Effect of a Specific Hand Intervention Program With Strength and Manipulative Dexterity Exercises in Women With Arthralgia Secondary to Hormone Therapy Following Breast Cancer.

This study aims to evaluate the impact of a 12-week hand exercise program on pain, manual dexterity, and hand function in women experiencing hand joint pain (arthralgia) due to hormone therapy after breast cancer. Participants will be randomly assigned to either an intervention group, where they will perform specific hand exercises, or a control group, which will not receive any exercise program. Pain levels, hand function, and manual dexterity will be assessed before and after the intervention using questionnaires and functional tests. The goal is to determine whether targeted hand exercises can improve pain and daily hand use in this population.

开始日期2025-04-01

申办/合作机构

Universidad Europea de Madrid SAU

NCT06855316

/ Not yet recruitingN/AIIT

Evaluating Combined Electromagnetic Stimulation for Enhanced Physical and Psychological Recovery in Athletes with DOMS: a Randomized Controlled Study

This randomized controlled trial explores the impact of a combined transcranial and peripheral electromagnetic stimulation over the potential correlation between psychological well-being and recovery outcomes of young athletes experiencing Delayed Onset Muscle Soreness.

开始日期2025-02-24

申办/合作机构

Universidad Europea de Madrid SAU

NCT06778759

/ Recruiting临床4期IIT

Pain Reduction Effect of a Combined Oral Ibuprofen Arginine and Neural Mobilization Treatment Versus an (Only) Oral Ibuprofen Arginine Treatment in Carpal Tunnel Syndrome

In the present investigation the pain reduction effects of a physiotherapy technique combined with pharmaceutical ibuprofen arginine treatment will be compared to those produced by ibuprofen (only) treatment, in subjects who suffer the signs and symptoms of carpal tunnel syndrome.

开始日期2025-02-19

申办/合作机构

Universidad Europea de Madrid SAU

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283

项与 Universidad Europea de Madrid SAU 相关的文献（医药）

2025-05-01·International Clinical Psychopharmacology

Cariprazine as a maintenance treatment in dual schizophrenia: a 6-month observational study in patients with schizophrenia and cannabis use disorder

Article

作者: Vega, Pablo ; Basurte-Villamor, Ignacio ; Szerman, Nestor ; Grau-López, Lara ; Roncero, Carlos ; Peris, Lola

Schizophrenia is often associated with substance use disorders, particularly cannabis use disorder (CUD). However, treatments frequently fail to address both conditions simultaneously. This study aimed to evaluate the antipsychotic effectiveness of cariprazine in patients with both schizophrenia and CUD in a real-world setting. A 6-month observational study was conducted on 58 patients diagnosed with schizophrenia and CUD, treated with cariprazine. Antipsychotic effectiveness was measured using the Positive and Negative Syndrome Scale and the Clinical Global Impression-Schizophrenia Scale, along with the Improvement and Severity scales. Cannabis consumption and addiction severity were assessed using the Cannabis Abuse Screening Test and the Severity of Dependence Scale, while functioning was evaluated with the Sheehan Disability Inventory. Cariprazine treatment resulted in significant improvements in schizophrenia symptoms (Positive and Negative Syndrome Scale change: −47.88 points, P < 0.0001; Clinical Global Impression-Schizophrenia Scale change: −8.26 points, P < 0.0001). Cannabis use and dependence also decreased (Cannabis Abuse Screening Test change: −7.0 points, P < 0.0001; Severity of Dependence Scale change: −7.88 points, P < 0.0001), alongside improvements in functioning (Sheehan Disability Inventory change: −9.48 points, P < 0.0001). These results suggest that cariprazine is effective for both schizophrenia and CUD, though further research is needed to confirm these findings.

2025-05-01·Pediatric Nephrology

Progression of serum creatinine and glomerular filtration rate in neonatal critical care patients during the first seven days of life

Article

作者: Tárraga López, Pedro Juan ; Cantó Cerdán, Mario ; Pino Vázquez, Asunción ; Medina Muñoz, María ; Alcaraz Romero, Andrés José ; Matías Del Pozo, Vanesa

BACKGROUNDSerum creatinine and estimated glomerular filtration rate (GFR) are key indicators of kidney function.METHODSThis descriptive, retrospective study included neonatal patients admitted to a tertiary hospital's neonatal intensive care unit from January 2013 to December 2016. Data on kidney function were collected from birth to 7 days of life. Patients were stratified into four gestational age groups: below 28 weeks, 28-31 weeks, 32-36 weeks, and term neonates. Qualitative variables were expressed as percentages. Quantitative variables were assessed using the Kruskal-Wallis/Wilcoxon tests. Chi-square analysis was performed for categorical variables. Statistical analysis was conducted using SPSS (Version 22.0), with significance set at p < 0.05.RESULTSAmong 138 patients, 99 (71.7%) were premature. Term neonates showed a gradual postnatal decline in creatinine, while premature infants exhibited an initial rise followed by a decline, with values inversely proportional to gestational age (at seven days: 0.70 ± 0.19 mg/dL in below 28 weeks vs. 0.39 ± 0.08 mg/dL in term, p < 0.001). Among the clinical-epidemiological variables of the included patients, seven significantly influenced serum creatinine. GFR decreased in premature neonates at 24 h, then increased throughout the study. Term neonates demonstrated a progressive GFR increase, with higher values associated with greater gestational age (at seven days:16.8 ± 5.0 ml/min/1.73m² in below 28 weeks vs. 41.8 ± 8.0 ml/min/1.73m² in term, p < 0.001).CONCLUSIONSEvaluating kidney function in neonates, based on serum creatinine and GFR, requires special attention during the first days of life, particularly in critically ill neonates due to multiple physiological changes and clinical factors that may influence these parameters.

2025-05-01·Current Opinion in Urology

Current role of salvage radiotherapy in oligometastatic prostate cancer at the time of recurrence

Review

作者: Duque Santana, Victor ; Sanmamed Salgado, Noelia ; Moreno Perez, Ignacio

Purpose of reviewTo review the evidence for metastasis-directed therapy (MDT) in oligometastatic (OM) prostate cancer (PC) and future directions in this clinical setting.Recent findingsThe indications for radiotherapy in PC have significantly increased over the last decade. The treatment of OM disease has been gaining popularity thanks to new molecular imaging techniques that allow more accurate identification of OM patients who may benefit from MDT. stereotactic body radiation therapy can offer potentially curative treatment with low toxicity rates. Although most published MDT studies focus on hormone-sensitive (HS) PC in the setting of recurrence, promising results have emerged in recent years even in patients with castration resistance.SummaryMDT has emerged as an effective treatment option for OM PC patients with favorable oncological outcomes and a low toxicity profile. Evidence suggests that MDT can be used to delay androgen deprivation therapy or in combination with systemic therapy to potentially improve efficacy outcomes. Molecular stratification is needed to determine who will benefit from treatment intensification with MDT +/− systemic therapies.

项与 Universidad Europea de Madrid SAU 相关的新闻（医药）

2024-08-01

·drugs

COVID-19 Vaccination May Increase Risk for Urinary Tract Symptoms

THURSDAY, Aug. 1, 2024 -- COVID-19 vaccination seems to have some side effects on the lower urinary tract and overactive bladder in younger adults, according to a study published online June 24 in Frontiers in Medicine . Marta de-la-Plaza-San-Frutos, from Universidad Europea de Madrid in Spain, and colleagues examined potential side effects of COVID-19 vaccination on the urinary tract among 1,563 individuals (74.7 percent women and 27.3 percent men), aged 18 to 45 years, who completed an online survey. The researchers found that the Pfizer-BioNTech vaccine was the most frequently administered vaccine type (42.2 percent), and most individuals received three doses. The proportion of individuals who received the AstraZeneca vaccine and did not need to urinate in the night was significantly higher for women than men (59.1 versus 33.3 percent). Compared with those who received three vaccine doses, a higher proportion of those who received a single dose urinate five or more times during the night (2.2 versus 0.1 percent). "Based on the results obtained in this study, monitoring and addressing urinary tract side effects of COVID-19 vaccination are important for vaccination programs to include the systematic collection of urinary tract side effect data, which will allow for ongoing evaluation of vaccine safety and efficacy," the authors write. "Health care professionals should be alert to the possibility of patients experiencing urinary tract symptoms following COVID-19 vaccination." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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