Phase I/II Study of Combination Golcadomide and Nivolumab in Patients with Non-Hodgkin Lymphoma with Refractory Disease After Chimeric Antigen T-cell Therapy

In this combined phase I/II, open label, single arm trial to study, the safety and efficacy of combination Golcadomide and nivolumab in patients with non-Hodgkin lymphoma (NHL) who have experienced refractory/residual disease, at or after 30 days of receiving chimeric antigen T-cell (CAR-T) therapy will be studied. A dose escalation phase will be followed by a dose expansion design.

开始日期2025-01-31

申办/合作机构

University of Pittsburgh

[+1]

CTIS2024-511304-16-00

/ Recruiting

A Phase 2 Randomized, Open Label Study to Evaluate the Efficacy and Safety of Golcadomide in Combination with Rituximab in Patients with Newly Diagnosed Advanced Stage Follicular Lymphoma - CA073-1022

开始日期2024-10-14

申办/合作机构

Celgene Corp.

CTR20242203

/ Recruiting临床3期

一项在未经治的高危大B细胞淋巴瘤受试者中对比Golcadomide联合R-CHOP化疗与安慰剂联合R-CHOP化疗的疗效和安全性的3期、多中心、随机、双盲、安慰剂对照研究

主要目的：在未经治的高危大B细胞淋巴瘤受试者中评价golcadomide+R-CHOP对比安慰剂-R-CHOP的研究者评估的PFS疗效。次要目的：在未经治的高危大B细胞淋巴瘤受试者中：评价golcadomide+R-CHOP对比安慰剂-R-CHOP的OS疗效、研究者评估的EFS疗效、IRAC评估的CMR疗效，以及EOT时MRD阴性的疗效。评价golcadomide+R-CHOP对比安慰剂-R-CHOP的IRAC评估的PFS疗效、研究者评估的OR疗效、研究者评估的CMR疗效、PFS24疗效、DoR疗效、PFS2疗效、CHOP细胞毒性组分的相对剂量强度暴露；通过EORTCQLQ-C30和FACT-LymS测量，比较golcadomide+R-CHOP与安慰剂-R-CHOP的疾病症状、功能和总体HRQoL。对比golcadomide+R-CHOP与安慰剂-R-CHOP的安全性。对比golcadomide+R-CHOP与安慰剂-R-CHOP治疗对HCRU的影响、对总体健康状况和效用的影响。

开始日期2024-09-03

申办/合作机构

百时美施贵宝（中国）投资有限公司

[+2]

100 项与 Golcadomide Hydrochloride 相关的临床结果

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100 项与 Golcadomide Hydrochloride 相关的转化医学

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100 项与 Golcadomide Hydrochloride 相关的专利（医药）

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项与 Golcadomide Hydrochloride 相关的文献（医药）

2023-01-01·Blood reviews

Targeting cereblon in hematologic malignancies

Review

作者: Fuchs, Ota

The protein cereblon (CRBN) is a substrate receptor of the cullin 4-really interesting new gene (RING) E3 ubiquitin ligase complex CRL4^CRBN. Targeting CRBN mediates selective protein ubiquitination and subsequent degradation via the proteasome. This review describes novel thalidomide analogs, immunomodulatory drugs, also known as CRBN E3 ubiquitin ligase modulators or molecular glues (avadomide, iberdomide, CC-885, CC-90009, BTX-1188, CC-92480, CC-99282, CFT7455, and CC-91633), and CRBN-based proteolysis targeting chimeras (PROTACs) with increased efficacy and potent activity for application in hematologic malignancies. Both types of CRBN-binding drugs, molecular glues, and PROTACs stimulate the interaction between CRBN and its neosubstrates, recruiting target disease-promoting proteins and the E3 ubiquitin ligase CRL4^CRBN. Proteins that are traditionally difficult to target (transcription factors and oncoproteins) can be polyubiquitinated and degraded in this way. The competition of CRBN neosubstrates with endogenous CRBN-interacting proteins and the pharmacology and rational combination therapies of and mechanisms of resistance to CRL4^CRBN modulators or CRBN-based PROTACs are described.

2022-10-01·Clinical Lymphoma Myeloma & Leukemia

ABCL-412 Clinical Activity of CC-99282, a Novel, Oral, Small Molecule Cereblon E3 Ligase Modulator (CELMoD) Agent, in Patients With Relapsed/Refractory Non-Hodgkin Lymphoma (R/R NHL) –Results From CC-99282-NHL-001 (NCT03930953) a First-in-Human, Phase 1, Open-Label, Multicenter Study

Article

作者: Nastoupil, Loretta ; Guarinos, Carla ; Patah, Poliana ; Bachy, Emmanuel ; Feldman, Tatyana A ; Carpio, Cecilia ; Wu, Fan ; Buchholz, Tonia J ; Chou, Wen-Chi ; Kuruvilla, John ; Pourdehnad, Michael ; Michot, Jean-Marie ; Carrancio, Soraya ; Morillo, Daniel ; Ribrag, Vincent ; Li, Shaoyi ; Ferrari, Silvia ; Pinto, Antonio ; Chavez, Julio C

CC-99282, a CELMoD® agent, co-opts cereblon to induce targeted degradation of Ikaros/Aiolos. In preclinical studies, CC-99282 exhibited stronger antiproliferative, apoptotic, and immunostimulatory activities compared with lenalidomide and other CELMoD agents. Here we present results of CC-99282 monotherapy in patients with R/R NHL. This 2-part study comprises CC-99282 monotherapy dose escalation (part A) and expansion ± combination partners (part B). Part A includes patients with R/R diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL) that progressed after ≥2 lines of therapy (LOTs) and patients with R/R DLBCL unfit for transplant who have received ≥1 standard LOT. CC-99282 at 0.2, 0.4, 0.6, or 0.8 mg is administered once daily in 3 intermittent, 28-day cycle dosing schedules, with ≥3 patients per cohort. By October 6, 2021, 50 patients received CC-99282 in part A (38 DLBCL, 12 FL; median age 66y; 58% male; 3 median prior LOTs [range 1-8]); 17 remain on treatment, 26 discontinued due to progressive disease. Treatment-related grade 3/4 adverse events were observed in 32 (64%) patients, primarily neutropenia (29 [58%] patients) which was managed with dose modifications and granulocyte colony-stimulating factors. Grade 4 neutropenia during the first month of CC-99282 treatment correlated with prior therapy with ≥4 lines of alkylating agents. All dose-limiting toxicities were hematologic. Maximal recommended doses on the 7/14- and 14/28-days schedules of interest were 0.6 mg and 0.4 mg, respectively. For doses ≥0.4 mg on schedules of interest, responses were durable, and overall response rate was 42% (15/36 evaluable patients; 6 complete and 9 partial responses; 6 FL, 9 DLBCL); responders included patients who progressed on/after cellular therapy and/or immunomodulatory/CELMoD agents. Responses also correlated with early reduction in circulating tumor DNA. CC-99282 was absorbed rapidly with a prolonged median terminal half-life (~50 hours [doses ≥0.4 mg]). Increase in CC-99282 plasma exposure and Ikaros/Aiolos degradation in peripheral T cells were dose-dependent (maximum degradation [>90%] by treatment day 4 [doses ≥0.4 mg]). CC-99282 monotherapy demonstrated a manageable safety profile, with promising efficacy in heavily pretreated patients with R/R NHL. Pharmacokinetic/pharmacodynamic data were consistent with robust/rapid CC-99282-mediated antitumor activity. This BMS-funded study is enrolling patients.

2021-12-01·Bioorganic & medicinal chemistry letters4区 · 医学

Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent

4区 · 医学

Article

作者: Shinozuka, Tsuyoshi ; Nakao, Akira ; Nakai, Daisuke ; Nagai, Yoko ; Naito, Satoru ; Saito, Keiji ; Kunikata, Tomonori

The continuing investigation of SAR of 3-aminothieno[2,3-b]pyridine-2-carboxamide derivatives has been described. In this study, C4-piperidine derivatives with polar functional groups were synthesized to develop orally available bone anabolic agents. The optimized compound 9o (DS96432529), which exhibited the best PK profile and high in vitro activity, showed the highest in vivo efficacy in this series. Moreover, significant synergistic effects were observed following co-administration of DS96432529 and alendronate or parathyroid hormone. The mechanism of action is most likely mediated through CDK8 inhibition.

项与 Golcadomide Hydrochloride 相关的新闻（医药）

2024-12-28

·药明康德

蛋白降解、AI火热，首款PROTAC呼之欲出 | 2024攻克难以成药靶点动向

▎药明康德内容团队编辑共价剂、别构剂和诱导接近分子等创新小分子药物技术的进展，使产业得以超越“锁-钥原理”来靶向以往被认为“难以成药”的靶点。 2024年，这一领域依然风起云涌，诸多重磅新闻正在预示小分子药物的新篇章：有助于加快难以成药靶点新药研发的AI解决方案摘得诺奖桂冠，多家新锐正在采用AI技术解决成药难题。针对难以成药靶点的新颖技术纷纷被大药企看好，拜耳就针对凝聚体的药物达成超4亿美元合作；耶鲁大学蛋白降解先驱Craig Crews教授创立的Arvinas与诺华达成超10亿美元合作；分子胶领域多笔高额合作，达歌生物与武田达成总额约12亿美元合作，SEED Therapeutics与卫材达成潜在总额15亿美元的合作，Monte Rosa Therapeutics与诺华达成潜在总额超过22亿美元的合作，Neomorph今年先后与诺和诺德、渤健达成合作，潜在总额超过29亿美元…… 而2025年第一季度，我们还有望迎来蛋白降解疗法研发的重要里程碑，潜在首款PROTAC疗法的3期临床研究数据揭晓在即。在这篇文章中，药明康德内容团队将为大家回顾2024年产业针对难以成药靶点或相关技术的新药获批和研发进展趋势。扫描文中二维码或点击文末“阅读原文”可申请获得完整报告，包括已获批疗法及2025即将获批疗法盘点、大型药企管线列表、融资新锐介绍等详尽信息。 ▲长按扫描二维码或点击文末“阅读原文/Read more”，即可填写问卷，申请获取攻克难以成药靶点研发进展完整报告新型小分子获批速度稳健，2024年再迎两款KRAS靶向药近3年来，全球范围内已有至少15款基于共价/别构/诱导接近的新颖机制开发的创新小分子首次获批，2024年也保持了稳健的获批速度。2024年4款基于共价机制的创新药在全球首次获批，包括2款治疗非小细胞肺癌（NSCLC）的KRAS共价抑制剂；此外，1款基于蛋白质-蛋白质相互作用的创新药revumenib问世，针对menin-KMT2A相互作用来抑制menin，用于治疗KMT2A易位的复发/难治性急性白血病，revumenib也是治疗此类患者群体的首款获批menin抑制剂。 ▲近3年全球首次获批的基于共价/别构/诱导接近分子机制开发的疗法（药明康德内容团队制图，数据截至2024年12月20日）基于当前研发与监管审评进展公开信息，3款共价抑制剂有望在2025年迎来首次批准：加科思研发的KRAS抑制剂戈来雷塞，用于治疗局部晚期或转移性NSCLC的上市申请已于2024年5月获中国国家药品监督管理局（NMPA）受理并纳入优先审评程序；赛诺菲旗下的两款BTK抑制剂，分别为治疗免疫性血小板减少症的rilzabrutinib和治疗多发性硬化的tolebrutinib，均已在3期试验中取得积极结果，正在准备向监管机构递交上市申请。 36家新锐完成早期融资：蛋白降解新模式、AI受青睐 2024年，共36家致力于攻克难以成药靶点或专注于相关技术的新锐获得总额近16亿美元的早期投融资。从技术特点来看，开发共价剂（多为抗癌疗法）、别构剂（大多聚焦神经系统疾病）的新锐占据半壁江山（17家），其中不乏新颖的共价机制，如结合非自然界氨基酸生成能与靶点共价结合的治疗性蛋白。专注于蛋白降解或调节蛋白-蛋白相互作用疗法的新锐持续涌现（12家），且不乏新模式。例如，Pinetree Therapeutics开发多特异性靶向蛋白质降解剂，A轮融资1700万美元，且与阿斯利康达成总额超5亿美元合作；Draupnir Bio和Booster Therapeutics基于溶酶体机制开发蛋白降解剂，种子轮融资逾千万美元；Firefly Bio由诺贝尔化学奖得主Carolyn Bertozzi教授联合创立，开发蛋白降解剂-抗体偶联药物（DAC），获得9400万美元A轮融资；Craig Crews教授创立的Halda Therapeutics开发基于诱导接近机制的RIPTAC（调节诱导接近靶向嵌合体）分子，完成1.26亿美元B轮融资。Halda自成立以来就与药明康德长期合作。药明康德针对蛋白降解疗法的研发搭建了完善的一体化赋能平台，服务了全球蛋白降解疗法开发领域66%的公司，助力前沿科学发现转化为创新疗法。也有多家新锐开发大环分子。与抗体等生物制品相比，大环分子的分子量更小，可以口服使用，并且可以穿过细胞膜靶向细胞内的蛋白。而与传统小分子相比，环状结构让大环分子更容易影响蛋白质之间的相互作用，从而靶向传统小分子药物和线性多肽难于靶向的靶点。 AI也是今年的一大热点。多家新锐基于AI平台攻克难成药靶点，加速疗法研发，包括由蛋白设计先驱David Baker教授联合创立的两家公司：Vilya基于AI平台从头设计大环分子，完成2100万A轮扩展融资，Archon Biosciences设计抗体笼，这类分子由抗体和AI生成蛋白结构域组成，该公司完成2000万美元种子轮融资。大药企临床管线：潜在首款PROTAC即将冲线，新一代KRAS靶向疗法涌现针对难以成药靶点或基于相关技术，全球20家大型药企已布局36款临床在研疗法。这些疗法中，近一半已处于后期研发阶段或正在拓展适应症。 ▲全球20家大型药企针对难以成药靶点或采用相关机制开发的管线分布；扫描文中二维码可申请获取完整管线列表（药明康德内容团队制图，数据来源为各药企公开信息，截至2024年12月，20家大型药企参考行业媒体Fierce Pharma 2024年榜单）其中广受关注的是潜在首款PROTAC疗法vepdegestrant。辉瑞与Arvinas在2021年就这款疗法达成超20亿美元研发合作，期望它能成为雌激素受体阳性（ER+）乳腺癌患者的支柱性疗法。两家公司预计在2025年第一季度公布其作为乳腺癌单药疗法的3期试验顶线数据。目前，vepdegestrant联合CDK4/6抑制剂的临床研究也在推进，已有两项1b期临床试验显示积极结果。其他处于3期临床开发阶段的在研疗法还包括：治疗NSCLC的2款KRAS抑制剂olomorasib和divarasib，治疗银屑病的TYK2抑制剂zasocitinib，治疗淋巴瘤、靶向Ikaros/Aiolos的分子胶golcadomide，治疗乳腺癌的多款雌激素受体降解剂，以及针对BTK、EGFR、HER2等经典靶点的共价抑制剂等。如前文所述，赛诺菲旗下2款BTK共价抑制剂均即将迈入监管申请阶段。多样化的技术正在解决更多靶点的成药性，如Helios、WRN、CK1α等靶点。新一代KRAS靶向疗法也是热门研发方向，如泛KRAS抑制剂、采用非共价机制的KRAS抑制剂。结语 2024年，解锁难以成药靶点的技术持续为患者带来创新疗法，资本市场继续扶植前沿技术的发展，尤其是在蛋白降解领域，在PROTAC和分子胶之外，更多异双功能分子等新颖技术的涌现正在拓展成药边界，而AI从头设计蛋白、抗体、环肽等药物则为加速新药研发注入强大推动力。我们坚信，攻克难以成药靶点的研发浪潮势不可挡，首款PROTAC疗法呼之欲出，更多靶点的突破也指日可待，将造福全球更多患者。 ▲长按扫描二维码或点击文末“阅读原文/Read more”，即可填写问卷，申请获取攻克难以成药靶点研发进展完整报告 ▲欲了解更多前沿技术在生物医药产业中的应用，请长按扫描上方二维码，即可访问“药明直播间”，观看相关话题的直播讨论与精彩回放免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：本文来自药明康德内容团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「药明康德」微信公众号回复“转载”，获取转载须知。分享，点赞，在看，聚焦全球生物医药健康创新

优先审批临床3期蛋白降解靶向嵌合体上市批准

2024-11-28

·PRNewswire

Follicular Lymphoma Clinical Trial Pipeline Appears Robust With 50+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight

Advances in immunotherapy have ushered in a new era of treatment for follicular lymphoma (FL), particularly for patients who have experienced relapse after conventional chemotherapy regimens. This paradigm shift is characterized by the emergence of innovative therapies like CAR T-cell therapy and bispecific antibodies, which have demonstrated remarkable efficacy in targeting and eradicating lymphoma cells. CAR T-cell therapy represents a groundbreaking approach where a patient's own T-cells are genetically engineered to recognize and attack cancer cells. This personalized treatment has shown significant promise, especially for individuals who have undergone extensive previous therapies. One notable example is Axicabtagene ciloleucel (Yescarta), a CAR T-cell therapy approved for use in patients with relapsed or refractory follicular lymphoma. Clinical trials have highlighted its ability to induce durable remissions, with some patients experiencing long-term remission even after multiple prior therapies. LAS VEGAS, Nov. 28, 2024 /PRNewswire/ -- DelveInsight's ' Follicular Lymphoma Pipeline Insight 2024 ' report provides comprehensive global coverage of pipeline follicular lymphoma therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the follicular lymphoma pipeline domain. Key Takeaways from the Follicular Lymphoma Pipeline Report DelveInsight's follicular lymphoma pipeline report depicts a robust space with 50+ active players working to develop 55+ pipeline therapies for follicular lymphoma treatment. Key follicular lymphoma companies such as Chia Tai Tianqing Pharmaceutical Group, Incyte Corporation, Mabworks, Johnson & Johnson Innovative Medicine, Nektar Therapeutics, Xynomic Pharmaceuticals, Merck Sharp & Dohme, Jiangsu HengRui Medicine Co., Ltd., ADC Therapeutics, Bristol-Myers Squibb, Swedish Orphan Biovitrum, Zhejiang DTRM Biopharma, Immpact Bio, Galapagos, Immunitas Therapeutics, Enterome, CRISPR Therapeutics, CHO Pharma, Shanghai Blueray Biopharma, BeiGene, AstraZeneca, AVM Biotechnology, Mustang Bio, Merck, Pell Bio-Med Technology, Schrodinger Inc., Sana Biotechnology, Poseida Therapeutics, OncoNano Medicine, Inc., Nurix Therapeutics, Inc., NovalGen, Pfizer, Xencor, Wellington Zhaotai Therapies, MEI Pharma, Sutro Biopharma, Synthekine, Verismo Therapeutics, Vincerx Pharma, Novartis, Century Therapeutics, Newave Pharmaceuticals, Bio-Path Holdings, Affimed GmbH, Iksuda Therapeutics, Allogene Therapeutics, Adicet Bio, Carna Biosciences, Inc., BeiGene, Boryung Pharmaceutical, Accutar Biotechnology, Atara Biotherapeutics, AbbVie, InnoCare Pharma, NeoImmuneTech, and others are evaluating new follicular lymphoma drugs to improve the treatment landscape. Promising follicular lymphoma pipeline therapies such as Parsaclisib, TQ-B3525, Tafasitamab, MIL62, Ibrutinib, AZD0486, NKTR-255, Abexinostat, Acalabrutinib, Zilovertamab vedotin, SHR2554, Nivolumab, Loncastuximab tesirine, Golcadomide, Emapalumab, DTRM-555, Capivasertib, IMPT 314, GLPG5101, IMT-009, EO2463, CTX112, CHO-H01, BR1733, BGB-16673, BGB-10188, AZD5492, AVM0703, MB106, MK-1026, PL001, SGR-1505, SC291, SC262, P-CD19CD20-ALLO1, ONM 501, NX-5948, NX 2127, NVG-111, Mevrometostat, Plamotamab, WZTL-002, Voruciclib, STRO001, SYNCAR-001 + STK-009, SynKIR-310, VIP-152, VAY736, CNTY-101, LP-168, BP1002, IOA-244, IKS 03, ALLO-501, ADI-001, AS-1763, BGB-21447, BR101801, AC676, ATA3219, ABBV-319, ABBV-101, ICP-B02, ICP-B05, C-CAR039, Efineptakin Alfa, and others are under different phases of follicular lymphoma clinical trials. In August 2024, the company expects to file a supplemental Biologics License Application for tafasitamab for the treatment of patients with FL who have failed at least one prior systemic anti-CD20 immunotherapy or chemo-immunotherapy by the end of 2024 based on the positive Phase III results. In June 2024, a consortium of Eugene Private Equity and Korea Development Bank Private Equity announced that they would acquire 80% of South Korean vaccine maker Boryung Biopharma Co. for 320 billion won (USD 231 million). In February 2024, Incyte announced that it had entered into an asset purchase agreement with MorphoSys AG, which gives Incyte exclusive global rights for tafasitamab. Incyte will now recognize revenue and cost for all US commercialization and clinical development and MorphoSys will no longer be eligible to receive future milestone, profit split and royalty payments. In September 2023, OncoNano Medicine, Inc. announced a clinical trial supply agreement with Regeneron for the use of Libtayo (cemiplimab), a PD-1 inhibitor, in the combination stage of the first human trial of ONM-501, a dual-activating STING (STimulator of INterferon Genes) agonist and lead therapeutic development candidate. The ONM-501 first-in-human trial is a multicenter Phase Ia/b dose escalation and dose expansion study of intratumoral ONM-501 as monotherapy and in combination with Libtayo in patients with advanced solid tumors and lymphomas. OncoNano is the sponsor of the clinical trial, and Regeneron will supply cemiplimab. In May 2023, Janssen Pharmaceutical Companies of Johnson & Johnson announced that it had entered into a worldwide collaboration and license agreement with Cellular Biomedicine Group Inc. (CBMG) to develop, manufacture, and commercialize next-generation chimeric antigen receptor (CAR) T-cell therapies for the treatment of B-cell malignancies. Under the terms of the agreement, CBMG will grant Janssen a worldwide license to develop and commercialize the CAR-T assets, except in Greater China. Janssen and CBMG will negotiate an option for Janssen to commercialize the products in the Chinese territory. Janssen will make an upfront payment of USD 245 million that will be accounted for in the second quarter as a research and development expense. Additional future payments will be based upon achieving certain development, regulatory, and sales milestones, as well as tiered royalty payments on worldwide net trade sales, excluding Greater China. Request a sample and discover the recent advances in follicular lymphoma treatment drugs @ Follicular Lymphoma Pipeline Report The follicular lymphoma pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage follicular lymphoma drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the follicular lymphoma clinical trial landscape. Follicular Lymphoma Overview Follicular lymphoma is a common type of non-Hodgkin lymphoma (NHL) that originates from B-cells, a kind of white blood cell responsible for producing antibodies. This cancer is characterized by the growth of abnormal lymphoid follicles, which can disrupt normal lymphatic function. While the exact causes of follicular lymphoma are not fully understood, certain factors may increase the risk, including age (most commonly affecting adults over 60), a family history of lymphoma, and potential environmental factors such as exposure to pesticides or chemicals. Symptoms of follicular lymphoma can vary widely but may include painless swelling of lymph nodes in the neck, armpit, or groin, unexplained weight loss, night sweats, fatigue, and fever. Some patients may remain asymptomatic for extended periods, as this type of lymphoma can progress slowly. Diagnosis typically involves a combination of physical examinations, blood tests, imaging studies (like CT scans), and a biopsy of affected lymph nodes. The biopsy helps determine the subtype and stage of the lymphoma, which is crucial for planning treatment. Treatment for follicular lymphoma depends on the stage of the disease and the patient's overall health. Options may include watchful waiting for asymptomatic cases, chemotherapy, immunotherapy (such as monoclonal antibodies), and targeted therapies. In some cases, stem cell transplants may be considered for patients with more aggressive forms or those who do not respond to initial treatments. Given the indolent nature of follicular lymphoma, ongoing management, and regular monitoring are vital for achieving the best possible outcomes. Find out more about follicular lymphoma treatment drugs @ Drugs for Follicular Lymphoma Treatment A snapshot of the Follicular Lymphoma Pipeline Drugs mentioned in the report: Learn more about the emerging follicular lymphoma pipeline therapies @ Follicular Lymphoma Clinical Trials Follicular Lymphoma Therapeutics Assessment The follicular lymphoma pipeline report proffers an integral view of the follicular lymphoma emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Follicular Lymphoma Pipeline Report Coverage: Global Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Therapeutics Assessment By Route of Administration: Intra-articular, Intraocular, Intrathecal, Intravenous, Oral, Parenteral, Subcutaneous, Topical, Transdermal Therapeutics Assessment By Molecule Type: Oligonucleotide, Peptide, Small molecule Therapeutics Assessment By Mechanism of Action: Phosphatidylinositol 3 kinase delta inhibitors, Phosphatidylinositol 3 kinase gamma inhibitors, Emt protein-tyrosine kinase inhibitors, Interleukin 15 receptor agonists, Histone deacetylase inhibitors, Rad51 recombinase inhibitors, Agammaglobulinaemia tyrosine kinase inhibitors, Apoptosis stimulants, Cell cycle inhibitors, Tubulin inhibitors, Tubulin polymerisation inhibitors, Enhancer of zeste homolog 2 protein inhibitors, Antibody-dependent cell cytotoxicity, Programmed cell death 1 receptor antagonists, T lymphocyte stimulants, Alkylating agents, DNA cross-linking agents Key Follicular Lymphoma Companies: Chia Tai Tianqing Pharmaceutical Group, Incyte Corporation, Mabworks, Johnson & Johnson Innovative Medicine, Nektar Therapeutics, Xynomic Pharmaceuticals, Merck Sharp & Dohme, Jiangsu HengRui Medicine Co., Ltd., ADC Therapeutics, Bristol-Myers Squibb, Swedish Orphan Biovitrum, Zhejiang DTRM Biopharma, Immpact Bio, Galapagos, Immunitas Therapeutics, Enterome, CRISPR Therapeutics, CHO Pharma, Shanghai Blueray Biopharma, BeiGene, AstraZeneca, AVM Biotechnology, Mustang Bio, Merck, Pell Bio-Med Technology, Schrodinger Inc., Sana Biotechnology, Poseida Therapeutics, OncoNano Medicine, Inc., Nurix Therapeutics, Inc., NovalGen, Pfizer, Xencor, Wellington Zhaotai Therapies, MEI Pharma, Sutro Biopharma, Synthekine, Verismo Therapeutics, Vincerx Pharma, Novartis, Century Therapeutics, Newave Pharmaceuticals, Bio-Path Holdings, Affimed GmbH, Iksuda Therapeutics, Allogene Therapeutics, Adicet Bio, Carna Biosciences, Inc., BeiGene, Boryung Pharmaceutical, Accutar Biotechnology, Atara Biotherapeutics, AbbVie, InnoCare Pharma, NeoImmuneTech, and others. Key Follicular Lymphoma Pipeline Therapies: Parsaclisib, TQ-B3525, Tafasitamab, MIL62, Ibrutinib, AZD0486, NKTR-255, Abexinostat, Acalabrutinib, Zilovertamab vedotin, SHR2554, Nivolumab, Loncastuximab tesirine, Golcadomide, Emapalumab, DTRM-555, Capivasertib, IMPT 314, GLPG5101, IMT-009, EO2463, CTX112, CHO-H01, BR1733, BGB-16673, BGB-10188, AZD5492, AVM0703, MB106, MK-1026, PL001, SGR-1505, SC291, SC262, P-CD19CD20-ALLO1, ONM 501, NX-5948, NX 2127, NVG-111, Mevrometostat, Plamotamab, WZTL-002, Voruciclib, STRO001, SYNCAR-001 + STK-009, SynKIR-310, VIP-152, VAY736, CNTY-101, LP-168, BP1002, IOA-244, IKS 03, ALLO-501, ADI-001, AS-1763, BGB-21447, BR101801, AC676, ATA3219, ABBV-319, ABBV-101, ICP-B02, ICP-B05, C-CAR039, Efineptakin Alfa, and others. Dive deep into rich insights for new drugs for follicular lymphoma treatment, visit @ Follicular Lymphoma Drugs Table of Contents For further information on the follicular lymphoma pipeline therapeutics, reach out @ Follicular Lymphoma Treatment Drugs Related Reports Follicular Lymphoma Market Follicular Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key follicular lymphoma companies including Epizyme, Eisai, Bayer Healthcare Pharmaceuticals, Verastem Oncology, Gilead Sciences, TG Therapeutics, Bristol-Myers-Squibb, Roche, Incyte Corporation, Bristol Myers Squibb, ADC Therapeutics, MorphoSys, Nordic Nanovector, AbbVie, Regeneron Pharmaceuticals, Janssen Research & Development, Novartis, MEI Pharma, and BeiGene, among others. Non-Hodgkin Lymphoma Market Non-Hodgkin Lymphoma Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key Non-Hodgkin lymphoma companies, including Roche, Pfizer, Amgen, Novartis, Teva Pharmaceuticals, Genentech, ACD Therapeutics, among others. Non-Hodgkin Lymphoma Pipeline Non-Hodgkin Lymphoma Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key Non-Hodgkin lymphoma companies, including Novartis, AstraZeneca, Genentech, BioInvent, Genmab, SystImmune, Nordic Nanovector, Pacylex Pharmaceuticals, Artiva Biotherapeutics, Inc., Chipscreen Biosciences, Ltd., Timmune Biotech Inc., Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Gilead Sciences, Acerta Pharma BV, Adagene Inc, Conjupro Biotherapeutics, Inc., Rhizen Pharmaceuticals, Juventas Cell Therapy Ltd., Incyte Corporation, HUYA Bioscience International, SecuraBio, Genor Biopharma Co., Ltd., Kyowa Kirin Co., Ltd., Antengene Therapeutics Limited, Regeneron Pharmaceuticals, Jiangsu HengRui Medicine Co., Ltd., Xynomic Pharmaceuticals, Inc., BioTheryX, Inc., UWELL Biopharma, Kronos Bio, Bio-Thera Solutions, Spectrum Pharmaceuticals, Inc., Aptose Biosciences Inc., Miltenyi Biomedicine GmbH, Precision BioSciences, Inc., Teneobio, Inc., TCR2 Therapeutics, IGM Biosciences, Inc, among others. Diffuse Large B-cell Lymphoma Market Diffuse Large B-cell Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key DLBCL companies, including AbbVie, Genmab, Merck, Roche, Xencor, Janssen, Denovo Biopharma, Calithera Biosciences IMV, Biogen, Autolus Therapeutics, Allogene Therapeutics, Novartis, Miltenyi Biomedicine, Regeneron Pharmaceuticals, Debiopharm, Seagen, Takeda, AstraZeneca, Gilead Sciences, among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . 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免疫疗法引进/卖出临床3期疫苗细胞疗法

2024-11-19

·医药观澜

2024年，这11款蛋白降解1类新药首次在中国获批临床！来自百济神州、华东医药等

▎药明康德内容团队报道靶向蛋白降解（TPD）技术的进展是药物发现领域的关键性转变，尤其是通过分子胶和蛋白降解靶向嵌合体（Proteolysis-Targeting Chimera，以下简称PROTAC），大大扩展了可成药的靶点，为治疗开辟了前所未有的可能性。当下，靶向蛋白降解领域正在蓬勃发展，新兴的技术和药物类型不断涌现。在中国，该领域今年以来也进展颇多，多款创新产品陆续进入临床阶段。根据NMPA药品审评中心（CDE）官网，今年以来（截至11月18日），至少有11款靶向蛋白降解疗法1类新药首次在中国获批IND，来自百济神州、华东医药、格博生物、睿跃生物、安斯泰来、百时美施贵宝等公司。这些产品拟开发的疾病领域涵盖实体肿瘤、血液肿瘤、自身免疫性疾病。本文将根据公开资料梳理这些产品的公开信息。格博生物：GLB-001胶囊作用机制：CK1α分子胶蛋白降解剂适应症：髓系恶性肿瘤 2024年2月，格博生物申报的GLB-001获批临床，拟开发用于髓系恶性肿瘤。GLB-001为格博生物自主研发的一款高选择性的酪蛋白激酶1α（CK1α）口服分子胶蛋白降解剂。GLB-001可通过与CRL4CRBN E3泛素连接酶复合物中的底物蛋白受体CRBN相结合，靶向降解CK1α，并触发p53的稳定与蓄积及其下游信号传导通路的激活，导致肿瘤细胞周期停滞和凋亡，发挥抑制肿瘤生长的作用。根据格博生物公开资料，该公司专注于靶向蛋白降解新药研发，成立至今已获得了高瓴创投、启明创投、礼来亚洲基金、凯泰资本和君联资本等多家知名投资机构近9000万美元融资。除了GLB-001胶囊，该公司研发的IKZF1/3选择性分子胶蛋白降解剂GLB-002此前也已经进入临床研究阶段。康朴生物：KPG-818胶囊作用机制：分子胶免疫调节药物适应症：系统性红斑狼疮 2024年3月，康朴生物研发的小分子1类新药KPG-818胶囊在中国获批临床，拟开发治疗系统性红斑狼疮（SLE）。KPG-818是康朴生物医药设计开发的新一代口服分子胶免疫调节药物，归属E3泛素连接酶复合物CRL4-CRBN调节剂，对靶点CRBN显示出极高的亲和力，可以高效降解与B淋巴细胞发育和增殖密切相关的锌指转录因子Aiolos（IKZF3）和Ikaros（IKZF1），有效调节TNF-α、IL-6、IL-2、IL-10等细胞因子的表达水平。值得一提的是，今年6月，KPG-818用于治疗系统性红斑狼疮的2a期临床研究结果已经发布。康朴生物是一家处于临床阶段的创新型生物医药公司，致力于开发小分子靶向免疫调节创新药物。该公司的研发管线中包含了CRL4-CRBN分子胶蛋白质降解剂产品，正在开发用于治疗系统性红斑狼疮、炎症性肠病、白塞氏病、多发性骨髓瘤等；还包括了多款处于临床前阶段的分子胶-抗体双重靶向药物。和径医药：HJ-002-03片作用机制：EGFR PROTAC 适应症：EGFR突变的晚期非小细胞肺癌今年4月和6月，和径医药研发的HJ-002-03片该产品相继在中国和美国获批临床，拟开发治疗EGFR突变的晚期非小细胞肺癌。HJ-002-03片是新一代口服、高选择性、广谱EGFR PROTAC，拟开发治疗EGFR突变晚期非小细胞肺癌。该产品旨在解决EGFR小分子抑制剂的耐药问题。和径医药聚焦肿瘤和中枢神经系统等疾病领域的药物开发，该公司研发管线涵盖PROTAC、抗体及小分子等。安斯泰来：ASP3082注射液作用机制：KRAS G12D PROTAC 适应症：KRAS G12D突变实体瘤 2024年6月，安斯泰来（Astellas）申报的ASP3082注射液在中国获批临床，拟开发用于携带KRAS G12D突变的既往经治局部晚期（不可切除）或转移性恶性实体瘤。公开资料显示，这是一款新型的小分子PROTAC，它结合并选择性靶向KRAS G12D突变蛋白，通过募集E3泛素连接酶蛋白进行降解。该产品正在国际范围内开展1期临床研究。根据安斯泰来官网介绍，该公司已经建立了一系列靶向蛋白降解剂研发管线，旨在创造下一代蛋白质降解物，用于治疗癌症和其它多个适应症。ASP3082正是该系列管线中的一款先导产品，其余还包括另一款KRAS G12D降解剂ASP4396以及一款尚处于临床前阶段的泛KRAS降解剂等。百时美施贵宝：golcadomide胶囊作用机制：CELMoD分子胶化合物适应症：大B细胞淋巴瘤 2024年6月，百时美施贵宝旗下新基（Celgene）公司1类新药golcadomide胶囊获批临床，拟开发用于未经治的高危大B细胞淋巴瘤。这是一款新型E3泛素连接酶Cereblon（CELMoD）分子，针对疾病特点做了优化，使其主要分布在淋巴器官。在针对B细胞淋巴瘤的1/2期临床研究中，该产品的客观缓解率（ORR）达到91.1%。百时美施贵宝公司的蛋白稳态（Protein Homeostasis）技术平台使用多种不同的方法来达到降解靶标蛋白的效果，其中包括被称为CELMoD的分子胶类化合物。它们通过与E3泛素连接酶Cereblon结合，改变其底物特异性，让它能够标记与癌症相关的蛋白，促使它们降解。超阳药业：HP-001胶囊作用机制：IKZF1/3分子胶降解剂适应症：血液系统恶性肿瘤 2024年7月，超阳药业1类新药HP-001胶囊获批临床，拟开发治疗血液系统恶性肿瘤。根据超阳药业新闻稿，HP-001胶囊是该公司首个1类创新药，为一款IKZF1/3分子胶降解剂。该产品属于新型CRBN E3连接酶调节剂，通过与CRBN结合，特异性招募转录因子IKZF1/3并启动对其蛋白的泛素化降解，激活多种抗肿瘤下游反应。超阳药业成立于2021年，该公司聚焦抗肿瘤适应症，已经搭建了包含多款分子胶和蛋白降解靶向嵌合体的研发管线。德亘生物：DG01片作用机制：双靶点 PROTAC 适应症：前列腺癌和肝癌等实体瘤 2024年8月，德亘生物申报的DG01片获批临床，拟开发治疗晚期或转移性去势抵抗性前列腺癌和肝癌等实体瘤。公开资料显示，DG01片为一款双靶点PROTAC药物。它可同时降解GSPT1和SRD5A3靶蛋白，双降解的作用机制诱导雄激素受体（AR）和AR-V7的下调，从而抑制前列腺癌细胞的增殖，达到治疗前列腺癌的效果。百济神州：BGB-45035片作用机制：靶向IRAK4的CDAC蛋白降解剂适应症：特应性皮炎 2024年8月，百济神州1类新药BGB-45035片获批临床，拟用于治疗中重度特应性皮炎。BGB-45035片是一款靶向IRAK4的蛋白降解剂，是百济神州在自有CDAC平台上研发的第二款靶向降解剂。该产品有潜力诱导更深、更快的IRAK4降解，并比其他同类药物具有更强的细胞因子抑制作用。IRAK4是Toll样受体（TLRs）和IL-1受体介导的炎症发生中的关键性蛋白。百济神州已经有多款CDAC产品进入临床研究阶段，除了BGB-45035片，还包括：包括BGB-16673（BTK CDAC），预计将于2025年上半年启动针对R/R CLL的3期临床试验；BG-60366（EGFR CDAC），近日已经向NMPA申报IND，有望在2024年第四季度进入临床开发阶段。睿跃生物：注射用CG009301 作用机制：GSPT1靶向蛋白降解剂适应症：血液恶性肿瘤 2024年10月，睿跃生物1类新药注射用CG009301获批临床，拟开发治疗复发/难治性血液恶性肿瘤（包括但不限于AML、ALL、高危型MDS等）。根据睿跃生物新闻稿介绍，CG009301是高选择性GSPT1靶向蛋白降解剂。GSPT1是一种在许多癌症中高度表达的蛋白质，包括血液学和实体瘤。睿跃生物（Cullgen）正在应用其专有的uSMITE™（ubiquitin-mediated, small molecule -induced target elimination）平台，通过小分子诱导、泛素化介导的方式将目标靶蛋白降解，使得传统基于功能位点抑制方式“不可成药”的蛋白可被靶向降解。该公司目前拥有三个降解剂项目正在或即将启动1期临床试验，还在推进其他几个靶向蛋白降解剂和降解剂-抗体偶联物（DACs）的研发。今年11月，睿跃生物宣布拟与Pulmatrix公司合并，旨在创建一家纳斯达克上市的公司。海创药业：HP568片作用机制：ERα PROTAC 适应症：ER+/HER2-乳腺癌 2024年10月，海创药业研发的1类新药HP568片获批临床，拟开展用于治疗ER阳性和HER2阴性的晚期乳腺癌的临床试验。HP568是一款靶向降解ERα的PROTAC药物，由靶蛋白配体、E3连接酶配体和两配体间的连接子3部分构成。研究表明该产品对ERα野生型蛋白和临床常见的ERα突变蛋白均具有极强的降解活性。海创药业专注于癌症和代谢性疾病领域新药研发，该公司拥有PROTAC靶向蛋白降解技术平台，目前其另一款口服AR PROTAC在研药物HP518已经进入临床研究阶段。华东医药：HDM2006片作用机制：HPK1 PROTAC 适应症：晚期实体瘤 2024年10月，华东医药1类新药HDM2006片获批临床，拟开发治疗晚期实体瘤。根据华东医药公告介绍，这是其首个自主研发的小分子抗肿瘤药物，为一款靶向造血祖激酶1（HPK1）的PROTAC药物。HPK1位于PD-1的上游通路，是免疫细胞表达的关键激酶，有可能成为免疫治疗的下一个潜力靶点。相较于HPK1小分子抑制剂，蛋白降解剂有望大幅提升药效和安全性。根据今年10月《自然》子刊Nature Reviews Drug Discovery近期发布的综述文章介绍，靶向蛋白降解剂的发现与设计仍面临诸多挑战，尤其在识别和验证适合降解的靶点方面。同时，识别新的E3连接酶也需要大量的发现与验证工作。尽管存在诸多挑战，但随着产业和学术界在科学与技术上的不断突破与创新，靶向蛋白降解技术有望在未来带来更多新药获批，造福广大患者。参考资料： [1]中国国家药监局药品审评中心（CDE）官网. Retrieved Nov 18，2024, From https://www.cde.org.cn/main/xxgk/listpage/4b5255eb0a84820cef4ca3e8b6bbe20c [2]各公司官网及公开资料本文来自药明康德内容团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权或其他合作需求，请联系wuxi_media@wuxiapptec.com。免责声明：药明康德内容团队专注介绍全球生物医药健康研究进展。本文仅作信息交流之目的，文中观点不代表药明康德立场，亦不代表药明康德支持或反对文中观点。本文也不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。

蛋白降解靶向嵌合体临床申请临床1期

100 项与 Golcadomide Hydrochloride 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
大B细胞淋巴瘤	临床3期	美国	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	日本	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	阿根廷	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	澳大利亚	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	奥地利	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	巴西	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	保加利亚	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	加拿大	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	智利	Bristol Myers Squibb Co.	2024-06-19
大B细胞淋巴瘤	临床3期	哥伦比亚	Bristol Myers Squibb Co.	2024-06-19

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临床结果

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分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASH2024	N/A	滤泡性淋巴瘤	-	GOLCA mono	鏇夢膚糧鹹鹹簾夢範顧(糧齋窪蓋觸觸膚淵鬱製) = The most frequent grade (G) 3+ TEAEs were neutropenia (44%) and anemia (12%). The incidence of febrile neutropenia was 7%. Serious adverse events occurred in 30% of pts, with febrile neutropenia and pneumonia being the most common, in 2 pts (5%) each, as well as pulmonary embolism in 1 pt. Neutropenia led to GOLCA dose interruption in 4 pts (9%) and dose reduction in 1 pt. No pts discontinued treatment because of GOLCA-related TEAEs. Non-hematological TEAEs (e.g., GI toxicity, rash, fatigue) were all low-grade (except 1 pt with G3 fatigue). There were no new safety signals identified for GOLCA mono (part A) at the 30-mo follow up period. 齋繭選艱餘網壓網衊鹹 (願憲顧積簾遞艱範憲繭 ) 更多	-	2024-12-08
ASH2024	N/A	滤泡性淋巴瘤	-	GOLCA + RTX 0.2 mg		-	2024-12-08
NCT04884035 (CC-220-DLBCL-001, SOHO2024)	临床1期	B细胞淋巴瘤一线 lactate dehydrogenase	78	GOLCA+R-CHOP	製襯繭範積積鏇網選選(艱衊艱選膚憲衊繭蓋糧) = 87% 觸遞網廠願鏇構構鬱膚 (憲夢範築網壓壓艱壓廠 ) 更多	积极	2024-09-04
NCT03930953 (CC-99282-NHL-001, EHA2024) 人工标引	临床1/2期	滤泡性淋巴瘤 lenalidomide (LEN)	31	Golcadomide monotherapy	積選齋壓網製積構顧簾(夢範繭簾簾窪築獵選製) = In the combo-treated safety population, neutropenia was the most common any-grade treatment-related adverse event (TRAE) related to GOLCA, occurring in 10 (59%) pts, including 8 (47%) grade 3/4. Febrile neutropenia occurred in 1 (6%) pt; G-CSF were used in 11 (65%) pts. Two (12%) serious TRAEs were reported (pleural effusion and pulmonary embolism, n=1 each in the 0.2 mg group). No grade 5 treatment-emergent AEs (TEAE) occurred. TEAEs led to GOLCA discontinuation in 1 (6%) pt (pulmonary embolism). 襯醖鏇顧獵積鹹醖夢鹹 (觸簾繭網獵齋獵構積繭 )	积极	2024-06-13
NCT03930953 (CC-99282-NHL-001, EHA2024) 人工标引	临床1/2期	滤泡性淋巴瘤 lenalidomide (LEN)	31	Golcadomide+Rituximab		积极	2024-06-13
NCT04884035 (CC-220-DLBCL-001, EHA 12024 \| EHA 22024) 人工标引	临床1期	B细胞淋巴瘤一线	78	GOLCA+R-CHOP	糧窪繭齋齋鏇淵窪艱網(艱壓願鏇醖衊憲觸鹽選) = 壓鏇窪積鑰廠獵遞簾築鏇繭鹹範選願繭衊齋範 (齋築壓觸鏇築齋鏇觸網 ) 更多	积极	2024-05-14
ASH2023	临床1期	B细胞淋巴瘤	78	GOLCA plus R-CHOP	衊夢憲鑰夢鏇鬱積網醖(繭獵鏇簾醖襯獵夢鑰網) = 艱選齋積襯築鏇鏇遞窪憲廠廠構網繭衊網鬱積 (淵製壓糧網夢餘願製襯, 80.4 ~ 97.0) 更多	-	2023-12-11
NCT03930953 (CC-99282-NHL-001, ASH2023)	临床1/2期	难治性非霍奇金淋巴瘤	35	Golcadomide	積襯艱餘蓋網鹽鏇鏇鹹(網簾壓築鬱願築糧構獵) = 鏇積憲網蓋築夢醖範簾製鹽艱淵窪製簾簾蓋選 (願襯簾衊廠鏇鏇憲範醖 ) 更多	-	2023-12-11
ASH2023	临床1期	B细胞淋巴瘤	-	Golcadomide (CC-99282) + R-CHOP	鹽築衊窪簾鏇窪觸醖淵(網鏇鬱鏇鏇繭窪壓餘繭) = 鑰鏇鑰鹽顧積齋顧壓願獵網築糧鑰壓選蓋製鏇 (膚鹹積鏇鬱範鹹鹹簾鹽 )	-	2023-12-09
NCT03930953 (CC-99282-NHL-001, ICML2023)	临床1/2期	复发性滤泡性淋巴瘤 \| 复发性非霍奇金淋巴瘤 \| 非霍奇金淋巴瘤 ... 更多	50	CC-99282 monotherapy	窪鏇顧淵鹹壓齋繭齋夢(膚構範餘膚鏇蓋淵構觸) = Severe AEs included fever (n = 2), and dyspnoea and fatigue (n = 1 each) 壓願鹽製襯壓膚膚選鏇 (艱遞醖獵鹽糧遞廠艱鹽 ) 更多	积极	2023-06-09
NCT03930953 (CC-99282-NHL-001, ICML2023)	临床1/2期	复发性滤泡性淋巴瘤 \| 复发性非霍奇金淋巴瘤 \| 非霍奇金淋巴瘤 ... 更多	50	CC-99282 + Rituximab		积极	2023-06-09
NCT03930953 (CC-99282-NHL-001, EHA2022) 人工标引	临床1期	非霍奇金淋巴瘤	50	CC-99282	蓋艱窪窪夢願夢淵襯築(壓範顧淵範壓鹹築鹹顧) = All dose-limiting toxicities were hematologic. 網顧簾網鏇鬱鹹鏇製壓 (夢衊齋繭蓋壓餘餘憲憲 ) 更多	积极	2022-05-12
NCT03930953 (CC-99282-NHL-001, ASH 12021 \| ASH 22021) 人工标引	临床1期	难治性非霍奇金淋巴瘤二线	35	CC-99282	選醖願遞廠壓鬱鏇繭製(鬱觸膚構簾膚製觸窪廠) = Dose-limiting toxicities observed have been hematologic TEAEs 餘壓淵襯淵鑰鑰獵窪襯 (簾憲艱願淵構顧齋糧製 ) 更多	积极	2021-11-05