Multicenter, Open-label, Randomized, Phase 2 Study of Venetoclax and Azacitidine Plus Cusatuzumab Versus Venetoclax and Azacitidine Alone in Newly Diagnosed AML Patients Who Are Not Candidates for Intensive Therapy

The goal of this clinical trial is to learn if participants treated with the experimental drug cusatuzumab added to venetoclax and azacitidine works to treat acute myeloid leukemia (AML) compared to venetoclax and azacitidine. Venetoclax and azacitidine are drugs commonly used to treat AML in patients that are unable to receive chemotherapy to treat AML. The main question the clinical trial aims to answer is does cusatuzumab added to venetoclax and azacitidine prolong the length of time participants live compared to venetoclax and azacitidine?

开始日期2024-07-22

申办/合作机构

Oncoverity, Inc.

NCT04264806

/ Withdrawn临床2期

A Phase 2, Randomized, Open-label Study of Cusatuzumab in Combination With Azacitidine Compared With Azacitidine Alone in Patients With Higher-risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) and Who Are Not Candidates for Hematopoietic Stem Cell Transplantation (HSCT)

The purpose of the study is to compare overall response rate (ORR) between treatment groups in participants with higher-risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) who are not eligible for Hematopoietic Stem Cell Transplantation (HSCT).

开始日期2021-05-06

申办/合作机构

Janssen Research & Development LLC

[+1]

NCT04241549

/ Completed临床1期

A Phase 1 Study of Cusatuzumab Plus Azacitidine in Japanese Patients With Newly Diagnosed Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome Who Are Not Candidates for Intensive Treatment

The purpose of this study is to determine the recommended Phase 2 dose and evaluate safety profile of cusatuzumab in combination with azacitidine in Japanese participants with treatment naïve acute myeloid leukemia (AML) who are not candidates for intensive treatment.

开始日期2020-03-25

申办/合作机构

Oncoverity, Inc.

[+2]

100 项与 Cusatuzumab 相关的临床结果

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100 项与 Cusatuzumab 相关的转化医学

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100 项与 Cusatuzumab 相关的专利（医药）

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项与 Cusatuzumab 相关的文献（医药）

2023-11-01·The Lancet. Haematology

Cusatuzumab plus azacitidine in newly diagnosed acute myeloid leukaemia ineligible for intensive chemotherapy (CULMINATE): part one of a randomised, phase 2, dose optimisation study

Article

作者: Wei, Andrew H ; Doronin, Vadim ; Johnson, Amy J ; Xiu, Liang ; Gyan, Emmanuel ; Hamad, Nada ; Özcan, Muhit ; Vey, Norbert ; Nottage, Kerri ; Langlois, Angélique ; Demirkan, Fatih ; Ofran, Yishai ; Hultberg, Anna ; Herrera, Pilar ; Martinelli, Giovanni ; Müller, Rouven ; Jacobs, Julie ; Trudel, Géralyn C ; Samoilova, Olga ; Fogliatto, Laura M ; Pabst, Thomas ; Papayannidis, Cristina ; Arnan, Montserrat ; Guttke, Christina ; Ma, Xuewen ; Tolbert, Jaszianne A

BACKGROUND:

Cusatuzumab, a high-affinity anti-CD70 antibody, has shown preliminary activity as a treatment for acute myeloid leukaemia when combined with azacitidine. We aimed to determine the optimum dose for future trials of cusatuzumab in combination with azacitidine in patients with previously untreated acute myeloid leukaemia who are not eligible for intensive chemotherapy.

METHODS:

In this randomised, phase 2, open-label, dose-optimisation study we enrolled adult patients aged 18 years or older with newly diagnosed acute myeloid leukaemia not eligible for intensive chemotherapy, and with Eastern Cooperative Oncology Group scores of 0-2, from 40 hospitals and centres across seven countries. In part one of the trial, participants were randomly allocated 1:1 to 10 mg/kg or 20 mg/kg intravenous cusatuzumab on days 3 and 17, combined with subcutaneous or intravenous azacitidine 75 mg/m² on days 1-7 in 28-day cycles. The primary efficacy outcome was the rate of complete remission in the intention-to-treat group. The two dose cohorts were evaluated independently without between-cohort statistical comparison. Safety analyses were performed in all patients who received one dose of study drug. Part two of the trial was planned to be a single-arm expansion to evaluate cusatuzumab plus azacitidine at the cusatuzumab dose level selected in part one (primary hypothesis ≥35% rate of complete remission vs null hypothesis of 20%); however, changes in the acute myeloid leukaemia treatment landscape during this trial made it unlikely that enrolment to part two of the study would be clinically feasible, so the study stopped at the end of part one. The trial was registered at ClinicalTrials.gov, NCT04023526.

FINDINGS:

103 patients were enrolled between Aug 30, 2019, and Feb 25, 2020, and randomly assigned to either cusatuzumab 10 mg/kg (n=51) or 20 mg/kg (n=52). Median follow-up was 7·2 months (IQR 10·7 months). 57 of 103 (55%) patients were male and 46 (45%) patients were female, 78 (76%) were White, one (1%) was Asian, and 24 (23%) did not report their race. In the 10 mg/kg group, complete remission rate was 12% (six of 51 patients; 95% CI 6-23) and in the 20 mg/kg group was 27% (14 of 52; 17-40). Grade 3 or worse treatment-emergent adverse events (TEAEs) were similar between the cusatuzumab 10 mg/kg (n=51) and 20 mg/kg (n=51) cohorts and included thrombocytopenia (24 patients [47%] vs 29 [57%]), anaemia (24 [47%] vs 17 [33%]), and neutropenia (20 [39%] in both cohorts). Serious TEAEs were also similar in the two cohorts (44 [86%] vs 40 [78%]). Treatment-related TEAEs leading to death were reported in both groups (three patients [6%] in the 10 mg/kg group vs one patient [2%] in the 20 mg/kg group); the reported causes of death were pneumonia (n=2) and septic shock (n=2).

INTERPRETATION:

Although part one of this study was not designed to formally compare the two dose cohorts for efficacy, the totality of clinical data for cusatuzumab studies performed to date indicate that cusatuzumab 20 mg/kg plus azacitidine represents the optimal dose for further studies. A phase 1b study investigating the triple combination of cusatuzumab with venetoclax and azacitidine is underway (NCT04150887).

FUNDING:

Janssen Research & Development and argenx.

2023-10-01·Cell death and differentiation

METTL3 inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via M6A-CD70-mediated immune suppression in thyroid cancer

Article

作者: Gao, Ming ; Ruan, Xianhui ; Zheng, Xiangqian ; Ning, Junya ; Zhang, Wei ; Hao, Jie ; Huang, Yue ; Hou, Xiukun ; Shi, Yi

The treatment options for advanced papillary thyroid cancer (PTC) and anaplastic thyroid cancer (ATC) refractory to standard therapies are limited. Although anti-PD-1 therapy has a manageable safety profile and has been effective in a small percentage of patients with advanced PTC and refractory ATC, the majority of the patients either do not respond or develop resistance to anti-PD-1 therapy. N6-methyladenosine (m6A) modification is a critical determinant of the complexity of the tumor microenvironment (TME). However, it is unclear whether and how m6A modification in tumor cells shapes the immune landscape of PTC and ATC. In this study, we performed bulk and single cell RNA sequencing analysis of PTC and ATC tissues, and found that low METTL3 expression not only correlated to poor response to immune checkpoint blockade (ICB) but was also associated with increased TNF family-related ligand-receptor interactions in the immunosuppressive Tregs and exhausted T cells. Furthermore, overexpression of METTL3 in PTC and ATC cells enhanced the efficacy of anti-PD-1 therapy in a peripheral blood mononuclear cell humanized NCG (huPBMC-NCG) mouse model. Mechanistically, M2 macrophage-derived extracellular vesicles (M2 EVs) inhibited METTL3 expression in PTC and ATC cells via miR-21-5p. Downregulation of METTL3 promoted demethylation of CD70 mRNA, which prevented YTHDF2-mediated degradation of the transcripts. The stabilization of CD70 mRNA, and the subsequent upregulation in CD70 protein levels increased the abundance of the immunosuppressive Tregs and terminally exhausted T cells, thereby inducing resistance to anti-PD-1 therapy. Furthermore, blocking CD70 using cusatuzumab, a high-affinity monoclonal antibody, reversed the anti-PD-1 therapy resistance induced by M2 EVs in vivo. Finally, we demonstrated that METTL3 expression negatively correlated with CD70 expression and M2 macrophages and Tregs infiltration in PTC and ATC tissues. Our findings provide new insights into developing novel therapies for advanced PTC and ATC.

2023-03-01·Cancer science

Cusatuzumab plus azacitidine in Japanese patients with newly diagnosed acute myeloid leukemia ineligible for intensive treatment

Article

作者: Hatayama, Tomoyoshi ; Shirahase, Toru ; Ikezoe, Takayuki ; Yamauchi, Takahiro ; Aida, Kensuke ; Usuki, Kensuke

Abstract:

We present the results of a phase 1 study that evaluated the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary disease response to cusatuzumab, a novel anti‐CD70 monoclonal antibody, in combination with azacitidine, in newly diagnosed acute myeloid leukemia Japanese participants who were not candidates for intensive treatment. In this multicenter, single‐arm study, six participants were enrolled and treated. Only in cycle 1, participants received cusatuzumab monotherapy on day 14. Subsequently, cusatuzumab was administered intravenously on days 3 and 17 at 20 mg/kg in combination with azacitidine (75 mg/m2) on days 1‐7 of each 28‐day cycle. All six participants had at least one treatment‐emergent adverse event, and the most common treatment‐emergent adverse events (all grades) were leukopenia (four participants [66.7%]) and constipation (three participants [50.0%]). No dose‐limiting toxicity was observed during the study period. The combination of cusatuzumab and azacitidine is generally well tolerated in Japanese participants, and further exploration of this combination is warranted.

项与 Cusatuzumab 相关的新闻（医药）

2025-02-05

·Business Wire

CD70 Targeting Therapies Clinical Trials & Market Opportunity Insight 2025: Cusatuzumab Emerges as Leading Phase II Candidate for Leukemia Treatment, Paving the Way for CD70 Therapy Evolution - ResearchAndMarkets.com

DUBLIN--( BUSINESS WIRE )--The "CD70 Targeting Therapies Clinical Trials & Market Opportunity Insight 2025" report has been added to ResearchAndMarkets.com's offering. CD70 targeting therapies are rapidly gaining recognition as a promising strategy for the treatment of various cancers and immune-related disorders, significantly transforming the therapeutic landscape. CD70, a cell surface protein, is crucial in regulating the immune system, making it an optimal target for therapies designed to selectively attack diseased cells while preserving healthy tissues. This movement towards precision medicine is particularly vital in oncology, where traditional treatments such as chemotherapy and radiation often lead to severe side effects and limited effectiveness. Global CD70 Targeting Therapies Clinical Trials & Market Opportunity Insight 2025 Report Highlights: CD70 Targeting Therapies In Clinical Trials: > 20 Therapies CD 70 Targeting Therapies Clinical Trials Insight By Company, Country, Indication and Phase Insight On CD70 Targeting Therapy Technology Platforms FDA & EMA Designations Insight: Orphan, FTD, RMAT Designation Global & Regional Market Development Insight Combination Strategies For CD70 Targeting Therapies In clinical practice, CD70 targeting therapies are demonstrating considerable potential in treating hematological malignancies, particularly acute myeloid leukemia (AML), as well as solid tumors like renal cell carcinoma (RCC). AML is particularly challenging to manage with standard therapies, especially in patients who are unsuitable for intensive chemotherapy. Clinical trials focused on CD70 targeted therapies have shown promise in addressing this issue, with monoclonal antibodies and engineered cell therapies offering new hope for patients with few treatment options. The most advanced CD70-targeting therapy currently in clinical development is Cusatuzumab, created by argenx, which is presently undergoing Phase 2 trials in conjunction with chemotherapeutic agents for AML patients. This combination strategy seeks to enhance the effectiveness of Cusatuzumab by tackling resistance mechanisms and improving overall patient outcomes. The application of CD70 targeting therapies extends beyond cancer treatment. These therapies are also being investigated for autoimmune diseases, viral infections, and graft-versus-host disease (GvHD), although they remain in the early stages of research. In these contexts, where immune responses are dysfunctional, CD70 targeting agents hold the potential to modulate the immune system and restore normal immune function. The expansion of therapeutic applications significantly fuels interest in this sector, as it broadens the potential market for these treatments. In commercial terms, the US stands as hub for CD70 targeting therapy research and development. A robust ecosystem comprising biotechnology companies, pharmaceutical enterprises, and research institutions has driven the advancement of these therapies. Notable institutions such as Baylor College of Medicine, the National Institutes of Health, and cancer centers like City of Hope are conducting crucial clinical trials. Furthermore, regulatory support from the US FDA, including the Fast Track Designation for Adicet Bio's ADI-270 and the Regenerative Medicine Advanced Therapy designation for Allogene Therapeutics' ALLO-316, has expedited the development and commercialization processes. This regulatory endorsement is vital in facilitating access to new treatments, positioning the US as the heart for both clinical development and market introduction. China is emerging as a significant contender in the global CD70 targeting therapy landscape. The country's rapidly growing biotechnology sector, bolstered by increased investments and partnerships with international companies, has enabled swift advancements in innovative therapies. Chinese research institutions are increasingly involved in clinical trials, while local biotech firms are progressing towards the commercialization of CD70 targeting therapies. The intensifying competition within the CD70 targeting therapy market is fostering innovation, with several companies, including Allogene Therapeutics, Seagen (Pfizer), and CRISPR Therapeutics, developing novel treatments. These organizations are engaged in comprehensive preclinical and clinical research to assess the safety and efficacy of their therapies, thereby enhancing the therapeutic potential of CD70 targeted interventions. As more therapies enter clinical trials and yield favorable outcomes, the commercial opportunities for CD70 targeting therapies are expanding. In conclusion, the integration of favorable clinical results and a dynamic commercial landscape establishes CD70 targeting therapies as a crucial component of the future of precision medicine. As an increasing number of companies and research organizations dedicate resources to these therapies, their capacity to tackle a diverse array of diseases expands, indicating the prospect of both clinical and commercial achievements ahead. Key Topics Covered: 1. Introduction To CD70 Targeting Therapy 1.1 CD70 Targeting Therapy Overview 1.2 The Prerequisite For CD70 Targeting Therapy 1.3 Dual Role of CD70 As Diagnostic & Prognostic Biomarker 2. CD70 Targeting Therapeutic Approaches 2.1 Monoclonal Antibody 2.2 Bispecific Antibody 2.3 Tetraspecific Antibody 2.4 CAR T Cell Therapy 2.5 Antibody Drug Conjugate 2.6 CAR-NK Therapy 3. CD70 Targeting Therapies Clinical Research & Development By Indications 3.1 Leukemia 3.2 Lymphoma 3.3 Gynecologic Cancer 3.4 Renal Cell Carcinoma 3.5 Lung Cancer 3.6 Autoimmune & Inflammatory Disease 3.7 Viral Infections 4. Global CD70 Targeting Therapies Clinical Trials Overview 4.1 By Phase 4.2 By Country 4.3 By Company 4.4 By Indication 4.5 By Priority Status 4.6 Patient Segment 5. CD70 Targeting Therapies Regulatory Designations: Fast Track & Orphan Designation 6. Global CD70 Targeting Therapies Clinical Trials Insight 6.1 Preclinical 6.2 Phase I 6.3 Phase I/II 6.4 Phase II 7. CD70 Targeting Therapies Development Platforms By Company & Technology 7.1 AlloCAR T Platform 7.2 Gamma Delta Cell Platform 7.3 Tailwind Platform 7.4 DARPin Platform 7.5 SIMPLE Antibody Platform 7.6 Potelligent Technology 7.7 Off The Shelf Allogeneic Manufacturing 8. Global CD70 Targeting Therapies Current Market Trend & Developments 8.1 Current Market Outline 8.2 Future Market Forecast 9. CD70 Targeting Therapies Market Opportunity & Clinical Trends By Region 9.1 US 9.2 China 9.3 Europe 10. Combination Strategies For CD70 Targeting Therapies 10.1 In Combination With Immunotherapy 10.2 In Combination With Epigenetic Modulators 10.3 In Combination With Targeted Therapy 10.4 In Combination With Oncolytic Virus Therapy 10.5 In Combination With Chemotherapy 11. Global CD70 Targeting Therapies Market Dynamics 11.1 Market Drivers 11.2 Market Challenges 12. Competitive Landscape Adaptimmune (TCR2 Therapeutics ) Adicet Bio Allogene Therapeutics Ambrx (Johnson & Johnson) Chongqing Precision Biotech Chinook Therapeutics (Novartis) CRISPR Therapeutics ImmuneOnco Biopharma Pfizer Poseida Therapeutics For more information about this report visit https://www.researchandmarkets.com/r/9qx332 About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

免疫疗法临床2期快速通道孤儿药细胞疗法

2024-11-22

·PipelineReview

OncoVerity Secures Extended Series A to Advance Cusatuzumab in Newly Diagnosed AML

First patients dosed in OV-AML-1231, a Phase 2 randomized controlled trial of cusatuzumab in newly diagnosed AML AURORA, CO, USA I November 21, 2024 I OncoVerity, a pioneer in applying advanced bioinformatics to drug development, announced today the closing of a Series A extension financing led by existing investors, argenx and RefinedScience. With this funding, OncoVerity aims to advance its mission to address the unmet medical need of cancer patients, leveraging a unique computational approach to inform a development strategy that seeks breadth and depth of response. The proceeds from the Series A extension will fund the Phase 2 OV-AML-1231 trial of cusatuzumab, a novel, first-in-class high-affinity monoclonal anti-CD70 antibody, in combination with venetoclax and azacitidine for the treatment of newly diagnosed acute myeloid leukemia (AML). The trial is enriched explicitly for patients with limited treatment options who show potential for responding to a cusatuzumab-based regimen, as informed by OncoVerity’s computational approach to guide its development. Patient enrollment is underway, and the first eight patients have been dosed. “This financing round is a critical step forward in accelerating the development of cusatuzumab,” said Max Colao, Chief Executive Officer at OncoVerity. “Cusatuzumab has the potential to treat a broad range of tumors, demonstrating a strong biologic rationale in AML. We are particularly excited about the potential of the Phase 2 trial, and look forward to sharing results from the interim analysis in the second half of 2025. These results will bring us closer to potentially offering a breakthrough new treatment option for AML patients. “This randomized phase 2 clinical trial was based on insights derived from machine learning-based approaches and will be analyzed using cutting-edge single cell omics technologies for depth and breadth of responses. This novel strategy was designed to optimize trial design and execution, address patient heterogeneity and other key patient specific needs and provide important insights into critical clinical and biologic areas. Together we hope this will help advance care for persons with AML and other cancers where there is urgent unmet medical need.” About OV-AML-1231 OV-AML-1231 is a randomized, open-label, multicenter, multinational, Phase 2 trial evaluating the safety and efficacy cusatuzumab combined with venetoclax, and azacitidine (VAC) to venetoclax and azacitidine (VA) in newly diagnosed AML patients not eligible for intensive chemotherapy. The planned enrollment is 120 newly diagnosed AML patients, randomized 2:1 to VAC (80 patients) and VA (40 patients). The trial population will be enriched for patients with adverse cytogenetic and molecular risk features. The primary end point is overall survival. Secondary endpoints include event-free survival, response rates including CR, CR+CRh, and rates of MRD negativity. About Cusatuzumab Cusatuzumab is a first-in-class high-affinity humanized monoclonal antibody targeting CD70, an immune checkpoint target involved in hematological malignancies, several solid tumors, and severe autoimmune diseases. Cusatuzumab is designed to: block CD70, kill cancer cells expressing CD70 through complement-dependent cytotoxicity, enhance antibody-dependent cell-mediated phagocytosis, enhance antibody-dependent cell-mediated cytotoxicity, and restore immune surveillance against solid tumors (Silence K. et al. mAbs 2014; 6 (2):523-532) . Cusatuzumab is currently being evaluated in patients with hematologic malignancies, including a Phase 2 trial in combination with azacitidine and a Phase 1b trial in combination with azacitidine and venetoclax in patients with newly diagnosed AML. About Acute Myeloid Leukemia Acute myeloid leukemia (AML) is a cancer of the bone marrow and the blood that progresses rapidly without treatment. It is a heterogeneous disease with variable prognosis for different patient subpopulations. Despite the advancements in medical research, there is still a significant need for new effective therapies to treat AML. The five-year survival rate for patients remains the lowest of all blood malignancies (5-20%), and relapse is common. Innovative therapies and targeted treatment approaches that can improve survival rates, reduce toxicity, and target specific subtypes of AML are urgently needed to address this unmet need. About OncoVerity OncoVerity is pioneering the use of computational tools applied to clinical and biological data to advance therapies that transform hope into reality for cancer patients. Through a strategic collaboration with Refined Science , OncoVerity’s approach leverages an advanced bioinformatics platform that applies single-cell multi-omics and machine learning technologies to a large AML patient database to identify biologic drivers to therapeutic resistance and insights on patient-specific risk factors. This approach not only holds promise for accelerating the development of cusatuzumab in AML, but also has the potential to be applied to its development in other hematologic malignancies, signifying a broader impact on the future of cancer treatment by bringing new hope to a wider range of patients. SOURCE: OncoVerity

临床2期免疫疗法

2024-05-17

·BioSpace

Emergence Of Anti CD70 Antibodies Clinical Trials

The emergence of immunotherapy has revolutionized cancer treatment by harnessing the power of the immune system to target and eliminate cancer cells. Among the diverse array of immune checkpoints and targets under investigation, CD70 has garnered significant attention as a promising therapeutic target in oncology. CD70, a member of the tumor necrosis factor (TNF) superfamily, is a cell surface protein that plays a crucial role in immune regulation and tumor biology. According to preliminary research, CD70 is mainly expressed on immune cells that have been activated, including dendritic cells, natural killer (NK) cells, T and B lymphocytes, and others. These cells use CD70 as a co-stimulatory molecule to help T cells activate and survive. Nonetheless, it has been noted that aberrant expression of CD70 occurs in cancer, either on the tumor cells themselves or in the surrounding tissue. “More Than 20 CD70 Targeting Antibodies Are In Clinical Trials With Some Antibodies Designated Orphan Drug & Fast Track Status” Renal cell carcinoma, glioblastoma, and B-cell lymphoma are among the cancers where increased proliferation, invasion, and metastasis have been associated with CD70 overexpression. Additionally, by encouraging the growth of regulatory T cells and preventing antitumor immune responses, CD70-mediated signaling pathways support immune evasion mechanisms. This increases the need for anti-CD70 targeting antibodies in the management of numerous illnesses. Download Research: Currently, the monoclonal antibody targeting CD70 protein exist in the laboratory and clinical stage of development, however continued research will aid to launch the novel therapeutic intervention in clinical market and, subsequently, in commercial market for the treatment of cancer and other disease across the globe. By binding CD70 on the surface of tumor cells, monoclonal antibodies inhibit CD70 mediated signaling pathways, thereby disrupting pro-tumorigenic signaling cascades involved in cell proliferation, survival, and metastasis. Monoclonal antibodies targeting CD70 have shown promising preclinical and clinical results in various cancer types. These antibodies are being investigated either as monotherapy or in combination with other treatment modalities, including chemotherapy, radiation therapy, and immune checkpoint inhibitors. The market for anti CD70 targeting antibodies is in its early stages, spurred by a variety of factors. The quest for increased efficacy and fewer adverse effects drives the development of novel drugs such as CD70 targeting antibodies. The involvement of the key players, such as OncoVerity, Argenx, Janssen Research & Development, ImmuneOnco Biopharmaceuticals (Shanghai), Seagen (a subsidiary of Pfizer), UTC Therapeutics and other in the market further aids in expanding the realm of anti CD70 antibody. While the role of anti-CD70 antibodies is primarily investigated in the context of cancer therapy, emerging evidence suggests their potential utility in other diseases beyond cancer treatment. CD70 is implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis. In these conditions, aberrant expression of CD70 on immune cells contributes to immune dysregulation and chronic inflammation. Anti-CD70 antibodies could potentially modulate immune responses, restore immune tolerance, and attenuate disease activity in autoimmune disorders. All these studies exemplify that the frontier of anti-CD70 antibodies is augmenting. The development of anti CD70 antibodies not only bestows to treat cancer disorders but also other ailments including autoimmune disease, viral infections and other diseases. The landscape of anti-CD70 antibody therapy is rapidly evolving, driven by advances in antibody engineering, preclinical research, and clinical development. Anti-CD70 antibodies hold promise as a novel immunotherapeutic approach for the treatment of cancer and other diseases characterized by dysregulated CD70 expression. In summation, anti CD70 targeting antibody therapy represents a promising avenue for cancer treatment, leveraging the dual benefits of directly inhibiting tumor cell growth and enhancing antitumor immune responses. Continued research efforts aimed at elucidating CD70 biology, optimizing therapeutic strategies, and conducting clinical trials will be instrumental in realizing the clinical utility of anti-CD70 targeting antibodies. By addressing the complexities of tumor-host interactions and overcoming therapeutic challenges, CD70 targeting has the potential to transform the landscape of cancer therapy and improve patient outcomes. The ongoing efforts to elucidate the role of CD70 in cancer biology and advance CD70 targeted therapies offer exciting prospects for improving patient outcomes. Future research should focus on refining therapeutic approaches, including the development of next-generation CD70 targeted agents with enhanced efficacy and reduced off-target effects. Ultimately, harnessing the therapeutic potential of CD70 inhibition clenches promise for realizing the full potential of immunotherapy for cancer and other disorder treatment.

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100 项与 Cusatuzumab 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
成人急性髓性白血病	临床2期	中国	argenx SE	2022-01-30
慢性粒单核细胞白血病	临床2期	澳大利亚	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	巴西	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	法国	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	德国	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	意大利	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	俄罗斯	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	沙特阿拉伯	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	西班牙	Janssen Research & Development LLC	2021-05-06
慢性粒单核细胞白血病	临床2期	瑞士	Janssen Research & Development LLC	2021-05-06

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04023526 (CULMINATE, CTgov)	临床2期	急性髓性白血病 \| 急性早幼粒细胞白血病	103	Cusatuzumab+Azacitidine (Cusatuzumab 10 mg/kg Plus Azacitidine)	願製積築簾範鹹製淵獵 = 鏇網繭襯鹹廠餘鑰獵鏇襯齋憲齋壓網膚鬱窪齋 (襯鬱蓋夢鹹淵積鏇淵鬱, 鹹網鹽夢淵鑰廠餘鹽繭 ~ 繭遞糧鹽選窪獵廠醖艱) 更多	-	2024-07-30
				Cusatuzumab+Azacitidine (Cusatuzumab 20 mg/kg Plus Azacitidine)	願製積築簾範鹹製淵獵 = 網鬱製艱衊鏇蓋顧窪鬱襯齋憲齋壓網膚鬱窪齋 (襯鬱蓋夢鹹淵積鏇淵鬱, 獵衊鑰獵糧醖積構糧獵 ~ 鑰鬱憲膚範淵築衊鬱糧) 更多
NCT04023526 \| NCT04150887 (Pubmed \| Lancet Haematol)	N/A	急性髓性白血病	-	Cusatuzumab 10 mg/kg	鏇積築選鬱網餘衊網獵(獵積築製鏇餘艱鑰鏇糧) = reported causes of death in the 10 mg/kg group: n=2 鹽蓋網觸構鏇觸衊範蓋 (夢積壓範鏇鏇鏇鹽觸膚 ) 更多	-	2023-11-01
				Cusatuzumab 20 mg/kg
NCT04023526 (CULMINATE, Corporate Publications) 人工标引	临床2期	急性髓性白血病	52	Azacitidine+cusatuzumab (cohort where patients received at least two treatment cycles)	衊積醖製淵網壓鏇醖艱(觸願範艱製網構齋顧觸) = 構窪鹽簾淵鑰醖製夢壓鹽獵鬱獵繭選製範夢襯 (衊憲網鏇廠壓糧艱壓蓋 ) 更多	积极	2021-01-08
				Azacitidine+cusatuzumab (20 mg/kg)	衊積醖製淵網壓鏇醖艱(觸願範艱製網構齋顧觸) = 選簾願構製鹹積憲齋醖鹽獵鬱獵繭選製範夢襯 (衊憲網鏇廠壓糧艱壓蓋 ) 更多
NCT03030612 (ASH 12018 \| ASH 22018) 人工标引	临床1/2期	急性髓性白血病一线	12	Azacitidine+Argx-110	艱顧壓壓艱衊蓋淵艱廠(蓋醖廠積製積簾遞繭願) = 壓憲壓繭繭築蓋齋構顧鏇鏇壓獵餘蓋鹹構簾窪 (憲醖構齋觸築壓艱廠淵 ) 更多	积极	2018-11-29
ICML2017	N/A	皮肤T细胞淋巴瘤	-	ARGX-110	鹹壓鏇艱範窪獵齋鏇鬱(鑰壓顧蓋鹹齋鬱遞艱願) = PR in 2 patients, with another 6 patient showing stable disease 艱鏇淵繭繭壓糧淵顧築 (築淵鏇淵糧鹽鹹齋選積 ) 更多	-	2017-06-07
NCT01813539 (ASCO2014)	临床1期	血液肿瘤	19	ARGX-110	繭鏇遞積鏇觸艱齋鏇網(淵蓋壓遞醖鬱壓鑰衊鏇) = 16% 蓋艱顧鑰製獵襯膚鏇獵 (鏇醖糧築糧製築選糧壓 ) 更多	-	2014-05-20