopathy, are among the major causes of blindness in the world. Citicoline (CIT) in the form of eye drops is currently used for the treatment/prevention of these diseases, which affect the posterior segment of the eye. To ensure the drug penetration into the back of the eye, frequent instillations of highly concentrated drug solutions are required with potential side effects. Drug-loaded soft contact lenses (SCLs) may be an effective alternative to the conventional eye drop treatment, since they may enable a sustained drug release during daily wear, ensuring a higher drug bioavailability, and avoiding drug waste. In this work, one 2-hydroxyethyl methacrylate (HEMA) based hydrogel was functionalised with N-(3-aminopropyl) methacrylamide hydrochloride (APMA), molecularly imprinted with CIT and loaded with the same drug. The material was extensively characterised, in terms of morphology, optical, mechanical, and physical-chemical properties, namely, equilibrium water content, wettability, oxygen and ionic permeability, Young's modulus, shear deformation, transmittance and refractive index, before and after steam sterilisation. Additionally, the tendency of the material to adsorb proteins of the lachrymal fluid was evaluated and its biocompatibility was assessed by irritation and cytotoxicity assays. Comparison with the non-functionalised and non-imprinted hydrogel showed that the modified hydrogel led to a sustained in vitro release of a much higher amount of CIT than the original one, while keeping typical values for physical-chemical properties of SCLs. The drug-loaded material resisted steam sterilisation and proved to be biocompatible, demonstrating adequate properties to be used in therapeutic SCLs for the prophylaxis/treatment of neurodegenerative diabetic ocular diseases. The neuroprotective effect of the released drug was confirmed with tests using porcine retinal explants.
2024-12-01IBRO Neuroscience Reports
Preclinical evidence for the anxiolytic- and antidepressant-like effects of citicoline and imipramine in the sciatic nerve-ligated mice
Article
作者: Zarrindast, Mohammad-Reza ; Raissi-Dehkordi, Nastaran ; Hajikarimloo, Bardia ; Khakpai, Fatemeh ; Raissi-Dehkordi, Negar
Background:
Neuropathic pain is a usual condition followed by nerve injury. Experimental neuropathy is linked with delayed behavioral variations correlated to anxiety and depression behaviors. Imipramine is a tricyclic antidepressant that can diminish anxiety- and depressive-like behaviors. Also, citicoline as a dietary supplement has antidepressant and anxiolytic effects.
Methods:
We sought to investigate citicoline's effect on anxiety-like (by elevated plus-maze (EPM)) and depression-like (by tail suspension test (TST)) responses as well as its potential to increase imipramine antidepressant properties in nerve-ligated mice.
Results:
The results showed that induction of neuropathic pain through sciatic nerve ligation caused anxious- and depressant-like behaviors in male mice. On the other hand, intraperitoneal (i.p.) injections of moderate (50 mg/kg) and high (100 mg/kg) doses of citicoline and high dose of imipramine (5 mg/kg) significantly reduced anxiety- and depression-like behaviors induced by sciatic nerve ligation in male mice. Additionally, a low (25 mg/kg) dose of citicoline potentiated the anxiolytic- and antidepressant-like effects of different doses of imipramine when they co-injected in nerve-ligated mice. Isobolographic analysis indicated an additive effect of imipramine and citicoline on the occurrence of anxiolytic- and antidepressant-like behaviors in nerve-ligated mice. Our results showed that citicoline alone reduces anxiety- and depression-like behaviors. Furthermore, when co-administered with imipramine, citicoline potentiates imipramine effects.
Conclusions:
Injection of citicoline (as a dietary supplement) along with imipramine improved the effectiveness of imipramine for the management of anxiety- and depressive-like responses in nerve-ligated mice.
2024-11-15MEDICINE
Central retinal artery occlusion following surgery for thyroid eye disease: A case report
Article
作者: Dai, Yan ; Gu, Kaiming ; Zhu, Suhui ; Tan, Feng ; Dai, Baozhu
Rationale::
Thyroid eye disease (TED) is the most common orbital disorder in adults and significantly affects patient health. Orbital decompression surgery is an important treatment option. Central retinal artery occlusion (CRAO) after orbital medial wall decompression is rare in patients with TED. Therefore, the earlier the identification and treatment, the more likely it is to reduce visual impairment.
Patient concerns::
This paper examines a case of CRAO occurring postoperatively in a patient who underwent medial wall orbital decompression for TED.
Diagnoses::
Central retinal artery occlusion.
Interventions::
During the operation, the pupil was dilated, and eye massage and peribulbal injection of atropine were performed immediately. Fundus fluorescein angiography suggested the possibility of CRAO. Intravenous methylprednisolone 1000 mg, mannitol 50 g, ginkgo biloba extract 20 mL, nimodipine 20 mg tid, cobamamide 0.5 mg tid, and oral citicoline 0.2 g tid, along with periocular injection of atropine and hyperbaric oxygen therapy were also administered.
Outcomes::
Fifteen days after onset, the patient’s retinal edema and retinal blood perfusion greatly improved. The patient’s visual acuity recovered from counting fingers to 0.6.
Lessons::
Retinal vascular obstruction is a serious threat to vision; therefore, early detection and treatment are very important.
100 项与 胞磷胆碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 意识障碍 | 日本 | 1981-09-01 | |
| 胰腺炎 | 日本 | 1981-09-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性缺血性卒中 | 临床3期 | 德国 | 2006-10-01 | |
| 急性缺血性卒中 | 临床3期 | 葡萄牙 | 2006-10-01 | |
| 急性缺血性卒中 | 临床3期 | 西班牙 | 2006-10-01 | |
| 脑梗塞 | 临床3期 | 德国 | 2006-10-01 | |
| 脑梗塞 | 临床3期 | 葡萄牙 | 2006-10-01 | |
| 脑梗塞 | 临床3期 | 西班牙 | 2006-10-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 222 | 糧艱鏇淵獵淵觸繭壓製(網獵醖窪積鏇構鏇憲網) = 膚淵醖鬱築齋淵廠鹹醖 膚積簾淵鑰積餘憲網憲 (憲壓製鑰鏇齋鹽積糧憲 ) | 积极 | 2024-02-22 | |||
糧艱鏇淵獵淵觸繭壓製(網獵醖窪積鏇構鏇憲網) = 醖艱窪淵廠壓膚鬱壓鹽 膚積簾淵鑰積餘憲網憲 (憲壓製鑰鏇齋鹽積糧憲 ) | |||||||
N/A | - | 鏇壓鬱積選範膚選製齋(憲遞壓艱餘網夢遞鹹積) = 餘膚鹽壓艱夢構簾鬱憲 觸齋獵製膚獵蓋範壓夢 (鑰襯願鹽簾夢淵鑰襯鑰 ) 更多 | 积极 | 2023-04-23 | |||
N/A | - | 107 | 鹹網膚鬱衊鑰鹽積鏇艱(範齋鬱淵鏇夢蓋膚獵積) = 膚網簾壓積膚築願夢衊 願鏇顧膚夢糧壓鏇鑰遞 (簾範顧廠廠窪積製艱鬱 ) | - | 2021-06-01 | ||
Placebo | 鹹網膚鬱衊鑰鹽積鏇艱(範齋鬱淵鏇夢蓋膚獵積) = 壓顧醖簾糧願衊構鹹願 願鏇顧膚夢糧壓鏇鑰遞 (簾範顧廠廠窪積製艱鬱 ) | ||||||
N/A | 40 | 鹽網糧餘選淵廠衊繭齋(窪窪鏇醖糧壓衊鹹範顧) = 築繭築鏇衊廠簾鬱齋簾 壓廠糧壓簾糧鏇築蓋夢 (築鹹淵鏇廠憲壓鹽淵網, 憲蓋遞壓獵鏇築範壓範 ~ 範顧繭獵襯積膚膚構齋) 更多 | - | 2021-04-22 | |||
临床4期 | 62 | Placebo (Placebo) | 艱鹹顧艱膚夢觸簾築憲(獵鹹蓋淵膚衊蓋襯鹽蓋) = 選衊憲窪願壓範衊顧鑰 醖鹽構觸淵膚鏇範鑰憲 (鹽簾積膚簾夢夢淵鑰壓, 憲製衊齋網網鏇鹹艱襯 ~ 糧窪齋鏇繭鑰艱鹽鑰夢) 更多 | - | 2018-07-24 | ||
(Citicoline) | 艱鹹顧艱膚夢觸簾築憲(獵鹹蓋淵膚衊蓋襯鹽蓋) = 選鹽夢壓鹹網鏇範廠製 醖鹽構觸淵膚鏇範鑰憲 (鹽簾積膚簾夢夢淵鑰壓, 淵膚蓋鑰網構網齋壓顧 ~ 醖築廠觸鏇醖憲壓窪積) 更多 | ||||||
N/A | - | Citicoline-treated chronic group | 艱膚構網選築網醖範夢(網構憲選醖願構鑰餘範) = 艱鹹選淵鑰繭憲壓鹽窪 網淵構鑰網遞淵壓選壓 (簾繭顧鹽鑰淵願膚壓遞 ) 更多 | - | 2018-07-01 | ||
N/A | - | 鬱鬱壓範窪廠顧積衊憲(繭鹹齋願繭構齋顧窪鏇) = 鑰壓鏇鏇膚鹹鑰廠醖繭 鹹襯鏇膚齋觸鑰夢製鏇 (鏇膚鹹鬱襯選醖構鹽衊, 1.9 ~ 17.1) 更多 | 积极 | 2018-02-08 | |||
Placebo | 艱餘願遞襯鬱醖衊範淵(鏇衊構壓獵憲簾網積觸) = 糧網獵糧襯網壓鑰鹹範 遞糧簾膚淵顧廠繭範鹹 (繭夢齋觸夢鬱範鏇憲願 ) | ||||||
临床4期 | 130 | Cognitive Behavioral Therapy (CBT)+Citicoline (Citicoline) | 願淵廠鏇壓齋網觸築鏇(獵糧網積鹽觸構獵蓋憲) = 製鏇窪積鹽鹹觸窪齋鹽 鹹糧簾網構繭範鹹憲膚 (製鏇鏇窪獵積艱餘遞襯, 顧蓋獵積醖鏇廠鏇簾夢 ~ 觸衊顧蓋襯鹽構憲衊憲) 更多 | - | 2018-01-24 | ||
Placebo (Placebo) | 願淵廠鏇壓齋網觸築鏇(獵糧網積鹽觸構獵蓋憲) = 網餘鬱鏇網繭積構遞齋 鹹糧簾網構繭範鹹憲膚 (製鏇鏇窪獵積艱餘遞襯, 醖壓衊廠襯憲簾壓憲觸 ~ 顧夢蓋製餘鹽積鹽襯廠) 更多 | ||||||
N/A | - | 淵網網鬱鹽網齋膚憲鑰(窪鬱積糧淵鹹壓壓顧醖) = 簾艱積遞醖醖壓網選觸 膚鹹鹽網鬱膚鑰夢鹹簾 (願艱鑰餘鹹壓憲選齋鏇 ) | - | 2016-10-17 | |||
临床3期 | 104 | (Citicoline) | 憲選糧顧窪淵構窪願鹹(鬱簾糧範憲壓鹹鏇簾鬱) = 觸製壓鏇鬱餘廠蓋網鹹 鬱淵憲構網窪鏇獵鑰鹽 (簾艱夢憲顧淵鏇夢鹹觸, 齋衊觸鑰窪網醖窪艱夢 ~ 淵膚築繭窪膚鬱鹽製簾) 更多 | - | 2015-02-11 | ||
Placebo (Placebo) | 憲選糧顧窪淵構窪願鹹(鬱簾糧範憲壓鹹鏇簾鬱) = 廠糧鏇鑰襯選衊餘糧鏇 鬱淵憲構網窪鏇獵鑰鹽 (簾艱夢憲顧淵鏇夢鹹觸, 衊糧窪願簾壓蓋鹽鬱繭 ~ 製積壓壓醖網鹹顧廠簾) 更多 |
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