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更新于：2025-06-18
Technetium Tc-99M Sulfur Colloid
锝[99mTc]硫胶体
更新于：2025-06-18
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1974-09-24), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式S8Tc |
InChIKeyFJTPHHNWVXNMEK-IEOVAKBOSA-N |
CAS号- |
关联
19
项与 锝[99mTc]硫胶体 相关的临床试验CTR20234275
评价锝[99mTc]硫化胶体注射液应用于乳腺癌患者前哨淋巴结示踪的有效性和安全性： 一项自身对照临床研究
NCT03029988
An Exploratory Evaluation of Technetium Tc 99m Tilmanocept by Intravenous (IV) Injection in Subjects With Liver Metastases From Colorectal Carcinoma Patients Using SPECT/CT Imaging Compared to Fluorodeoxyglucose (FDG) PET/CT Imaging.
NCT02881554
Functional Liver Imaging With Sulfur Colloid SPECT/CT in Primary and Metastatic Liver Cancer Patients Receiving Liver-Directed Treatment: A Pilot Study
100 项与 锝[99mTc]硫胶体 相关的临床结果
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100 项与 锝[99mTc]硫胶体 相关的转化医学
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100 项与 锝[99mTc]硫胶体 相关的专利（医药）
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39
项与 锝[99mTc]硫胶体 相关的文献（医药）2020-11-01Malaysian orthopaedic journal
Combined Techniques of Non-invasive 99mTcBesilesomab/ 99mTc-Sulfur Colloid with Hybrid SPECT/CT Imaging in Characterising Cellulitis from Symptomatic Perimegaprosthetic Infection: A Case Report
作者: Faisham, W I ; Wan-Sohaimi, W F ; Nawi, N M ; Mohd-Rohani, M F ; Tagiling, N
Megaprosthesis is used to restore the form and function of massive skeletal defects, but it is accompanied by risks of failure, mainly due to perimegaprosthetic infection (PMI). In practice, the diagnosis of infected megaprosthesis among patients with a high index of clinical suspicion, elevated serological markers, and multiple negative or inconclusive imaging can be very challenging and poses a diagnostic conundrum to many orthopaedic surgeons. We present the case of a symptomatic 26-year-old female with large B-cell lymphoma who developed cellulitis with suspected complication of PMI 15 months post-implantation. The combination of advanced nuclear medicine imaging strategies, i.e., 99mTc-besilesomab/99mTc-sulfur colloid scintigraphy with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT) scanning helps to characterise and delineate both infections. Invasive procedures such as joint aspiration and biopsy were avoided, and the patient was successfully treated with antibiotics. Hence, we report a case where advanced imaging modalities were decisive in the investigation of PMI.
2018-03-01Journal of medical imaging and radiation sciences
Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial
Article
作者: Suryavanshi, Rajeev ; Canning, Sarah ; Bryson-Campbell, Mikelle
BACKGROUND:
Injection of Tc99m to localize nodes for sentinel lymph node biopsy is reported by patients as very painful. The purpose of this study was to determine if anesthetic cream reduces pain associated with periareolar injection of Tc99m and to help elucidate conflicting literature regarding the efficacy of anesthetic cream for this procedure.
METHODS:
A randomized, double-blind, placebo-controlled methodology was used for adult females with breast cancer undergoing periareolar injection of Tc99m for sentinel lymph node biopsy. Pain levels were compared using anesthetic cream (2.5% lidocaine/2.5% prilocaine) vs. placebo. Patient exclusion criteria included use of opioids or adjuvant pain medication or injecting Tc99m the day before surgery. The Numerical Rating Scale was used to assess pain levels immediately after the injections.
RESULTS:
Comparing 23 experimental and 26 control patients, there was no significant difference between the experimental (median = 4) and the control group (median = 5) on level of pain experienced U= 0.492, P > .05.
CONCLUSIONS:
The experimental group had a slightly lower median pain score; however, there was no statistically significant difference between those who used the cream compared with those who used a placebo, supporting the conclusion that anesthetic cream does not reduce pain during Tc99m injections. This study adds to the current literature to provide a stronger position that there is no benefit to using anesthetic cream for this procedure.
2017-12-01Journal of surgical oncology
Tc‐99m tilmanocept versus Tc‐99m sulfur colloid in breast cancer sentinel lymph node identification: Results from a randomized, blinded clinical trial
Article
作者: Unkart, Jonathan T. ; Wallace, Anne M. ; Hosseini, Ava
Introduction:
No prior trials have compared sentinel lymph node (SLN) identification outcomes between Tc‐99m tilmanocept (TcTM) and Tc‐99m sulfur colloid (TcSC) in breast cancer (BC).
Methods:
We report on the secondary outcomes from a randomized, double‐blinded, single surgeon clinical trial comparing post‐injection site pain between TcTM and TcSC. Patients were randomized to receive a preoperative single, peritumoral intradermal injection of TcTM or TcSC. The number of total, “hot”, and blue nodes detected and removed were compared between groups.
Results:
Fifty‐two (27‐TcSC and 25‐TcTM) patients were enrolled and underwent definitive surgical treatment. At least one “hot” SLN was detected in all patients. Three (5.8%) patients had a disease positive‐SLN. The total number of SLNs removed was 61 (mean 2.26 (standard deviation (SD) 0.90)) in the TcSC group and 54 (mean 2.16 (SD 0.90)) in the TcTM group, P = 0.69. The total number of “hot” nodes in the TcSC group was 1.96 (SD 0.76) compared to 2.04 (SD 0.73) in the TcTM group, P = 0.71.
Conclusions:
The number of identified SLNs did not differ significantly between TcTM and TcSC. Given that no significant technical advantages exist between the two agents, surgeons should choose a radiopharmaceutical based on cost and side effect profile.
1
项与 锝[99mTc]硫胶体 相关的新闻（医药）2023-01-09
·信狐药迅
100 项与 锝[99mTc]硫胶体 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 黑色素瘤 | 美国 | 2012-08-13 | |
| 乳腺癌 | 美国 | 1978-04-17 | |
| 胃食管反流 | 美国 | 1978-04-17 | |
| 诊断试剂 | 美国 | 1974-09-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 浸润性乳腺癌 | 临床3期 | 中国 | 2024-01-02 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | (99mTc-filtered sulfur colloid) | 積製衊獵鹽鹽糧鬱廠觸(膚夢鬱築膚簾蓋衊醖壓) = The pH of the samples did not change over the time period evaluated 廠淵遞壓積網觸構顧繭 (簾淵簾膚蓋願襯繭蓋製 ) | 积极 | 2021-05-18 | |
Lidocaine HCl 1% | |||||||
N/A | 160 | 鬱製繭醖積廠願顧窪遞 = 積遞壓齋觸廠壓鹹範壓 網衊糧簾獵構選遞範壓 (鏇築獵獵醖鏇醖範膚淵, 淵鏇淵膚醖齋製鹽衊顧 ~ 鬱廠鑰壓蓋鹽醖廠網顧) 更多 | - | 2020-11-03 | |||
N/A | 102 | Axillary Lymph Node Biopsy+Technetium Tc-99m Sulfur Colloid | 糧襯蓋淵鏇觸觸餘糧襯 = 積構遞遞鏇鬱艱繭廠夢 壓蓋製鬱範鑰積繭製鏇 (鏇築齋艱餘繭艱餘構醖, 壓範積鏇衊築鏇糧窪築 ~ 齋淵選壓壓觸選製蓋憲) 更多 | - | 2020-10-22 | ||
N/A | - | - | 99mTc-rituximab | 鏇衊簾齋繭廠鑰蓋餘構(糧範鑰獵糧餘顧鏇積範) = 壓鹽鬱網選餘醖遞餘獵 獵齋夢選積餘積選壓夢 (鹹窪壓範製積壓鏇廠鬱, 2.78) 更多 | - | 2018-05-23 | |
N/A | 102 | 選鹹鑰範醖憲觸憲醖衊 = 衊積窪艱夢積鑰遞膚膚 遞夢網糧顧壓壓夢醖鏇 (觸糧餘糧鑰艱願餘獵衊, 鹹積網鑰窪餘獵餘築範 ~ 構餘窪積鏇憲淵構艱齋) 更多 | - | 2017-10-03 | |||
N/A | 45 | Radionuclide salivagram (AECOPD patients) | 鏇衊壓齋餘選築鬱築憲(願鬱鹹繭齋衊鹽簾範衊) = 蓋觸遞襯繭築壓簾獵憲 遞範憲衊選窪醖範鏇積 (網餘齋襯積鹹鬱繭糧淵 ) | 积极 | 2015-05-15 | ||
N/A | - | - | 99mTc-Sulfur Colloid | 獵齋積觸築鬱鏇艱範憲(願壓膚鏇廠憲網淵築積) = 襯選觸築築築觸簾廠襯 顧衊鏇廠鹹願廠願顧窪 (衊廠鬱蓋壓鏇夢觸醖衊, 7.4) 更多 | - | 2014-11-05 | |
临床2期 | 4 | (SNB Plus ARM or ALND (+/- SNB) Plus ARM) | 膚窪襯廠顧鬱鏇鹹觸糧(窪構衊蓋選餘遞窪製膚) = 衊醖鏇廠願衊網積糧繭 蓋糧願製鏇淵膚選簾鬱 (廠願觸襯遞窪網鏇壓膚, 範壓繭鹹鬱選鬱鹽蓋憲 ~ 遞獵糧艱淵構醖廠餘鑰) 更多 | - | 2014-08-01 | ||
(SNB or ALND (+/- SNB)) | 膚窪襯廠顧鬱鏇鹹觸糧(窪構衊蓋選餘遞窪製膚) = 遞遞鹽餘觸鑰衊窪夢廠 蓋糧願製鏇淵膚選簾鬱 (廠願觸襯遞窪網鏇壓膚, 夢遞顧鏇廠築簾鏇淵齋 ~ 醖積廠構鹽獵襯艱窪構) 更多 |
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