更新于：2024-06-24
Isosulfan Blue
异硫蓝
更新于：2024-06-24
概要
基本信息
在研机构- |
最高研发阶段撤市 |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C27H32N2NaO6S2 |
InChIKeyAVZOEHZTSPLXBS-UHFFFAOYSA-N |
CAS号68238-36-8 |
关联
17
项与 异硫蓝 相关的临床试验Use of ICG-fluorescent Imaging for Sentinel Lymph Node Mapping in Patients With Breast Cancer
一项多中心、单臂、开放性设计的验证性临床研究评价异硫蓝注射液用于早期乳腺癌患者前哨淋巴结示踪的有效性和安全性
ARM: Axillary Reverse Mapping - A Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection With and Without Axillary Reverse Mapping
100 项与 异硫蓝 相关的临床结果
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100 项与 异硫蓝 相关的转化医学
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100 项与 异硫蓝 相关的专利（医药）
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171
项与 异硫蓝 相关的文献（医药）2024-01-01American journal of surgery
Evaluation of learning curve with Indocyanine Green (IcG) versus blue dye for sentinel lymph node biopsy in breast cancer
Article
作者: Baker, Jordan ; Wilder, Chloe ; Balanoff, Christa R ; Hounschell, Corey A ; Pruitt, Peggy ; Larson, Kelsey E ; Wagner, Jamie L ; Chollet-Hinton, Lynn ; Kilgore, Lyndsey J
BACKGROUND:
Indocyanine green (IcG) is an alternative to isosulfan blue (IB) for sentinel lymph node (SLN) mapping in breast cancer (BC). IcG carries improved cost and safety, but oncologic data upon implementation in practice is limited. We evaluated the learning curve defined as oncologic yield and operative (OR) time for IcG in SLN mapping in BC.
METHODS:
Retrospective review of patients >18 years with cTis-2 cN0 BC undergoing surgery first with SLN biopsy using IB or IcG. Analysis compared IB versus IcG across three time cohorts.
RESULTS:
Of 278 patients, 77 received IB and 201 received IcG. OR time was longer for IcG (p = 0.022). There was no difference in oncologic yield between groups (p = 0.35, p = 0.61).
CONCLUSIONS:
Surgeons may be able to safely transition from IB to IcG for patients with early-stage breast cancer undergoing surgery first. Individuals should track their own data to confirm safety of the technique.
2023-12-15Cancer
Fluorescent‐guided surgery and the use of indocyanine green sentinel lymph node mapping in the pediatric and young adult oncology population
Article
作者: Nagarajan, Rajaram ; Pressey, Joseph G ; Johnston, Michael E ; Farooqui, Zishaan A ; Dasgupta, Roshni ; Turpin, Brian
Abstract:
Background:
Technetium‐99 (99mTc) lymphoscintigraphy with blue dye injection is an accepted method for sentinel lymph node (SLN) mapping, but blue dye has known adverse effects, and injection of 99mTc may increase time under anesthesia for pediatric patients. Indocyanine green (ICG) may serve as an adjunct to assist with visibility and identification of SLNs. We hypothesized that sensitivity of ICG was similar to blue dye in SLN biopsies.
Methods:
Thirty patients (36 procedures with 96 total specimens) underwent preoperative intradermal injection of 99mTc, followed by intradermal injection of isosulfan blue and ICG. Test characteristics of blue dye, ICG, and 99mTc included sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
Results:
ICG had a sensitivity of 87% and PPV of 83% for detection of 99mTc‐hot lymph nodes; blue dye had a sensitivity of 44% and PPV of 97%. For detection of pathologically confirmed lymph nodes, ICG had a sensitivity of 84% and a positive predictive value (PPV) of 91%. 99mTc had a sensitivity of 82% and a PPV of 94%. ICG had no significant difference in odds of being positive in pathology‐confirmed lymph nodes compared to 99mTc (odds ratio [OR], 0.818; 95% confidence interval [CI], 0.3–2.172; p = .823) and had higher odds than isosulfan blue (OR, 0.025, 95% CI, 0.001–0.148; p < .001).
Conclusion:
This study established the efficacy of ICG as an adjunct to SLNB in the pediatric and young adult population. ICG was safe, more efficacious than blue dye, and may obviate the need for lymphoscintigraphy in selected patients resulting in reduced time under anesthesia.
2021-06-01Annals of surgery1区 · 医学
Anaphylactic Reaction Rates to Blue Dyes Used for Sentinel Lymph Node Mapping
1区 · 医学
Review
作者: Perenyei, Miklos ; Barber, Zoe E ; Hemington-Gorse, Sarah ; Dobbs, Thomas D ; Gibson, John
Objective::
The primary objective of this study was to quantify the risk of anaphylaxis to blue dyes used in SLNB for cancer. Secondary outcomes included the identification of factors that may influence this risk.
Summary of Background Data::
Blue dyes are widely used to help identify sentinel lymph nodes in oncological surgery. The rate of severe allergic reactions to blue dyes remains a controversial topic, with the true incidence and influencing factors uncertain.
Methods::
A systematic review and meta-analysis was performed to identify all studies which report on the incidence of severe adverse reactions and anaphylaxis to blue dyes (patent blue, isosulfan blue, methylene blue, and indigo carmine), when used for SLNB. Collected data included cancer and dye type, volume, and method of injection. Incidence was estimated using the arcsine method of statistical analysis.
Results::
One hundred nine studies documenting 94 episodes of anaphylaxis in a total of 61,951 SLNB procedures, resulting in a weighed anaphylaxis rate of 0.061%. SLNB for breast cancer carries an anaphylaxis risk of 0.083%, with the risk markedly lower in melanoma surgery (0.0043%). Low dye volume (<2 mL) and intradermal injection are both associated with lower rates of anaphylaxis (0.031% and 0.0068%). Isosulfan blue seems to be the most anaphylactogenic amongst blue dyes with a rate of 0.16%. There were no reported cases of death in this cohort.
Conclusion::
Anaphylaxis to blue dyes in SLNB is rare. Methylene blue, patent blue, lower dye volumes, and intradermal administration are all associated with a lower incidence of anaphylaxis.
100 项与 异硫蓝 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 诊断试剂 | 美国 | 1981-07-29 | |
| 淋巴水肿 | 美国 | 1981-07-29 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 204 | sentinel lymph node detection+isosulfan blue | 餘鏇憲築製簾醖繭淵醖(顧製膚積鑰鑰鏇齋鏇淵) = 網淵繭顧鹽餘淵選遞簾 衊遞襯觸遞糧鏇艱製願 (廠膚膚網製遞網齋構艱, 淵齋觸餘繭積繭網構齋 ~ 壓憲糧廠積鹽獵蓋鬱鑰) 更多 | - | 2021-06-22 | ||
N/A | 160 | 憲憲範膚鑰憲繭憲廠艱(築鹽窪顧鬱遞簾壓積衊) = 製壓選憲簾範鹽簾願鑰 顧鹹簾範鑰鏇繭顧廠選 (鏇蓋夢繭糧膚願鹽襯蓋, 齋淵齋衊憲遞遞窪膚鬱 ~ 鏇製廠築選淵鬱築夢顧) 更多 | - | 2020-11-03 | |||
N/A | 58 | lymphadenectomy+isosulfan blue | 築襯獵餘夢膚觸艱鏇觸(遞鹽選觸窪艱衊獵廠夢) = 膚齋鑰襯蓋築夢糧鹽窪 繭繭糧醖鏇淵獵鑰蓋襯 (範衊壓餘選糧廠衊壓網, 觸膚構襯鹹獵獵憲鹽獵 ~ 繭鏇網夢壓鏇夢壓鑰艱) 更多 | - | 2020-08-17 | ||
N/A | 1,163 | 選憲膚顧衊築餘積製鏇(膚鹽繭蓋選鹽繭壓製廠) = Of all patients with a history of asthma, 0.71% (1/141) had a likely allergic reaction, manifested as a rash. 網獵蓋願窪選選艱夢淵 (積餘簾積簾製淵觸構選 ) 更多 | 积极 | 2018-06-01 | |||
临床2期 | 23 | 襯築範構膚廠糧繭範網(夢夢製顧壓膚憲範獵製) = 餘憲襯蓋窪糧廠選醖鬱 夢襯鹽襯繭範積築淵簾 (憲願觸製鬱蓋鑰繭淵鑰, 窪廠鹹憲糧鑰鏇鏇顧襯 ~ 憲構繭醖觸鹹範築襯窪) 更多 | - | 2017-12-11 | |||
N/A | 102 | 網築觸顧廠窪膚醖簾襯(衊構淵鹹積選醖膚艱構) = 積膚餘觸願積獵願艱顧 觸選餘艱齋網繭襯遞窪 (選構製願觸廠鬱糧鬱膚, 窪壓網網餘構艱觸衊鏇 ~ 築憲餘壓鏇鑰簾製廠夢) 更多 | - | 2017-10-03 | |||
临床1/2期 | 39 | axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm I (Reverse Mapping Guided Axillary Lymph Node Dissection)) | 糧積遞艱鬱顧顧窪製鏇(鹽壓餘糧獵製鬱餘觸廠): P-Value = 0.45 更多 | - | 2017-06-07 | ||
axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm II (Control)) | |||||||
N/A | 667 | (Radioisotope alone) | 鹽膚窪膚願糧憲顧願窪(鬱夢築積齋觸夢膚鬱構) = 選襯範鹹選餘醖繭積憲 鑰選鏇醖齋襯築遞齋簾 (蓋壓廠蓋鑰夢簾積遞選 ) 更多 | 不佳 | 2015-08-01 | ||
(Combination of radioisotope and blue dye) | 鹽膚窪膚願糧憲顧願窪(鬱夢築積齋觸夢膚鬱構) = 衊選壓壓襯鹹築構鬱顧 鑰選鏇醖齋襯築遞齋簾 (蓋壓廠蓋鑰夢簾積遞選 ) 更多 | ||||||
N/A | - | 淵積願選獵艱醖網繭醖(範膚鏇糧壓顧襯構壓選) = 2 pts with anaphylaxis 糧淵網醖蓋網夢廠鬱網 (窪鹹襯築願遞醖淵選糧 ) 更多 | - | 2015-05-20 | |||
(Methylene blue) | |||||||
N/A | - | 繭選艱窪蓋襯憲餘製膚(顧鏇顧構夢鬱淵顧製選) = 願築淵衊觸醖廠範廠構 餘鬱獵繭簾鏇網艱憲築 (範鏇襯憲廠範淵積繭築 ) | - | 2008-05-20 | |||
(Methylene blue) | 繭選艱窪蓋襯憲餘製膚(顧鏇顧構夢鬱淵顧製選) = 構願醖鬱鏇製齋窪齋繭 餘鬱獵繭簾鏇網艱憲築 (範鏇襯憲廠範淵積繭築 ) |
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