预约演示
更新于：2025-05-10
Imexon
更新于：2025-05-10
概要
基本信息
原研机构 |
在研机构- |
非在研机构 |
权益机构- |
最高研发阶段终止临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国)、孤儿药 (欧盟) |
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结构/序列
分子式C4H5N3O |
InChIKeyBIXBBIPTYBJTRY-UHFFFAOYSA-N |
CAS号59643-91-3 |
关联
8
项与 Imexon 相关的临床试验NCT01314014
A Phase II Study of Amplimexon® (Imexon for Injection) for the Treatment of Previously Treated Follicular and Aggressive Lymphoma in Adults
NCT00697060
A Multicenter, Phase II Trial of the Safety and Efficacy of Amplimexon® (Imexon for Injection) in Combination With Taxotere® (Docetaxel) for Previously Treated Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT00637247
A Phase 2 Randomized, Double-Blind, Multicenter Trial of Amplimexon® Plus Gemcitabine Versus Gemcitabine Plus Placebo in Patients With Metastatic Chemotherapy Naïve Pancreatic Adenocarcinoma (Stage IV)
100 项与 Imexon 相关的临床结果
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100 项与 Imexon 相关的转化医学
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100 项与 Imexon 相关的专利（医药）
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110
项与 Imexon 相关的文献（医药）2024-11-01Translational Oncology
Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance
Article
作者: Zhang, Kangnan ; Zhou, Jingyi ; Zhu, Zhenhua ; Wang, Na ; Xu, Ling ; Yu, Fudong ; Shi, Min
The onset of drug resistance in advanced cancer patients markedly diminishes their prognosis. Recently, disulfidptosis, a novel form of cell death, has been identified, triggered by excessive disulfide formation leading to cell shrinkage and F-actin contraction. Previous studies have identified 15 essential genes (FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11) associated with disulfidptosis. This study sourced pan-cancer mRNA expression data from Xena to thoroughly evaluate the molecular and clinical characteristics of disulfidptosis-related genes. Through unsupervised clustering, mRNA expression data identified the expression levels of disulfidptosis-related genes and potential clusters related to this form of cell death. Kaplan-Meier survival curves illustrated the correlation between different clusters and overall survival. The findings reveal that high expression of disulfidptosis-related genes is linked to poor survival in liver cancer. The GDSC database was utilized to analyze the relationship between disulfidptosis-related genes and the AUC of 198 drugs. The results demonstrate that 12 disulfidptosis-related genes influence sorafenib resistance, as revealed by the intersection of differential genes related to sorafenib resistance from the GSE109211 dataset. Among them, the MYH9 gene was found to play a crucial role in both. Finally, experimental evidence confirmed that MYH9 mitigates sorafenib resistance in hepatocellular carcinoma through disulfidptosis-like changes. This study identifies disulfidptosis as a promising avenue for enhancing the sensitivity of tumor cells to drugs, offering new therapeutic perspectives for future research on disulfidptosis and drug resistance in cancer patients.
2024-08-01CELL BIOLOGY INTERNATIONAL
Single‐cell and bulk RNA‐sequencing reveals mitosis‐involved gene HAUS1 is a promising indicator for predicting prognosis and immune responses in prostate adenocarcinoma (PRAD)
Article
作者: Yu, Yang ; Xu, Jie ; Wang, Yi ; Li, Deng ; Liu, Shiwei
Abstract:
It was imperative to identify latent biomarkers pertinent to malignancies, given the pivotal role targeted molecular therapies play in tumor treatment investigations. This study aimed to assess the validity of HAUS1 as an indicator for survival prognosis and immune responses in prostate adenocarcinoma (PRAD) via single‐cell and bulk RNA‐sequencing. Related data on HAUS1 expression in PRAD were obtained from online databases, followed by comprehensive analyses to delineate its associations with survival prognosis, implicated pathways, and immune responses. Besides, the expression pattern of HAUS1 in PRAD was also verified in vitro, by using qRT‐PCR, Western blot analysis, and immunohistochemistry. We found HAUS1 was downregulated in PRAD compared with normal tissues, as verified in vitro by qRT‐PCR, Western blot, and immunohistochemistry (p < 0.05). Single‐cell RNA‐sequencing analysis indicated that HAUS1 had relatively higher expressions in B cells, Mono/Macro cells, and Endothelial cells compared with other cell types. Cox regression analysis revealed HAUS1 could serve as an independent indicator for the overall survival prognosis of PRAD (p < 0.05). Spearman correlation analyses revealed HAUS1 was closely related to the tumor microenvironment, immune cell infiltration levels, immune checkpoints, and immune cell pathways (p < 0.05). Furthermore, HAUS1 expression was found to be closely related to the immunotherapeutic response of patients receiving clinical intervention (p < 0.05). Collectively, our findings underscored the significant role of HAUS1 in PRAD prognosis and immune response, thereby presenting a novel and promising avenue for investigating the clinical utility of immunotherapy in PRAD.
2023-05-01JOURNAL OF MOLECULAR LIQUIDS
Adsorption of 40 low molecular weight drugs on pristine and fluorinated C60 fullerenes: Ab initio, statistical and neural networks analysis
作者: Kochaev, Alexey I. ; Grekova, Anastasiya A. ; Maslov, Mikhail M. ; Katin, Konstantin P. ; Bondarev, Nikolay V. ; Kaya, Savas ; Bauetdinov, Yusupbek A. ; Kalika, Elizaveta B.
Loading of 40 small drugs mols. with mol. weights in 47-210 g/mol range consisted of H, C, N, O, F, S elements on C60, C60F2 and C60F48 fullerenes are studied with the d. functional theory.Adsorption energies as well as deformation energies of fullerenes and drugs are calculatedThe C60F2 is recognized as the most active drugs adsorbent.Mean adsorption energies averaged over all considered drugs are 0.41, 0.59 and 0.54 eV with standard deviations of 0.10, 0.09 and 0.14 eV for C60, C60F2 and C60F48 fullerenes, resp.Mean energies of drug-induced deformations of C60, C60F2 and C60F48 are 8.6, 12.0 and 16.6 meV, resp.Multilinear regressions and neural networks were proposed for prediction of adsorption energies based on dipole moments and frontier MOs of the drugs.Achievable accuracy of such predictions is about 0.1 eV.Altretamine antibiotic is recognized as the notable drug possessing extremely high binding energies about 1 eV with fullerenes.IR spectral shifts due to its loading on fullerene carriers are calculated
100 项与 Imexon 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 转移性非小细胞肺癌 | 临床2期 | 美国 | 2010-08-01 | |
| 转移性胰腺腺癌 | 临床2期 | 美国 | 2008-04-01 | |
| 多发性骨髓瘤 | 临床2期 | 美国 | 2005-10-01 | |
| 不可切除的黑色素瘤 | 临床2期 | 美国 | 2005-07-01 | |
| 乳腺癌 | 临床1期 | 美国 | 2005-10-01 | |
| 去势抵抗性前列腺癌 | 临床1期 | 美国 | 2005-10-01 | |
| 晚期胰腺腺癌 | 临床1期 | 美国 | 2004-02-01 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | B细胞淋巴瘤 CD68 | GPX1 | SOD2 | - | Imexon 1000 mg/m(2) | 築膚餘襯衊壓鏇鏇鹽遞(膚網觸憲構衊遞鑰選餘) = 遞鹽淵膚襯顧窪獵艱鬱 鏇窪廠醖範構網顧廠夢 (觸齋餘糧製齋製簾糧憲 ) | - | 2014-08-21 | |
临床2期 | 22 | 鏇夢窪醖鏇鏇獵膚積壓 = 顧衊獵廠網齋衊選選範 鏇淵範鹽糧願繭獵範膚 (構範淵遞築憲願襯網艱, 構壓糧鏇夢衊築衊艱鹽 ~ 築醖膚選觸鹽鹹襯鹽簾) 更多 | - | 2014-07-01 | |||
临床2期 | 142 | (Imexon + Gemcitabine) | 艱艱淵範製醖鹽顧繭繭 = 夢獵糧積餘淵觸鹹衊蓋 艱夢範鑰鹽顧範淵製餘 (膚襯糧願鏇鹽簾餘淵遞, 鹹憲窪淵膚鹹淵鏇餘鹽 ~ 繭鹽選蓋獵醖襯齋醖齋) | - | 2010-11-30 | ||
(Placebo + Gemcitabine) | 艱艱淵範製醖鹽顧繭繭 = 醖繭顧艱憲襯獵簾醖艱 艱夢範鑰鹽顧範淵製餘 (膚襯糧願鏇鹽簾餘淵遞, 遞齋鹽鑰鹹淵鹽顧淵繭 ~ 憲齋鬱簾範蓋淵選遞窪) | ||||||
临床1期 | 34 | 壓網糧壓憲壓餘觸鏇夢(獵窪範膚繭襯衊餘窪鬱) = 窪醖膚夢醖觸簾餘淵積 壓鹽襯鹽製繭夢鑰鏇積 (窪襯蓋願衊築鏇顧獵齋 ) | - | 2010-10-01 | |||
临床1/2期 | 68 | 餘網鏇鬱製積觸鏇壓繭(網積夢築積積憲鑰淵遞) = 鹽糧膚蓋糧鹽網夢觸顧 鹹鏇製醖鑰積齋醖衊憲 (簾壓鏇簾糧夢選觸選壓 ) 更多 | - | 2010-08-01 | |||
临床1期 | 胰腺癌 一线 | 105 | 鬱齋範醖觸鏇獵鹽壓糧(顧鏇觸觸鹽衊憲壓願獵) = 夢獵範顧糧鹹廠糧夢觸 淵鬱構製顧廠築觸構範 (鏇顧願窪積鏇鹹艱鹹願 ) | - | 2010-07-01 | ||
临床1/2期 | 68 | 鑰鑰構蓋選選淵廠壓遞(鑰鹹艱鏇齋餘簾淵廠蓋) = Seven Pts had SAEs that were possibly or definitely related to treatment 膚衊顧願範顧鏇窪艱顧 (選願夢顧鹽簾鏇齋醖網 ) 更多 | - | 2008-05-20 | |||
临床1期 | 29 | 簾艱膚製窪顧積構構醖(遞襯醖觸願積齋積淵築) = transient, grade 3–4 non cardiac chest pain (w/o enzyme elevations or EKG changes) in 3/3 pts with pulmonary metastases 鹽夢網齋遞簾鹽夢觸鹹 (壓選鏇衊齋範憲築顧廠 ) 更多 | - | 2008-05-20 | |||
临床1期 | 30 | 襯膚艱鏇積窪選膚餘醖(壓糧製遞網廠選積窪網) = 齋醖齋觸憲鹽選顧網壓 簾願範製鏇製鹹鹽淵獵 (鹹淵憲繭壓構鹹網膚願 ) | - | 2005-06-01 |
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