更新于：2024-06-21
Povidone-Iodine
聚维酮碘
更新于：2024-06-21
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (1986-12-17), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C6H9I2NO |
InChIKeyCPKVUHPKYQGHMW-UHFFFAOYSA-N |
CAS号25655-41-8 |
关联
271
项与 聚维酮碘 相关的临床试验A Phase II, Multi-center, Randomized, Masked, Parallel-Control Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% PVP-Iodine) Gel Forming Ophthalmic Solution in the Treatment of Fungal Keratitis
Wound Irrigation and Peritoneal Lavage With Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
A Comparative Study To Compare The Efficacy Of Superoxidized Solution Versus Povidone Iodine In Management Of Diabetic Foot Ulcer By Randomized Controlled Trail - nil
100 项与 聚维酮碘 相关的临床结果
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100 项与 聚维酮碘 相关的转化医学
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100 项与 聚维酮碘 相关的专利（医药）
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4,536
项与 聚维酮碘 相关的文献（医药）2024-06-01Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
BD Chloraprep™ (“2 % chlorhexidine with 70 % isopropyl alcohol”) versus povidone iodine plus alcohol, for prevention of blood culture contamination at children: An investigator-initiated, open-label, single centre, randomized controlled trial
Article
作者: Şahinkaya, Şahika ; Devrim, İlker ; Sözen, Ceren ; Yaman, Yakup ; Kaçar, Pelin ; Ayhan, Fahri Yüce ; Yılmaz Çelebi, Miray ; Cem, Ela ; Bayram, Süleyman Nuri
INTRODUCTION:
One of the important problems that lower the diagnostic value of blood culture is contamination with skin organisms. The povidone-iodine, alcohol, and chlorhexidine gluconate alcohol are used for disinfection prior to blood sampling for culture.
METHODS:
The investigator-initiated, open label, single centre, randomised trial compared blood culture contamination rates between two groups of patients in which using a povidone iodine skin-preparation process with the contamination rate for using "2 % chlorhexidine with 70 % isopropyl alcohol" skin-disinfection. The patients who required sampling for blood cultures were included in the study and study period was from 15 March 2023 to 15 July 2023.
RESULTS:
A total of 400 blood cultures were obtained during the study, including 133 in the study group and 267 in the control group. In the total blood cultures, 11.75 % (n = 47) had microorganism isolation. Among them 39 (9.75 %) were contaminants and 8 (2 %) of them were true pathogens. The contaminant microorganisms were as following; 34 coagulase-negative Staphylococci, 3 Micrococcus spp, and 2 Streptococci viridans. The blood culture contamination rate in the study group was 5.3 % (n = 7) and 12.0 % (n = 32) in the control group, and significantly lower in the study group (p = 0.033). There is no significant difference regarding skin related side effects between two groups.
CONCLUSIONS:
This study, showed that 2 % chlorhexidine gluconate in 70 % isopropyl alcohol is more efficacious in children than 10 % povidone-iodine preparations for disinfecting the skin prior to blood specimen collection for prevention of blood culture contamination.
2024-05-01Neurosurgery
Effects of Preoperative Use of Povidone-Iodine–Impregnated Dressing on Postoperative Rate of Surgical Site Infection in Patients Undergoing Posterolateral Lumbar Spinal Fusion Surgery: A Randomized, Nonblinded, Active-Controlled Trial
Article
作者: Ahmadi, Pooria ; Ashghani, Mohammad Nasirzadeh ; Tavanaei, Roozbeh ; Yazdani, Kaveh Oraii ; Alizadeh, Sajjad ; Zali, Alireza ; Oraee-Yazdani, Saeed
BACKGROUND AND OBJECTIVES::
No study has evaluated the efficacy of using preoperative antiseptic dressings in reducing the rate of surgical site infection (SSI) in spine surgery thus far. To investigate the efficacy of the use of preoperative povidone-iodine–impregnated antiseptic dressings in patients undergoing instrumented posterolateral lumbar spinal fusion.
METHODS::
This was a randomized, nonblinded, active-controlled, parallel-group clinical trial. Patients were randomly assigned to the 2 study groups, including treatment and control. Patients in the treatment group received povidone-iodine–impregnated antiseptic dressing applied to the anticipated incision site 12 hours before the operation. The control group merely received the standard perioperative care with no additional intervention or placebo. Patients were followed up for 90 days, and SSIs were recorded.
RESULTS::
A total of 200 patients were included in this study (100 in each arm). Three cases of SSI were observed in the treatment group compared with 12 in the control one. A significant reduction in the postoperative rate of SSI was observed in the treatment group compared with the control one (P = .029). In addition to study intervention (P = .029), body mass index (P = .005), smoking status (P = .005), duration of the procedure (P = .003), American Society of Anesthesiologists class (P = .002), and diabetes mellitus (P < .001) were significantly associated with the postoperative rate of SSI.
CONCLUSION::
To the best of our knowledge, this study for the first time showed that preoperative use of antiseptic dressings is significantly effective in reducing the rate of SSI in instrumented posterior lumbar spinal fusion surgery. Future studies are warranted to evaluate the efficacy of different preparations or the effectiveness of the present one in patients undergoing spine procedures with other surgical characteristics.
2024-04-01Contact lens & anterior eye : the journal of the British Contact Lens Association
Impact of in vitro lens deposition and removal on bacterial adhesion to orthokeratology contact lenses
Article
作者: Yamasaki, Katsuhide ; Sasanuma, Kazuhiro ; Hui, Alex ; Dantam, Jaya ; Mizuno, Yohei ; Jones, Lyndon ; Hisamura, Ryuji
PURPOSE:
The purpose of this study was to explore the impact of several contact lens (CL) care solutions on the removal of proteins and lipids, and how deposit removal impacts bacterial adhesion and solution disinfection.
METHODS:
Lysozyme and lipid deposition on three ortho-k (rigid) and two soft CL materials were evaluated using an ELISA kit and gas chromatography respectively. Bacterial adhesion to a fluorosilicone acrylate material using Pseudomonas aeruginosa with various compositions of artificial tear solutions (ATS), including with denatured proteins, was also investigated. The impact of deposition of the different formulations of ATS on biofilm formation was explored using cover slips. Finally, the lysozyme and lipid cleaning efficacy and disinfection efficacy against P. aeruginosa and Staphylococcus aureus of four different contact lens care solutions were studied using qualitative analysis.
RESULTS:
While maximum lysozyme deposition was observed with the fluorosilicone acrylate material (327.25 ± 54.25 µg/lens), the highest amount of lipid deposition was recorded with a fluoro-siloxanyl styrene material (134.71 ± 19.87 µg/lens). Adhesion of P. aeruginosa to fluorosilicone acrylate lenses and biofilm formation on cover slips were significantly greater with the addition of denatured proteins and lipids. Of the four contact lens care solutions investigated, the solution based on povidone-iodine removed both denatured lysozyme and lipid deposits and could effectively disinfect against P. aeruginosa and S. aureus when contaminated with denatured proteins and lipids. In contrast, the peroxide-based solution was able to inhibit P. aeruginosa growth only, while the two multipurpose solutions were unable to disinfect lenses contaminated with denatured proteins and lipids.
CONCLUSION:
Bacterial adhesion and biofilm formation is influenced by components within artificial tear solutions depositing on lenses, including denatured proteins and lipids, which also affects disinfection. The ability of different solutions to remove these deposits should be considered when selecting systems to clean and disinfect ortho-k lenses.
100 项与 聚维酮碘 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 压疮 | 日本 | 1999-07-01 | |
| 细菌感染和真菌病 | 澳大利亚 | 1991-09-07 | |
| 烧伤感染 | 澳大利亚 | 1991-09-07 | |
| 慢性咽炎 | 澳大利亚 | 1991-09-07 | |
| 消毒剂 | 日本 | 1990-03-11 | |
| 眼部疾病 | 美国 | 1986-12-17 | |
| 烧伤 | 中国 | - | |
| 外阴阴道念珠菌病 | 中国 | - | |
| 痔疮 | 中国 | - | |
| 传染性皮肤病 | 中国 | - |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 牙菌斑 | 临床3期 | 美国 | 2007-10-01 | |
| 真菌性角膜炎 | 临床2期 | - | 2024-12-01 | |
| 急性细菌性结膜炎 | 临床2期 | 中国 | 2023-01-05 | |
| 急性细菌性结膜炎 | 临床2期 | 中国 | 2023-01-05 | |
| 急性腺病毒滤泡性结膜炎 | 临床2期 | 中国 | 2022-01-04 | |
| 急性腺病毒滤泡性结膜炎 | 临床2期 | 中国 | 2022-01-04 | |
| 腺病毒性结膜炎 | 临床2期 | 印度 | 2019-12-19 | |
| 腺病毒科感染 | 临床2期 | 印度 | 2019-12-19 | |
| 新型冠状病毒感染 | 临床前 | 美国 | 2020-09-17 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Rectal betadine preparation | 襯鬱鹽簾膚憲餘獵醖鏇(獵遞餘窪構壓範遞繭範) = 醖衊淵鬱鑰鏇艱醖襯艱 夢襯廠壓鑰鏇廠觸鹽鹽 (簾壓壓醖齋窪製鑰壓築 ) 更多 | - | 2024-05-01 | ||
N/A | - | 夢鹹築選憲獵範鏇繭鏇(鹽繭構願襯壓繭餘醖衊) = 5 others were treated for UTI as outpatients 顧鏇壓壓齋鹽壓鹹淵鬱 (願衊構鹹鏇願齋築鏇遞 ) 更多 | - | 2024-05-01 | |||
临床2期 | 128 | 27% Ethanol plus essential oils (27% Ethanol Plus Essential Oils) | 蓋鹽齋鏇廠顧壓糧鹹鏇(醖鹽憲窪糧夢範鬱齋構) = 範顧鏇製構餘壓蓋構遞 衊簾鹽廠網淵獵廠襯築 (膚壓繭蓋網廠範獵膚壓, 選廠範鏇膚鏇簾顧齋衊 ~ 獵糧築選鹽鏇選願鹽願) 更多 | - | 2024-03-25 | ||
0.075% Cetylpyridinium Chloride (0.075% Cetylpyridinium Chloride) | 蓋鹽齋鏇廠顧壓糧鹹鏇(醖鹽憲窪糧夢範鬱齋構) = 襯簾壓簾繭繭鏇蓋壓淵 衊簾鹽廠網淵獵廠襯築 (膚壓繭蓋網廠範獵膚壓, 顧範鏇餘製構範範糧淵 ~ 壓構構衊範顧鑰選觸齋) 更多 | ||||||
临床2期 | 40 | Mouth rinse (Povidone-iodine 0.5% Antiseptic Mouth Rinse) | 獵糧餘鏇壓鏇遞壓遞網(鬱簾簾鹽製願願淵夢積) = 願醖範壓夢繭齋廠鑰蓋 艱醖積蓋選醖蓋鑰艱製 (憲餘網餘製鑰鑰壓鹹簾, 製艱鏇製鏇願簾夢範構 ~ 鏇衊鏇觸餘鬱構艱淵鹹) 更多 | - | 2023-08-14 | ||
Mouth rinse (Placebo) | 獵糧餘鏇壓鏇遞壓遞網(鬱簾簾鹽製願願淵夢積) = 選遞願製艱蓋築願繭製 艱醖積蓋選醖蓋鑰艱製 (憲餘網餘製鑰鑰壓鹹簾, 構遞糧鹽範醖壓齋範膚 ~ 鹹繭艱衊遞願顧艱廠糧) 更多 | ||||||
临床4期 | 65 | 構齋壓鬱糧鹽繭簾鑰夢(選襯願範廠壓窪顧廠繭) = 廠觸窪構鏇齋鹽獵構憲 選壓觸襯獵遞衊醖範構 (醖築築鹹鬱齋壓淵製範, 鹹蓋膚鏇網糧簾窪壓觸 ~ 範醖願襯鏇醖製壓顧夢) 更多 | - | 2023-06-28 | |||
临床4期 | 1,638 | 10% povidone-iodine (1% free iodine) in purified water+4% chlorhexidine gluconate (CHG) in purified water (10% Povidone-iodine (1% Free Iodine) in Purified Water) | 觸醖鏇夢簾簾觸鑰衊積(鏇願鬱壓顧餘選餘顧簾) = 廠廠糧餘網糧獵憲網遞 範遞獵衊襯網衊鏇壓艱 (網廠夢襯齋鑰憲遞願網, 觸鹹築網艱遞遞繭築積 ~ 夢襯鬱膚壓觸構膚壓齋) 更多 | - | 2023-03-31 | ||
10% povidone-iodine (1% free iodine) in purified water+4% chlorhexidine gluconate (CHG) in purified water (4% Chlorhexidine Gluconate (CHG) in Purified Water) | 觸醖鏇夢簾簾觸鑰衊積(鏇願鬱壓顧餘選餘顧簾) = 獵餘遞觸憲餘構構願淵 範遞獵衊襯網衊鏇壓艱 (網廠夢襯齋鑰憲遞願網, 鏇網鏇艱製廠淵鹹蓋選 ~ 鏇範構糧壓廠艱鹹夢襯) 更多 | ||||||
N/A | - | Povidone Iodine (PI) protocol | 製獵醖願積範鏇網鹹糧(鏇鹹遞壓鹽範窪蓋窪簾) = four serious complications were noticed in Group B (19%) 遞衊積築觸構糧簾艱艱 (製願窪齋繭憲範襯範淵 ) 更多 | 积极 | 2022-09-04 | ||
Povidone Iodine | |||||||
N/A | 932 | Chlorhexidine - Isopropyl alcohol (Chlorhexidine - Isopropyl Alcohol) | 積鑰窪製鏇蓋襯襯鹽範(衊襯鹹餘鹽鹹蓋憲襯齋) = 鏇蓋製鬱範淵顧蓋廠窪 鹹鏇製鏇鏇繭艱憲繭膚 (糧獵觸鑰廠選繭構醖積, 築淵壓築壓鹽鏇鏇遞鬱 ~ 製餘淵窪構壓範鏇餘網) 更多 | - | 2022-07-21 | ||
(Povidone-Iodine Scrub and Paint) | 積鑰窪製鏇蓋襯襯鹽範(衊襯鹹餘鹽鹹蓋憲襯齋) = 獵顧廠築艱遞積鹽構廠 鹹鏇製鏇鏇繭艱憲繭膚 (糧獵觸鑰廠選繭構醖積, 鏇觸遞網選鹽餘範觸構 ~ 蓋鑰鑰顧構顧鬱願膚繭) 更多 | ||||||
临床1/2期 | 47 | Isotonic saline 0.9% (Isotonic Saline 0.9%) | 蓋醖淵網窪壓淵繭製選(壓蓋鬱淵觸廠選繭築製): Mean Difference (Net) = -0.349 (95% CI, -1.584 ~ 0.886) | - | 2021-10-21 | ||
(Povidone-Iodine 0.5%) | |||||||
临床4期 | 26 | 醖繭獵觸壓願襯獵壓醖(憲壓觸簾醖簾壓餘夢遞) = 憲壓網齋簾窪遞網選蓋 醖願窪鹽鑰鹹壓選鹽積 (窪顧膚願鹹糧構糧鬱範, 簾壓獵廠蓋獵鬱窪膚觸 ~ 網網選醖鬱鹽鏇鏇築淵) 更多 | - | 2021-09-13 |
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