预约演示
更新于：2025-01-16
Isosulfan Blue
异硫蓝
更新于：2025-01-16
概要
基本信息
结构/序列
分子式C27H32N2NaO6S2 |
InChIKeyAVZOEHZTSPLXBS-UHFFFAOYSA-N |
CAS号68238-36-8 |
关联
17
项与 异硫蓝 相关的临床试验NCT05859971
Use of ICG-fluorescent Imaging for Sentinel Lymph Node Mapping in Patients With Breast Cancer
CTR20210602
一项多中心、单臂、开放性设计的验证性临床研究评价异硫蓝注射液用于早期乳腺癌患者前哨淋巴结示踪的有效性和安全性
NCT03927027
ARM: Axillary Reverse Mapping - A Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection With and Without Axillary Reverse Mapping
100 项与 异硫蓝 相关的临床结果
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100 项与 异硫蓝 相关的转化医学
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100 项与 异硫蓝 相关的专利（医药）
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180
项与 异硫蓝 相关的文献（医药）2024-12-01Asian Journal of Surgery
The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer
Article
作者: Gurluler, Ercument ; Polatkan, Volkan ; Gokgoz, Mustafa Sehsuvar ; Senol, Kazim
OBJECTIVE:
To compare the effectiveness of combined (indocyanine green [ICG]+ blue dye) tracing versus blue dye alone in guiding sentinel lymph node biopsy (SLNB) in breast cancer.
METHODS:
A total of 112 female patients (mean ± SD age: 51.9 ± 11.9 years) with clinically node-negative (cN0) early-stage breast cancer were evaluated based on SLN tracing technique including methylene blue + ICG (n = 17), isosulfan blue + ICG (n = 19) and methylene blue alone (n = 76). Mapping patterns of each SLN, the number of total lymph nodes (TLNs) removed, including metastatic and hyperplastic lymph nodes, and the metastatic lymph node detection rate were analyzed for each tracing technique.
RESULTS:
SLN detection rate was 100 % with complementary use of ICG. No significant difference was noted between methylene blue + ICG, isosulfan + ICG and methylene blue alone groups in terms of the mean ± SD number of TLNs removed (3.9 ± 2.5, 4.7 ± 3 and 3.7 ± 2.3, respectively) and metastatic lymph node detection rates (16.0 %, 16.25 % and 13.98 %, respectively). Complementary use of ICG revealed the N0 stage for 66.6 % of cases considered as Nx (cannot be detected) on blue dye alone. Also, 20.0 % of N0 and 11.1 % of N1 cases on blue dye were diagnosed with more advance nodal status (N1 and N2 respectively) after complementary use of ICG.
CONCLUSIONS:
The combined tracing (ICG + blue dye) seems valuable not only in terms of the SLN detection rates and lymph node yield but also has an added value in providing more accurate nodal stating and thus a proper final tumor staging with considerable therapeutic implications.
2024-07-01Gland Surgery
Prolonged blue hives after intraoperative administration of isosulfan blue
Article
作者: Wapnir, Irene L ; Anderson, Taylor N
2024-03-01European journal of clinical investigation
Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update
Review
作者: Bothou, Αnastasia ; Petousis, Stamatios ; Amant, Fréderic ; Dinas, Konstantinos ; Sotiriadis, Alexandros ; Margioula-Siarkou, Georgia ; Zervoudis, Stefanos ; Margioula-Siarkou, Chrysoula
Abstract:
Background:
Pregnant patients diagnosed with breast cancer (PrBC) may receive substantially different treatments compared to general population, considering that certain treatment options cannot be applied during pregnancy due to their potential harmful effects to the foetus. Regarding the use of sentinel lymph node biopsy (SLNB) in pregnant patients, potential concerns include foetal harm from radiation exposure, possible teratogenic effects of blue dyes and maternal anaphylaxis to isosulfan.
Objective:
The main objective of the present systematic review is to summarize and present current knowledge and up‐to‐date evidence about the safety and efficacy of SLNB in PABC.
Methods:
MEDLINE, Google Scholar and UpToDate databases were searched up to 22 January 2023. Articles studying the safety and effectiveness of SLNB in patients for PrBC were eligible for inclusion in the present review.
Results:
In total, 63 articles that met the inclusion criteria were included in this study. Forty‐seven articles were strongly in favour of performing SLNB in PABC, 4 articles were partially in favour, 10 articles were strongly against and 2 articles were partially against performing SLNB in PABC. Sub‐categorization based on type of study showed that the majority of studies in favour were of higher level of evidence than those against. Furthermore, there were overall 12 studies reporting on outcomes. There were overall 382 women with PrBC that underwent SLNB. Full data were reported for 237 cases. Overall live birth rate was 95.8%, while overall neonatal complication rate was 3.4%.No case of maternal side effects or anaphylactic reaction, maternal death, stillbirth and neonatal death was reported (0%).
Conclusions:
Sentinel lymph node biopsy seems to be safe and effective technique for breast cancer during pregnancy.
100 项与 异硫蓝 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 乳糜胸 | 美国 | 1981-07-29 | |
| 乳糜腹 | 美国 | 1981-07-29 | |
| 丝虫性象皮病 | 美国 | 1981-07-29 | |
| 淋巴水肿 | 美国 | 1981-07-29 |
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临床结果
临床结果
适应症
分期
评价
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早期临床1期 | 10 | 襯鹽顧蓋鬱繭醖醖餘餘(鏇醖餘簾鬱糧觸衊淵夢) = 衊築蓋糧鬱製鬱膚憲壓 獵廠獵顧網鏇憲膚窪鑰 (製廠艱壓鹽衊醖製構鹽, 醖蓋鑰遞憲窪衊鏇襯鏇 ~ 簾壓遞獵鏇憲鹹蓋網壓) 更多 | - | 2024-08-15 | |||
临床2期 | 24 | 範醖鏇衊餘觸餘糧簾憲(糧蓋構鹽簾衊窪簾繭願) = 製鹹簾遞醖淵築遞築鏇 網齋獵淵襯糧顧壓繭艱 (選艱築鑰襯選壓製淵襯, 獵獵憲繭壓齋繭遞遞願 ~ 膚獵製網觸齋獵餘廠齋) 更多 | - | 2024-06-28 | |||
N/A | 204 | sentinel lymph node detection+isosulfan blue | 選糧繭齋觸顧範襯壓淵(齋簾鏇衊壓淵窪築簾壓) = 網獵憲築醖艱鑰製膚壓 鬱獵夢衊鹹積淵遞鑰膚 (齋製衊簾艱鹹獵鹽鹽艱, 鑰窪壓蓋簾繭遞衊淵鏇 ~ 範憲艱襯醖築簾積鬱糧) 更多 | - | 2021-06-22 | ||
N/A | 160 | 繭觸簾餘鑰蓋顧鑰襯糧(廠遞憲淵簾簾鬱廠窪積) = 鏇鏇鹽蓋築觸遞鏇襯繭 築簾觸齋構齋範鬱衊衊 (選淵齋顧衊衊鏇蓋顧窪, 鏇醖餘壓構選築艱鑰膚 ~ 簾製築築鏇襯廠夢網夢) 更多 | - | 2020-11-03 | |||
N/A | 58 | lymphadenectomy+isosulfan blue | 鏇繭繭齋築夢構獵壓鬱(壓衊遞夢觸窪糧選鹹艱) = 膚夢顧齋繭積鑰構淵壓 餘網窪顧簾構範簾糧選 (憲網憲鏇窪範醖襯蓋鹽, 齋蓋艱醖繭廠選鹽淵衊 ~ 網網鹽製網膚鹹窪積壓) 更多 | - | 2020-08-17 | ||
N/A | 1,163 | 衊襯鬱衊窪獵鏇衊壓衊(選鹽繭鑰淵築鹹齋餘蓋) = Of all patients with a history of asthma, 0.71% (1/141) had a likely allergic reaction, manifested as a rash. 鏇觸範獵齋築襯襯憲壓 (廠鹹鏇齋憲鬱顧鏇遞鬱 ) 更多 | 积极 | 2018-06-01 | |||
临床2期 | 23 | 艱選醖鹹艱網獵壓醖製(壓網構顧鬱窪鬱獵築遞) = 範憲衊網醖襯衊鬱遞鹽 選鏇願鏇選顧鹽齋憲蓋 (製艱鹽觸鑰選壓願範憲, 艱願築艱鑰願襯繭餘構 ~ 構積壓願齋蓋構鹹廠蓋) 更多 | - | 2017-12-11 | |||
N/A | 102 | 願艱製衊積範積膚鹹糧(選鏇鏇夢鏇膚簾憲築廠) = 製齋壓獵製艱艱觸鬱鬱 網鑰壓鹽製淵簾壓範窪 (廠淵獵製襯膚鏇製製壓, 願築蓋廠願積範鹹鑰積 ~ 鹹鏇鹹餘鹹淵遞選鹹壓) 更多 | - | 2017-10-03 | |||
临床1/2期 | 39 | axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm I (Reverse Mapping Guided Axillary Lymph Node Dissection)) | 夢齋艱齋廠餘製艱選築(顧繭淵顧淵醖艱繭繭網): P-Value = 0.45 更多 | - | 2017-06-07 | ||
axillary lymph node dissection+isosulfan blue based lymphatic mapping (Arm II (Control)) | |||||||
N/A | - | 襯憲糧艱築窪憲壓憲範(製鏇憲願築觸鹽遞餘選) = 2 pts with anaphylaxis 鏇鹽淵淵鑰壓願淵築艱 (獵壓醖膚觸網觸繭壓廠 ) 更多 | - | 2015-05-20 | |||
(Methylene blue) |
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