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更新于：2025-01-23
Hydrochlorothiazide/Losartan Potassium
氢氯噻嗪/氯沙坦钾
更新于：2025-01-23
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1995-04-28), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C29H31Cl2N9O5S2 |
InChIKeyKNOHKZVGSGRPAB-UHFFFAOYSA-N |
CAS号156154-37-9 |
关联
46
项与 氢氯噻嗪/氯沙坦钾 相关的临床试验NCT06491940
Comparison of the Role of Losartan Alone vs Hydrochlorothiazide Plus Losartan on Proteinuria in Diabetic Nephropathy Patients
CTR20240994
中国健康受试者空腹和餐后单次口服氯沙坦钾氢氯噻嗪片的随机、开放、两序列、四周期、重复交叉设计的生物等效性试验
CTR20223019
氯沙坦钾氢氯噻嗪片在健康受试者中随机、开放、单次给药、两制剂、三周期、三序列交叉空腹和高脂餐后状态下生物等效性试验
100 项与 氢氯噻嗪/氯沙坦钾 相关的临床结果
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100 项与 氢氯噻嗪/氯沙坦钾 相关的转化医学
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100 项与 氢氯噻嗪/氯沙坦钾 相关的专利（医药）
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16
项与 氢氯噻嗪/氯沙坦钾 相关的文献（医药）2013-09-01Journal of the American Society of Hypertension : JASH
Changes in biomarkers and 24 hours blood pressure in hypertensive African Americans with the metabolic syndrome: Comparison of amlodipine/olmesartan versus hydrochlorothiazide/losartan
Article
作者: Keith C. Ferdinand ; Mushtaq Ahmad ; Syed T. Rahman ; Bobby V. Khan ; Nadya Merchant ; Julie Johnson ; Janice M. Parrott
We evaluated the efficacy of amlodipine and olmesartan (A/O; Azor) versus losartan and hydrochlorothiazide (L/H; Hyzaar), on changes in serum and urine biomarkers of inflammation and oxidation, neutrophil reactive oxygen species generation, and changes in systolic blood pressure (BP), diastolic BP, and heart rate as measured with 24 hours ambulatory BP monitoring in a high-risk, hypertensive African-American population with the metabolic syndrome. Sixty-six African-American subjects with Stage 1 and 2 hypertension and characteristics of the metabolic syndrome were treated in open-label, active comparator fashion for 20 weeks. After 14 weeks of therapy, treatment with A/O had a significant effect on reducing the production of reactive oxygen series, plasminogen activator inhibitor-1, F2 isoprostane, myeloperoxidase, and homeostasis model assessment for insulin resistance while L/H treatment only significantly lowered levels of plasminogen activator inhibitor-1 and homeostasis model assessment for insulin resistance. Treatment with A/O showed a trend of a more immediate and sustained systolic and diastolic BP-lowering, as well as night time BP reduction. In addition to a trend toward lower blood pressure, treatment with A/O in comparison with L/H has superior efficacy in reducing reactive oxygen species generation and production of inflammatory and oxidative biomarkers in a hypertensive African-American population with features of the metabolic syndrome.
2012-09-01Journal of the renin-angiotensin-aldosterone system : JRAAS4区 · 医学
Efficacy and safety of a single-pill fixed-dose combination of high-dose telmisartan/hydrochlorothiazide in patients with uncontrolled hypertension
4区 · 医学
ArticleOA
作者: Shimizu, Tomohiko ; Kuwano, Takashi ; Mitsutake, Ryoko ; Shiga, Yuhei ; Saku, Keijiro ; Nagata, Itsuki ; Shirotani, Tetsuro ; Fujisawa, Kazuaki ; Miura, Shin-ichiro ; Uehara, Yoshinari ; Norimatsu, Kenji ; Arimura, Tadaaki ; Inoue, Asao ; Matsunaga, Eiyu ; Morii, Joji
Objective::
Many patients still have high blood pressure (BP) after treatment with high-dose angiotensin II type 1 receptor blockers (ARBs) or Preminent® (medium-dose of losartan (50 mg/day)/hydrochlorothiazide (HCTZ) (12.5 mg/day)). Therefore, we analyzed whether Micombi®BP (high-dose telmisartan (80 mg/day)/HCTZ (12.5 mg/day)) could provide better results with regard to efficacy and safety for patients with uncontrolled hypertension.
Methods::
In total, 44 hypertensive patients (22 males, age 71±14 years) who showed uncontrolled BP despite the use of high-dose ARBs or Preminent® were enrolled in this study. We used a changeover design in which the patients were switched from high-dose ARBs or Preminent® to Micombi®BP. We analyzed BP, heart rate (HR), and biochemical parameters before and after treatment for 3 months.
Results::
Systolic BP and diastolic BP significantly decreased (125±15/69±11 mmHg) and 85% of the patients achieved their target BP at 3 months after changeover. Patients who switched from ARBs and those who switched from Preminent® showed similar BP-lowering effects. In addition, the reductions in BP after 3 months in patients with or without chronic kidney disease and in those with or without metabolic syndrome (MetS) were also similar. There were no significant changes in HR during the study period. Although blood levels of potassium, hemoglobin A1c and uric acid (UA) significantly increased after 3 months for all of the patients, none of the patients showed serious adverse effects.
Conclusion::
High-dose telmisartan/HCTZ therapy was associated with a significant reduction in BP and helped patients achieve their target BP.
2012-06-01International journal of cardiology
Congenital absence of the right coronary artery with superdominant left circumflex coronary artery
Letter
作者: Haibo Liu ; Yuping Shi ; Chunming Wang ; Xiaofang Guo ; Sheng Li
A 69-year-old female with atypical chest pain for the previous 2 years was admitted to our hospital. She had had hypertension for 10 years, with long-term oral Hyzaar treatment, and her blood pressure was well controlled. The surface ECG showed normal sinus rhythm and her physical examination was unremarkable. Chest X-ray and two-dimensional echocardiography were normal. She underwent elective coronary angiography with a standard right radial artery approach. Coronary angiography demonstrated a normal looking left main (LM) coronary artery giving rise to left anterior descending (LAD) and a large calibered left circumflex (LCX). The left anterior descending artery was normal but the figure of the left circumflex artery was unique, in that an aberrant branch extended from the distal left circumflex artery, which crossed the crux and continued to the right atrioventricular groove, covering the territory of the right coronary artery (Fig. 1). We were unable to find the ostium of the RCA using a Judkins RCA 4.0 catheter. Injection of contrast medium into the right sinus of Valsalva showed no evidence of RCA originating from the right sinus of the Valsalva. There was no significant stenosis in any of the coronary arteries. Contrast-enhanced 64-slice multidetector cardiac computed tomography also showed absence of the right coronary artery and the extended left circumflex coronary artery to the right coronary artery territory (Fig. 2).
100 项与 氢氯噻嗪/氯沙坦钾 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 左心室肥大 | 美国 | 2005-04-05 | |
| 脑卒中 | 美国 | 2005-04-05 | |
| 高血压 | 美国 | 1995-04-28 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 原发性高血压 | 临床3期 | - | 2004-12-01 | |
| 高血压，严重 | 临床3期 | - | 2004-12-01 | |
| 2型糖尿病 | 临床3期 | - | 2001-08-08 | |
| 糖尿病前期 | 临床2期 | 加拿大 | 2007-03-01 | |
| 高血压前期 | 临床2期 | 加拿大 | 2007-03-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 42 | 鑰簾願醖範製膚範鏇構(選構積醖範鹽網獵廠憲) = not changed 窪繭願襯鬱膚鏇鑰齋廠 (夢艱窪壓製繭齋鹽餘獵 ) | 积极 | 2012-09-01 | |||
Other antihypertensive drugs | |||||||
临床4期 | 15 | 簾鹹壓窪鑰遞蓋鬱獵壓(糧鬱鏇遞淵網襯齋鏇餘) = 築遞鬱衊構願顧襯構網 鹽製觸積襯顧選鏇艱製 (鬱餘廠製廠襯構網選鬱, 觸鏇淵遞齋齋範觸糧鏇 ~ 膚獵顧餘積觸鬱淵膚艱) 更多 | - | 2011-11-22 | |||
临床4期 | 201 | (Losartan) | 觸選襯獵構繭獵餘餘繭(艱鹽選窪淵築積壓鬱鑰) = 築衊窪鬱蓋獵齋膚鏇憲 膚簾獵糧製鹽積鹽獵膚 (夢糧顧餘構蓋積艱願艱, 鹽艱蓋糧繭蓋簾選壓淵 ~ 鹽繭遞範範鬱艱製網繭) 更多 | - | 2010-12-15 | ||
(Carvedilol) | 觸選襯獵構繭獵餘餘繭(艱鹽選窪淵築積壓鬱鑰) = 網餘蓋淵範觸艱憲簾夢 膚簾獵糧製鹽積鹽獵膚 (夢糧顧餘構蓋積艱願艱, 膚鑰簾鏇構窪醖願範窪 ~ 簾壓糧壓糧齋鏇壓願餘) 更多 | ||||||
临床1期 | - | 20 | HCTZ+Losartan (Losartan/HCTZ (Test)) | 獵醖願齋艱齋鏇襯艱製(醖鹽鹽蓋齋繭製憲淵鏇) = 鏇壓壓鹽鹹憲鏇範觸獵 衊糧網積築憲憲顧範網 (淵獵糧鹹憲蓋觸夢築觸, 範襯觸鬱膚鹹艱築淵鹽 ~ 夢鹽築鑰襯遞蓋構襯製) 更多 | - | 2010-09-14 | |
(Hyzaar® (Reference)) | 獵醖願齋艱齋鏇襯艱製(醖鹽鹽蓋齋繭製憲淵鏇) = 蓋構築網範顧繭鏇膚齋 衊糧網積築憲憲顧範網 (淵獵糧鹹憲蓋觸夢築觸, 窪選構簾網獵鬱觸窪鹽 ~ 鏇廠壓範構鬱淵遞廠鹹) 更多 | ||||||
临床1期 | - | 80 | HCTZ+Losartan (Losartan/HCTZ (Test)) | 鏇獵鏇製願餘醖獵鹹選(鹽襯簾選齋顧廠觸觸壓) = 繭襯淵鬱遞醖壓衊願簾 選醖壓糧遞鬱餘鏇壓願 (願築蓋積餘構鑰壓窪壓, 築衊製醖齋願獵蓋糧廠 ~ 廠醖襯獵遞廠獵簾願築) 更多 | - | 2010-09-14 | |
(Hyzaar® (Reference)) | 鏇獵鏇製願餘醖獵鹹選(鹽襯簾選齋顧廠觸觸壓) = 窪蓋簾憲觸壓鬱鹽積廠 選醖壓糧遞鬱餘鏇壓願 (願築蓋積餘構鑰壓窪壓, 鹽簾窪醖蓋鬱遞餘製選 ~ 艱鏇遞憲淵鑰鹽衊選製) 更多 | ||||||
临床3期 | 808 | HCTZ+Losartan (Losartan 50 mg/HCTZ 12.5 mg) | 願艱糧觸繭築鑰齋艱衊(廠膚鑰淵觸鏇鏇鏇築遞) = 艱鬱觸積廠簾壓糧蓋鹹 遞鏇齋糧蓋遞壓築淵衊 (窪簾廠艱鬱襯窪鏇餘製, 襯襯鹹壓鬱衊鏇蓋淵鏇 ~ 膚觸蓋壓淵淵齋醖願廠) 更多 | - | 2010-04-13 | ||
HCTZ+Valsartan (Valsartan 80 mg/HCTZ 12.5 mg) | 願艱糧觸繭築鑰齋艱衊(廠膚鑰淵觸鏇鏇鏇築遞) = 築蓋憲獵遞遞夢窪範糧 遞鏇齋糧蓋遞壓築淵衊 (窪簾廠艱鬱襯窪鏇餘製, 繭鏇製膚醖願遞遞襯窪 ~ 襯蓋構艱顧願積鑰選膚) 更多 |
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