更新于：2024-11-16
Tandospirone Citrate
枸橼酸坦度螺酮
更新于：2024-11-16
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C27H37N5O9 |
InChIKeyDMLGUJHNIWGCKM-DPFKZJTMSA-N |
CAS号112457-95-1 |
关联
33
项与 枸橼酸坦度螺酮 相关的临床试验枸橼酸坦度螺酮片在健康受试者中随机、开放、两制剂、两序列、四周期、单次给药、完全重复交叉设计空腹和高脂餐后状态下生物等效性试验
枸橼酸坦度螺酮片在中国健康人群中空腹和餐后状态下单次给药的人体生物等效性临床试验
枸橼酸坦度螺酮片在健康受试者中单中心、开放、随机、单剂量、两制剂、两序列、四周期、完全重复空腹状态下的生物等效性试验
100 项与 枸橼酸坦度螺酮 相关的临床结果
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100 项与 枸橼酸坦度螺酮 相关的转化医学
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100 项与 枸橼酸坦度螺酮 相关的专利（医药）
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255
项与 枸橼酸坦度螺酮 相关的文献（医药）2024-04-01Neurobiology of disease
Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice
Article
作者: Moquin, Luc ; Rosa-Neto, Pedro ; Amilhon, Bénédicte ; Lee, Karen Ka Yan ; Di Cristo, Graziella ; Chattopadhyaya, Bidisha ; do Nascimento, Antônia Samia Fernandes
Children who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which displays recognition and spatial memory impairments and dysfunctional cognitive flexibility. We found that 5-HT expression levels, quantified by immunohistochemistry, and 5-HT release, quantified by in vivo microdialysis in awake mice, are reduced in PFC of adult MPA mice. MPA mice also show impaired body temperature regulation following injection of the 5-HT1A receptor agonist 8-OH-DPAT, suggesting the presence of deficits in 5-HT auto-receptor function on raphe neurons. Finally, chronic treatment of adult MPA mice with fluoxetine, an inhibitor of 5-HT reuptake transporter, or the 5-HT1A receptor agonist tandospirone rescues cognitive flexibility and memory impairments. All together, these data demonstrate that the development of 5-HT system function is vulnerable to moderate perinatal asphyxia. 5-HT hypofunction might in turn contribute to long-term cognitive impairment in adulthood, indicating a potential target for pharmacological therapies.
2024-03-01CNS neuroscience & therapeutics
Efficacy and safety of venlafaxine hydrochloride combined with tandospirone citrate for patients with vascular depression accompanied by somatic symptoms: An open‐labeled randomized control trial
Article
作者: Liu, Nan ; Chen, Ronghua ; Zeng, Guiying ; Chen, Hongbin ; Zhao, Zijun ; Xiao, Yingchun ; Wu, Weiwei ; Lin, Yongsen ; Lin, Qianwen ; Chen, Xinyan ; Chen, Hui ; Wu, Shufang ; Lin, Ting
Abstract:
Aims:
To explore the pharmacological treatment of vascular depression (VaDep) and whether the blood levels of neurotransmitters can reflect the VaDep severity.
Methods:
VaDep patients with somatic symptoms were enrolled and randomly received venlafaxine + tandospirone (Combined Group) or venlafaxine (Monotherapy Group). The treatment efficacy was assessed by Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Patient Health Questionnaire‐15 (PHQ‐15). The levels of blood monoamine neurotransmitters were measured by enzyme‐linked immunosorbent assay.
Results:
Both groups reported a progressive decrease in HAMD, HAMA, and PHQ‐15 scores to below the baseline after the respective treatment. Compared with the Monotherapy Group, the Combined Group reported a significant decrease in HAMD score at week 2 and markedly lower HAMA and PHQ‐15 scores at weeks 1, 2, 4, and 8. Both groups showed a decrease in the levels of blood monoamine neurotransmitters at weeks 4 and 8 when compared with the baseline. A strong positive association was evident between the plasma 5‐HT levels and the HAMD score.
Conclusion:
The combined therapy rapidly acts on VaDep comorbid with anxiety and somatic symptoms and significantly alleviates the anxiety and somatic symptoms. The plasma levels of 5‐HT may serve as potential objective candidates in evaluating VaDep severity and the efficacy of the undertaken treatment regimen.
2024-01-24Emergency medicine international
Retracted: Clinical Analysis on the Effects of Tandospirone Citrate Assisted by Drawing Therapy on Medication Compliance and Sleep Quality in Patients with Anxiety Disorders
作者: International, Emergency Medicine
[This retracts the article DOI: 10.1155/2022/9295627.].
100 项与 枸橼酸坦度螺酮 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 焦虑症 | 中国 | 2003-05-21 | |
| 神经症性障碍 | 日本 | 1996-07-10 | |
| 心理生理性障碍 | 日本 | 1996-07-10 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 年龄相关性黄斑变性 | 临床3期 | - | 2009-04-01 | |
| 地图样萎缩 | 临床3期 | - | 2009-04-01 |
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临床结果
临床结果
适应症
分期
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临床4期 | 274 | High-dose tandospirone (60 mg/d) | 鏇網衊積淵範鏇膚繭餘(選遞鏇簾艱範壓網壓衊) = 糧壓構選製繭鹽艱廠憲 鏇製糧積鑰鹽鏇簾艱鹽 (範選鏇鏇鹹醖製願顧積 ) 更多 | - | 2023-02-26 | ||
Low-dose tandospirone (30 mg/d) | 鏇網衊積淵範鏇膚繭餘(選遞鏇簾艱範壓網壓衊) = 壓淵蓋衊繭壓選齋廠餘 鏇製糧積鑰鹽鏇簾艱鹽 (範選鏇鏇鹹醖製願顧積 ) 更多 | ||||||
临床4期 | 274 | 60 mg/day tandospirone | 餘鬱憲壓遞選願膚艱顧(壓顧繭鑰積鹽網鹽構選) = 積選憲膚選獵憲壓網鑰 選簾衊製衊鬱淵築觸觸 (鬱齋選艱艱觸淵構廠顧 ) | - | 2022-08-01 | ||
30 mg/day tandospirone | 餘鬱憲壓遞選願膚艱顧(壓顧繭鑰積鹽網鹽構選) = 膚廠糧簾醖繭鏇襯鑰餘 選簾衊製衊鬱淵築觸觸 (鬱齋選艱艱觸淵構廠顧 ) | ||||||
临床3期 | 772 | (AL-8309B 1.0%) | 觸簾構鹽積鏇鏇鑰膚構(憲窪築獵網壓蓋觸網廠) = 鬱範構鏇鹽窪醖廠艱淵 構廠顧鬱鹽構衊範餘鬱 (範糧廠醖選觸構淵構鑰, 獵顧遞蓋艱鏇鹽膚襯遞 ~ 憲鏇夢蓋顧醖選範觸鹹) 更多 | - | 2014-07-03 | ||
(AL-8309B 1.75%) | 觸簾構鹽積鏇鏇鑰膚構(憲窪築獵網壓蓋觸網廠) = 選廠獵繭廠膚鑰鏇選簾 構廠顧鬱鹽構衊範餘鬱 (範糧廠醖選觸構淵構鑰, 醖窪觸製積簾蓋艱艱憲 ~ 淵壓壓網簾鹽鑰觸範窪) 更多 |
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