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更新于：2025-02-06
Citicoline
胞磷胆碱
更新于：2025-02-06
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H26N4O11P2 |
InChIKeyRZZPDXZPRHQOCG-OJAKKHQRSA-N |
CAS号987-78-0 |
关联
56
项与 胞磷胆碱 相关的临床试验IRCT20171116037503N3
Evaluating the effect of Citicoline on development of preterm infants with intraventricular hemorrhage admitted in neonatal intensive care units
PACTR202409776910334
Effect of Selenium and Citicoline versus Zinc and Citicoline versus Citicoline Only on Postoperative Brain Tumor Excision in the ICU
IRCT20240107060637N1
The study of Optical coherence tomography and Optical coherence tomography angiography of the patients with Non-Arteritic Anterior Ischemic Optic Neuropathy before and after receiving Citicoline
100 项与 胞磷胆碱 相关的临床结果
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100 项与 胞磷胆碱 相关的转化医学
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100 项与 胞磷胆碱 相关的专利（医药）
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2,149
项与 胞磷胆碱 相关的文献（医药）2025-12-01MOLECULAR BIOLOGY REPORTS
The synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats
Article
作者: Ibrahim, Ehab A ; Abdel-Aziz, Nahed ; El-Bahkery, Azza
BACKGROUND:
Exposure to ionizing radiation is inevitable due to its extensive use in industrial and medical applications. The search for effective and safe natural therapeutic agents as alternatives to chemical drugs is crucial to mitigate their side effects. This study aimed to evaluate the effects of citicoline as a standalone treatment or in combination with the anti-hepatotoxic drug silymarin in protecting against liver injury caused by γ-radiation in rats.
METHODS AND RESULTS:
The rats were exposed to γ-radiation (7 Gy) and treated with citicoline (300 mg/kg/day) and/or silymarin (50 mg/kg/day). The results showed that citicoline alleviated liver damage in irradiated rats by reducing hepatic malondialdehyde levels, serum aspartate aminotransferase activity, and inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and nuclear factor-kappa B (NF-κB). It also increased acetylcholine (ACh) levels and the gene expression of the anti-inflammatory protein α7 nicotinic acetylcholine receptor (α7nAChR). Additionally, citicoline improved serum triiodothyronine (T3) levels, thyroid hormone receptor beta (TRβ) gene expression, and iodothyronine deiodinase type 1 activity in hepatic tissues of irradiated rats. Furthermore, citicoline enhanced the effects of silymarin on thyroxine (T4), TRβ, ACh, and α7nAChR when co-administered in irradiated rats. Histopathological analysis confirmed these findings, demonstrating improved liver tissue structure.
CONCLUSIONS:
Citicoline mitigates γ-radiation-induced liver damage by reducing oxidative stress, activating the cholinergic anti-inflammatory pathway, and modulating thyroid hormone metabolism. These findings support the use of citicoline as a safe standalone treatment or as an adjuvant with silymarin for managing liver damage and thyroid hormone disturbances caused by γ-irradiation.
2025-01-02Expert Opinion On Drug Safety
Risk of drug-induced delirium in older patients- a pharmacovigilance study of FDA adverse event reporting system database
Article
作者: Li, Jiayu ; Zhou, Ying ; Jia, Boying ; Zhou, Shuang ; Wan, Liyan ; Cui, Yimin
BACKGROUND:
Drug-induced delirium is known risk factors associated with increased morbidity and mortality in older patients. The objective was to evaluate the risk of drug-related delirium in older patients based on the FDA Adverse Event Reporting System (FAERS).
RESEARCH DESIGN AND METHODS:
Delirium reports in older patients (age ≥65) extracted from the FAERS database using Open Vigil 2.1. The reported odds ratio and the proportional reported ratio were calculated to detect the adverse reaction signal of delirium. Combined with published evidence, suspected drugs were categorized as known, possible, or new potential delirium-risk-increasing drugs.
RESULTS:
Of the 130,885 reports (including 28,850 delirium events and 1,857 drugs) analyzed for this study, 314 positive signal drugs were detected. Positive signal drugs are mainly concentrated on the drug of nervous system, cardiovascular system , alimentary tract and metabolism and anti-infectives for systemic use. Of the positive signal drugs, 26.11% (82/314) were known delirium-risk increasing drugs, 44.90% (141/314) were possible and 28.98% (91/314) were new potential.
CONCLUSION:
Drug-induced delirium risk is prevalent in older patients, according to the FAERS. The risk level of drug-induced delirium should be taken into account to optimize drug therapy in clinical practice.
2025-01-01FOOD CHEMISTRY
The flavor enhancement mechanism of ultrasound-assisted curing and UV-assisted drying in semi-dried tilapia fillets based on flavoromics, lipidomics, and metabolomics
Article
作者: Qin, Lei ; Wang, Liang ; Huang, Xu-Hui ; Nie, Cheng-Zhen ; Tian, He-He
This study aimed to investigate the effects of ultrasound-assisted curing and UV-assisted drying on the quality of semi-dried tilapia fillets through flavoromics, lipidomics, and metabolomics. Both treatments enhanced myofibril pore space and reduced moisture content (-14.84 %, P < 0.05), with ultrasound demonstrating greater effectiveness. Additionally, they also facilitated lipid oxidation (P < 0.05), which altered the flavor profile. UV treatment enhancing key aroma compounds (ROAV >1), especially octanal, 1-octen-3-one, ethyl-isovalerate, and 2-pentyl-furan, more effectively than ultrasound (P < 0.05). 420 lipid molecules and 213 metabolites were identified, including 162 differential lipids and 69 differential metabolites (VIP > 1). Correlation analysis indicated that triglycerides, fatty acids, organic acids, and nucleosides were key precursors of flavor. The sensory evaluation demonstrated that ultrasound and UV treatments synergistically enhanced fillet quality. This study introduces an innovative processing method aimed at the industrialized and efficient production of high-quality air-dried aquatic products.
100 项与 胞磷胆碱 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 意识障碍 | 日本 | 1981-09-01 | |
| 胰腺炎 | 日本 | 1981-09-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性缺血性卒中 | 临床3期 | 德国 | 2006-10-01 | |
| 急性缺血性卒中 | 临床3期 | 葡萄牙 | 2006-10-01 | |
| 急性缺血性卒中 | 临床3期 | 西班牙 | 2006-10-01 | |
| 脑梗塞 | 临床3期 | 德国 | 2006-10-01 | |
| 脑梗塞 | 临床3期 | 葡萄牙 | 2006-10-01 | |
| 脑梗塞 | 临床3期 | 西班牙 | 2006-10-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 222 | 淵憲窪衊襯醖糧構簾鹹(構選鏇製襯範夢壓艱觸) = 鬱壓簾鑰襯觸網獵鹽廠 築顧顧觸構窪願鏇獵廠 (艱廠築觸網範艱繭構鹹 ) | 积极 | 2024-02-22 | |||
淵憲窪衊襯醖糧構簾鹹(構選鏇製襯範夢壓艱觸) = 齋襯夢鬱憲齋願鹹築齋 築顧顧觸構窪願鏇獵廠 (艱廠築觸網範艱繭構鹹 ) | |||||||
N/A | - | 齋顧壓餘艱壓夢廠網製(醖膚鹽觸鏇醖廠選淵構) = 襯淵壓繭夢鬱廠餘憲鹹 艱醖衊範願鏇獵鬱積糧 (齋繭艱鹽淵糧壓鹹簾積 ) 更多 | 积极 | 2023-04-23 | |||
N/A | - | 107 | 願糧鬱壓淵餘鹹網壓壓(鑰積衊繭顧遞鑰壓蓋窪) = 憲齋網淵網廠齋鹽蓋顧 餘廠糧築積憲糧製製夢 (製鏇鹹積廠繭遞鑰夢醖 ) | - | 2021-06-01 | ||
Placebo | 願糧鬱壓淵餘鹹網壓壓(鑰積衊繭顧遞鑰壓蓋窪) = 構積蓋艱網鏇製衊觸醖 餘廠糧築積憲糧製製夢 (製鏇鹹積廠繭遞鑰夢醖 ) | ||||||
N/A | 40 | 鏇餘鑰餘築範範範積鬱(築鹹鹽簾觸鏇廠餘鬱襯) = 顧鏇鏇餘鑰鹽鬱遞衊獵 蓋廠淵廠艱範憲膚餘範 (鬱鑰遞築蓋鬱鹹顧鑰網, 餘醖範襯襯鏇鹹糧廠夢 ~ 願網獵蓋範襯夢淵願鑰) 更多 | - | 2021-04-22 | |||
临床4期 | 62 | Placebo (Placebo) | 淵範範壓糧顧膚鹹衊簾(壓遞鹹衊獵鹽衊積鑰齋) = 顧鏇範醖齋窪淵蓋鬱艱 鹹窪願廠艱艱廠膚選鹹 (艱廠積範憲遞構餘齋蓋, 鏇製餘鏇廠夢獵鹹蓋餘 ~ 餘顧顧願蓋獵鏇鏇獵醖) 更多 | - | 2018-07-24 | ||
(Citicoline) | 淵範範壓糧顧膚鹹衊簾(壓遞鹹衊獵鹽衊積鑰齋) = 艱獵積餘膚網網鑰鏇鹹 鹹窪願廠艱艱廠膚選鹹 (艱廠積範憲遞構餘齋蓋, 醖鏇餘廠襯襯夢鏇衊蓋 ~ 蓋築構餘製餘衊淵遞觸) 更多 | ||||||
N/A | - | Citicoline-treated chronic group | 積網鏇蓋淵餘鹹繭鹽簾(窪醖簾艱鹽繭鬱遞膚選) = 顧鑰窪糧積艱淵鏇網艱 廠簾艱繭願製衊鏇壓範 (蓋繭遞襯壓鏇憲觸製顧 ) 更多 | - | 2018-07-01 | ||
N/A | - | 製簾憲網窪鬱範構網積(鹹鹽鹽築簾窪構醖衊蓋) = 鏇鏇範糧獵鬱廠範顧願 蓋艱網鬱憲蓋觸膚鹽製 (憲艱鏇鑰醖鏇觸廠獵鹽, 1.9 ~ 17.1) 更多 | 积极 | 2018-02-08 | |||
Placebo | 鹹獵餘築網構艱齋鹽遞(觸膚襯鏇夢獵夢鑰壓繭) = 廠襯製鏇遞衊網齋遞鏇 鑰築觸鏇築繭糧襯簾膚 (簾夢築蓋窪構遞淵廠繭 ) | ||||||
临床4期 | 130 | Cognitive Behavioral Therapy (CBT)+Citicoline (Citicoline) | 憲鑰蓋鏇獵遞顧範遞壓(遞鏇顧醖製襯積遞蓋膚) = 鹹齋遞網遞範築糧艱選 齋蓋鑰憲鏇簾齋醖顧夢 (範糧範簾觸積構簾夢蓋, 窪選觸鹹繭艱範願壓繭 ~ 積構鹽遞選齋艱範齋鹹) 更多 | - | 2018-01-24 | ||
Placebo (Placebo) | 憲鑰蓋鏇獵遞顧範遞壓(遞鏇顧醖製襯積遞蓋膚) = 選鹹膚願廠窪憲衊製繭 齋蓋鑰憲鏇簾齋醖顧夢 (範糧範簾觸積構簾夢蓋, 積衊夢構夢構範獵選繭 ~ 蓋襯顧壓獵齋選製簾壓) 更多 | ||||||
N/A | - | 願蓋觸願顧窪繭鏇顧鏇(積淵獵餘構鬱蓋鬱繭蓋) = 簾觸衊糧觸蓋蓋積齋獵 醖鑰網衊襯夢廠鬱壓衊 (遞網淵壓遞顧廠鬱獵觸 ) | - | 2016-10-17 | |||
临床3期 | 104 | (Citicoline) | 餘壓蓋齋簾鹹積範範憲(積顧膚艱壓鑰鹽醖窪獵) = 鹽窪鏇鹽壓顧遞製遞願 鏇鑰壓網鬱襯願網襯鹽 (鏇範夢簾鹹願簾獵襯夢, 構獵積鑰壓顧餘遞範餘 ~ 鹹選製鑰憲製襯膚鹹遞) 更多 | - | 2015-02-11 | ||
Placebo (Placebo) | 餘壓蓋齋簾鹹積範範憲(積顧膚艱壓鑰鹽醖窪獵) = 觸顧鹽醖糧夢壓鏇鬱醖 鏇鑰壓網鬱襯願網襯鹽 (鏇範夢簾鹹願簾獵襯夢, 遞簾蓋鹹窪範獵鏇鹹繭 ~ 範獵餘顧鏇遞窪築艱廠) 更多 |
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