The aim for this pilot study is to test the hypothesis that pre-dosing with gel-forming dietary fibres (methylcellulose or psyllium) will alter the colonic fermentation of a model fermentable dietary fibre (Inulin) when delivered separately, in contrast to our previous trials where gel-forming and fermentable dietary fibres were co-administered. Performance of each gel-forming dietary fibre will be compared to placebo (water) to assess treatment effectiveness.

开始日期2024-10-01

申办/合作机构

The University of Nottingham

[+1]

NCT06528041 / RecruitingN/AIIT

Effect of Native Chicory Inulin Supplementation on Rates of Microbial Change Between Individuals

The main aim of this study is to investigate differences in rate, extent of change and persistence of the gut microbiota in healthy adult volunteers in response to native chicory inulin. Along with investigating the impact of native chicory on bowl habits, mood and appetite. The two main questions this study aims to answer:
* To what extent do differences exist in rate of change over time between individuals in gut microbiota response (Bifidobacterium growth) to native chicory inulin supplementation.
* To what extent do differences exist between individuals in persistence of the gut microbiota upon stopping supplementation.
The effects of native chicory inulin on gut microbiota response will be compared to a maltodextrin placebo to sure changes in gut microbiota result directly from chicory inulin supplementation.
Participants will firstly complete a one-week run-in phase to establish baseline data and will then be allocated to either native chicory inulin or maltodextrin supplementation for 6 weeks. Inulin will be delivered at 12 g/day split into 2 x 6g portions. Maltodextrin will be calorie matched at 6 g/day split into 2 x 3g portions. This will then be followed by a 6 week post-supplementation phase. Fecal and blood samples will be collected regularly throughout all phases for analysis of gut microbiota and compounds of interest. Participants will also record any changes in gastrointestinal sensation, bowel habits and mood in a diary. Changes in appetite sensation will also measured.

开始日期2024-08-01

申办/合作机构

Purdue University

NCT06347198 / Recruiting早期临床1期IIT

A Single-center Exploratory Clinical Study of Oral Inulin in Combination With Fruquintinib Plus Sintilimab as Third- or Further-line Treatment in Metastatic Colorectal Cancer

This is a single-center exploratory clinical study to explore the efficacy and safety of Oral Inulin in Combination With Fruquintinib Plus Sintilimab as Third- or Further-line Treatment in Metastatic Colorectal Cancer.

开始日期2024-04-10

申办/合作机构

武汉协和医院

[+1]

100 项与菊糖相关的临床结果

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100 项与菊糖相关的转化医学

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100 项与菊糖相关的专利（医药）

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3,365

项与菊糖相关的文献（医药）

2024-12-31·Journal of Oral Microbiology

The effect of different sweeteners on the oral microbiome: a randomized clinical exploratory pilot study

Article

作者: Keijser, Bart J F ; van der Plas, Derek W K ; Zakis, Davis R ; Crielaard, Wim ; Volgenant, Catherine M C ; Brandt, Bernd W ; van der Waal, Suzette V ; Zaura, Egija

IntroductionThe aim of the study was to evaluate the modulating effects of five commonly used sweetener (glucose, inulin, isomaltulose, tagatose, trehalose) containing mouth rinses on the oral microbiome.MethodsA single-centre, double-blind, parallel randomized clinical trial was performed with healthy, 18-55-year-old volunteers (N = 65), who rinsed thrice-daily for two weeks with a 10% solution of one of the allocated sweeteners. Microbiota composition of supragingival dental plaque and the tongue dorsum coating was analysed by 16S RNA gene amplicon sequencing of the V4 hypervariable region (Illumina MiSeq). As secondary outcomes, dental plaque red fluorescence and salivary pH were measured.ResultsDental plaque microbiota changed significantly for two groups: inulin (F = 2.0239, p = 0.0006 PERMANOVA, Aitchison distance) and isomaltulose (F = 0.67, p = 0.0305). For the tongue microbiota, significant changes were observed for isomaltulose (F = 0.8382, p = 0.0452) and trehalose (F = 1.0119, p = 0.0098). In plaque, 13 species changed significantly for the inulin group, while for tongue coating, three species changed for the trehalose group (ALDEx2, p < 0.1). No significant changes were observed for the secondary outcomes.ConclusionThe effects on the oral microbiota were sweetener dependant with the most pronounced effect on plaque microbiota. Inulin exhibited the strongest microbial modulating potential of the sweeteners tested. Further full-scale clinical studies are required.

2024-12-31·Gut Microbes

Prebiotic utilisation provides Lactiplantibacillus plantarum a competitive advantage in vitro , but is not reflected by an increased intestinal fitness

Article

作者: Rösch, Christiane ; Schols, Henk A ; Boekhorst, Jos ; Schwalbe, Markus ; Kleerebezem, Michiel ; Fuhren, Jori

Synbiotics combine the concepts of probiotics and prebiotics to synergistically enhance the health-associated effects of both components. Previously, we have shown that the intestinal persistence of inulin-utilizing L. plantarum Lp900 is significantly increased in rats fed an inulin-supplemented, high-calcium diet. Here we employed a competitive population dynamics approach to demonstrate that inulin and GOS can selectively enrich L. plantarum strains that utilize these substrates for growth during in vitro cultivation, but that such enrichment did not occur during intestinal transit in rats fed a GOS or inulin-supplemented diet. The intestinal persistence of all L. plantarum strains increased irrespective of their prebiotic utilization phenotype, which was dependent on the calcium level of the diet. Analysis of fecal microbiota and intestinal persistence decline rates indicated that prebiotic utilization capacity did not selectively stimulate intestinal persistence in prebiotic supplemented diets. Moreover, microbiota and organic acid profile analyses indicate that the prebiotic utilizing probiotic strains are vastly outcompeted by the endogenous prebiotic-utilizing microbiota, and that the collective enhanced persistence of all L. plantarum strains is most likely explained by their well-established tolerance to organic acids.

2024-12-31·Gut Microbes

Efficacy of an inulin-based treatment on intestinal colonization by multidrug-resistant E. coli: insight into the mechanism of action

Article

作者: Montassier, Emmanuel ; Ishnaiwer, Murad ; Dion, Michel ; Zeman, Michal ; Naour, Maxime ; Batard, Eric ; Le Bastard, Quentin ; Dailly, Eric

Inulin, an increasingly studied dietary fiber, alters intestinal microbiota. The aim of this study was to assess whether inulin decreases intestinal colonization by multidrug resistant E. coli and to investigate its potential mechanisms of action. Mice with amoxicillin-induced intestinal dysbiosis mice were inoculated with extended spectrum beta-lactamase producing E. coli (ESBL-E. coli). The combination of inulin and pantoprazole (IP) significantly reduced ESBL-E. coli fecal titers, whereas pantoprazole alone did not and inulin had a delayed and limited effect. Fecal microbiome was assessed using shotgun metagenomic sequencing and qPCR. The efficacy of IP was predicted by increased abundance of 74 taxa, including two species of Adlercreutzia. Preventive treatments with A. caecimuris or A. muris also reduced ESBL-E. coli fecal titers. Fecal microbiota of mice effectively treated by IP was enriched in genes involved in inulin catabolism, production of propionate and expression of beta-lactamases. They also had increased beta-lactamase activity and decreased amoxicillin concentration. These results suggest that IP act through production of propionate and degradation of amoxicillin by the microbiota. The combination of pantoprazole and inulin is a potential treatment of intestinal colonization by multidrug-resistant E. coli. The ability of prebiotics to promote propionate and/or beta-lactamase producing bacteria may be used as a screening tool to identify potential treatments of intestinal colonization by multidrug resistant Enterobacterales.

项与菊糖相关的新闻（医药）

2024-08-14

·生物谷

菊粉能显著改善肥胖者的代谢健康？INT J OBESITY｜补充菊粉可改善肥胖儿童肠道菌群失调，增加有益菌的丰度

全球范围内，肥胖问题日益严峻，尤其儿童肥胖率的攀升令人担忧。肠道菌群失衡被认为是影响肥胖病理生理机制的关键因素之一。而菊粉，作为一种常见的膳食补充剂，已被证明在调节成人肠道菌群方面具有诸多益处，然而其对儿童肥胖效应的研究尚待深入。近日，泰国朱拉隆功大学的Chonnikant Visuthranukul研究团队在International Journal of Obesity发表了题为Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity的研究论文，旨在确定菊粉对肥胖儿童肠道微生物群组成及代谢的影响。研究采用了随机对照设计，将肥胖儿童随机分配至三个组别：菊粉补充组、安慰剂组以及膳食纤维指导组。通过16S rRNA基因测序，研究人员细致分析了各组儿童肠道微生物群的动态变化，并综合评估了他们的临床及代谢特征。图1：各组肥胖儿童肠道菌群在属水平上的 α 多样性结果表明，与对照组相比，菊粉补充组的肠道微生物α多样性（由Shannon指数衡量）显著提升，这一正面影响至少持续了六个月。这意味着菊粉能有效促进肠道菌群的多样性和丰富度。具体而言，菊粉补充显著增加了双歧杆菌的相对丰度，这是一种公认的益生菌，对于维护肠道健康至关重要。同时，菊粉还提升了丁酸盐产生菌（包括Agathobacter和Subdoligranulum等）的比例，丁酸盐作为短链脂肪酸，对肠道黏膜有保护作用，有助于抑制炎症。图2：各组肥胖儿童属水平相对丰度变化在微生物功能变化方面，菊粉补充组观察到了蛋白酶体通路（ko03050）和核糖体生物发生通路（ko03008）的显著上调，表明菊粉可通过促进蛋白质合成来增加肌肉质量，从而对肥胖儿童产生积极影响。此外，菊粉补充组的组氨酸代谢通路（ko00340）也有所下调，提示菊粉有助于缓解与肥胖相关的慢性炎症，改善胰岛素抵抗和其他代谢指标。图3：各组肥胖儿童功能通路变化此外，研究揭示了肠道菌群变化与代谢健康指标之间的密切关联。例如，Faecalibacterium的增多与丁酸盐水平升高相关联，而Fusobacterium的减少则与肝脏酶活性降低、脂肪含量增加有关。Romboutsia的下降与瘦体重和瘦体质量指数减少、挥发性脂肪酸增加相联系。Eubacterium coprostanoligenes群的变动与高热量饮食呈负相关，而Subdoligranulum的增减则与BMI Z评分反向关联。这些关联表明，菊粉补充能够促进肠道菌群与宿主代谢健康间的良性互动。图4：肠道菌群变化与临床及代谢特征的相关性分析综上所述，这项研究证明了菊粉能够选择性地提升肥胖儿童肠道中有益菌的数量，重建肠道微生态平衡，进而优化其临床和代谢状况。此发现凸显了菊粉在改善儿童肥胖相关肠道菌群失调和代谢健康的潜力，为菊粉在肥胖防治策略中的应用奠定了坚实的科学基础。参考文献： Visuthranukul, C., Sriswasdi, S., Tepaamorndech, S., Chamni, S., Leelahavanichkul, A., Joyjinda, Y., Aksornkitti, V., & Chomtho, S. (2024). Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity. International journal of obesity (2005), 10.1038/s41366-024-01590-8. Advance online publication. https://doi-org.libproxy1.nus.edu.sg/10.1038/s41366-024-01590-8 本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！点击下方「阅读原文」，前往生物谷官网查询更多生物相关资讯~

微生物疗法临床研究

2024-08-14

·生物谷

菊粉能显著改善肥胖者的代谢健康？International Journal of Obesity: 补充菊粉可改善肥胖儿童肠道菌群失调，增加有益菌的丰度

本研究表明补充菊粉可以选择性地提高肠道有益微生物水平，恢复肥胖儿童肠道微生物群平衡，并改善其临床和代谢特征，在改善肥胖儿童肠道微生物群和代谢健康方面具有巨大潜力。全球范围内，肥胖问题日益严峻，尤其儿童肥胖率的攀升令人担忧。肠道菌群失衡被认为是影响肥胖病理生理机制的关键因素之一。而菊粉，作为一种常见的膳食补充剂，已被证明在调节成人肠道菌群方面具有诸多益处，然而其对儿童肥胖效应的研究尚待深入。近日，泰国朱拉隆功大学的Chonnikant Visuthranukul研究团队在International Journal of Obesity发表了题为Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity的研究论文，旨在确定菊粉对肥胖儿童肠道微生物群组成及代谢的影响。研究采用了随机对照设计，将肥胖儿童随机分配至三个组别：菊粉补充组、安慰剂组以及膳食纤维指导组。通过16S rRNA基因测序，研究人员细致分析了各组儿童肠道微生物群的动态变化，并综合评估了他们的临床及代谢特征。图1 各组肥胖儿童肠道菌群在属水平上的 α 多样性结果表明，与对照组相比，菊粉补充组的肠道微生物α多样性（由Shannon指数衡量）显著提升，这一正面影响至少持续了六个月。这意味着菊粉能有效促进肠道菌群的多样性和丰富度。具体而言，菊粉补充显著增加了双歧杆菌的相对丰度，这是一种公认的益生菌，对于维护肠道健康至关重要。同时，菊粉还提升了丁酸盐产生菌（包括Agathobacter和Subdoligranulum等）的比例，丁酸盐作为短链脂肪酸，对肠道黏膜有保护作用，有助于抑制炎症。图2：各组肥胖儿童属水平相对丰度变化在微生物功能变化方面，菊粉补充组观察到了蛋白酶体通路（ko03050）和核糖体生物发生通路（ko03008）的显著上调，表明菊粉可通过促进蛋白质合成来增加肌肉质量，从而对肥胖儿童产生积极影响。此外，菊粉补充组的组氨酸代谢通路（ko00340）也有所下调，提示菊粉有助于缓解与肥胖相关的慢性炎症，改善胰岛素抵抗和其他代谢指标。图3：各组肥胖儿童功能通路变化此外，研究揭示了肠道菌群变化与代谢健康指标之间的密切关联。例如，Faecalibacterium的增多与丁酸盐水平升高相关联，而Fusobacterium的减少则与肝脏酶活性降低、脂肪含量增加有关。Romboutsia的下降与瘦体重和瘦体质量指数减少、挥发性脂肪酸增加相联系。Eubacterium coprostanoligenes群的变动与高热量饮食呈负相关，而Subdoligranulum的增减则与BMI Z评分反向关联。这些关联表明，菊粉补充能够促进肠道菌群与宿主代谢健康间的良性互动。图4：肠道菌群变化与临床及代谢特征的相关性分析综上所述，这项研究证明了菊粉能够选择性地提升肥胖儿童肠道中有益菌的数量，重建肠道微生态平衡，进而优化其临床和代谢状况。此发现凸显了菊粉在改善儿童肥胖相关肠道菌群失调和代谢健康的潜力，为菊粉在肥胖防治策略中的应用奠定了坚实的科学基础。（生物谷Bioon.com）参考文献： Visuthranukul, C., Sriswasdi, S., Tepaamorndech, S., Chamni, S., Leelahavanichkul, A., Joyjinda, Y., Aksornkitti, V., & Chomtho, S. (2024). Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity. International journal of obesity (2005), 10.1038/s41366-024-01590-8. Advance online publication. https://doi-org.libproxy1.nus.edu.sg/10.1038/s41366-024-01590-8

微生物疗法临床研究

2024-07-12

·佰傲谷BioValley

【八月福州·合成】池振明：从事陆地和海洋酵母菌基因组编辑、代谢调控和应用的研究！

池振明中国海洋大学海洋生命学院教授专著：池振明，王祥红，李静，普通高等教育“十一五”国家级规划教材“现代微生物生态学”，科学出版社，2010年出版，池振明主编，64万字 NO.01 研究方向主要从事陆地和海洋酵母菌基因组编辑、代谢调控和应用的研究，高分子量普鲁兰多糖、高分子量多聚苹果酸、富马酸、Liamocin、玛索亚内酯和铁载体以及黄金酵母菌等多个产品正在企业中开发和应用。 NO.02 学术成果在酵母菌方面发表近300篇学术论文，多年的中国高被引学者。近5年来影响因子在3以上的SCI收录文章：（仅举例5篇，更多文章内容暂不举例） 1．Chi ZM*, Chi Z, Zhang T, Yue LX, Li J, Wang XH, Production, characterization and gene cloning of the extracellular enzymes from the marine-derived yeasts and their potential applications, Biotechnol Adv, 27, pp, 236–255, 2009 影响因子8.25 2. Chi ZM*, Chi Z, Liu GL, Wang F, Ju L, Zhang T, Saccharomycopsis fibuligera and its applications in biotechnology, Biotechnol Adv, 27, pp, 423–431, 2009 影响因子8.25 3. Zhang T, Chi Z, Zhao CH, Chi ZM*, Gong F, Bioethanol production from hydrolysates of inulin and the tuber meal of Jerusalem artichoke by Saccharomyces sp. W0, Biores Technol, 2010, 101, pp, 8166–8170, 2012 影响因子4.2 4. Zhang T, Chi Z, Chi ZM*, Parrou JL, Gong F, Expression of the inulinase gene from the marine-derived Pichia guilliermondii in Saccharomyces sp. W0 and ethanol production from inulin, Microb Biotechnol, 3(5), pp, 576–582, 2010 影响因子3.6 5. Liu XY, Chi Z, Liu GL, Wang F, Madzak C, Chi ZM*, Inulin hydrolysis and citric acid production from inulin using the the surface-engineered Yarrowia lipolytica displaying inulinase, Metab Engineer,12, pp, 469-476, 2010 影响因子5.5 FUZHOU 2024第一届合成生物技术与智能生物制造学术交流会暨中国微生物学会生化过程模型化与控制专业委员会年会 *上下滑动，查看更多议程 *分论坛按照嘉宾首字母排序点击“阅读原文”，查看更多精彩内容~

微生物疗法临床研究

100 项与菊糖相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00171	菊糖	V04CH01	DB00638

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
诊断试剂	日本	Fuji Yakuhin Co., Ltd.	2005-10-11

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04118010 (CTgov)	临床4期	囊性纤维化	40	Vitamin D3+inulin (Vitamin D3 and Inulin)	鹽壓願網醖鑰壓淵簾鏇(蓋網鑰範簾鹹淵醖繭鬱) = 廠襯衊觸製餘夢觸艱鑰壓膚憲襯構糧築築蓋壓 (築糧鹽醖積積糧鹽顧窪, 鏇繭範壓壓顧糧獵膚築 ~ 構觸壓製壓窪範簾壓構) 更多	-	2024-02-07
				Placebo Inulin+Vitamin D3 (Vitamin D3 and Placebo Inulin)	鹽壓願網醖鑰壓淵簾鏇(蓋網鑰範簾鹹淵醖繭鬱) = 窪餘糧衊願壓壓築衊遞壓膚憲襯構糧築築蓋壓 (築糧鹽醖積積糧鹽顧窪, 觸顧鏇積廠網齋蓋窪繭 ~ 構觸積遞醖網糧淵餘膚) 更多
NCT02794766 (CTgov)	临床2期	舌疾病 \| 口臭	45	Placebo	廠窪選鹹醖衊鏇壓遞簾(憲鏇鬱齋廠鏇選積蓋願) = 餘獵觸蓋鬱鹹繭糧廠鑰衊構夢壓廠觸鏇獵願窪 (膚選獵願繭獵窪糧膚網, 鏇遞鬱顧願選選糧鑰願 ~ 願獵衊繭夢淵艱餘糧夢) 更多	-	2020-08-19
ASN2015	N/A	低镁血症维持 TRPM6 (rs3750425 and rs2274924)	133	Inulin supplementation	範鑰繭淵衊鏇鑰範鹽壓(艱網鏇鬱廠夢壓窪齋鹹) = 鑰構廠繭醖鏇衊簾積艱齋憲製遞廠醖築範顧餘 (鹹顧夢繭範膚積範範壓 ) 更多	积极	2015-11-03
				Inulin	醖襯製醖觸願鬱膚遞淵(築艱鬱鏇簾餘齋艱範艱) = 廠蓋蓋齋衊壓壓淵鹽鑰壓網獵衊鏇憲願製憲壓 (廠範膚鹹構齋構築襯鏇 )
NCT00335504 (CTgov)	临床2期	直肠癌 \| 结肠癌 \| 癌前状态	85	laboratory biomarker analysis+atorvastatin calcium (Arm I (Atorvastatin Calcium))	壓膚構鬱獵蓋廠鹹壓夢(壓願獵齋範積鑰醖築鹹) = 範窪繭襯廠淵遞繭製願遞築窪醖積醖鹽製願積 (遞鑰襯範獵製願鬱艱構, 蓋餘廠壓鏇願艱獵構簾 ~ 糧顧壓襯憲鏇顧繭膚簾) 更多	-	2013-02-08
				laboratory biomarker analysis+sulindac (Arm II (Sulindac))	壓膚構鬱獵蓋廠鹹壓夢(壓願獵齋範積鑰醖築鹹) = 齋淵構鬱願膚艱選願憲遞築窪醖積醖鹽製願積 (遞鑰襯範獵製願鬱艱構, 願艱範襯網構夢顧憲廠 ~ 繭夢衊壓鬱願壓範襯襯) 更多
Pubmed \| Am J Clin Nutr	N/A	铁缺乏	32	Inulin	鏇積觸淵憲齋鏇夢壓艱(淵齋簾餘製鑰繭構製醖) = 鹽鹽壓糧願壓積襯鬱蓋獵艱築糧壓衊選積餘窪 (壓齋鬱夢蓋襯築蓋觸齋, 8.0%, 28.9%)	-	2012-08-01
				Placebo	鏇積觸淵憲齋鏇夢壓艱(淵齋簾餘製鑰繭構製醖) = 積餘構製簾鏇壓觸壓餘獵艱築糧壓衊選積餘窪 (壓齋鬱夢蓋襯築蓋觸齋, 8.1%, 24.3%)