Bioverativ Therapeutics, Inc.

Therapeutic advancements for sickle cell disease, RSV, breast cancer, Crohn's and other ailments poised to advance patient health despite urgent challenges facing life science companies LONDON, Jan. 8, 2024 /PRNewswire/ -- Clarivate Plc (NYSE:CLVT), a global leader in connecting people and organizations to intelligence they can trust to transform their world, today announced the release of its annual Drugs to Watch™ report. The report provides in-depth predictive analysis of drugs with the potential for standout commercial and/or clinical success. The report, a key industry resource in the evolving healthcare landscape, has identified over 85 Drugs to Watch over the 11-year course of its publication. This year, analysts identified 13 new-to-market therapeutics and drugs poised to launch in 2024 which Clarivate predictive analytics project will achieve blockbuster status by 2029 or deliver game-changing benefits to patients. These promising advancements include a broad spectrum of therapeutic innovation for conditions including breast cancer, hemophilia A, sickle cell disease, Crohn's disease, ulcerative colitis, respiratory syncytial virus (RSV) and multiple myeloma, among others. In addition, the report spotlights the growing chronic disease market in Mainland China, highlighting seven drugs that are likely to achieve $1 billion blockbuster status by 2029 or to have a significant impact for Chinese patients in need of better treatment options. Mike Ward, Global Head of Thought Leadership, Life Sciences and Healthcare, Clarivate said: "The fundamentals underpinning the biopharma sector have never been stronger, with new technologies fueling medical advancements and providing treatment options to patients with previously unmet needs. Leveraging deep industry expertise and comprehensive therapeutic area differentiated data, this year's Drugs to Watch report identifies innovative medicines based on recent scientific breakthroughs poised to have extraordinary impacts on patient outcomes." 2024 is anticipated to be a transformational year of innovation for the pharma industry. New modalities like antibody drug conjugates and AI/machine learning, underpinned by scientific breakthroughs in the past decade, are achieving clinical successes and providing therapies for patients with limited treatment options. However, external influences such as government initiatives to contain healthcare costs, the sustained high cost of capital and global geopolitical disputes are negatively impacting investor appetites for the sector. The 2024 edition of Drugs to Watch highlights trends that will likely be consequential to the discovery, development and delivery of new medicines, and spotlights drugs and drug candidates that are likely to achieve important milestones in the coming years as they establish themselves as either blockbuster or breakthrough medicines. The 2024 Drugs to Watch, are: Aflibercept (high dose; EYLEA® HD), developed by Bayer and Regeneron Pharmaceuticals Inc For individuals with wet age-related macular degeneration (AMD), diabetic macular edema (DME) or diabetic retinopathy (DR) whose treatment choices include invasive, burdensome administration that limits treatment uptake, high-dose aflibercept offers less-frequent administration while achieving similar efficacy and safety as the current standard of care. Budesonide (TARPEYO®/Kinpeygo®/Nefecon), developed by Calliditas Therapeutics AB, Everest Medicines and STADA Arzneimittel AG TARPEYO®/Kinpeygo® (developed under the project name Nefecon) is a second-generation, synthetic, non-halogenated form of the corticosteroid budesonide. The delayed release formulation of budesonide has shown greater efficacy for protein reduction and slowing the decline in kidney function in primary immunoglobulin A (IgA) as well as a much better safety profile than conventional corticosteroids. Datopotamab deruxtecan (Dato-DXd), developed by AstraZeneca and Daiichi Sankyo With the potential to become the best-in-class TROP2-targeted antibody drug conjugate (ADC), datopotamab deruxtecan is set to be second to market (after TRODELVY®; Gilead Sciences Inc) for both HR-positive/HER2-negative and triple-negative breast cancer, and to enter the non-small cell lung cancer (NSCLC) market. The collaboration between AstraZeneca and Daiichi Sankyo combines the former's strategic focus on NSCLC and breast cancers and investment in ADCs with the latter's proprietary DXd ADC technology. Efanesoctocog alfa (ALTUVIIIO™/BIVV001), developed by Sanofi (Bioverativ Therapeutics Inc) and Swedish Orphan Biovitrum AB (Sobi®) Efanesoctocog alfa is the first once-weekly factor VIII (FVIII) replacement intravenous infusion therapy, which will help reduce the burden associated with the injection frequency of other currently available FVIII therapies. For patients reluctant to receive novel therapies, such as mAbs or gene therapy, efanesoctocog alfa will likely be an appealing option. Clinicians also view efanesoctocog alfa favorably given the attainable FVIIII levels, injection frequency and safety profile demonstrated in clinical trials to date. Ensifentrine (RPL554), developed by Verona Pharma Ensifentrine is an inhaled dual phosphodiesterase (PDE)3 and PDE4 inhibitor that is expected to reduce exacerbations in moderate to severe chronic obstructive pulmonary disease (COPD) without the systemic side effects of current PDE inhibitors that are delivered orally. If approved, it would be the first in class as well as the first novel mechanism that has become available for maintenance COPD treatment in more than 10 years. The clinical and safety profile of ensifentrine makes it a promising addition to the limited treatment class options available for this patient population. Exagamglogene autotemcel (CASGEVY™ /exa-cel) and lovotibeglogene autotemcel (LYFGENIA™/lovo-cel/formerly LentiGlobin™), developed by CRISPR Therapeutics and Vertex Pharmaceuticals Inc (exa-cel) and Bluebird Bio (lovo-cel) All eyes are on exagamglogene autotemcel (exa-cel) and lovotibeglogene autotemcel, which are set become the first disease-modifying therapies for sickle cell disease (SCD) and beta-thalassemia, a significant achievement for a patient population with debilitating, life-altering diseases that have limited symptomatic and curative treatments currently available. The excitement around exagamglogene autotemcel also stems from the landmark first approval of a CRISPR/Cas9 gene-edited therapy globally, and the approval sets the stage for upcoming approvals in other regions. Mirikizumab (Omvoh™/ LY-3074828), developed by Eli Lilly and Company Mirikizumab, an mAb targeting the p19 subunit of IL-23, was approved as first-in-class therapy for ulcerative colitis by the EMA and the U.S. FDA and will likely be the third in the class approved for Crohn's disease. Included in Drugs to Watch 2023, a delayed U.S. launch meant that it remains a drug to watch for 2024. Niraparib + abiraterone acetate (AKEEGA™), developed by Johnson & Johnson Innovative Medicine This is the first and only dual action (or fixed-dose combination [FDC]) tablet combining a PARP inhibitor (niraparib) and a next-generation hormonal therapy (abiraterone acetate). Its ability to serve as a treatment for patients with deleterious or suspected deleterious BRCA-mutated, metastatic castration-resistant prostate cancer (mCRPC) should help to fullfil the need for more effective treatments. RSVpreF (ABRYSVO™/PF-06928316) and RSVpreF3 (AREXVY/GSK-3844766A), developed by Pfizer Inc (ABRYSVO) and GSK plc (AREXVY) Respiratory syncytial virus (RSV) infections continue to be a public health concern, particularly for infants and older adults (65 years and older). A common upper respiratory infection that can result in hospitalizations in severe cases, RSV infection tends to be seasonal and present with symptoms similar to those of influenza and COVID-19. The first approvals of RSV vaccines (RSVpreF and RSVpreF3) targeted at infants and older adults mark a significant public health milestone. Talquetamab (TALVEY™), developed by Johnson & Johnson Innovative Medicine After receiving conditional and accelerated approval from the European Commission and FDA, respectively, talquetamab became the first-in-class bispecific antibody targeted to CD3 and GPRC5D to treat multiple myeloma. It was approved based on the pivotal phase 1/2 MonumenTAL-1 trial for heavily pretreated patients with relapsed or refractory (R/R) multiple myeloma. Ongoing phase 3 trials are expected to provide confirmation of clinical benefit in talquetamab's approved setting and lead to label expansions in other multiple myeloma patient populations, including in combination with other approved agents. Talquetamab is poised as an important addition to the treatment armamentarium for this incurable, often-relapsing disease. Zolbetuximab (IMAB362), developed by Astellas Pharma Inc Metastatic HER2-negative gastric and gastroesophageal junction (GEJ) adenocarcinoma is notoriously difficult to treat and has a significant unmet need for new efficacious treatments. In contrast to HER2-positive disease (for which HER2-targeted agents such as trastuzumab [Genentech] and ENHERTU [Daiichi Sankyo] are available), targeted treatment options are more limited for HER2-negative patients. Zolbetuximab would address some of that unmet need as a first-in-class claudin 18.2 (CLDN18.2) inhibitor in oncology as well as first-line metastatic HER2-negative gastric or GEJ adenocarcinoma. New technology platforms that are likely to achieve significant proof of medical use in the market in 2024 include CRISPR-Cas9 gene-editing as well as artificial intelligence (AI)/machine learning (ML) tool applications in drug discovery, clinical development and commercial launch. In the long run, the latter technologies hold enormous potential to help drugmakers cut costs and shorten innovation cycles, enabling the delivery of more innovative drugs to patients faster going forward. Access the Drugs to Watch 2024 report from Clarivate, here. For more Drugs to Watch updates and analyses throughout the year, visit the Drugs to Watch web page and follow Clarivate for Life Sciences & Healthcare on LinkedIn and X. Join the conversation, using #DrugstoWatch2024. To learn more about how Clarivate can help healthcare companies inform and shape the drug discovery, development and delivery process, visit . Methodology for the Clarivate Drugs to Watch 2024 Report To identify this year's Drugs to Watch, Clarivate drew from the expertise of over 160 analysts covering hundreds of diseases, drugs and markets, along with 11 integrated data sets that span the R&D and commercialization lifecycle, including: Cortellis Competitive Intelligence™, Disease Landscape & Forecast, BioWorld™, Drug Timeline & Success Rates, Cortellis Clinical Trials Intelligence™, Cortellis Generics Intelligence™, Cortellis Deals Intelligence™, Access & Reimbursement payer studies, Clarivate Real World Data and Analytics, Web of Science™ Derwent Innovation™, and other industry sources including biopharma company press releases, filings and peer-reviewed publications. Candidate drugs in phase 2 or phase 3 trials, at pre-registration or registration stage, or already launched in 2023 were selected for analysis, including both novel treatments and already-marketed drugs pursuing new indications that could be particularly impactful. Drugs launched prior to 2023 were excluded. The dataset was filtered for drugs that had total forecast sales of $1 billion or more by 2029. Clarivate experts and analysts evaluated each drug in its individual context, based on factors such as expected approval or launch dates, competitive landscape, regulatory status, trial results, market dynamics and other key factors, and added novel drugs that, while likely to fall short of blockbuster status, are poised to be therapeutic game-changers. Please note that Clarivate analysts generated the data shown in this report prior to December 31, 2023. The Drugs to Watch 2024 Report and the treatments referenced in this release are based on Clarivate's current expectations per existing data, but actual results derived from the drugs named in the report and here may differ significantly. Clarivate is committed to comprehensively supporting customers across the entire drug, device and medical technology lifecycles to advance human health. By combining patient journey data, therapeutic area expertise, artificial intelligence and analytics in ways that unlock hidden insights, data-driven decisions and accelerating innovation, Clarivate's end-to-end research intelligence is designed to enable customers to make informed evidence-based decisions. About Clarivate Clarivate is a leading global information services provider. We connect people and organizations to intelligence they can trust to transform their perspective, their work and our world. Our subscription and technology-based solutions are coupled with deep domain expertise and cover the areas of Academia & Government, Life Sciences & Healthcare and Intellectual Property. For more information, please visit clarivate.com. Media Contact: Catherine Daniel Director, External Communications, Life Sciences & Healthcare [email protected] SOURCE Clarivate Plc

近十年，诸多自免领域靶向药物不断涌出，前有阿达木单抗多年蝉联“药王”，现有度普利尤单抗强势增长，自免药物市场一直风风火火，药企纷纷加注。9月27日，Immunovant公布了旗下FcRn抗体IMVT-1402的最新临床Ⅰ期结果，基于Ⅰ期临床数据，IMVT-1402被称之为潜在同类最优的FcRn拮抗剂，一时间，自免领域后起之秀靶向FcRn药物研发再次引发广泛关注。PART 01自免新药市场火热自身免疫疾病又被患者称之为“不死的癌症”，主要包括类风湿关节炎、强直性脊柱炎、重症肌无力、银屑病、克罗恩氏病、系统性红斑狼疮等，自免疾病发病机制复杂，需长期用药，耐药性、依从性等问题比较普遍，常常需要更新换代，这也推动着自身免疫疾病药物行业的持续发展。根据《柳叶刀》杂志数据，2019 年-2020 年，全球约有7.6%~9.4%的人群患有各种类型的自免疫性疾病，且每年患病数量逐年递增。庞大的患病人群催生免疫疾病治疗需求快速增长，用药方案逐步从化学制剂向生物制剂/新一代靶向药升级，潜市场空间巨大。根据弗若斯特沙利文数据显示，2021年全球自身免疫性疾病生物制剂市场规模为891亿美元，预计到2030年将增至1421亿美元。目前，全球自免药物市场销售火热，据公开数据统计，2021年全球药品销售额TOP100就有21个自免药物，且销售总金额高达936亿美元，2022年阵容继续扩大，前100位共有22个自免库领域药物，总销售额继续增加到974亿美元。此外，诸多跨国制药巨头旗下的销售冠军也都来自于自免领域，比如成就艾伯维的Humira（阿达木单抗）、赛诺菲的Dupixent（度普利尤单抗）、罗氏Ocrevus（奥瑞珠单抗）、强生的Stelara（乌司奴单抗）等。当前，超千亿的市场吸引药企们纷纷布局，自免新药开发正在加速，不过不再局限于类风湿关节炎、炎症性肠病、银屑病等热门疾病，以及IL-4、IL-13、IL-17、IL-23、JAK等热门靶点，新一代靶点如IL-4R、TSLP、FcRn等为自免疾病带来疗效提升的同时，也带来了新一阶段的市场机会，正逐渐兴起。PART 02FcRn 拮抗剂：自身免疫病的新兴疗法在五种类型的免疫球蛋白（IgA、IgD、IgE、IgG和IgM）中，IgG在人体血清中的含量是最多的（约占Ig的75%）。IgG是机体病原体和抗毒素的重要成分，在机体免疫反应中起到了重要作用。此外，IgG是已知的能从母体转移至胎儿，从而使胎儿获得短期被动免疫能力的抗体。而这种IgG的特异性转运是由neonatal Fc receptor（FcRn）所介导。FcRn能保护IgG和白蛋白在细胞内“不被降解”，并将其释放回血液循环中，可以起到增长IgG体内半衰期的作用，参与到IgG 的体内转运、维持和分布代谢过程中。这一过程也可被抗体设计过程所利用以增强药物抗体半衰期。IgG在人体内半衰期长达2～4周，影响半衰期主要归因于FcRn介导的再循环机制，而这种机制是通过IgG的Fc片段和血清白蛋白与FcRn的pH依赖性结合而实现。FcRn介导的IgG和血清蛋白再循环示意图图片来源：ACROBiosystems官方FcRn在全身中都有广泛表达，扮演着IgG循环并达到长效的角色，阻断FcRn则可以直接抑制浆B细胞的效应蛋白-IgG抗体，许多自身免疫病的致病机制正是其自身抗体，FcRn可治疗已知由致病IgG 抗体驱动导致的自身免疫性疾病，包括全身性重症肌无力（gMG）寻常性天疮（PV)、原发免疫性血小板减少症（ITP）慢性脱髓鞘性多发性神经病（CIDP）等。靶向FcRn的药物，并不像其他常规靶点一样将FcRn作为治疗干预的直接靶点，而是利用其细胞药物传递的优势，被称为可将所有自身免疫性疾病一网打尽的“革命性疗法”，具备极高的潜力。PART 03两款上市新药揭开FcRn靶点面纱20世纪60年代F.W.罗杰斯·布拉姆贝尔率先预测FcRn作为运输和保护受体，进入70年代，Jones等首次在新生大鼠肠道发现通过转运母体IgG给新生儿的受体，新生儿Fc受体（Neonatal Fc receptor, FcRn）也由此命名而来。经历了三十年，直到2021年12月，Argenx宣布FDA批准艾加莫德（Efgartigimod）上市，用于治疗抗乙酰胆碱受体（AChR）抗体阳性的成人全身性重症肌无力（gMG)，人类终于迎来了是全球首款FcRn靶向药物，靶点FcRn不再神秘。在关键性的三期临床试验ADAPT中，艾加莫德显示出了良好的疗效和安全性，78.5%的患者在前两个周期实现了日常活动能力显著改善。相对于传统的重症肌无力（MG）治疗药物，靶向创新药相对较少，作为全球首款以FcRn为靶点的MG新药，艾加莫德作以独特的作用机制逐渐成为所有重症肌无力靶向药物中，兼顾疗效与安全性的最佳选择。艾加莫德自2021年上市，销售表现非常可观，2022年艾加莫德的销售额就达4亿美元，2023Q2单季收入2.69亿美元。时隔十八个月，今年6月底，FDA批准第二款FcRn拮抗剂洛利昔珠单抗（Rozanolixizumab）上市，用于治疗两种最常见的成人全身型MG亚型，即抗乙酰胆碱受体（AchR）或抗肌肉特异性酪氨酸激酶（MuSK）抗体阳性。洛利昔珠单抗是目前FDA批准的唯一一种治疗这两种最常见的全身型MG亚型的药物。洛利昔珠单抗在试验中证实了其在治疗全身性重症肌无力（gMG）方面的显著效果。2019年，美国FDA曾授予洛利昔珠单抗孤儿药称号，用于治疗全身性重症肌无力；欧盟委员会也于2020年4月授予孤儿药资格，洛利昔珠单抗的加入，重症肌无力FcRn靶向药物市场更加热闹。目前两款已经上市的FcRn拮抗剂的首发适应症都是重症肌无力，不过FcRn阻断是一种新的、有效的策略，可降低致病性IgG自身抗体的循环水平，并减少IgG介导的疾病，有望用于治疗几十种不同的自身免疫性疾病。除重症肌无力，艾加莫德目前正在开展治疗原发性免疫性血小板减少症、治疗寻常型天疱疮/落叶型天疱疮、慢性脱髓鞘性多发性神经根神经病等适应症的试验；刚获批上市的洛利昔珠单抗也在开展MOG和NMOSD脊髓炎的试验。基于靶向FcRn的药物在自免药物领域的潜力，以及艾加莫德上市之后的优异表现，诸多药企看好FcRn拮抗剂赛道并纷纷入场布局，据不完全统计，目前全球在研的FcRn近十种，海外市场涉及的企业有强生、亚力兄、优时比、Argenx、Immunovant、Syntonix Pharmaceuticals、AnaptysBio等。其中Immunovant是在该领域最多的企业，专攻重磅靶点FcRn，其管线中有Batoclimab（巴托利单抗，以前称为IMVT-1401）和IMVT-1402这两种FcRn 抗体在研，其中巴托利单抗在全球最高研发进度是在中国，已提交上市申请；IMVT-1402有望成为同类最佳，目前已完成临床Ⅰ期，和铂医药拥有巴托利单抗的大中华区权益。此外，强生也加码自免领域，2020年强生斥资65亿美元收购Momenta Pharmaceuticals，从而获得Momenta旗下的FCRn抗体Nipocalimab(尼卡利单抗)的全部全球权利，目前尼卡利单抗全球最快进展到临床Ⅲ期。PART 04再鼎医药领先国产    和铂携手石药即将入场    截至目前，国内仅上市艾加莫德这一款FcRn靶点药物，艾加莫德是再鼎医药于2021年1月以1.75亿美元预付款和里程碑付款从Argenx手里引进，于今年6月底获NMPA批准上市，并于9月初在国内正式开售，成为再鼎医药在自身免疫领域里的第一款成功商业化的产品。在MG适应症上，Argen/再鼎医药还开发了艾加莫德（Efgartigimod PH20）皮下注射剂，今年6月艾加莫德皮下注射剂已在美国上市。在研方面，目前国内进展最快的是石药集团与和铂医药的巴托利单抗以及艾加莫德的皮下注射剂型，其中巴托利单抗于6月底已提交上市申请，艾加莫德的皮下注射剂型在今年7月上市申请已获NMPA受理，此外刚在美上市的洛利昔珠单抗和强生的尼卡利单抗中国也进入了临床Ⅲ期，适应症均是重症肌无力。国内FcRn在研情况数据来源：根据公开数据整理根据和铂与石药在今年3月公布的巴托利单抗治疗全身重症肌无力（gMG）的Ⅲ期试验数据，结果显示已达到主要研究终点及关键次要研究终点，同时治疗总体上安全且耐受性良好，未发现新的安全性信号，这是首个在中国gMG人群中被证实有效且安全的抗FcRn疗法。也就是说，巴托利单抗如若顺利获批，将成为艾加莫德在中国市场的头号挑战者，同时，根据公开信息，和铂与石药还在拓展巴托利单抗更多适应症，免疫性血小板减少症（ITP）正在开展 Ⅱ/Ⅲ 期临床研究，此外，视神经脊髓炎谱系疾病（NMOSD）、慢性炎性脱髓鞘性多发性神经根神经病（CIDP）、天疱疮（PV）等均已进入临床阶段，失去先发优势的巴托利单抗，力求在MG适应症之外寻求更多差异化优势。总之，国内拥有庞大的自身免疫疾病人群，免疫疾病治疗需求快速增长，市场提升空间巨大，当下，火热的自免药物领域暗流涌动，以艾加莫德为代表的拥有独特的作用机制的FcRn拮抗剂正崛起。来源 | 博药（药智网获取授权转载）撰稿 | 米朵责任编辑 | 八角声明：本文系药智网转载内容，图片、文字版权归原作者所有，转载目的在于传递更多信息，并不代表本平台观点。如涉及作品内容、版权和其它问题，请在本平台留言，我们将在第一时间删除。商务合作 | 王存星 19922864877（同微信） 阅读原文，是受欢迎的文章哦

Appointments strengthen the leadership team and deepen expertise in drug discovery, oncology research, and strategic partnerships Dr. Brian Jones appointed to Scientific Advisory Board LEXINGTON, MA / ACCESSWIRE / September 12, 2023 / Triana Biomedicines, Inc. (TRIANA), a leading biopharmaceutical company focused on advancing a target-first and rational molecular glue discovery platform to address difficult to drug disease targets, today announced the appointments of Dr. Vito Palombella as Chief Scientific Officer and Dr. Reza Mazhari as Chief Business Officer. Additionally, Dr. Brian Jones is appointed to the growing Scientific Advisory Board (SAB). "I am thrilled to have Vito and Reza join the team at such a pivotal time for the company. As we rapidly advance our discovery pipeline currently focused on targeted protein degradation, Vito's oncology and drug development expertise and Reza's prowess in business development and portfolio strategy complement and strengthen our growing team. Both share a depth in translational sciences that will play a central role in the development of TRIANA's future molecular glue products," said Dr. Patrick Trojer, President and CEO of TRIANA. "Also, I am delighted to welcome Dr. Brian Jones to our Scientific Advisory Board. We are privileged to have the opportunity to work with a premier group of molecular glue thought leaders on drug development initiatives from discovery through drug commercialization. Their insights will help advance our efforts to build our world class molecular glue discovery platform and a robust pipeline of innovative molecular glue therapeutics." "I joined TRIANA because of its high powered scientific team and its product-focused approach to exploit this exciting new modality to tackle undrugged cancer targets," said Dr. Vito Palombella. "We are at the cusp of creating transformative medicines for patients." "I am very pleased to join the TRIANA team as we explore opportunities which leverage the company's proprietary scientific platform and discovery pipeline," said Dr. Reza Mazhari. "There is a growing interest in unlocking the full potential of molecular glues to develop precision medicines for a broad range of indications, allowing TRIANA to consider various value-creating asset- and/or platform-focused business development opportunities in the months and years ahead." "This is an exciting time for TRIANA as they deliver on the potential of molecular glue therapies. I look forward to working with the company and the other members of the SAB in guiding the company to address the undruggable dilemma facing many patients with first-in-class therapies," said Dr. Brian Jones. Vito J. Palombella, PhD, joins TRIANA with 30 years of scientific leadership and experience advancing first-in-class therapeutic programs, as well as a successful track record of building drug discovery and development organizations. Prior to joining TRIANA, he was the Chief Scientific Officer (CSO) at Surface Oncology, where he led the non-clinical research and development organization. Prior to that, Dr. Palombella was EVP and CSO at Infinity Pharmaceuticals, where he was responsible for drug discovery and preclinical development. He held roles of increasing scientific responsibility at Syntonix Pharmaceuticals, Millennium Pharmaceuticals, LeukoSite Inc, and ProScript. Dr. Palombella was involved in the discovery and development of bortezomib and duvelisib, both for cancer therapy. Dr. Palombella holds a PhD in Viral Oncology and Immunology from the New York University Medical Center and completed his postdoctoral fellowship at Harvard University. Reza Mazhari, PhD, brings to TRIANA more than twenty years of business development as well as drug discovery and development experience. Prior to joining TRIANA, he was the Head of Search and Evaluation for Oncology at Novartis, where he led numerous successful in-licensing deals that contributed to the early-stage oncology pipeline and expanded the portfolio of enabling technologies. Dr. Mazhari was also responsible for out-licensing and divestment efforts at Novartis Institutes for BioMedical Research (NIBR). Previously, Dr. Mazhari was the Vice President of Translational Medicine at Rexahn Pharmaceuticals. Prior to that, he held dual responsibilities for leading drug discovery and early development in addition to leading the company's business development efforts at Cerecor. He was the co-founder of Cardioxyl Pharmaceuticals which was acquired by Bristol-Myers Squibb for $1.8 billion. He began his career as a faculty member at the School of Medicine in The Johns Hopkins University. Dr. Mazhari holds a PhD in Bioengineering from University of California at San Diego and a post-doctoral research fellowship in Cardiovascular Medicine from The Johns Hopkins School of Medicine. Brian Jones, PhD, is a seasoned drug discovery leader with over 30 years of industry experience. He is responsible for over 20 INDs across a broad spectrum of therapeutic indications. Most recently, he incubated, launched and was the CSO at Cedilla Therapeutics, which successfully discovered distinctive conditional modulators of targeted cancer biology. He was Entrepreneur in Residence at Third Rock Ventures, with active involvement in a wide variety of therapeutic areas and responsible for the incubation and launch of several private biotech companies. Previously, he was Head of Discovery Chemistry and Chemical Biology at Novartis Institute for Biomedical Research. Dr. Jones holds a PhD in Organic Chemistry from Imperial College of Science at University of London and a NATO post-doctoral research fellowship from Yale University. About TRIANA Biomedicines, Inc. TRIANA Biomedicines is a private biotechnology company, headquartered in Lexington, Massachusetts and focused on building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA's drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA's target first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-pro targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients. Contact IR@trianabio.com SOURCE: TRIANA Biomedicines, Inc. View source version on accesswire.com: