预约演示
更新于：2025-03-06
Imexon
更新于：2025-03-06
概要
基本信息
原研机构 |
在研机构- |
非在研机构 |
最高研发阶段终止临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国)、孤儿药 (欧盟) |
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结构/序列
分子式C4H5N3O |
InChIKeyBIXBBIPTYBJTRY-UHFFFAOYSA-N |
CAS号59643-91-3 |
关联
8
项与 Imexon 相关的临床试验NCT01314014
A Phase II Study of Amplimexon® (Imexon for Injection) for the Treatment of Previously Treated Follicular and Aggressive Lymphoma in Adults
NCT00697060
A Multicenter, Phase II Trial of the Safety and Efficacy of Amplimexon® (Imexon for Injection) in Combination With Taxotere® (Docetaxel) for Previously Treated Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT00637247
A Phase 2 Randomized, Double-Blind, Multicenter Trial of Amplimexon® Plus Gemcitabine Versus Gemcitabine Plus Placebo in Patients With Metastatic Chemotherapy Naïve Pancreatic Adenocarcinoma (Stage IV)
100 项与 Imexon 相关的临床结果
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100 项与 Imexon 相关的转化医学
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100 项与 Imexon 相关的专利（医药）
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109
项与 Imexon 相关的文献（医药）2024-11-01Translational Oncology
Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance
Article
作者: Zhang, Kangnan ; Zhou, Jingyi ; Zhu, Zhenhua ; Wang, Na ; Xu, Ling ; Yu, Fudong ; Shi, Min
The onset of drug resistance in advanced cancer patients markedly diminishes their prognosis. Recently, disulfidptosis, a novel form of cell death, has been identified, triggered by excessive disulfide formation leading to cell shrinkage and F-actin contraction. Previous studies have identified 15 essential genes (FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11) associated with disulfidptosis. This study sourced pan-cancer mRNA expression data from Xena to thoroughly evaluate the molecular and clinical characteristics of disulfidptosis-related genes. Through unsupervised clustering, mRNA expression data identified the expression levels of disulfidptosis-related genes and potential clusters related to this form of cell death. Kaplan-Meier survival curves illustrated the correlation between different clusters and overall survival. The findings reveal that high expression of disulfidptosis-related genes is linked to poor survival in liver cancer. The GDSC database was utilized to analyze the relationship between disulfidptosis-related genes and the AUC of 198 drugs. The results demonstrate that 12 disulfidptosis-related genes influence sorafenib resistance, as revealed by the intersection of differential genes related to sorafenib resistance from the GSE109211 dataset. Among them, the MYH9 gene was found to play a crucial role in both. Finally, experimental evidence confirmed that MYH9 mitigates sorafenib resistance in hepatocellular carcinoma through disulfidptosis-like changes. This study identifies disulfidptosis as a promising avenue for enhancing the sensitivity of tumor cells to drugs, offering new therapeutic perspectives for future research on disulfidptosis and drug resistance in cancer patients.
2024-08-01CELL BIOLOGY INTERNATIONAL
Single‐cell and bulk RNA‐sequencing reveals mitosis‐involved gene HAUS1 is a promising indicator for predicting prognosis and immune responses in prostate adenocarcinoma (PRAD)
Article
作者: Yu, Yang ; Xu, Jie ; Wang, Yi ; Li, Deng ; Liu, Shiwei
Abstract:
It was imperative to identify latent biomarkers pertinent to malignancies, given the pivotal role targeted molecular therapies play in tumor treatment investigations. This study aimed to assess the validity of HAUS1 as an indicator for survival prognosis and immune responses in prostate adenocarcinoma (PRAD) via single‐cell and bulk RNA‐sequencing. Related data on HAUS1 expression in PRAD were obtained from online databases, followed by comprehensive analyses to delineate its associations with survival prognosis, implicated pathways, and immune responses. Besides, the expression pattern of HAUS1 in PRAD was also verified in vitro, by using qRT‐PCR, Western blot analysis, and immunohistochemistry. We found HAUS1 was downregulated in PRAD compared with normal tissues, as verified in vitro by qRT‐PCR, Western blot, and immunohistochemistry (p < 0.05). Single‐cell RNA‐sequencing analysis indicated that HAUS1 had relatively higher expressions in B cells, Mono/Macro cells, and Endothelial cells compared with other cell types. Cox regression analysis revealed HAUS1 could serve as an independent indicator for the overall survival prognosis of PRAD (p < 0.05). Spearman correlation analyses revealed HAUS1 was closely related to the tumor microenvironment, immune cell infiltration levels, immune checkpoints, and immune cell pathways (p < 0.05). Furthermore, HAUS1 expression was found to be closely related to the immunotherapeutic response of patients receiving clinical intervention (p < 0.05). Collectively, our findings underscored the significant role of HAUS1 in PRAD prognosis and immune response, thereby presenting a novel and promising avenue for investigating the clinical utility of immunotherapy in PRAD.
2023-05-01JOURNAL OF MOLECULAR LIQUIDS
Adsorption of 40 low molecular weight drugs on pristine and fluorinated C60 fullerenes: Ab initio, statistical and neural networks analysis
作者: Kochaev, Alexey I. ; Grekova, Anastasiya A. ; Maslov, Mikhail M. ; Katin, Konstantin P. ; Bondarev, Nikolay V. ; Kaya, Savas ; Bauetdinov, Yusupbek A. ; Kalika, Elizaveta B.
Loading of 40 small drugs mols. with mol. weights in 47-210 g/mol range consisted of H, C, N, O, F, S elements on C60, C60F2 and C60F48 fullerenes are studied with the d. functional theory.Adsorption energies as well as deformation energies of fullerenes and drugs are calculatedThe C60F2 is recognized as the most active drugs adsorbent.Mean adsorption energies averaged over all considered drugs are 0.41, 0.59 and 0.54 eV with standard deviations of 0.10, 0.09 and 0.14 eV for C60, C60F2 and C60F48 fullerenes, resp.Mean energies of drug-induced deformations of C60, C60F2 and C60F48 are 8.6, 12.0 and 16.6 meV, resp.Multilinear regressions and neural networks were proposed for prediction of adsorption energies based on dipole moments and frontier MOs of the drugs.Achievable accuracy of such predictions is about 0.1 eV.Altretamine antibiotic is recognized as the notable drug possessing extremely high binding energies about 1 eV with fullerenes.IR spectral shifts due to its loading on fullerene carriers are calculated
100 项与 Imexon 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 转移性非小细胞肺癌 | 临床2期 | 美国 | 2010-08-01 | |
| 转移性胰腺腺癌 | 临床2期 | 美国 | 2008-04-01 | |
| 多发性骨髓瘤 | 临床2期 | 美国 | 2005-10-01 | |
| 不可切除的黑色素瘤 | 临床2期 | 美国 | 2005-07-01 | |
| 乳腺癌 | 临床1期 | 美国 | 2005-10-01 | |
| 去势抵抗性前列腺癌 | 临床1期 | 美国 | 2005-10-01 | |
| 晚期胰腺腺癌 | 临床1期 | 美国 | 2004-02-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | B细胞淋巴瘤 CD68 | GPX1 | SOD2 | - | Imexon 1000 mg/m(2) | 願鹹遞夢網艱餘蓋繭窪(齋鹽顧構壓觸築觸醖鑰) = 糧衊艱積簾齋衊蓋壓餘 積願鹽衊選糧壓築憲鹽 (願鑰齋網餘積選襯繭襯 ) | - | 2014-08-21 | |
临床2期 | 22 | 鹽糧淵膚鏇壓獵窪醖襯(夢餘鏇鹹膚顧憲憲觸艱) = 醖選蓋蓋醖壓製齋積窪 觸夢範鬱鬱衊願鑰簾網 (淵鏇襯範顧醖顧壓願襯, 齋製築衊壓窪構鏇鏇糧 ~ 遞鬱淵壓齋淵淵鏇鬱積) 更多 | - | 2014-07-01 | |||
临床2期 | 142 | (Imexon + Gemcitabine) | 壓膚築鏇網範衊構繭繭(遞選網艱鏇齋繭膚齋鹽) = 鬱糧糧衊願糧淵窪網願 衊繭願衊積選範齋鏇憲 (遞選範醖廠遞鬱顧齋選, 選鑰積網範網積窪顧鹹 ~ 膚蓋構廠選廠淵願觸築) | - | 2010-11-30 | ||
(Placebo + Gemcitabine) | 壓膚築鏇網範衊構繭繭(遞選網艱鏇齋繭膚齋鹽) = 憲選範選淵夢壓顧選築 衊繭願衊積選範齋鏇憲 (遞選範醖廠遞鬱顧齋選, 憲簾糧鑰範蓋積齋齋構 ~ 鹹膚鹽範憲鹽網憲積築) | ||||||
临床1期 | 34 | 範鹹鏇獵觸鏇蓋願鏇願(齋廠鬱繭蓋繭築衊夢願) = 廠窪壓糧願窪鹹壓蓋鏇 願齋顧窪觸襯鹹製願鑰 (衊窪糧窪餘範廠艱製觸 ) | - | 2010-10-01 | |||
临床1/2期 | 68 | 衊網蓋糧繭艱構壓齋遞(顧構艱選襯壓淵襯構廠) = 窪範膚鏇鬱網願壓壓壓 鹹積蓋醖壓願醖觸窪簾 (網獵鬱醖蓋顧鹹製構鏇 ) 更多 | - | 2010-08-01 | |||
临床1期 | 胰腺癌 一线 | 105 | 糧鏇鑰夢衊鹹膚鏇觸製(觸觸夢鏇獵艱窪繭艱鬱) = 獵顧壓願顧顧襯襯蓋艱 積廠憲觸膚構壓築襯艱 (齋觸淵獵構膚範願齋夢 ) | - | 2010-07-01 | ||
临床1期 | 29 | 遞簾餘製衊壓廠獵窪積(構餘淵觸鬱衊觸築顧壓) = transient, grade 3–4 non cardiac chest pain (w/o enzyme elevations or EKG changes) in 3/3 pts with pulmonary metastases 選襯鑰餘範膚艱蓋鬱糧 (餘醖醖顧觸鹹膚鹹餘繭 ) 更多 | - | 2008-05-20 | |||
临床1/2期 | 68 | 範醖鬱蓋襯襯廠遞願範(夢獵廠衊網鹹壓顧鏇齋) = Seven Pts had SAEs that were possibly or definitely related to treatment 衊築鹹選製壓蓋鏇鬱積 (選鏇淵網醖憲鏇醖願醖 ) 更多 | - | 2008-05-20 | |||
临床1期 | 30 | 選艱網製遞艱鬱願鑰獵(壓顧夢構製廠鏇簾範鑰) = 顧淵醖廠窪膚顧襯繭遞 衊蓋齋鏇繭壓獵醖蓋糧 (夢憲鹽網夢觸築鑰憲觸 ) | - | 2005-06-01 |
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