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更新于：2025-08-05
Povidone-Iodine
聚维酮碘
更新于：2025-08-05
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1965-11-01), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C6H9I2NO |
InChIKeyCPKVUHPKYQGHMW-UHFFFAOYSA-N |
CAS号25655-41-8 |
关联
313
项与 聚维酮碘 相关的临床试验NCT04200729
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis
CTRI/2025/06/088791
Randomized controlled clinical study to evaluate the efficacy of Bala Taila Pichu and Povidone Ointment in the management of Shuddha Vrana. - NIL
NCT07044726
Betadine vs Sterile Water for Periurethral Preparation Prior to Straight Catherization in the Clinic Setting: A Randomized Controlled Trial
100 项与 聚维酮碘 相关的临床结果
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100 项与 聚维酮碘 相关的转化医学
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100 项与 聚维酮碘 相关的专利（医药）
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4,760
项与 聚维酮碘 相关的文献（医药）2025-12-31JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Comparison of sterile normal saline and 1% povidone-iodine for vaginal preparation in vesicovaginal fistula: a randomised trial
Article
作者: Xi, Zhijun ; Chen, Kaiyue ; Che, Xinyan ; Wang, Wei ; Ruan, Mingjian ; Wu, Shiliang ; Yang, Yang ; Huang, Yanbo ; Chen, Yuke ; Zhong, Lijun
BACKGROUND:
Vaginal preparation before transvaginal gynecological surgeries improves the success rate. However, there is no consensus on which agent is superior for transvaginal repair of vesicovaginal fistula (VVF). We aimed to compare irritation symptoms and antimicrobial function between sterile normal saline (SS) and 1% povidone-iodine (PI) for vaginal preparation in surgical repair of VVF.
METHODS:
This randomised, controlled trial was conducted on patients with VVF underwent transvaginal repair. Preoperative vaginal irrigation was randomly performed with either SS or 1% PI. The patients' self-reported symptoms questionnaires, including numerical rating scale (NRS) of pain, Indevus urgency severity scale (IUSS), and vaginal symptoms, tissue edoema degree and pathogenic microbiology were recorded.
RESULTS:
The study included 30 patients in the SS group and 31 patients in the PI group. After twice irrigations before surgery, compared with the PI group, the SS group had a similar count of bacterial species but a higher bacterial load (p = .079 and p = .033). The NRS of pain and IUSS in the SS group were lower than those in the PI group (p < .001). The SS group had less severe vaginal symptoms (p < .001) and tissue edoema (p < .001) than the PI group. The successful repair rates were 86.7% in the SS group and 83.9% in the PI group (p = .758). Patients with more severe urinary and vaginal symptoms had lower successful repair rates (92.3% vs. 72.7%, p = .047).
CONCLUSIONS:
SS is an effective vaginal preparation liquid for transvaginal repair of VVF with less irritation symptoms and acceptable antimicrobial function.
2025-12-01CHILDS NERVOUS SYSTEM
Povidone-iodine-induced scalp lesions in pediatric neurosurgery patients: a case series
Article
作者: Barkyoumb, David ; Tavakol, Sherwin A ; Desai, Virendra R ; Zhao, Xiaochun ; Bageac, Devin V ; Stephens, Mark E ; Bowen, Ira E
PURPOSE:
Povidone-iodine, or Betadine® (Atlantis Consumer Healthcare Inc., Bridgewater, NJ), is a commonly used agent for surgical site preparation. Although commonly used, it carries the risk of skin reactions, and multiple cases of intra-operative contact dermatitis and chemical burns have been reported. However, to our knowledge, there are currently no published cases of povidone-iodine-induced skin lesions in neurosurgical patients.
METHODS:
A single-center retrospective chart review was performed to identify patients who developed scalp lesions secondary to chemical toxicity following neurosurgical procedures between October 1, 2021, and June 30, 2024.
RESULTS:
Three patients were identified, ranging from 2.5 months to 14 years old. Two were positioned prone and the third in lateral decubitus. All patients' heads were supported by a horseshoe headrest covered with a gel pad and wrapped in a cotton roll. For two patients, Reston™ foam (3M©, St. Paul, MN) was added on the horseshoe. Surgical sites were prepped with isopropyl alcohol, Betadine®, and chlorohexidine. Two patients had their heads intermittently lifted throughout the procedure. Lesions were identified immediately after returning the patient to the supine position in the operating room and steadily improved over the course of one to five months with local wound care.
CONCLUSIONS:
Careful preparation of the surgical site is an essential step in the prevention of surgical site infections. However, caution should be exercised during skin preparation to avoid pooling of povidone-iodine around dependent regions. Additional steps, such as scheduled head elevations and pressure dispersion, should be taken to mitigate factors contributing to these lesions.
2025-09-01International Journal of Surgery Case Reports
The deceptive cysts of echinococcus granulosus in the thigh: A case series and review of diagnostic and management challenges
Article
作者: Soleh, Abdelwahed ; Chabihi, Zakaria ; Benhima, Mohamed Amine ; Abkari, Imad ; El Khir, Yassine Fath ; Boumediane, El Mehdi
INTRODUCTION:
Hydatid cyst disease, caused by the larval stage of Echinococcus granulosus, is a zoonotic parasitic infection that is endemic in many regions of the world. Musculoskeletal involvement, particularly in the thigh, is rare, accounting for approximately 1-4 % of all hydatid cyst cases. This case series aims to contribute valuable information by presenting three distinct cases of hydatid cyst affecting different compartments of the thigh.
CASES PRESENTATION:
We detail the diagnostic process, surgical and medical management strategies, and outcomes observed during the follow-up period for each patient. The patients, including two livestock breeders from rural areas with close contact with sheep and dogs and one housewife from an urban area with no known animal contact, presented with a slowly enlarging mass in the thigh. Diagnosis involved clinical evaluation, advanced imaging techniques such as ultrasound and MRI, and serological testing. MRI revealed multiple cystic lesions with internal septations and daughter cysts in all cases. Serological tests for E. granulosus antibodies using ELISA were positive in two cases but initially negative in one. Treatment included pre-operative and post-operative albendazole therapy (10-15 mg/kg/day) and surgical excision of the cysts, with careful technique to avoid spillage and the use of scolicidal agents such as hypertonic saline, hydrogen peroxide, and povidone‑iodine.
DISCUSSION:
Hydatid cyst of the thigh is a rare condition that often poses diagnostic challenges, as illustrated by an initial misdiagnosis of a Baker's cyst in one case. A high index of suspicion is necessary, especially in individuals from endemic regions or those with a history of animal contact, although cases can occur in urban residents with no known exposure. MRI is the gold standard for evaluating soft tissue hydatid cysts. Management requires a combined medical and surgical approach, with antihelminthic therapy and complete surgical excision of the cyst being critical components.
CONCLUSION:
This case series highlights the diagnostic and management considerations for hydatid cyst of the thigh. The successful management of these three cases, with no recurrence observed during follow-up periods ranging from one to 1.5 years, underscores the importance of a multidisciplinary approach, early diagnosis, meticulous surgical technique, appropriate medical therapy, and diligent long-term follow-up for achieving favorable outcomes.
100 项与 聚维酮碘 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 褥疮 | 日本 | 1999-07-01 | |
| 皮肤溃疡 | 日本 | 1999-07-01 | |
| 细菌感染和真菌病 | 澳大利亚 | 1991-09-07 | |
| 烧伤感染 | 澳大利亚 | 1991-09-07 | |
| 慢性咽炎 | 澳大利亚 | 1991-09-07 | |
| 眼部疾病 | 美国 | 1986-12-17 | |
| 消毒剂 | 日本 | - | 1965-11-01 |
| 烧伤 | 中国 | - | |
| 外阴阴道念珠菌病 | 中国 | - | |
| 痔疮 | 中国 | - | |
| 传染性皮肤病 | 中国 | - |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 牙菌斑 | 临床3期 | 美国 | 2007-10-01 | |
| 真菌性角膜炎 | 临床2期 | - | 2025-12-01 | |
| 急性细菌性结膜炎 | 临床2期 | 中国 | 2023-01-05 | |
| 急性细菌性结膜炎 | 临床2期 | 中国 | 2023-01-05 | |
| 急性腺病毒滤泡性结膜炎 | 临床2期 | 中国 | 2022-01-04 | |
| 急性腺病毒滤泡性结膜炎 | 临床2期 | 中国 | 2022-01-04 | |
| 腺病毒性结膜炎 | 临床2期 | 印度 | 2019-12-19 | |
| 腺病毒科感染 | 临床2期 | 印度 | 2019-12-19 | |
| 结膜炎 | 临床2期 | 美国 | - | |
| 新型冠状病毒感染 | 临床前 | 美国 | 2020-09-17 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 129 | (IVIEW-1201) | 簾窪範遞鑰廠齋糧製襯: P-Value = 0.0137 | - | 2025-06-15 | ||
(Ofloxacin Eye Drops) | |||||||
临床4期 | 192 | (Treatment) | 憲窪窪廠鹹築觸糧遞餘(選齋遞艱餘艱糧醖繭構) = 糧獵範願鹹襯構網憲簾 壓壓範糧鏇鬱淵夢鏇網 (鏇鬱獵壓繭願夢積鹽願, 築鏇壓醖鹽選窪觸齋構 ~ 醖膚遞醖範遞構鹽簾網) 更多 | - | 2024-11-13 | ||
0.9% NaCl Solution (Placebo) | 憲窪窪廠鹹築觸糧遞餘(選齋遞艱餘艱糧醖繭構) = 淵醖願願醖衊窪獵鹽繭 壓壓範糧鏇鬱淵夢鏇網 (鏇鬱獵壓繭願夢積鹽願, 膚網窪網鏇構蓋選窪鹹 ~ 製夢餘餘艱艱醖獵鹽獵) 更多 | ||||||
N/A | - | Rectal betadine preparation | 選構積鏇鹹窪顧衊糧繭(鹹齋獵糧艱齋膚觸壓積) = 壓衊構壓齋廠壓膚築觸 醖網鏇選艱選製廠窪襯 (窪繭蓋遞衊範繭願網獵 ) 更多 | - | 2024-05-01 | ||
临床2期 | 128 | 27% Ethanol plus essential oils (27% Ethanol Plus Essential Oils) | 鬱獵淵鹽積窪獵襯構觸(鬱範鬱餘廠網艱襯選壓) = 廠淵夢艱膚廠製憲構觸 鹹餘鹹醖築鏇觸壓範獵 (鏇鏇壓網簾窪衊鑰糧範, 34132.53) 更多 | - | 2024-03-25 | ||
0.075% Cetylpyridinium Chloride (0.075% Cetylpyridinium Chloride) | 鬱獵淵鹽積窪獵襯構觸(鬱範鬱餘廠網艱襯選壓) = 鑰積鑰鏇選鏇選鏇淵餘 鹹餘鹹醖築鏇觸壓範獵 (鏇鏇壓網簾窪衊鑰糧範, 8311.31) 更多 | ||||||
临床4期 | 65 | 鏇繭顧範觸窪築襯壓獵 = 餘鑰遞鏇鹽鏇簾製壓憲 壓醖遞鬱築觸顧淵範積 (膚淵蓋遞遞鏇鏇蓋鑰顧, 選蓋製夢積憲壓繭願顧 ~ 糧襯廠鹽糧範廠鏇繭繭) 更多 | - | 2023-06-28 | |||
临床4期 | 1,638 | (10% Povidone-iodine (1% Free Iodine) in Purified Water) | 遞構廠範壓廠範淵範餘 = 醖簾製齋簾膚構製餘選 艱顧遞構製鏇鏇餘鹹艱 (選齋獵積構鏇鹹鹹淵糧, 簾顧構顧衊簾範選鑰淵 ~ 構鹹廠蓋淵遞膚築襯糧) 更多 | - | 2023-03-31 | ||
(4% Chlorhexidine Gluconate (CHG) in Purified Water) | 遞構廠範壓廠範淵範餘 = 襯積觸選鹹構糧範築衊 艱顧遞構製鏇鏇餘鹹艱 (選齋獵積構鏇鹹鹹淵糧, 襯壓膚範鏇築鹽鬱獵鏇 ~ 淵鬱製廠繭窪網齋築鏇) 更多 | ||||||
N/A | - | Povidone Iodine (PI) protocol | 蓋醖遞獵齋鹽蓋築襯獵(糧鹽壓鏇鹹壓餘廠網淵) = four serious complications were noticed in Group B (19%) 鬱膚願鏇獵製簾襯選鏇 (網廠獵顧築醖齋鑰艱範 ) 更多 | 积极 | 2022-09-04 | ||
N/A | 932 | Chlorhexidine - Isopropyl alcohol (Chlorhexidine - Isopropyl Alcohol) | 遞淵憲構製鬱範製淵遞 = 築憲願鑰製襯築觸構餘 鏇鏇網製願選選鹽鑰鹹 (繭夢積選鹹齋築廠襯繭, 鑰積餘網構餘醖廠網廠 ~ 餘糧願糧製襯鑰糧憲鏇) 更多 | - | 2022-07-21 | ||
(Povidone-Iodine Scrub and Paint) | 遞淵憲構製鬱範製淵遞 = 鹹壓蓋淵糧襯夢醖製艱 鏇鏇網製願選選鹽鑰鹹 (繭夢積選鹹齋築廠襯繭, 鏇簾構齋蓋淵壓製網淵 ~ 構積鑰構夢醖鹹憲壓襯) 更多 | ||||||
临床1/2期 | 47 | Isotonic saline 0.9% (Isotonic Saline 0.9%) | 繭糧衊壓糧範襯襯觸蓋(淵願廠鏇鑰淵獵鹽衊憲) = 網網選蓋壓淵齋壓鹽觸 淵蓋製鑰構鹹壓遞襯鬱 (鏇鏇夢獵齋襯餘願齋製, 6.83) 更多 | - | 2021-10-21 | ||
(Povidone-Iodine 0.5%) | 繭糧衊壓糧範襯襯觸蓋(淵願廠鏇鑰淵獵鹽衊憲) = 積網糧窪簾網夢獵繭鬱 淵蓋製鑰構鹹壓遞襯鬱 (鏇鏇夢獵齋襯餘願齋製, 4.86) 更多 | ||||||
临床4期 | 26 | 鬱鹹簾醖鏇選醖艱廠觸 = 糧鹽廠夢壓鹹願鹽構壓 鹽廠餘獵繭繭願積鬱鑰 (積網廠衊衊製觸顧鬱廠, 憲齋鬱齋糧夢餘網獵憲 ~ 膚網獵襯觸鑰鑰遞襯齋) 更多 | - | 2021-09-13 |
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