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更新于：2025-05-16
Technetium Tc-99M Sulfur Colloid
锝[99mTc]硫胶体
更新于：2025-05-16
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1974-09-24), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构/序列
分子式S8Tc |
InChIKeyFJTPHHNWVXNMEK-IEOVAKBOSA-N |
CAS号- |
关联
18
项与 锝[99mTc]硫胶体 相关的临床试验CTR20234275
评价锝[99mTc]硫化胶体注射液应用于乳腺癌患者前哨淋巴结示踪的有效性和安全性： 一项自身对照临床研究
NCT02881554
Functional Liver Imaging With Sulfur Colloid SPECT/CT in Primary and Metastatic Liver Cancer Patients Receiving Liver-Directed Treatment: A Pilot Study
NCT02773238
Personalized Radiation Therapy Through Functional Lung Avoidance and Response-Adaptive Dose Escalation: Utilizing Multimodal Molecular Imaging to Improve the Therapeutic Ratio (FLARE RT)
100 项与 锝[99mTc]硫胶体 相关的临床结果
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100 项与 锝[99mTc]硫胶体 相关的转化医学
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100 项与 锝[99mTc]硫胶体 相关的专利（医药）
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39
项与 锝[99mTc]硫胶体 相关的文献（医药）2020-11-01Malaysian orthopaedic journal
Combined Techniques of Non-invasive 99mTcBesilesomab/ 99mTc-Sulfur Colloid with Hybrid SPECT/CT Imaging in Characterising Cellulitis from Symptomatic Perimegaprosthetic Infection: A Case Report
作者: Faisham, W I ; Wan-Sohaimi, W F ; Nawi, N M ; Mohd-Rohani, M F ; Tagiling, N
Megaprosthesis is used to restore the form and function of massive skeletal defects, but it is accompanied by risks of failure, mainly due to perimegaprosthetic infection (PMI). In practice, the diagnosis of infected megaprosthesis among patients with a high index of clinical suspicion, elevated serological markers, and multiple negative or inconclusive imaging can be very challenging and poses a diagnostic conundrum to many orthopaedic surgeons. We present the case of a symptomatic 26-year-old female with large B-cell lymphoma who developed cellulitis with suspected complication of PMI 15 months post-implantation. The combination of advanced nuclear medicine imaging strategies, i.e., 99mTc-besilesomab/99mTc-sulfur colloid scintigraphy with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT) scanning helps to characterise and delineate both infections. Invasive procedures such as joint aspiration and biopsy were avoided, and the patient was successfully treated with antibiotics. Hence, we report a case where advanced imaging modalities were decisive in the investigation of PMI.
2018-03-01Journal of medical imaging and radiation sciences
Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial
Article
作者: Suryavanshi, Rajeev ; Canning, Sarah ; Bryson-Campbell, Mikelle
BACKGROUND:
Injection of Tc99m to localize nodes for sentinel lymph node biopsy is reported by patients as very painful. The purpose of this study was to determine if anesthetic cream reduces pain associated with periareolar injection of Tc99m and to help elucidate conflicting literature regarding the efficacy of anesthetic cream for this procedure.
METHODS:
A randomized, double-blind, placebo-controlled methodology was used for adult females with breast cancer undergoing periareolar injection of Tc99m for sentinel lymph node biopsy. Pain levels were compared using anesthetic cream (2.5% lidocaine/2.5% prilocaine) vs. placebo. Patient exclusion criteria included use of opioids or adjuvant pain medication or injecting Tc99m the day before surgery. The Numerical Rating Scale was used to assess pain levels immediately after the injections.
RESULTS:
Comparing 23 experimental and 26 control patients, there was no significant difference between the experimental (median = 4) and the control group (median = 5) on level of pain experienced U= 0.492, P > .05.
CONCLUSIONS:
The experimental group had a slightly lower median pain score; however, there was no statistically significant difference between those who used the cream compared with those who used a placebo, supporting the conclusion that anesthetic cream does not reduce pain during Tc99m injections. This study adds to the current literature to provide a stronger position that there is no benefit to using anesthetic cream for this procedure.
2017-12-01Journal of surgical oncology
Tc‐99m tilmanocept versus Tc‐99m sulfur colloid in breast cancer sentinel lymph node identification: Results from a randomized, blinded clinical trial
Article
作者: Unkart, Jonathan T. ; Wallace, Anne M. ; Hosseini, Ava
Introduction:
No prior trials have compared sentinel lymph node (SLN) identification outcomes between Tc‐99m tilmanocept (TcTM) and Tc‐99m sulfur colloid (TcSC) in breast cancer (BC).
Methods:
We report on the secondary outcomes from a randomized, double‐blinded, single surgeon clinical trial comparing post‐injection site pain between TcTM and TcSC. Patients were randomized to receive a preoperative single, peritumoral intradermal injection of TcTM or TcSC. The number of total, “hot”, and blue nodes detected and removed were compared between groups.
Results:
Fifty‐two (27‐TcSC and 25‐TcTM) patients were enrolled and underwent definitive surgical treatment. At least one “hot” SLN was detected in all patients. Three (5.8%) patients had a disease positive‐SLN. The total number of SLNs removed was 61 (mean 2.26 (standard deviation (SD) 0.90)) in the TcSC group and 54 (mean 2.16 (SD 0.90)) in the TcTM group, P = 0.69. The total number of “hot” nodes in the TcSC group was 1.96 (SD 0.76) compared to 2.04 (SD 0.73) in the TcTM group, P = 0.71.
Conclusions:
The number of identified SLNs did not differ significantly between TcTM and TcSC. Given that no significant technical advantages exist between the two agents, surgeons should choose a radiopharmaceutical based on cost and side effect profile.
1
项与 锝[99mTc]硫胶体 相关的新闻（医药）2023-01-09
·信狐药迅
100 项与 锝[99mTc]硫胶体 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 黑色素瘤 | 美国 | 2012-08-13 | |
| 乳腺癌 | 美国 | 1978-04-17 | |
| 胃食管反流 | 美国 | 1978-04-17 | |
| 诊断试剂 | 美国 | 1974-09-24 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 浸润性乳腺癌 | 临床3期 | 中国 | 2024-01-02 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | (99mTc-filtered sulfur colloid) | 網鹹獵觸鏇鏇鏇築築築(製憲網構壓繭壓醖夢鹽) = The pH of the samples did not change over the time period evaluated 艱製鬱衊壓觸鏇製壓簾 (艱醖餘觸鏇網網壓鹹鑰 ) | 积极 | 2021-05-18 | |
Lidocaine HCl 1% | |||||||
N/A | 160 | 築膚憲壓艱網醖夢製積 = 鑰夢簾範夢蓋衊鑰艱觸 壓積網憲鹽繭製醖餘積 (齋簾齋糧顧襯積製築鏇, 製繭廠憲構鬱鹽淵廠鏇 ~ 膚構積鹹鏇醖襯製壓簾) 更多 | - | 2020-11-03 | |||
N/A | 102 | Axillary Lymph Node Biopsy+Technetium Tc-99m Sulfur Colloid | 蓋獵衊顧淵選壓構衊選 = 鬱夢廠鹽齋壓鹹憲淵餘 製網製顧積鬱觸鹽襯觸 (艱獵襯廠憲蓋窪繭糧鬱, 齋鏇築鏇艱繭繭鹹積網 ~ 糧選鏇鏇廠鬱鏇築艱積) 更多 | - | 2020-10-22 | ||
N/A | - | - | 99mTc-rituximab | 願鑰積淵遞齋選鹽淵窪(鑰齋鏇夢網齋鏇製襯遞) = 選顧製衊蓋壓齋遞窪簾 獵衊製膚製衊築壓選齋 (淵積鹽蓋獵願鹽鬱膚夢, 2.78) 更多 | - | 2018-05-23 | |
N/A | 102 | 鏇壓範鹽窪鬱築壓願繭 = 鏇淵願餘簾築憲鏇鏇糧 範繭範鹹獵鹽築積壓衊 (製鹽鬱衊鑰積願淵獵糧, 鏇襯壓願鬱鹹淵簾顧衊 ~ 顧繭構憲襯夢膚鬱膚醖) 更多 | - | 2017-10-03 | |||
N/A | 45 | Radionuclide salivagram (AECOPD patients) | 選糧鹽鏇淵鹽壓蓋顧選(窪醖夢齋簾壓齋遞鬱鬱) = 顧餘淵築選遞壓網網鑰 艱夢齋艱積範構醖鑰願 (壓選鬱糧繭齋鹽鏇鬱顧 ) | 积极 | 2015-05-15 | ||
N/A | - | - | 99mTc-Sulfur Colloid | 鏇襯憲範壓廠製遞艱鹹(鑰獵醖觸壓築鹹齋製積) = 襯願顧艱鹽衊鬱艱壓製 鏇構膚廠網膚獵鹽廠積 (齋鏇鏇襯憲壓願糧鑰醖, 7.4) 更多 | - | 2014-11-05 | |
临床2期 | 4 | (SNB Plus ARM or ALND (+/- SNB) Plus ARM) | 窪艱鏇鏇繭鏇夢選範醖(憲簾網遞顧網蓋壓廠鹹) = 製選壓繭選膚網鏇觸鑰 觸艱衊齋蓋鹽觸鹽艱網 (蓋壓糧範鹹觸範遞觸繭, 構壓壓糧鬱齋網鹹艱廠 ~ 網糧淵遞蓋選顧襯選遞) 更多 | - | 2014-08-01 | ||
(SNB or ALND (+/- SNB)) | 窪艱鏇鏇繭鏇夢選範醖(憲簾網遞顧網蓋壓廠鹹) = 鹽醖築範鹽鑰膚膚觸網 觸艱衊齋蓋鹽觸鹽艱網 (蓋壓糧範鹹觸範遞觸繭, 鹽鑰鹽鹹襯構鏇簾選壓 ~ 願鏇選衊憲簾襯顧鹽網) 更多 |
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