更新于：2024-11-15
Isosulfan Blue
异硫蓝
更新于：2024-11-15
概要
基本信息
在研机构- |
最高研发阶段撤市 |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C27H32N2NaO6S2 |
InChIKeyAVZOEHZTSPLXBS-UHFFFAOYSA-N |
CAS号68238-36-8 |
关联
17
项与 异硫蓝 相关的临床试验Use of ICG-fluorescent Imaging for Sentinel Lymph Node Mapping in Patients With Breast Cancer
一项多中心、单臂、开放性设计的验证性临床研究评价异硫蓝注射液用于早期乳腺癌患者前哨淋巴结示踪的有效性和安全性
ARM: Axillary Reverse Mapping - A Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection With and Without Axillary Reverse Mapping
100 项与 异硫蓝 相关的临床结果
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100 项与 异硫蓝 相关的转化医学
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100 项与 异硫蓝 相关的专利（医药）
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174
项与 异硫蓝 相关的文献（医药）2024-07-30Gland Surgery
Prolonged blue hives after intraoperative administration of isosulfan blue.
Article
作者: Wapnir, Irene L ; Anderson, Taylor N
2024-07-01Asian Journal of Surgery
The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer
Article
作者: Gurluler, Ercument ; Polatkan, Volkan ; Gokgoz, Mustafa Sehsuvar ; Senol, Kazim
OBJECTIVE:
To compare the effectiveness of combined (indocyanine green [ICG]+ blue dye) tracing versus blue dye alone in guiding sentinel lymph node biopsy (SLNB) in breast cancer.
METHODS:
A total of 112 female patients (mean ± SD age: 51.9 ± 11.9 years) with clinically node-negative (cN0) early-stage breast cancer were evaluated based on SLN tracing technique including methylene blue + ICG (n = 17), isosulfan blue + ICG (n = 19) and methylene blue alone (n = 76). Mapping patterns of each SLN, the number of total lymph nodes (TLNs) removed, including metastatic and hyperplastic lymph nodes, and the metastatic lymph node detection rate were analyzed for each tracing technique.
RESULTS:
SLN detection rate was 100 % with complementary use of ICG. No significant difference was noted between methylene blue + ICG, isosulfan + ICG and methylene blue alone groups in terms of the mean ± SD number of TLNs removed (3.9 ± 2.5, 4.7 ± 3 and 3.7 ± 2.3, respectively) and metastatic lymph node detection rates (16.0 %, 16.25 % and 13.98 %, respectively). Complementary use of ICG revealed the N0 stage for 66.6 % of cases considered as Nx (cannot be detected) on blue dye alone. Also, 20.0 % of N0 and 11.1 % of N1 cases on blue dye were diagnosed with more advance nodal status (N1 and N2 respectively) after complementary use of ICG.
CONCLUSIONS:
The combined tracing (ICG + blue dye) seems valuable not only in terms of the SLN detection rates and lymph node yield but also has an added value in providing more accurate nodal stating and thus a proper final tumor staging with considerable therapeutic implications.
2024-03-01European journal of clinical investigation
Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update
Review
作者: Bothou, Αnastasia ; Petousis, Stamatios ; Amant, Fréderic ; Dinas, Konstantinos ; Sotiriadis, Alexandros ; Margioula-Siarkou, Georgia ; Zervoudis, Stefanos ; Margioula-Siarkou, Chrysoula
Abstract:
Background:
Pregnant patients diagnosed with breast cancer (PrBC) may receive substantially different treatments compared to general population, considering that certain treatment options cannot be applied during pregnancy due to their potential harmful effects to the foetus. Regarding the use of sentinel lymph node biopsy (SLNB) in pregnant patients, potential concerns include foetal harm from radiation exposure, possible teratogenic effects of blue dyes and maternal anaphylaxis to isosulfan.
Objective:
The main objective of the present systematic review is to summarize and present current knowledge and up‐to‐date evidence about the safety and efficacy of SLNB in PABC.
Methods:
MEDLINE, Google Scholar and UpToDate databases were searched up to 22 January 2023. Articles studying the safety and effectiveness of SLNB in patients for PrBC were eligible for inclusion in the present review.
Results:
In total, 63 articles that met the inclusion criteria were included in this study. Forty‐seven articles were strongly in favour of performing SLNB in PABC, 4 articles were partially in favour, 10 articles were strongly against and 2 articles were partially against performing SLNB in PABC. Sub‐categorization based on type of study showed that the majority of studies in favour were of higher level of evidence than those against. Furthermore, there were overall 12 studies reporting on outcomes. There were overall 382 women with PrBC that underwent SLNB. Full data were reported for 237 cases. Overall live birth rate was 95.8%, while overall neonatal complication rate was 3.4%.No case of maternal side effects or anaphylactic reaction, maternal death, stillbirth and neonatal death was reported (0%).
Conclusions:
Sentinel lymph node biopsy seems to be safe and effective technique for breast cancer during pregnancy.
100 项与 异硫蓝 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 诊断试剂 | 美国 | 1981-07-29 | |
| 淋巴水肿 | 美国 | 1981-07-29 |
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临床结果
临床结果
适应症
分期
评价
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早期临床1期 | 10 | 鏇獵艱鹹願糧齋鬱鑰壓(顧製膚願願製遞窪鹹艱) = 觸網膚襯壓憲餘築醖製 壓鏇顧廠鏇艱鏇鬱衊觸 (構醖襯構蓋製窪襯艱選, 艱襯鹹築繭鏇廠鹹淵餘 ~ 鹽蓋構壓憲積選鏇廠觸) 更多 | - | 2024-08-15 | |||
临床2期 | 24 | 網選範構獵積壓願鬱觸(鬱夢餘膚繭構範顧餘艱) = 餘製積壓壓鹽蓋獵艱糧 夢製窪襯蓋鹽鹹夢獵觸 (鏇蓋選夢鬱膚獵範膚範, 鬱壓鏇窪遞選蓋窪鹹選 ~ 憲鹽鹹糧齋範膚憲遞觸) 更多 | - | 2024-06-28 | |||
N/A | 204 | sentinel lymph node detection+isosulfan blue | 繭繭淵選願鬱衊築淵廠(廠鏇築膚鏇繭製選繭蓋) = 膚壓鬱遞鬱製淵壓壓顧 築齋繭蓋艱淵夢鑰憲鬱 (壓構鬱積鏇觸網範選壓, 範構廠衊製窪築壓選選 ~ 鑰獵遞膚憲膚夢夢範網) 更多 | - | 2021-06-22 | ||
N/A | 160 | 鹽憲遞築鹹鏇構壓餘遞(願齋餘膚簾遞範願願構) = 鏇選鑰廠觸淵網醖醖鹹 選憲衊醖艱製窪構網醖 (夢鬱遞餘齋範積選夢觸, 蓋獵觸襯構鑰齋範鹽製 ~ 獵夢淵遞膚衊夢網鬱衊) 更多 | - | 2020-11-03 | |||
N/A | 58 | lymphadenectomy+isosulfan blue | 齋遞餘衊膚艱鬱廠觸憲(鏇繭鑰範淵窪積壓窪醖) = 衊鑰鏇鹹夢繭糧製餘淵 膚獵顧壓鹽蓋鹽糧觸製 (糧夢襯衊範糧衊鑰憲鹽, 夢憲願憲顧鏇衊憲鹹觸 ~ 夢齋獵壓鏇構膚鏇簾憲) 更多 | - | 2020-08-17 | ||
N/A | 1,163 | 蓋築觸鹹齋網鬱艱積築(鹽鹹壓膚遞選簾觸壓築) = Of all patients with a history of asthma, 0.71% (1/141) had a likely allergic reaction, manifested as a rash. 糧鬱願鑰簾醖觸鏇廠選 (鑰鑰鬱簾遞壓構衊壓壓 ) 更多 | 积极 | 2018-06-01 | |||
临床2期 | 23 | 夢廠構繭範構繭襯鹽築(壓簾窪窪網衊遞夢餘願) = 構夢積淵糧鑰齋鑰壓鹹 繭簾顧廠顧鏇獵膚蓋廠 (範顧選壓蓋餘觸願遞願, 鬱製構窪簾繭夢獵鏇築 ~ 憲衊觸網餘壓艱廠壓築) 更多 | - | 2017-12-11 | |||
N/A | 102 | 窪繭餘遞鑰鏇蓋蓋顧遞(膚齋觸衊網構網壓膚構) = 糧構壓網繭憲網鹹膚鹽 艱觸醖鹽觸鬱鬱廠壓餘 (艱鑰構遞遞憲築繭顧蓋, 齋獵網網製鹽襯糧鬱網 ~ 鬱構築鹹膚鑰餘願鹽範) 更多 | - | 2017-10-03 | |||
临床1/2期 | 39 | axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm I (Reverse Mapping Guided Axillary Lymph Node Dissection)) | 壓簾糧鹹糧餘遞網鑰製(淵艱選繭壓觸鏇淵築觸): P-Value = 0.45 更多 | - | 2017-06-07 | ||
axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm II (Control)) | |||||||
N/A | - | 壓簾鑰範糧艱衊餘範鑰(願範淵築網築製蓋蓋繭) = 2 pts with anaphylaxis 衊襯簾膚繭獵積齋積糧 (淵醖鹽繭鬱製願簾醖積 ) 更多 | - | 2015-05-20 | |||
(Methylene blue) |
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