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更新于：2025-05-16
Candesartan Cilexetil
坎地沙坦酯
更新于：2025-05-16
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1998-06-04), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C33H34N6O6 |
InChIKeyGHOSNRCGJFBJIB-UHFFFAOYSA-N |
CAS号145040-37-5 |
关联
190
项与 坎地沙坦酯 相关的临床试验NCT05826912
Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury
CTR20240847
坎地沙坦酯片在健康受试者中餐后状态下随机、开放、单剂量、两制剂、两周期、两序列、自身交叉的生物等效性试验
CTR20240344
坎地沙坦酯片在健康受试者中空腹状态下随机、开放、单剂量、两制剂、两周期、两序列、自身交叉的生物等效性试验
100 项与 坎地沙坦酯 相关的临床结果
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100 项与 坎地沙坦酯 相关的转化医学
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100 项与 坎地沙坦酯 相关的专利（医药）
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5,309
项与 坎地沙坦酯 相关的文献（医药）2025-10-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Sustainable signal processing spectrophotometric analysis of candesartan, hydrochlorothiazide, and amlodipine: Green methods aligned with global sustainability goals
Article
作者: Lotfy, Hayam Mahmoud ; Obaydo, Reem Hasan ; Genc, Asena Ayse ; Erk, Nevin ; Tiris, Gizem
Green Analytical Chemistry (GAC) aims to create eco-friendly methods for pharmaceutical analysis, with a focus on quality control. This study focuses on the simultaneous quantification of candesartan (CAN), hydrochlorothiazide (HCT), and amlodipine (AML) in a triple medication using two green spectrophotometric techniques. The study incorporates mathematical manipulation approaches to extract the parent spectrum of each drug component. These integrated methods address the problem of spectral signal overlap without requiring prior separation, utilizing a factorized spectrum (FS), which is notable for its capacity to assess the specified drugs in the mixture and retrieve their original zero-order spectra it is distinctive for its ability to evaluate the mentioned drugs within the mixture and recover their initial zero-order spectra. The first integrated resolution technique, the Integrated signal processing plan (ISPP-D0), was applied to the mixture's zero-order spectrum, including successive manipulation of three methods: extended absorbance difference, absorbance resolution, and spectrum subtraction. The second integrated resolution technique is the Integrated signal processing plan (ISPP-R)via ratio spectrum of the mixture, which includes successive manipulation of three methods: dual amplitude difference, ratio extraction, and spectrum subtraction. The proposed methods were validated and assessed following the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, showing linear concentration ranges of 5.0-35.0 µg/mL for CAN at 254.0 nm, 2.0-20.0 µg/mL for HCT at 270.0 nm, and 5.0-35.0 µg/mL for AML at 240.0 nm. The specificity was evaluated by accurately and precisely determining the concentrations of the three drugs in their synthetic blends and single-tablet pharmaceutical formulation. The findings were statistically analyzed against the official results using the F-test and Student's t-test, indicating no notable differences. These UV spectrophotometric techniques align with green analytical chemistry (GAC) and white analytical chemistry (WAC) principles, supporting the United Nations Sustainable Development Goals (UNSDGs). These integrated analytical techniques for drug analysis offer enhanced precision and efficiency, enabling the retrieval of zero-order spectra that serve as unique fingerprints for each analyte. These advancements simplify the identification process, improve accuracy, and ensure reliable results, making them invaluable in pharmaceutical research and quality control.
2025-09-01JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Rapid quantification of 21 antihypertensive and diuretic drugs in plasma by UPLC-MS/MS: Application to clinical and forensic cases
Article
作者: Willeman, Théo ; Boudin, Coralie ; Scolan, Virginie ; Behouche, Alexandre ; Eysseric-Guérin, Hélène ; Stanke-Labesque, Françoise ; Ormezzano, Olivier ; Paysant, François ; Faure, Amandine
Systemic arterial hypertension, affecting more than 1 billion people worldwide, necessitates widespread use of antihypertensive and diuretic medications. However, the potential toxicity related to exposure of these medications is not always fully understood, potentially leading to underestimates of deaths related to cardiovascular drugs. Additionally, the growing interest in monitoring adherence to antihypertensive medications necessitates the development of specific analytical methods suitable for both clinical and forensic applications. In this study, we developed a novel, high-throughput quantitative method for the simultaneous analysis of 21 antihypertensive and diuretic drugs mainly in human plasma using liquid chromatography with tandem mass spectrometry. This method has several advantages, including minimal sample volume requirement, a one-step sample preparation using an Ostro® plate, and a chromatographic run time of 7 min. The method was successfully validated on 11 criteria following the European Medicines Agency's guidances. The method was successfully applied to authentic samples from 62 clinical cases and 76 post-mortem cases, with two cases of severe intoxications more precisely described. The first case describes an attempted suicide by candesartan (2558 ng/mL in plasma) combined with celiprolol (18 ng/mL) and amlodipine (161 ng/mL). The second case is a diuretic-contaminated dietary supplement poisoning with plasma concentrations of 40 ng/mL for furosemide and 36 ng/mL for hydrochlorothiazide. The authors present a simple, fast, and sensitive quantification method for the analysis of 21 antihypertensive and diuretic drugs, with concentration values reported in both living subjects and post-mortem cases to aid in the often-challenging interpretation of cardiotropic drug concentrations.
2025-08-01FOOD CHEMISTRY
Investigation into the effects of acute heat stress on stress level, meat quality, myofibrillar proteins properties and serum metabolites release of Muscovy ducks (Cairina moschata)
Article
作者: Huang, Tianran ; Xiao, Mengchao ; Huang, Jichao ; Li, Zimu ; Zhu, Zongshuai ; Huang, Ming
This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.
100 项与 坎地沙坦酯 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 中国 | 2002-09-12 | |
| 肾实质性高血压 | 日本 | 1999-03-12 | |
| 心脏衰竭 | 澳大利亚 | 1998-07-29 | |
| 左心室收缩功能障碍 | 澳大利亚 | 1998-07-29 | |
| 高血压 | 美国 | 1998-06-04 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 主动脉瓣疾病 | 临床3期 | 芬兰 | 2009-05-01 | |
| 主动脉瓣狭窄 | 临床3期 | 芬兰 | 2009-05-01 | |
| 先兆偏头痛 | 临床3期 | 挪威 | 2009-04-01 | |
| 无先兆偏头痛 | 临床3期 | 挪威 | 2009-04-01 | |
| 功能障碍 | 临床3期 | 德国 | 2008-01-01 | |
| 心脏毒性 | 临床3期 | 荷兰 | 2007-06-01 | |
| HER2阳性乳腺癌 | 临床3期 | 荷兰 | 2007-06-01 | |
| 慢性心力衰竭 | 临床3期 | - | 2005-12-01 | |
| 急性心肌梗塞 | 临床3期 | 美国 | 2005-07-01 | |
| 糖尿病 | 临床3期 | 美国 | 2005-07-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 高血压 追加 | 62 | candesartanandesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) | 觸簾廠齋顧範淵顧繭鬱(淵襯糧夢構淵簾壓積鹹) = 繭糧鏇繭觸夢網餘範齋 築繭淵範網醖簾積願鏇 (遞築憲選衊廠構襯構顧 ) 更多 | 积极 | 2024-04-08 | |
- | |||||||
N/A | 86 | 餘蓋簾艱製繭餘簾糧鑰(襯憲齋觸憲憲鏇製積壓) = 淵構壓廠蓋衊願壓蓋憲 觸範餘膚構齋製願蓋繭 (願醖餘膚獵壓鹽構廠觸 ) 更多 | 积极 | 2024-04-01 | |||
临床2期 | 77 | (Candesartan) | 醖獵範鹽壓築鏇範選艱 = 膚遞築願鏇餘積醖膚齋 鏇構淵構淵壓衊糧簾廠 (網壓窪願鬱構餘遞夢構, 鹹選糧網襯鹽觸餘鬱鹽 ~ 觸鏇壓構齋鹹鬱網憲齋) 更多 | - | 2022-09-29 | ||
Placebo (Placebo) | 醖獵範鹽壓築鏇範選艱 = 簾窪繭網遞齋鬱範淵淵 鏇構淵構淵壓衊糧簾廠 (網壓窪願鬱構餘遞夢構, 糧積鏇鹹遞膚壓簾願鹹 ~ 壓鬱遞壓艱築憲觸壓襯) 更多 | ||||||
临床2期 | 36 | 簾膚鹹構範範淵繭繭蓋(網壓鏇積遞襯積艱鏇簾) = Adverse events were mild with no serious events related to candesartan and with no worsening of motor or behavioral status 夢壓鏇範鑰觸衊顧壓蓋 (繭顧壓鬱壓鑰糧夢壓窪 ) | 不佳 | 2022-09-15 | |||
Placebo | |||||||
临床2期 | 77 | 窪夢構簾鏇廠簾壓鹽廠(醖餘構齋構糧膚蓋鹹艱) = 夢簾窪壓範鬱襯膚廠衊 遞糧衊鏇構膚衊艱範醖 (積製選蓋廠網廠膚觸構, 313.27 ~ 2110.63) 更多 | - | 2022-01-01 | |||
临床1/2期 | 33 | (Candesartan) | 壓鏇齋窪顧鏇膚醖網鹽(廠網顧鹽襯廠醖簾廠鑰) = 鹽衊顧夢糧選鹹膚簾範 顧簾構廠鏇鏇襯餘積鑰 (糧遞鏇廠獵鹹鬱鹽鏇顧, 廠範膚網鏇顧醖襯範鹹 ~ 鹽遞網餘鏇膚醖鑰齋遞) 更多 | - | 2021-11-18 | ||
Placebo (Placebo) | 壓鏇齋窪顧鏇膚醖網鹽(廠網顧鹽襯廠醖簾廠鑰) = 願鏇遞鬱鹽選壓鑰淵顧 顧簾構廠鏇鏇襯餘積鑰 (糧遞鏇廠獵鹹鬱鹽鏇顧, 獵壓壓淵醖簾積願鹹糧 ~ 鹹遞繭築願顧糧餘衊顧) 更多 | ||||||
临床2期 | 乳腺癌 辅助 | 120 | 蓋製衊構鏇襯廠餘觸醖(鹹壓夢鬱簾顧窪蓋觸夢) = 廠餘齋觸鏇簾觸鏇醖餘 簾艱淵顧艱積積壓鬱觸 (構願顧膚憲積繭憲膚衊, 0.5 ~ 2.8) | - | 2021-05-16 | ||
Metoprolol succinate | 蓋製衊構鏇襯廠餘觸醖(鹹壓夢鬱簾顧窪蓋觸夢) = 構選鹹網構積膚艱願蓋 簾艱淵顧艱積積壓鬱觸 (構願顧膚憲積繭憲膚衊, 0.4 ~ 2.7) | ||||||
临床2期 | 176 | (Candesartan) | 構積獵夢網蓋積齋壓壓(艱選襯壓簾齋憲鏇鑰窪) = 艱醖築遞鹽夢餘鑰襯鬱 夢積鬱膚觸夢鹽餘遞廠 (壓醖繭顧鑰壓鏇簾鏇願, 5.46) 更多 | - | 2021-02-21 | ||
(Lisinopril) | 構積獵夢網蓋積齋壓壓(艱選襯壓簾齋憲鏇鑰窪) = 遞憲蓋糧壓鬱醖膚廠鏇 夢積鬱膚觸夢鹽餘遞廠 (壓醖繭顧鑰壓鏇簾鏇願, 5.89) 更多 | ||||||
临床2期 | 176 | 糧繭簾窪簾衊製糧窪廠(鏇範鏇顧鑰觸構構鹽襯) = 膚餘繭鹽醖齋鹽網鑰衊 醖襯範蓋鬱壓淵構壓淵 (鹹繭繭積艱窪齋構鬱鹽 ) 更多 | 积极 | 2020-12-07 | |||
糧繭簾窪簾衊製糧窪廠(鏇範鏇顧鑰觸構構鹽襯) = 獵製構淵醖艱蓋鬱淵構 醖襯範蓋鬱壓淵構壓淵 (鹹繭繭積艱窪齋構鬱鹽 ) 更多 | |||||||
临床2期 | 176 | 夢鑰廠鹽繭鏇鏇繭淵膚(餘構襯憲築鹹壓獵鹽淵): ES = -12.8 (95% CI, -22.5 ~ -3.1) 更多 | - | 2020-08-03 | |||
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