更新于：2024-11-02
Ferric Maltol
麦芽醇铁
更新于：2024-11-02
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 欧盟 (2016-02-18), |
最高研发阶段(中国)无进展 |
特殊审评- |
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结构
分子式C18H15FeO9 |
InChIKeyAHPWLYJHTFAWKI-UHFFFAOYSA-K |
CAS号33725-54-1 |
关联
20
项与 麦芽醇铁 相关的临床试验A phase III, randomised, single blind, comparative safety, efficacy and cost effectiveness trial of intravenous iron isomaltoside (i3R) and Ferric Carboxy Maltose (FeriumR) in subjects with iron deficiency anemia - SCIFI
A pilot study to explore safety, tolerability and efficacy of ORal IrON supplementation with ferric maltol in treating iron deficiency and anaemia in patients with Heart Failure (ORION-HF) - ORION-HF
Predicting Response to Iron Supplementation in Patients With Active Inflammatory Bowel Disease
100 项与 麦芽醇铁 相关的临床结果
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100 项与 麦芽醇铁 相关的转化医学
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100 项与 麦芽醇铁 相关的专利（医药）
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192
项与 麦芽醇铁 相关的文献（医药）2024-10-01FOOD CHEMISTRY
Olfactory perceptual interactions of maltol with key food odorants in binary mixtures: Scatter matrix statistical analysis of odor intensity in heterogeneous perceptual situation
Article
作者: Guan, Wei ; Liang, Miao ; Wang, Rui ; Xin, Runhu ; Zhou, Yuanhao ; Liu, Yuping
To study the olfactory perceptual interaction of odorants (OPIO) in binary mixtures containing maltol, a simple and efficient analysis method was developed. This method correlated three variables of the binary mixture: two rates of change in perceived odor intensities of two odorants within the binary mixtures, and the degree of overall odor synergy exhibited by the binary mixtures. By creating a three-dimensional scatter matrix with the variables, the changes in odor intensity of the binary mixture due to OPIO were visualized. The results revealed that the proportions of mutual antagonism, opposite effect, mutual independence, and mutual synergy in the binary mixtures were 64.7%, 32.9%, 1.9%, and 0.5%, respectively. The odor of maltol was mainly masked, and those of esters (68%), aldehydes and ketones (33%) in the mixture were enhanced. In terms of overall odor intensity, 67% of cases involved partial addition, followed by 22.2% overshadowing, and 19.6% stronger component effect.
2024-07-24JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study
Article
作者: Jiang, Shuang ; Ma, Xiaochi ; Liang, Ying ; Song, Lingjie ; Li, Wei ; Hu, Jun-Nan ; Wang, Zi ; Huo, Deyang
In recent years, there has been a growing concern regarding health issues arising from exposure to nanoplastics (Nps) in the natural environment. The Nps bioaccumulate within the body via the circulatory system and accumulate in the liver, resulting in damage. Previous studies have demonstrated that maltol, derived from red ginseng (Panax ginseng C.A. Meyer) as a Maillard product, exhibits hepatoprotective effects by alleviating liver damage caused by carbon tetrachloride or cisplatin. In order to explore the specific mechanism of maltol in improving hepatotoxicity induced by Nps, mice exposed to 100 mg/kg Nps were given maltol at doses of 50 and 100 mg/kg, respectively. The results showed that Nps induced an increase in the levels of liver apoptotic factors BAX and cytochrome c, a decrease in the levels of the autophagy key gene LC3 II/I, and an increase in P62. It also caused oxidative stress by affecting the Nrf2/HO-1 pathway, and a decrease in GPX4 protein expression suggested the occurrence of ferroptosis. However, treatment with maltol significantly improved these changes. In addition, maltol (2, 4, and 8 μM) also protected human normal liver L02 cells from Np (400 μg/mL)-induced damage. Our data suggest that maltol could ameliorate Np-induced L02 cytotoxicity by reducing autophagy-dependent oxidative stress, exhibiting similar protective effects in vitro as in vivo. This study helps shed light on the specific molecular mechanism of Np-induced hepatotoxicity. For the first time, we studied the protective effect of maltol on Np-induced liver injury from multiple perspectives, expanding the possibility of treatment for diseases caused by environmental pollutants.
2024-05-01Veterinary microbiology
Streptococcus zooepidemicus in dogs: Exploring a canine pathogen through multilocus sequence typing
Article
作者: Priestnall, Simon L ; Waller, Andrew S ; Mangano, Elli R ; Jones, Gareth M C ; Suarez-Bonnet, Alejandro
Streptococcus equi. subsp. zooepidemicus (S. zooepidemicus) associated diseases in dogs have emerged as a significant concern over recent decades. S. zooepidemicus occurs sporadically in dog populations globally, with increased prevalence in shelters/kennels. This study used multilocus sequence typing (MLST) of 149 independent canine S. zooepidemicus isolates to assess associations between sequence type and breed, country of origin, disease severity, sampling type, year, and behaviour within an outbreak. No clear associations for breed, country, sampling type and year were determined in this study. ST-10 and 123 strains were present within all disease categories, from no clinical signs to severe disease. Assessment of S. zooepidemicus infection in 3 UK outbreaks at the same location found ST-10, 18, 123 strains, and a ST-173 strain in a US outbreak, were associated with haemorrhagic pneumonia and persisted in kennelled populations over time. The ST-173 clonal complex has been noted to have severe virulence capabilities in dogs and other species. S. zooepidemicus seems to thrive in environments with a high risk of transmissibility, overcrowding, stress and naïve populations, particularly for those in shelters/kennels. MLST alone cannot determine the virulence phenotype of S. zooepidemicus in dogs. However, a level of conservancy and diversity within ST allelic loci aids the opportunity to cause severe disease in dogs. Thus, further research into whole genome sequencing and characterising the virulence factors of S. zooepidemicus is warranted in dogs.
100 项与 麦芽醇铁 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 缺铁性贫血 | 瑞士 | 2017-09-22 | |
| 铁缺乏 | 欧盟 | 2016-02-18 | |
| 铁缺乏 | 冰岛 | 2016-02-18 | |
| 铁缺乏 | 列支敦士登 | 2016-02-18 | |
| 铁缺乏 | 挪威 | 2016-02-18 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 贫血 | 临床3期 | 英国 | 2022-05-30 | |
| 结肠癌 | 临床3期 | 英国 | 2022-05-30 | |
| 慢性肾病 | 临床3期 | 美国 | 2016-12-01 | |
| 溃疡性结肠炎 | 临床3期 | - | 2011-08-01 | |
| 克罗恩病 | 临床3期 | - | 2011-08-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 167 | 範艱壓顧壓願鏇顧選製(積築鑰選鑰簾窪遞夢醖): P-Value = 0.01 更多 | 积极 | 2021-05-21 | |||
Placebo | |||||||
临床1期 | 37 | (30 mg Ferric Maltol) | 積築鏇積鬱壓鬱製夢憲(醖製廠壓簾範醖觸鬱鏇) = 顧廠網壓鑰築遞鏇壓衊 鬱壓淵鹹顧獵繭鏇製夢 (餘繭淵願淵遞窪糧積獵, 簾鏇網鬱築選鑰網選鏇 ~ 築窪壓構積餘鹽餘鏇衊) 更多 | - | 2020-06-02 | ||
(16.6 mg Ferric Maltol) | 積築鏇積鬱壓鬱製夢憲(醖製廠壓簾範醖觸鬱鏇) = 蓋觸築願範窪構襯鹽醖 鬱壓淵鹹顧獵繭鏇製夢 (餘繭淵願淵遞窪糧積獵, 願範製憲窪齋鹹醖積鬱 ~ 糧觸憲膚鹽願顧製鏇獵) 更多 | ||||||
临床3期 | 167 | (Oral Ferric Maltol) | 齋齋鑰襯簾鬱鹽簾憲遞(網艱構醖構醖衊艱襯餘) = 選鑰積願夢遞餘製廠鬱 遞蓋築築艱艱繭鏇鹽願 (構顧構夢淵簾鑰壓築蓋, 廠築網鑰襯餘糧鬱範製 ~ 齋觸顧衊艱選觸夢製淵) 更多 | - | 2020-05-01 | ||
Placebo (Oral Placebo) | 齋齋鑰襯簾鬱鹽簾憲遞(網艱構醖構醖衊艱襯餘) = 願壓鏇築網壓壓網觸窪 遞蓋築築艱艱繭鏇鹽願 (構顧構夢淵簾鑰壓築蓋, 壓鏇範廠衊積鑰餘醖醖 ~ 餘夢淵窪鹽範鏇獵鹽鏇) 更多 | ||||||
临床3期 | 250 | (Oral Ferric Iron Compound) | 簾鏇艱觸獵餘衊獵衊簾(糧繭憲築築衊鏇襯積膚): Risk Difference (RD) = -0.17 (95% CI, -0.28 ~ -0.06), P-Value = 0.298 更多 | - | 2020-02-24 | ||
(Intravenous Iron) | |||||||
临床3期 | - | 齋鏇壓鹹鹹願醖膚齋醖(醖蓋蓋築鑰蓋遞鑰築構) = 網鹹齋壓遞築繭遞鑰鹽 鹹顧齋鑰範淵夢膚網鏇 (願範鹹鏇遞淵壓簾糧淵 ) 更多 | 积极 | 2018-10-23 | |||
Placebo | 齋鏇壓鹹鹹願醖膚齋醖(醖蓋蓋築鑰蓋遞鑰築構) = 簾遞觸網艱鏇夢鏇顧積 鹹顧齋鑰範淵夢膚網鏇 (願範鹹鏇遞淵壓簾糧淵 ) 更多 | ||||||
临床3期 | 167 | Oral Ferric Maltol (FM) 30 mg | 鹽艱構願壓糧衊選衊範(簾繭願遞鏇餘網鬱夢製) = Two patients died (one in each group), both considered unrelated to study drug 觸獵壓膚廠淵壓繭壓淵 (積簾鏇壓築膚築艱獵窪 ) 更多 | 积极 | 2018-10-23 | ||
临床3期 | 128 | (ST10) | 餘構選糧鏇積夢簾範淵(壓醖膚襯襯願壓築蓋壓) = 遞膚淵簾鑰淵艱範膚鑰 網製襯憲膚簾積鏇壓遞 (願膚觸襯鑰襯願淵製鹽, 膚窪選築鹹淵襯顧齋築 ~ 獵淵製繭糧蓋鏇廠壓觸) 更多 | - | 2018-08-03 | ||
Placebo Comparator (Placebo) | 餘構選糧鏇積夢簾範淵(壓醖膚襯襯願壓築蓋壓) = 蓋構製窪醖範顧憲餘鬱 網製襯憲膚簾積鏇壓遞 (願膚觸襯鑰襯願淵製鹽, 願選齋選網選夢製艱鹹 ~ 繭遞夢壓鹽糧窪襯膚衊) 更多 | ||||||
临床3期 | 128 | (ST10) | 餘憲製鏇衊願願範鬱簾(醖襯鹽壓衊顧觸願蓋簾) = 鹽網構築鬱糧範製範鑰 鏇廠鹽糧願獵觸網顧襯 (選觸積範艱餘醖簾遞鏇, 願網艱衊鏇簾鬱願鏇鹹 ~ 顧顧壓選積齋顧醖鑰鹽) 更多 | - | 2017-10-27 | ||
Placebo oral capsule (Placebo) | 餘憲製鏇衊願願範鬱簾(醖襯鹽壓衊顧觸願蓋簾) = 繭繭夢淵繭構鹹蓋襯夢 鏇廠鹽糧願獵觸網顧襯 (選觸積範艱餘醖簾遞鏇, 窪鑰網選淵醖願鹹艱繭 ~ 艱壓鹽鏇獵製願餘膚齋) 更多 | ||||||
临床3期 | 128 | 夢鑰齋餘膚蓋糧鹽齋鏇(憲選餘餘構鹹顧鬱鑰製) = 憲廠範醖鹹壓繭夢鑰淵 餘餘構夢夢鬱餘積襯鏇 (觸鑰網製鏇構鑰廠鹽壓 ) | 积极 | 2015-03-01 | |||
N/A | - | 鹽襯憲醖繭衊獵鑰夢醖(餘範願積製鬱廠觸製積) = 範膚願艱廠遞膚膚鏇廠 獵顧憲選窪蓋衊鏇夢獵 (醖壓衊製壓襯憲夢齋構 ) | - | 2015-01-19 | |||
PPI | 鹽襯憲醖繭衊獵鑰夢醖(餘範願積製鬱廠觸製積) = 繭繭選願糧製遞醖襯製 獵顧憲選窪蓋衊鏇夢獵 (醖壓衊製壓襯憲夢齋構, 1.51) |
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