Benfotiamine

July 7, 2022 13:10 UTC WHITE PLAINS, N.Y.--(BUSINESS WIRE)-- The Burke Neurological Institute (BNI) has received a five year award expected to total $45 million from the National Institutes of Health (NIH) to launch a large-scale, multi-center clinical trial to evaluate benfotiamine, a synthetic precursor of thiamine (vitamin B1), as a potentially effective therapy for mild Alzheimer’s disease (AD) or mild cognitive impairment (MCI). This follow-up trial will expand on previous work completed at BNI, suggesting that high levels of benfotiamine significantly slowed the rate of functional decline in participants with mild cognitive impairment or early AD. This press release features multimedia. View the full release here: Gary Gibson, Ph.D, Burke Neurological Institute; Weill Cornell Medicine (Photo: Business Wire) “It is gratifying to see research which the Alzheimer’s Drug Discovery Foundation initially identified as promising and supported in a pilot study continue to be pushed forward with funding from the NIH’s National Institute on Aging,” said Dr. Howard Fillit, Co-Founder and Chief Science Officer of the Alzheimer’s Drug Discovery Foundation (ADDF). “With the improved biomarkers that have been developed since the pilot, this next phase will provide a deeper understanding of how benfotiamine works in the brain. Novel approaches that target the many biological factors which contribute to Alzheimer’s, like metabolic dysfunction, are essential to finding effective treatments for this disease.” Dysfunction in the brain’s ability to metabolize glucose is a known marker of AD and other dementias and can begin decades before a person has clinical symptoms or memory loss. Previous work by Burke Neurological Institute/Weill Cornell Medicine researcher Dr. Gary E. Gibson, who will also be a leader of the upcoming clinical trial, suggested that reduction in glucose metabolism is due to a decline in thiamine-dependent processes. Using multiple experimental models, he and others have shown that increasing thiamine to very high levels via benfotiamine was protective against Alzheimer’s-like symptoms. Dr. Gibson noted, “I am particularly excited about this trial because it will determine how relevant these decades of research are to the treatment of Alzheimer’s disease. If our hypothesis is correct, we will advance an exciting investigative clinical treatment pathway relevant for millions of patients, and with potential advantages in safety and value.” These foundational experiments led to a recent pilot study, published in the Journal of Alzheimer’s Disease in 2020 and carried out by Dr. Gibson along with research partners at Weill Cornell Medicine, Burke Rehabilitation Institute, and Columbia University Irving Medical Center. The study suggested a slowed rate of cognitive decline in 35 participants with mild MCI or early AD who took 300-mg benfotiamine pills twice daily, and the treatment was completely safe. The larger upcoming clinical trial will be carried out in collaboration with leading researchers in AD and related dementias; Dr. Howard Feldman, director of the Alzheimer’s Disease Cooperative Study (ADCS) at the University of California, San Diego and Dr. Jose Luchsinger, investigator at Columbia University Irving Medical Center. “We are excited to receive this funding which will enable the further testing of benfotiamine through to its clinical proof of concept, including adaptively testing for the optimal dose and treatment response across clinical and biomarker measures,” said Dr Feldman. Dr. Luchsinger stated “I have been conducting research to understand the metabolic contributions to AD for 20 years and believes that understanding the role of thiamine in AD is an important step in this field.” Enrolling roughly 400 patients in up to 50 US-based clinical trial sites, with study coordination by the ADCS, will support the new study to be among the first to select patients and follow progression over 18 months, using several measures, including cognitive tests and blood markers that signal AD and MCI status and progression. The trial will provide a larger and more robust evaluation of benfotiamine’s potential use in treating AD by following cognitive measures as well as a number of blood markers that reflect the brain’s glucose use, neuron loss, inflammation, and even aspects of brain pathology. These promising blood markers to track AD progression have themselves been under investigation for many years and represent the cumulative work of researchers across the globe. Additional academic institutions partnering with BNI to support this trial include the University of Gothenberg (Gothenberg, Sweden), the University of Cambridge (Cambridge, United Kingdom) and Georgetown University (Washington, DC). BNI is also pleased to collaborate with C2N Diagnostics (St. Louis, MO), a company focused on advanced brain health diagnostics. There is enormous unmet need regarding both treatment and prevention of AD in the growing and aging population. More than six million Americans are living with AD, which is forecasted to rise to nearly 13 million by 2050. Globally, the prevalence of AD is projected to rise from 57 million to 153 million in 2050. There is no true cure for the disease and no effective treatments exist. Clinical trials over the last decade have frequently failed, and the most recently approved therapy has been met with controversy regarding efficacy, safety, value and pricing. Treatments for AD and MCI that are effective, safe, and affordable are critically needed across the globe. Enrollment of trial participants is expected to begin in the first quarter of 2023. The Phase II randomized controlled trial of benfotiamine in early Alzheimer's Disease is funded by NIH grant R01AG076634. The content of this press release is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. About Alzheimer’s Disease Cooperative Study: The Alzheimer’s Disease Cooperative Study (ADCS) is an academic research organization located at UC San Diego which is dedicated to developing treatments for those at risk or affected by Alzheimer’s disease. For upwards of 30 years, with funding including the National Institute on Aging, it has been a field leader in progressing potential new treatments through innovation in clinical trials with design, methods, and analytics. It has a trials coordinating center in San Diego and a network of participating sites across the United States. About Alzheimer’s Drug Discovery Foundation Founded in 1998 by Leonard A. and Ronald S. Lauder, the Alzheimer's Drug Discovery Foundation (ADDF) is dedicated to rapidly accelerating the discovery of drugs to prevent, treat and cure Alzheimer's disease. The ADDF is the only public charity solely focused on funding the development of drugs for Alzheimer's, employing a venture philanthropy model to support research in academia and the biotech industry. Through the generosity of its donors, the ADDF has awarded more than $209 million to fund over 690 Alzheimer's drug discovery programs, biomarker programs and clinical trials in 19 countries. To learn more, please visit: . About Burke Neurological Institute The Burke Neurological Institute is based in White Plains, NY, and was established in 1978 by Dr. Fletcher McDowell as a research institute dedicated to finding cures for chronic neurological disabilities. The Institute transforms groundbreaking research into clinical treatments so that people can see, talk, and walk again. Their goal is to combine the most rigorous, contemporary brain science with heartfelt compassionate care to innovate and develop novel cures for stable disability in those afflicted with neurological conditions such as stroke, traumatic brain injury or spinal cord injury. Burke Neurological Institute is an academic affiliate of Weill Cornell Medicine.

Grand Cayman, CI, April 23, 2021 (GLOBE NEWSWIRE) -- Losing weight is one of the hardest things to do when you grow old. Most people don't lose weight no matter how many diets they tried. Others keep regaining it to the point that they lost their will to achieve their ideal weight. But, what if you are given the perfect solution to lose weight without going into diet or exercise? What if you can still lose weight even if you eat your favorite carb-loaded foods? These are entirely possible thanks to the CarboFix weight loss supplement. CarboFix is one of the most-sought weight loss supplements nowadays because of its potent formula that has already been proven to turn on that "switch" that makes a person lose weight even without dieting and exercising. A person can still lose weight even if he stuffs himself with foods rich in carbohydrates sounds too good to be true. The great thing is, it's true. Most people who have difficulty losing weight haven't activated their fat-burning metabolism yet. This fat-burning metabolism is called the AMPK, a fuel-sensing enzyme that, when activated, helps a person burns his stored fat. Each CarboFix capsule is loaded with ingredients that can help individuals activate their AMPk. If you are one of the millions of people who haven't found an effective way to solve their weight loss problem, continue reading this CarboFix review. << BUY NOW: From Official Website >> What is CarboFix Weight Loss Supplement? CarboFix is a weight loss supplement consisting of a 6-ingredient blend that helps activate AMP-activated protein kinase (AMPK), a fat-burning metabolism that is usually deactivated, the reason why so many people have difficulty losing weight. This product is named CarboFix because it "fixes" the way a person's body process carbs. Instead of instantly storing carbs as fat, daily usage of CarboFix can help an individual effectively use the carbs he eats as energy. Matt Stirling, the man behind CarboFix, claimed that the product effectively reduces belly fat, controlling weight gain and curbing hunger and cravings. He shared on CarboFix's official website that his trip to Ecuador is the turning point of the creation of CarboFix. He discovered the secret why most people in the village of his wife's family are all fit, healthy, and live longer. The secret has to do with the herbs and plants the villagers have been consuming for centuries. Matt uses these herbs and plants as the main ingredients of CarboFix. CarboFix Top Six Potent Ingredients As an all-natural weight loss supplement, CarboFix is proven effective because its formula is jam-packed with these potent ingredients famous for their weight loss properties. 1. Berberine This natural chemical is primarily found in plants such as tree turmeric, Oregon grape, and goldthread. It mainly helps in reducing body weight. It also improves glucose tolerance even the person doesn't go on a diet. Aside from the fact that it helps activate AMPK, Berberine is also good in managing blood sugar levels, the reason it's popular among people who have diabetes. Because of its natural weight loss effects, Berberine also slows down the breakdown of carbohydrates in the gut, minimizes sugar production in the liver, and reduces total cholesterol. Studies have also suggested that it can help treat inflammation and good prevention against heart diseases. 2. Cinnamon Bark Cinnamon Bark is a good regulator of the AMPK enzyme. It has properties that prevent cells from being filled with fat, which results in the reduction of weight gain. Its potency in reducing the harmful effects of high-fat foods makes it popular among dieters. It is also reported that Cinnamon Bark contains a chemical that helps lower blood sugar levels. It also reduces the build-up of white fat in the body. 3. Alpha Lipoic Acid Alpha Lipoic Acid is an antioxidant commonly found in spinach, potatoes, kidney, liver, and broccoli. It is a naturally occurring compound that helps enzymes turn nutrients into energy. Because Alpha Lipoic Acid or ALA activates AMPK in skeletal muscle, it helps increase insulin sensitivity, reduce body weight, and boost a person's fat-burning capabilities. 4. Chromium This essential mineral is proven to increase the amount of AMPK in skeletal muscles. Its effectiveness in helping curb hunger and food cravings is already established through a study. Chromium positively impacts glucose metabolism in skeletal and heart muscles and helps lower blood sugar levels. Its powerful anti-hunger effects make it one of the essential ingredients in CarboFix. 5. Benfotiamine This B vitamin is primarily found in nuts, legumes, fish, pasta, seeds, and wheat. It mainly helps in reducing pain, inflammation levels, and cellular damage. When a person's body is not inflamed, its fat-burning capability won't be interrupted. Benfotiamine is also taken by people who have diabetes, arthritis, Alzheimer's disease, and alcoholism. 6. Naringin This flavonoid is commonly found in the skin of grapefruits and oranges. It is known for its potent anti-inflammatory effects. It's also an antioxidant that helps boost the body's immune system. Because it helps activate AMPK, Naringin brings excellent results to people who want to lose weight without watching their diet. It is beneficial for people suffering from obesity, hypertension, diabetes, and metabolic syndrome. These six ingredients make CarboFix an effective weight loss supplement that allows people to continue enjoying the foods they love without the fear of gaining weight. 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When a person takes CarboFix daily, he doesn't need to rely on willpower to keep himself from overeating. The body is naturally burning more fat for energy. Level 3: By blocking carbs from being stored as fat Another factor that makes CarboFix unique from other weight loss supplements and where most diets fail is its properties that block carbohydrates from being stored as fat. This enables people to eat any foods they want without feeling guilty about gaining weight. The Chromium in CarboFix makes it possible to prevent carbohydrates from being stored as fat. It helps the body metabolize carbs, improves blood sugar levels, reduces cholesterol, increases brain health, improves skin, and protects bone health. Purchasing CarboFix Weight Loss Supplement At the moment, CarboFix can only be purchased at their official website. They offer the following packages: 1 bottle for 30-day supply - $49 + shipping 3 bottles for 90-day supply - $126 + shipping 6 bottles for 180-day supply - $204 + shipping Those who buy the three-bottle package would save $171 per order, and those who buy the six-bottles package would save $390. Once the customer clicks the package he wants to buy, he will be directed to CarboFix Clickbank secure page to input his payment information. Discover, American Express, Diners Club, MasterCard, and Visa credit cards are the accepted payment modes. << BUY NOW: From Official Website >> CarboFix Frequently Asked Questions As CarboFix cements its name as one of the fast-rising effective weight loss supplements in the market, these are the questions frequently asked by prospective customers before they buy the product. When can I expect to see results? Most customers see results within the first 72 hours, but this varies from person to person. 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CarboFix provides a 60-day money-back guarantee if in case the customer is unsatisfied with the product. Those who want to return the product should contact Gold Vida customer support at support@goldvida.com. << BUY NOW: From Official Website >> Gold Vida is the company behind CarboFix. Their physical address is Gold Vida, 2283 Yellowbirch Way, London, ON, N6G0N3. Will CarboFix work for someone my age? CarboFix works for men and women in their 40s, 50s, 60s, and up. It is effective for these ages because most people in this range have a very slow metabolism. The Berberine in CarboFix is the primary activator of AMPK, the "switch" that activates the body's fat-burning metabolism. How long will the discounted packages be available? The discounted packages only run for a limited time. Prospective customers are encouraged to take advantage of it while it's still available. How to Know if the CarboFix You Bought is Legit or Scam? 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Wrapping Up Losing weight even if you are not dieting or exercising is too good to be true, but the good news is, it can be done by taking CarboFix daily. CarboFix proves that it is the ultimate weight loss solution for people who can't lose any because of their slow metabolism. The secret to losing weight has been revealed. It has nothing to do with the food a person eats or how long he exercises. It has to do with activating the AMPK enzyme in the body so that carbs will be blocked and not be stored as fat. Activating the body's fat-burning metabolism is the key that helps CarboFix users shed their excess weight and maintain it even if they continue eating their favorite foods. The six potent ingredients jam-packed in each capsule of CarboFix have made it one of the most effective weight loss and health supplements in the market today. << BUY NOW: From Official Website >> Sources & References: +For maximum results, combine CarboFix with a healthy calorie reduced diet and regular exercise to help manage weight and avoid storing body fat. We’re confident that you’ll love CarboFix but if you’re not completely satisfied for any reason, keep your opened bottle of CarboFix and return the rest of your unopened CarboFix bottle(s) within 60 days of purchase for a full refund minus shipping and handling. Return shipping is the responsibility of the customer. Contact our Customer Support team for more information and return instructions at support@goldvida.com. Special offers are not valid on previous purchases and can not be combined with other offers or discounts. ClickBank is the retailer of products on this site. CLICKBANK® is a registered trademark of Click Sales, Inc., a Delaware corporation located at 1444 S. Entertainment Ave., Suite 410 Boise, ID 83709, USA and used by permission. ClickBank's role as retailer does not constitute an endorsement, approval or review of these products or any claim, statement or opinion used in promotion of these products. *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. support@goldvida.com