预约演示
更新于：2025-02-07
Flurbiprofen Axetil
氟比洛芬酯
更新于：2025-02-07
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C19H19FO4 |
InChIKeyALIVXCSEERJYHU-UHFFFAOYSA-N |
CAS号91503-79-6 |
关联
65
项与 氟比洛芬酯 相关的临床试验ChiCTR2400092360
Effect of perioperative application of flurbiprofen axetil on postoperative acute kidney injury in high-risk elderly patients
CTR20231947
评价氟比洛芬酯注射液用于治疗术后镇痛的多中心、随机、双盲、阳性药物平行对照的有效性及安全性的临床研究
CTR20223269
评价氟比洛芬酯注射液用于术后镇痛的多中心、随机、双盲、平行、阳性对照临床试验
100 项与 氟比洛芬酯 相关的临床结果
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100 项与 氟比洛芬酯 相关的转化医学
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100 项与 氟比洛芬酯 相关的专利（医药）
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575
项与 氟比洛芬酯 相关的文献（医药）2024-10-01ANAESTHESIA
Comparison of opioid‐free and opioid‐inclusive propofol anaesthesia for thyroid and parathyroid surgery: a randomised controlled trial
Article
作者: Zhu, Ya‐Juan ; Sun, Yan ; Ji, Fu‐Hai ; Wang, Dan ; Shan, Xi‐Sheng ; Liu, Hong ; Peng, Ke
Summary:
Background:
Postoperative nausea and vomiting occur frequently following thyroid and parathyroid surgery and are associated with worse patient outcomes. We hypothesised that opioid‐free propofol anaesthesia would reduce the incidence of postoperative nausea and vomiting compared with opioid‐inclusive propofol anaesthesia in patients undergoing these procedures.
Methods:
We conducted a randomised, double‐blinded controlled trial in adult patients scheduled to undergo thyroid and parathyroid surgery at two medical centres in mainland China. Patients were allocated randomly (1:1, stratified by sex and trial site) to an opioid‐free anaesthesia group (esketamine, lidocaine, dexmedetomidine and propofol) or an opioid‐inclusive group (sufentanil and propofol). Propofol infusions were titrated to bispectral index 45–55. Patients received prophylaxis for nausea and vomiting using dexamethasone and ondansetron and multimodal analgesia with paracetamol and flurbiprofen axetil. The primary outcome was the incidence of postoperative nausea and vomiting in the first 48 h after surgery.
Results:
We assessed 557 patients for eligibility and 394 completed this trial. The incidence of postoperative nausea and vomiting in the first postoperative 48 h was lower in the opioid‐free anaesthesia group (10/197, 5%) compared with opioid‐inclusive group (47/197, 24%) (OR (95%CI) 0.17 (0.08–0.35), p < 0.001), yielding a number needed to treat of 5.3. Additionally, opioid‐free propofol anaesthesia was associated with a reduced need for rescue anti‐emetics, lower rates of hypotension and desaturation after tracheal extubation, and higher patient satisfaction. Time to tracheal extubation was prolonged slightly in the opioid‐free group. The two groups had similar postoperative pain scores and 30‐day outcomes.
Discussion:
Opioid‐free propofol anaesthesia reduced postoperative nausea and vomiting in patients undergoing thyroid and parathyroid surgery. An opioid‐free anaesthetic regimen can optimise anaesthetic care during thyroid and parathyroid surgery.
2024-08-02MEDICINE
Thoracoscopic wedge resection of the upper lobe of the left lung achieved by a new approach of laryngeal mask general anesthesia with preservation of spontaneous breathing: A case report
Article
作者: Meng, Yu ; Pei, Huanshuang ; Xie, Mengran
Introduction::
General laryngeal mask anesthesia with the preservation of spontaneous breathing has accelerated the advancement of the enhanced recovery after surgery concept in thoracoscopic surgery. However, the need for increased doses of anesthetic drugs to reduce laryngeal mask airway (LMA) stimulation poses challenges due to the increased risk of hypotension, respiratory depression, susceptibility to hypoxemia, and carbon dioxide retention, particularly in the lateral position.
Patient concerns::
During the perioperative period, reducing the dose of anesthetic drugs while simultaneously improving LMA tolerance and preventing circulatory and respiratory depression poses a challenge.
Diagnoses::
The patient was diagnosed with a nodule in the upper lobe of the left lung.
Interventions::
In this case, we chose remimazolam sedation, which mildly inhibits circulatory respiration, and used mucosal surface anesthesia in the pharynx. This approach improved the patient’s tolerance to LMA, reduced the dose of anesthetic drugs, and facilitated the successful thoracoscopic wedge resection of the upper lobe of the left lung with preservation of spontaneous respiration.
Outcomes::
During 2 weeks follow-up, the patient recovered satisfactorily and did not report any discomfort.
Conclusion::
We used pharyngeal mucosal surface anesthesia and thoracic paravertebral nerve block in combination with remimazolam sedation to provide precise analgesia, moderate sedation, and successful LMA general anesthesia with preservation of spontaneous respiration in patients undergoing thoracoscopic pulmonary wedge resection.
2024-07-02Zhonghua yi xue za zhi
[Effectiveness and safety of multimodal analgesia in open gastrostomy in patients with end-stage head and neck cancer].
Article
作者: Wang, G Y ; Hu, C H ; Chen, Y M ; Yuan, S ; Chen, H Y ; Wu, L L
Objective: To investigate the effectiveness and safety of multimodal analgesia in patients with end-stage head and neck cancer in open gastrostomy surgery. Methods: This was a randomized controlled trial. From June to December 2023, 50 patients with end-stage head and neck cancer who underwent elective open gastrostomy surgery in Beijing Tongren Hospital Affiliated to Capital Medical University were prospectively selected. The patients were divided into multimodal analgesia group and local anesthesia group using the random number table method according to different anesthesia methods, with 25 cases in each group. In multimodal analgesia group, a multimodal analgesia regimen was adopted: ultrasound-guided abdominal wall nerve block (rectus sheath block and transverse abdominis plane block)+intravenous injection of oxycodone+intravenous injection of flurbiprofen axetil and dexamethasone. In local anesthesia group, local infiltration anesthesia with ropivacaine was adopted. The main outcome measure was the incidence of intraoperative pain numeric rating scale (NRS) score>3 points in the two groups. The secondary observation indicators included NRS score and hemodynamic indexes [mean arterial pressure (MAP) and heart rate (HR)] at various time points during surgery [before anesthesia (T0), at the time of incision (T1), 10 minutes after surgery (T2), during gastric body traction (T3), and at the end of surgery (T4)], incidence of adverse reactions, postoperative patient satisfaction score, as well as the NRS scores at rest and activity (coughing) within 24 hours after surgery. Results: The multimodal analgesia group included 21 males and 4 females, aged (61.4±9.9) years. There were 19 males and 6 females in the local anesthesia group, aged (58.6±10.8) years. The incidence of intraoperative NRS score>3 points and the incidence of salvage analgesia in the multimodal analgesia group were both 12.0% (3/25), which were lower than 60.0% (15/25) in the local anesthesia group, and the differences were statistically significant (all P<0.001); The NRS score [M (Q1, Q3)] at T3 in the multimodal analgesia group was 2 (2, 3) points, which were lower than 5 (3, 6) points in the local anesthesia group (P<0.05). There were smaller variabilities in MAP and HR in the multimodal analgesia group than those in the local anesthesia group (all P<0.05). The incidence of intraoperative tachycardia, surgical traction reaction, and nausea in the multimodal analgesia group was lower than that in the local anesthesia group (all P<0.05). The postoperative satisfaction score of patients in the multimodal analgesia group was (9.25±0.71) points, which were higher than (7.33±0.87) points in the local anesthesia group (P<0.001). NRS score during postoperative activity within 24 hours in the multimodal analgesia group were (2.36±0.75) points, which were lower than (3.03±0.81) points of the local anesthesia group (P=0.005). No adverse reactions such as urinary retention, nausea, vomiting and dizziness occurred in both groups. Conclusion: Compared with local anesthesia, the multimodal analgesic strategy could provide better analgesic effect and longer duration, better hemodynamic stability, and fewer intraoperative adverse reactions in patients with end-stage head and neck cancer undergoing open gastrostomy.
100 项与 氟比洛芬酯 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 癌症疼痛 | 日本 | 1992-03-27 | |
| 术后疼痛 | 日本 | 1992-03-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 疼痛 | 临床3期 | 中国 | 2018-01-02 | |
| 急性发热 | 临床2期 | 中国 | 2017-12-29 | |
| 急性发热 | 临床2期 | 中国 | 2017-12-29 |
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临床结果
临床结果
适应症
分期
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N/A | - | 200 | 築築鹽鑰獵製觸窪廠繭(夢鹹選窪遞顧鹽淵願簾) = 壓顧網顧遞壓願鹹齋鬱 簾艱鑰膚遞選觸鑰製築 (衊築築願醖觸艱鑰齋顧 ) 更多 | 积极 | 2017-10-01 | ||
Placebo | 築築鹽鑰獵製觸窪廠繭(夢鹹選窪遞顧鹽淵願簾) = 鏇衊夢鏇鏇壓壓繭範繭 簾艱鑰膚遞選觸鑰製築 (衊築築願醖觸艱鑰齋顧 ) 更多 | ||||||
N/A | 180 | (Normal Saline) | 觸構積襯願顧廠築簾網(鏇衊淵構淵簾蓋壓選獵) = 艱範憲夢鹽鑰糧餘衊襯 醖鏇憲憲顧獵選鹽艱製 (獵顧範壓壓壓構遞艱獵, 膚鬱簾網窪襯醖簾獵網 ~ 構廠範築範壓齋網鏇夢) 更多 | - | 2015-09-28 | ||
(Flurbiprofen AxetilⅠ) | 觸構積襯願顧廠築簾網(鏇衊淵構淵簾蓋壓選獵) = 艱願膚廠蓋鏇壓醖築糧 醖鏇憲憲顧獵選鹽艱製 (獵顧範壓壓壓構遞艱獵, 觸壓鏇遞鬱鏇衊壓願餘 ~ 衊網鹽艱獵鏇膚簾積壓) 更多 |
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