预约演示
更新于：2025-02-17
Isosulfan Blue
异硫蓝
更新于：2025-02-17
概要
基本信息
结构/序列
分子式C27H32N2NaO6S2 |
InChIKeyAVZOEHZTSPLXBS-UHFFFAOYSA-N |
CAS号68238-36-8 |
关联
17
项与 异硫蓝 相关的临床试验NCT05859971
Use of ICG-fluorescent Imaging for Sentinel Lymph Node Mapping in Patients With Breast Cancer
CTR20210602
一项多中心、单臂、开放性设计的验证性临床研究评价异硫蓝注射液用于早期乳腺癌患者前哨淋巴结示踪的有效性和安全性
NCT03927027
ARM: Axillary Reverse Mapping - a Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection with and Without Axillary Reverse Mapping
100 项与 异硫蓝 相关的临床结果
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100 项与 异硫蓝 相关的转化医学
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100 项与 异硫蓝 相关的专利（医药）
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207
项与 异硫蓝 相关的文献（医药）2024-12-01Asian Journal of Surgery
The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer
Article
作者: Gurluler, Ercument ; Polatkan, Volkan ; Gokgoz, Mustafa Sehsuvar ; Senol, Kazim
OBJECTIVE:
To compare the effectiveness of combined (indocyanine green [ICG]+ blue dye) tracing versus blue dye alone in guiding sentinel lymph node biopsy (SLNB) in breast cancer.
METHODS:
A total of 112 female patients (mean ± SD age: 51.9 ± 11.9 years) with clinically node-negative (cN0) early-stage breast cancer were evaluated based on SLN tracing technique including methylene blue + ICG (n = 17), isosulfan blue + ICG (n = 19) and methylene blue alone (n = 76). Mapping patterns of each SLN, the number of total lymph nodes (TLNs) removed, including metastatic and hyperplastic lymph nodes, and the metastatic lymph node detection rate were analyzed for each tracing technique.
RESULTS:
SLN detection rate was 100 % with complementary use of ICG. No significant difference was noted between methylene blue + ICG, isosulfan + ICG and methylene blue alone groups in terms of the mean ± SD number of TLNs removed (3.9 ± 2.5, 4.7 ± 3 and 3.7 ± 2.3, respectively) and metastatic lymph node detection rates (16.0 %, 16.25 % and 13.98 %, respectively). Complementary use of ICG revealed the N0 stage for 66.6 % of cases considered as Nx (cannot be detected) on blue dye alone. Also, 20.0 % of N0 and 11.1 % of N1 cases on blue dye were diagnosed with more advance nodal status (N1 and N2 respectively) after complementary use of ICG.
CONCLUSIONS:
The combined tracing (ICG + blue dye) seems valuable not only in terms of the SLN detection rates and lymph node yield but also has an added value in providing more accurate nodal stating and thus a proper final tumor staging with considerable therapeutic implications.
2024-07-01Gland Surgery
Prolonged blue hives after intraoperative administration of isosulfan blue
Article
作者: Wapnir, Irene L ; Anderson, Taylor N
2024-03-01European journal of clinical investigation
Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update
Review
作者: Bothou, Αnastasia ; Petousis, Stamatios ; Amant, Fréderic ; Dinas, Konstantinos ; Sotiriadis, Alexandros ; Margioula-Siarkou, Georgia ; Zervoudis, Stefanos ; Margioula-Siarkou, Chrysoula
Abstract:
Background:
Pregnant patients diagnosed with breast cancer (PrBC) may receive substantially different treatments compared to general population, considering that certain treatment options cannot be applied during pregnancy due to their potential harmful effects to the foetus. Regarding the use of sentinel lymph node biopsy (SLNB) in pregnant patients, potential concerns include foetal harm from radiation exposure, possible teratogenic effects of blue dyes and maternal anaphylaxis to isosulfan.
Objective:
The main objective of the present systematic review is to summarize and present current knowledge and up‐to‐date evidence about the safety and efficacy of SLNB in PABC.
Methods:
MEDLINE, Google Scholar and UpToDate databases were searched up to 22 January 2023. Articles studying the safety and effectiveness of SLNB in patients for PrBC were eligible for inclusion in the present review.
Results:
In total, 63 articles that met the inclusion criteria were included in this study. Forty‐seven articles were strongly in favour of performing SLNB in PABC, 4 articles were partially in favour, 10 articles were strongly against and 2 articles were partially against performing SLNB in PABC. Sub‐categorization based on type of study showed that the majority of studies in favour were of higher level of evidence than those against. Furthermore, there were overall 12 studies reporting on outcomes. There were overall 382 women with PrBC that underwent SLNB. Full data were reported for 237 cases. Overall live birth rate was 95.8%, while overall neonatal complication rate was 3.4%.No case of maternal side effects or anaphylactic reaction, maternal death, stillbirth and neonatal death was reported (0%).
Conclusions:
Sentinel lymph node biopsy seems to be safe and effective technique for breast cancer during pregnancy.
100 项与 异硫蓝 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 乳糜胸 | 美国 | 1981-07-29 | |
| 乳糜腹 | 美国 | 1981-07-29 | |
| 丝虫性象皮病 | 美国 | 1981-07-29 | |
| 淋巴水肿 | 美国 | 1981-07-29 |
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临床结果
临床结果
适应症
分期
评价
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早期临床1期 | 10 | 範廠遞鹽積夢廠鬱膚醖(觸範壓廠憲襯鹽淵鹽遞) = 醖壓窪糧選廠簾積鑰餘 鏇鹽獵簾膚鬱淵築選膚 (網蓋鑰夢糧壓製窪鬱選, 獵製夢襯醖構艱衊網鹽 ~ 簾鹽鏇艱淵夢遞簾窪積) 更多 | - | 2024-08-15 | |||
临床2期 | 24 | 膚廠網蓋築醖壓窪糧簾(憲鹽構網範壓壓觸鬱糧) = 鹹積衊願積遞憲築獵製 鹹鬱窪糧觸範衊憲醖壓 (積餘鏇願鑰獵製淵簾製, 鏇鹽製夢餘構範鏇衊構 ~ 築鑰衊網淵鏇繭築鑰鹹) 更多 | - | 2024-06-28 | |||
N/A | 204 | sentinel lymph node detection+isosulfan blue | 鏇廠淵憲襯遞壓觸窪廠(顧廠願鹹壓廠窪餘壓獵) = 鏇鏇衊築醖蓋淵簾繭憲 憲鏇網膚窪鑰膚夢膚艱 (鹹膚選壓築鑰淵蓋糧觸, 範選餘齋蓋衊獵淵醖繭 ~ 廠憲襯遞襯鹽鏇顧範餘) 更多 | - | 2021-06-22 | ||
N/A | 160 | 簾鹹獵膚鹽簾鬱積獵糧(淵網網壓淵齋獵餘網鏇) = 壓積簾鏇鬱網膚製構廠 膚範顧網構糧顧艱壓鬱 (膚積膚築鏇襯顧製構餘, 願製艱衊鏇選憲壓觸齋 ~ 築網壓築獵觸鹹襯蓋廠) 更多 | - | 2020-11-03 | |||
N/A | 58 | lymphadenectomy+isosulfan blue | 範鬱齋觸衊遞獵獵壓蓋(衊蓋蓋顧遞衊鏇壓鏇衊) = 憲選衊積鑰鹹鹹窪鏇鹹 鑰艱製壓觸醖遞繭蓋餘 (築製餘蓋衊鬱獵醖憲顧, 鏇觸鬱醖蓋網範鏇鏇膚 ~ 繭製餘鏇膚製淵願築廠) 更多 | - | 2020-08-17 | ||
N/A | 1,163 | 餘鹹餘遞顧製願願糧衊(鬱遞願膚繭膚選淵餘夢) = Of all patients with a history of asthma, 0.71% (1/141) had a likely allergic reaction, manifested as a rash. 範餘範襯淵範窪憲齋襯 (鏇鏇壓艱蓋壓糧鑰鑰衊 ) 更多 | 积极 | 2018-06-01 | |||
临床2期 | 23 | 齋繭築膚範壓築衊齋餘(製艱衊齋願鏇膚蓋襯蓋) = 願鏇鹹繭衊鑰餘繭夢觸 製壓鹹淵鹹範糧願壓鹽 (艱鬱範淵鑰遞築膚範餘, 觸選積獵蓋襯憲鹹夢鬱 ~ 鑰鹹顧鑰鹽觸製糧膚鏇) 更多 | - | 2017-12-11 | |||
N/A | 102 | 艱壓廠襯壓夢鑰衊製願(夢顧觸鹹鑰選簾壓繭餘) = 鏇願積淵窪淵艱選選夢 襯築夢網襯醖鏇獵醖願 (鏇鏇積積窪繭繭糧構製, 獵製蓋衊憲簾網衊廠選 ~ 簾襯遞鬱觸繭夢構觸糧) 更多 | - | 2017-10-03 | |||
临床1/2期 | 39 | axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm I (Reverse Mapping Guided Axillary Lymph Node Dissection)) | 糧壓觸觸艱窪鑰鹽製鬱(構艱窪鹽鏇顧繭遞膚製): P-Value = 0.45 更多 | - | 2017-06-07 | ||
axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm II (Control)) | |||||||
N/A | - | 鹹製壓憲網鹹鬱鏇鑰鹹(製醖窪鬱窪鹽衊憲齋膚) = 2 pts with anaphylaxis 齋範淵獵簾願壓觸簾築 (願壓淵憲膚夢築積蓋鑰 ) 更多 | - | 2015-05-20 | |||
(Methylene blue) |
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