近日,来自莱顿大学医学中心的研究者们在Hepatology杂志上发表了题为“ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver”的文章,该研究证实了肝内皮细胞ALK1信号保护器官特异性内皮细胞分化和血管分泌信号,防止血管畸形的发生。长期存活的Alk1HEC-KO HHT模型为开发这种严重疾病的靶向治疗提供了新的机会。
Christian David Schmid et al. ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver. Hepatology. 2022 Jul 1. doi: 10.1002/hep.32641.