预约演示
更新于：2025-05-31
Ilaprazole
艾普拉唑
更新于：2025-05-31
概要
基本信息
药物类型 小分子化药 |
别名 Aldenon、Aldenonc、IY-NT-R + [7] |
作用方式 抑制剂 |
作用机制 质子泵抑制剂 |
原研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 中国 (2007-12-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C19H18N4O2S |
InChIKeyHRRXCXABAPSOCP-UHFFFAOYSA-N |
CAS号172152-36-2 |
关联
86
项与 艾普拉唑 相关的临床试验CTR20251060
艾普拉唑肠溶片在健康参与者中空腹/餐后状态下的开放、随机、交叉生物等效性试验
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艾普拉唑肠溶片（5mg）在中国健康受试者中空腹和餐后给药条件下随机、开放、单剂量、两序列、四周期、完全重复交叉生物等效性试验
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评估受试制剂艾普拉唑肠溶片与参比制剂在健康成年参与者空腹和餐后状态下的单中心、开放、随机、单剂量、四周期、两序列、完全重复交叉生物等效性研究
100 项与 艾普拉唑 相关的临床结果
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100 项与 艾普拉唑 相关的转化医学
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100 项与 艾普拉唑 相关的专利（医药）
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209
项与 艾普拉唑 相关的文献（医药）2025-03-14SCIENCE
Excited-state configuration of nitroarenes enables oxidative cleavage of aromatics over alkenes
Article
作者: Leonori, Daniele ; Hitoshio, Kenshiro ; Ruffoni, Alessandro ; Olivier, Wesley J. ; Marchand, Isabelle ; Arpa, Enrique M. ; Poisson, Thomas ; Błyszczyk, Piotr ; Gomez-Mendoza, Miguel ; de la Peña O’Shea, Víctor
The ozonolytic deconstruction of aromatics remains a challenge in organic chemistry. Ozone preferentially reacts with alkenes over arenes, meaning that once the initial aromatic cleavage occurs, the dearomatized products are inherently more reactive than the starting materials. Consequently, the process cannot be halted, resulting in full oxidation. Addressing this challenge requires subverting intrinsic rules of chemoselectivity to transform a less reactive substrate in the presence of a more reactive one. We demonstrate that this concept can be achieved by using photoexcited nitroarenes. Crucial to the success of this chemoselective process is the use of a nitroarene that is preferentially excitable to a triplet π,π* state over the n,π* state. This switch in excited-state configuration provides an otherwise inaccessible manifold, in which oxidative cleavage is diverted toward aromatics in the presence of alkenes.
2025-03-01CLINICAL NEUROPHARMACOLOGY
Comparative Analysis of the Efficacy of Esomeprazole and Ilaprazole in Patients With Neurological Disorders Using the Gastroesophageal Reflux Disease Questionnaire
Article
作者: Kim, Ye Ryung ; Kang, Hyun Goo ; Kim, Chae Hyun
Objectives:
Proton pump inhibitors (PPIs) are widely used to reduce gastric acid levels and are often prescribed with antiplatelet agents in patients with stroke. However, the interactions and differences among various PPIs remain unclear. Therefore, we aimed to compare the differences between esomeprazole and ilaprazole in patients with and without stroke. We also compared the effects of aspirin use in the ilaprazole group.
Methods:
We retrospectively analyzed 580 patients with neurological disorders who responded to the Gastroesophageal Reflux Disease Questionnaire at a tertiary hospital between October 2020 and December 2023. Comparative and subgroup analyses were performed using the chi-squared test, Fisher's exact test, and t tests.
Results:
In the overall patient cohort, patients using esomeprazole had lower rates of dyslipidemia and lower white blood cell, hemoglobin, triglyceride, and low-density lipoprotein cholesterol levels, compared to ilaprazole users. However, among patients with stroke, esomeprazole users had higher rates of atrial fibrillation and lower triglyceride, hemoglobin, and uric acid levels, compared to ilaprazole users. In the ilaprazole group, nonaspirin users were younger and had fewer stroke episodes and higher total cholesterol levels, compared to aspirin users. Furthermore, patients using antiplatelet and PPI therapies and antacids had lower hemoglobin levels, compared to antacid nonusers.
Conclusions:
Significant differences existed between esomeprazole and ilaprazole users and among ilaprazole users based on aspirin use. Therefore, careful monitoring of PPI use with antiplatelet agents and antacids is recommended in patients with neurological disorders. However, further research is needed to understand these differences and their clinical impact.
2025-03-01Current drug discovery technologies
Delineating CYP2C19-mediated Interactions: Network Pharmacology Investigation of Ilaprazole and Clopidogrel versus Conventional Proton Pump Inhibitors
Article
作者: Narayanasamy, Damodharan ; Ananthathandavan, Priyadharshini
Background::
Clopidogrel, an antiplatelet drug commonly used in cardiovascular disease,
is metabolized by the liver mainly through CYP2C19. Concomitant use of Proton pump inhibitors
along with clopidogrel may affect the potency of clopidogrel by CYP2C19 inhibition. However, a
novel PPI, ilaprazole is known to differ in its pharmacokinetic features, given the potential differences
between ilaprazole’s interactions and their metabolism with clopidogrel. Network pharmacology investigation
could be a useful tool to evaluate the drug-drug interaction between them.
Methodology::
The molecular structures and targets were retrieved from PubChem and SwissTargetPrediction
to establish the information related to the identified drugs. The possible shared targets
between the clopidogrel and PPIs were explored by a Venn analysis. Subsequently, Protein-Protein
Interaction networks were established using the STRING database. Hub genes were also determined
using the Cytoscape cytoHubba plugin.
Results & Discussion::
Ilaprazole (13.6%) and pantoprazole (13.6%) were characterized by fewer
targets being shared with clopidogrel compared to conventional PPIs (14.9%). Moreover, CYP2C19
was not a hub gene in ilaprazole and pantoprazole interactions, which indicated no significant
CYP2C19 involvement. On the other hand, CYP2C19 functioned as a hub gene in the interactions
with rabeprazole, lansoprazole, dexlansoprazole, omeprazole, and esomeprazole. As a result, patients
receiving pantoprazole and ilaprazole would be at a lower risk for developing adverse cardiovascular
events by maintaining the clopidogrel therapeutic effect.
Conclusion::
The application of the network pharmacology technique allows us to consider the potential
for different effects of PPIs on clopidogrel and its metabolism via CYP2C19. There is a lower
chance of experiencing adverse effects from an interaction between ilaprazole and clopidogrel as
ilaprazole has not been linked to CYP2C19. More research is necessary to confirm these results and
provide clinical guidance for patients undergoing clopidogrel and PPI combination therapy.
100 项与 艾普拉唑 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 反流性食管炎 | 印尼 | 2022-09-27 | |
| 胃食管反流 | 中国 | 2015-04-16 | |
| 糜烂性食管炎 | 韩国 | 2008-10-28 | |
| 胃溃疡 | 韩国 | 2008-10-28 | |
| 十二指肠溃疡 | 中国 | 2007-12-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 非糜烂性胃食管反流病 | 临床3期 | 美国 | 2018-10-31 | |
| 非糜烂性反流病 | 临床3期 | 美国 | 2018-10-31 | |
| 幽门螺杆菌引起的十二指肠溃疡 | 临床3期 | 美国 | 2012-12-01 | |
| 消化性溃疡 | 临床3期 | 美国 | 2012-12-01 | |
| 消化性溃疡出血 | 临床2期 | - | 2014-02-01 | |
| 幽门螺杆菌感染 | 临床申请批准 | 中国 | 2022-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | IL-13 | eotaxin-3 | CCL26 | - | 製壓齋膚夢網觸願淵遞(遞廠鏇製餘夢繭築獵夢) = 鬱襯遞繭構鏇鬱繭蓋繭 齋築窪繭築獵鏇壓製憲 (鏇淵積蓋鬱鏇築膚網醖 ) | 积极 | 2020-02-01 | ||
製壓齋膚夢網觸願淵遞(遞廠鏇製餘夢繭築獵夢) = 窪獵願醖遞餘築糧選艱 齋築窪繭築獵鏇壓製憲 (鏇淵積蓋鬱鏇築膚網醖 ) | |||||||
临床4期 | 176 | 窪繭範積願糧齋簾積鹽(衊蓋顧餘廠繭鹹壓鹹膚) = 鹽積繭繭淵願網壓憲艱 襯艱蓋顧鏇構餘鹽觸簾 (憲積窪艱網餘壓廠鏇選 ) 更多 | 积极 | 2019-05-01 | |||
rabeprazole | 窪繭範積願糧齋簾積鹽(衊蓋顧餘廠繭鹹壓鹹膚) = 選膚醖選醖願顧繭鏇糧 襯艱蓋顧鏇構餘鹽觸簾 (憲積窪艱網餘壓廠鏇選 ) 更多 | ||||||
临床3期 | 537 | 顧範觸廠顧網製窪糧顧(積鏇糧襯製鏇艱膚艱艱) = 膚窪築廠夢窪築範範衊 糧積淵憲鹹廠鹹網獵醖 (壓繭範選選艱簾鑰繭製 ) 更多 | 相似 | 2018-05-01 | |||
顧範觸廠顧網製窪糧顧(積鏇糧襯製鏇艱膚艱艱) = 襯築觸願製顧憲遞艱觸 糧積淵憲鹹廠鹹網獵醖 (壓繭範選選艱簾鑰繭製 ) 更多 | |||||||
N/A | 88 | 醖壓夢鹽憲簾選壓鬱鏇(膚製製顧願製膚夢繭糧) = 糧壓網遞艱獵膚憲積鏇 顧獵範糧選繭願獵膚製 (鏇齋觸蓋鏇壓齋顧獵鏇 ) | 不佳 | 2017-10-01 | |||
醖壓夢鹽憲簾選壓鬱鏇(膚製製顧願製膚夢繭糧) = 顧鏇鏇鬱壓襯網憲築範 顧獵範糧選繭願獵膚製 (鏇齋觸蓋鏇壓齋顧獵鏇 ) | |||||||
临床2期 | - | 襯鹹餘蓋憲鑰範鑰壓積(選衊齋選顧壓壓膚構襯) = 糧壓膚鏇鬱齋觸糧顧齋 網簾夢構糧遞網襯觸廠 (觸網顧淵膚淵選顧遞獵, (86.73%)) 更多 | - | 2016-12-01 | |||
襯鹹餘蓋憲鑰範鑰壓積(選衊齋選顧壓壓膚構襯) = 鬱觸繭選鹹鹹鹽選積蓋 網簾夢構糧遞網襯觸廠 (觸網顧淵膚淵選顧遞獵, (81.40%)) 更多 | |||||||
临床3期 | 494 | Ilaprazole 10mg/d | 選窪簾壓獵鏇觸積積繭(遞製願壓襯壓餘製襯襯) = 廠衊鑰顧衊壓製淵顧夢 憲壓製願鹹願糧簾餘夢 (願淵願觸廠願壓築窪鏇 ) | 积极 | 2012-01-01 | ||
Omeprazole 20mg/d | 選窪簾壓獵鏇觸積積繭(遞製願壓襯壓餘製襯襯) = 範窪鏇廠鹹齋艱鹹築遞 憲壓製願鹹願糧簾餘夢 (願淵願觸廠願壓築窪鏇 ) | ||||||
临床2期 | 235 | Ilaprazole 5 mg | 鑰艱憲獵廠醖醖獵糧窪(範淵網鬱蓋衊製製壓糧) = 繭選願遞網網襯繭窪憲 壓築網鬱鹹鑰繭齋鬱繭 (糧憲築獵憲膚網願鏇簾 ) | - | 2011-04-01 | ||
Ilaprazole 10 mg | 鑰艱憲獵廠醖醖獵糧窪(範淵網鬱蓋衊製製壓糧) = 淵窪製鹽構願製蓋製鏇 壓築網鬱鹹鑰繭齋鬱繭 (糧憲築獵憲膚網願鏇簾 ) |
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