别名 Mouth SCC、Mouth Squamous Cell Carcinoma、Oral Cavity SCC + [24] |
简介 A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status. |
靶点 |
作用机制 CTLA4抑制剂 |
在研机构 |
原研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2022-10-21 |
靶点 |
作用机制 PD-1抑制剂 [+2] |
在研机构 |
原研机构 |
最高研发阶段批准上市 |
首次获批国家/地区 中国 |
首次获批日期2019-05-29 |
靶点 |
作用机制 PD-1抑制剂 |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2018-09-28 |
开始日期2026-12-01 |
申办/合作机构 |
开始日期2025-07-15 |
开始日期2025-06-15 |
申办/合作机构 |