更新于：2024-12-06
Rupatadine Fumarate
富马酸卢帕他定
更新于：2024-12-06
概要
基本信息
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C30H30ClN3O4 |
InChIKeyJYBLCDXVHQWMSU-WLHGVMLRSA-N |
CAS号182349-12-8 |
关联
62
项与 富马酸卢帕他定 相关的临床试验Study on the Effect and Mechanism of Lupatadine Fumarate in the Treatment of Allergic Rhinitis
富马酸卢帕他定片在健康成年受试者中进行的单中心、随机、开放、单次给药、两序列、四周期、完全重复交叉、空腹和餐后生物等效性试验
富马酸卢帕他定片在健康受试者中的单中心、单剂量、2制剂、2周期、2序列、开放、随机、交叉的平均生物等效性试验
100 项与 富马酸卢帕他定 相关的临床结果
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100 项与 富马酸卢帕他定 相关的转化医学
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100 项与 富马酸卢帕他定 相关的专利（医药）
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184
项与 富马酸卢帕他定 相关的文献（医药）2024-11-01TOXICOLOGY AND APPLIED PHARMACOLOGY
Protective effect of rupatadine on testicular ischemia/reperfusion injury in rats: Modulation of IL-6/STAT3, Akt/ mTOR signaling pathways
Article
作者: Ahmed, Sara M ; Abdel-Aziz, Asmaa Mohamed ; Thabit, Dina Moustafa ; Ahmed, Sara M. ; Abdelmonaem, Alyaa Abdelfattah ; Marey, Heba
BACKGROUNDS & AIM:
Spermatic cord rotation is a common problem in the field of urology, that finally results in necrosis of testicular tissue as well as male infertility. Rupatadine (RUP); a second-generation antihistaminic drug; demonstrated to have a possible protective effect in variable ischemia/reperfusion (I/R) rat models, but its role has not been studied yet in testicular I/R model.
MATERIAL & METHODS:
The present study investigated RUP ability to ameliorate testicular I/R injury. The study includes four groups (6 rats/group); sham group, sham group pretreated with RUP (6 mg/kg/day; orally) for 14 days, I/R group, and RUP-I/R pretreated group.
KEY FINDINGS:
The results demonstrated that I/R significantly lowered serum testosterone level and testicular tissue content of reduced glutathione. Besides, a significant elevation in malondialdehyde level, hypoxia-inducible factor-1, signal transducers and activators of transcription-3 (STAT-3), interleukin-6 (IL-6), histamine, and platelet activating factor levels along with an inhibition in testicular tissue level of vascular endothelial growth factor-A (VEGF-A) with an evident increase in caspase-3 immunoexpression in germ cells. Also, I/R significantly lowered p-AKT and mTOR testicular expression. While, RUP-I/R pretreated group showed a reversal in the testicular I/R damaging effects in a significant manner in the all the aforementioned parameters.
CONCLUSION:
Based on these findings; RUP was proved to have a possible protective effect in testicular I/R injury via its antioxidant effect and its ability to modulate IL-6/STAT3, Akt/ mTOR inflammatory signaling pathways with improvement in the testicular VEGF-A level.
2024-07-16ACS Omega
Antihistamines H1 as Potential Anthelmintic Agents against the Zoonotic Parasite Angiostrongylus cantonensis
Article
作者: de Moraes, Josué ; Lopes, Flavia B. ; Spoladore, Sophia C. ; Fernandes, João Paulo S. ; Roquini, Daniel B. ; Lemes, Bruna L. ; Kreutz, Amanda L. B. ; Amaro, Monique C.
Infections caused by parasitic helminths pose significant health concerns for both humans and animals. The limited efficacy of existing drugs underscores the urgent need for novel anthelmintic agents. Given the reported potential of antihistamines against various parasites, including worms, this study conducted a screening of clinically available antihistamines against Angiostrongylus cantonensis-a nematode with widespread implications for vertebrate hosts, including humans. Twenty-one anti-H1 antihistamines were screened against first-stage larvae (L1) of A. cantonensis obtained from the feces of infected rats. Standard anthelmintic drugs ivermectin and albendazole were employed for comparative analysis. The findings revealed four active compounds (promethazine, cinnarizine, desloratadine, and rupatadine), with promethazine demonstrating the highest potency (EC50 = 31.6 μM). Additionally, morphological analysis showed that antihistamines induced significant changes in larvae. To understand the mechanism of action, antimuscarinic activities were reported based on average pK i values for human muscarinic receptor (mAChR) subtypes of the evaluated compounds. Furthermore, an analysis of the physicochemical and pharmacodynamic properties of antihistamines revealed that their anthelmintic activity does not correlate with their activity at H1 receptors. This study marks the first documentation of antihistamines' activity against A. cantonensis, offering a valuable contribution to the quest for novel agents effective against zoonotic helminths.
2024-07-05MEDICINE
Case report of an unusual allergic reaction to a routine skin prick test performed in an outpatient clinic: Diagnosis, management, and knowledge gaps
Article
作者: Cherrez-Ojeda, Ivan ; Robles-Velasco, Karla ; Mosnaim, Giselle ; Fok, Jie Shen ; Cevallos-Levicek, Denisse
Background::
The skin prick test (SPT) is a standard procedure in allergy/immunology clinics, crucial for evaluating conditions like allergic rhinitis and food allergies. As a cornerstone in investigating immunoglobulin E-mediated allergy, it plays a vital role in diagnosing allergies, including those triggered by common dust mites like Dermatophagoides pteronyssinus, Dermatophagoides farinae, Euroglyphus maynei, and Blomia tropicalis. Despite its widespread use, adverse reactions to SPT are uncommon (15 per 100,000 patients), though the procedure is not entirely risk-free. This article presents a clinical case involving a 17-year-old female who experienced a moderately delayed allergic reaction 120 minutes post-SPT, managed effectively with subsequent symptom resolution.
Methods::
The patient, with a history of persistent rhinorrhea, itchy nose, eyes, and postnasal drip, sought consultation due to worsening symptoms. Diagnostic measures, including patient-reported outcomes and SPT with a standard aeroallergen panel, revealed sensitization to various allergens.
Results::
Post-test, the patient reported ocular pruritus, left eyelid swelling, and moderate rhinorrhea, persisting for about 24 hours. On the subsequent medical visit, the patient received rupatadine and deflazacort, leading to symptom resolution within 3 hours.
Conclusion::
This article delves into a systemic allergic reaction post-SPT, emphasizing the 2 main stages of type I hypersensitivity reactions. While the acute phase involves mast cell-driven mediators within 15 minutes, the delayed phase (4–8 hours) includes de novo cytokine release. Vigilance regarding symptom onset and differentiation between mild and severe reactions is crucial. Notably, the absence of specific waiting time guidelines post-SPT underscores the need for reporting to enhance understanding and subsequent management. Performing these procedures in specialized centers with qualified professionals is essential for effectively managing potential anaphylactic reactions. Addressing these knowledge gaps will contribute to enhanced patient safety during diagnostic procedures.
100 项与 富马酸卢帕他定 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 皮炎 | 日本 | 2017-09-27 | |
| 皮炎 | 日本 | 2017-09-27 | |
| 湿疹 | 日本 | 2017-09-27 | |
| 湿疹 | 日本 | 2017-09-27 | |
| 湿疹 | 日本 | 2017-09-27 | |
| 瘙痒 | 日本 | 2017-09-27 | |
| 慢性荨麻疹 | 加拿大 | 2017-01-16 | |
| 常年性变应性鼻炎 | 加拿大 | 2017-01-16 | |
| 季节性过敏性鼻炎 | 加拿大 | 2016-07-20 | |
| 过敏性鼻炎 | 西班牙 | 2001-10-30 | |
| 荨麻疹 | 西班牙 | 2001-10-30 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | - | Standard Premedications | 夢範鹹鑰壓選蓋壓構憲(醖衊廠製淵獵夢夢糧鑰) = 範廠憲構壓範製選願鹹 夢鏇膚壓鹹築蓋廠憲衊 (齋廠淵襯襯遞窪製築鏇, 0 ~ 63) 更多 | - | 2019-06-12 | |
夢範鹹鑰壓選蓋壓構憲(醖衊廠製淵獵夢夢糧鑰) = 醖築簾蓋壓繭築夢鏇顧 夢鏇膚壓鹹築蓋廠憲衊 (齋廠淵襯襯遞窪製築鏇, 0 ~ 50) 更多 | |||||||
临床2期 | 248 | (築簾齋膚膚廠範憲糧觸) = 4.35% for placebo, 2.86% for 5 mg-, 4.05% for 10 mg- and 4.29% for 20 mg-rupatadine-treated group 糧鹽醖範窪廠觸製鏇壓 (網襯顧網餘鬱壓齋積糧 ) 更多 | - | 2007-06-30 | |||
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