更新于：2024-12-09
Imidafenacin
咪达那新
更新于：2024-12-09
概要
基本信息
药物类型 小分子化药 |
别名 Imidafenacin (JAN/INN)、KRP 197、KRP-197 + [9] |
作用机制 M1 receptor拮抗剂(毒蕈碱型乙酰胆碱受体M1拮抗剂)、M3 receptor拮抗剂(毒蕈碱型乙酰胆碱受体M3拮抗剂) |
治疗领域 |
非在研适应症- |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 日本 (2007-04-18), |
最高研发阶段(中国)临床1期 |
特殊审评- |
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结构
分子式C20H21N3O |
InChIKeySQKXYSGRELMAAU-UHFFFAOYSA-N |
CAS号170105-16-5 |
关联
47
项与 咪达那新 相关的临床试验咪达那新片在中国健康受试者中的单中心、随机、开放、双周期、双交叉空腹及餐后状态下的生物等效性试验
A randomized, open-label, two-formulation, two-period, crossover study of the bioequivalence of a single oral dose of Imidafenacin tablets in fasted and fed healthy Chinese subjects
咪达那新片（0.1mg）在中国健康人群中空腹和餐后状态下单次给药的人体生物等效性临床试验
100 项与 咪达那新 相关的临床结果
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100 项与 咪达那新 相关的转化医学
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100 项与 咪达那新 相关的专利（医药）
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106
项与 咪达那新 相关的文献（医药）2024-04-19ACS chemical biology
Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES
Article
作者: Kim, Ki Hyun ; Kim, Chung Sub ; Kim, Jonghwan ; Lee, Seoung Rak ; Song, Jeongwon ; Lee, Gyu Sung ; Park, Sehwan ; Lee, Bum Soo ; Lee, Da Yeong
In the field of natural product research, the rediscovery of already-known compounds is one of the significant issues hindering new drug development. Recently, an innovative approach called bioactivity-HiTES has been developed to overcome this limitation, and several new bioactive metabolites have been successfully characterized by this method. In this study, we applied bioactivity-HiTES to Corynebacterium matruchotii, the human oral bacterium, with 3120 clinical drugs as potential elicitors. As a result, we identified two cryptic metabolites, methylindole-3-acetate (MIAA) and indole-3-acetic acid (IAA), elicited by imidafenacin, a urinary antispasmodic drug approved by the Japanese Pharmaceuticals and Medical Devices Agency (PMDA). MIAA showed weak antibacterial activity against a pulmonary disease-causing Mycobacterium conceptionense with an IC50 value of 185.7 μM. Unexpectedly, we also found that C. matruchotii metabolized fludarabine phosphate, a USFDA-approved anticancer drug, to 2-fluoroadenine which displayed moderate antibacterial activity against both Bacillus subtilis and Escherichia coli, with IC50 values of 8.9 and 20.1 μM, respectively. Finally, acelarin, a prodrug of the anticancer drug gemcitabine, was found to exhibit unreported antibacterial activity against B. subtilis with an IC50 value of 33.6 μM through the bioactivity-HiTES method as well. These results indicate that bioactivity-HiTES can also be applied to discover biotransformed products in addition to finding cryptic metabolites in microbes.
2024-01-01Investigative and Clinical Urology
Efficacy and safety evaluation of imidafenacin administered twice daily for continency recovery following radical prostatectomy in prostate cancer patients: Prospective open-label case-controlled randomized trial
Article
作者: Kim, Soodong ; Goh, Hyeok Jun ; Lee, Kwang Min ; Lee, Jun Hee ; Choi, Dong Won ; Lee, Kisoo
PURPOSE:
This study aims to prospectively analyze the effects of anticholinergic therapy using imidafenacin on detrusor overactivity occurring after robot-assisted radical prostatectomy (RARP).
MATERIALS AND METHODS:
Patients were followed-up at outpatient visits 2-4 weeks post-surgery (visit 2) to confirm the presence of urinary incontinence. Those confirmed with urinary incontinence were randomly assigned in a 1:1 ratio to the anticholinergic medication group (imidafenacin 0.1 mg twice daily) or the control group. Patients were followed-up at 1, 3, and 6 months post-surgery for observational assessments, including the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS).
RESULTS:
A total of 49 patients (25 in the treatment group and 24 in the control group) were randomized for the study. There were no differences observed between the groups in terms of age, comorbidities, prostate size, or pathological staging. According to the IPSS questionnaire results, there was no statistically significant difference between the medication and control groups (p=0.161). However, when comparing storage and voiding symptoms separately, there was a statistically significant improvement in storage symptom scores (p=0.012). OABSS also revealed statistically significant improvement in symptoms from 3 months post-surgery (p=0.005), which persisted until 6 months post-surgery (IPSS storage: p=0.023, OABSS: p=0.013).
CONCLUSIONS:
In the case of urinary incontinence that occurs after RARP, even if the function of the intrinsic sphincter is sufficiently preserved, if urinary incontinence persists due to changes in the bladder, pharmacological therapy using imidafenacin can be beneficial in managing urinary incontinence.
2023-05-01Lower urinary tract symptoms
Efficacy and safety of vibegron compared with mirabegron for overactive bladder: A systematic review and network meta‐analysis
Review
作者: He, Wenjuan ; Zhang, Yuqian ; Sun, Qian ; Liu, Xiuju ; Huang, Guangliang ; Tian, Yunfei
Abstract:
Objectives:
The aim of this study was to indirectly compare the efficacy and safety of mirabegron and vibegron in patients with overactive bladder.
Methods:
A systematic search was performed on Pubmed, Web of Science, Embase, and the Cochrane Central Register of Controlled Trials databases to identify studies from the date of database inception to January 1, 2022. All randomized controlled trials comparing mirabegron or vibegron with tolterodine, imidafenacin, or placebo were eligible. One reviewer extracted data, and a second reviewer checked. Included trials were assessed for similarity, and networks were developed using Stata 16.0 software. Mean differences for continuous variables and odds ratios for dichotomous variables together with their 95% confidence intervals (CIs) were used to rank treatments and compare the differences, respectively.
Results:
A total of 11 randomized controlled trials and 10 806 patients were included. For each outcome, results for all licensed treatment doses were included. Both vibegron and mirabegron were more efficacious than placebo at reducing the frequency of micturition, incontinence, urgency, urgency incontinence, and nocturia. Vibegron was more efficacious than mirabegron in reducing mean voided volume/micturition (95% CI [5.15, 14.98]). Safety outcomes for vibegron and mirabegron were similar to those in the placebo group, except for mirabegron, which had a higher risk of nasopharyngitis and cardiovascular adverse events than placebo.
Conclusions:
Both drugs seem to be comparable and well tolerated, particularly as direct comparisons are not available. However, vibegron may be more effective than mirabegron in reducing mean voided volume.
1
项与 咪达那新 相关的新闻（医药）2024-01-15
·信狐药迅
100 项与 咪达那新 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 膀胱过度活动症 | 日本 | 2007-04-18 | |
| 膀胱过度活动症 | 日本 | 2007-04-18 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 尿频 | 申请上市 | 俄罗斯 | 2022-01-30 | |
| 急迫性尿失禁 | 临床1期 | 中国 | 2015-06-17 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | 300 | 範鹽鹽選壓顧淵築積製(遞廠鹹構襯觸範網廠衊) = 鬱鹽築選範窪蓋構醖窪 顧夢願願壓鬱觸觸繭積 (築廠觸繭範膚鏇鏇顧膚, 2.2) 更多 | 非劣 | 2019-06-01 | |||
範鹽鹽選壓顧淵築積製(遞廠鹹構襯觸範網廠衊) = 醖壓鏇願簾築蓋鬱簾範 顧夢願願壓鬱觸觸繭積 (築廠觸繭範膚鏇鏇顧膚, 1.8) 更多 | |||||||
临床3期 | 300 | (Uritos®) | 餘艱顧鑰膚築窪憲構衊(壓夢鏇鏇範範網觸鏇鹽) = 艱築窪廠齋鹹範窪膚觸 範簾廠顧憲淵築鹽構鑰 (艱窪夢顧膚齋鹽淵憲觸, 選鬱艱鏇夢鑰膚鑰繭繭 ~ 衊鏇壓觸獵觸範鏇衊顧) 更多 | - | 2019-05-21 | ||
(Urotol®) | 餘艱顧鑰膚築窪憲構衊(壓夢鏇鏇範範網觸鏇鹽) = 獵廠廠衊襯鬱願築壓觸 範簾廠顧憲淵築鹽構鑰 (艱窪夢顧膚齋鹽淵憲觸, 範蓋積蓋選網鹽襯齋簾 ~ 觸鬱憲製繭繭願憲淵顧) 更多 | ||||||
临床4期 | 649 | (Mirabegron + Solifenacin) | 顧艱齋餘鹽廠觸顧製糧(構築網網遞糧壓鏇遞醖) = 夢鹽淵願醖襯積獵鑰願 選繭築膚鑰遞襯積鑰築 (網觸願積範積繭淵遞鑰, 艱衊鏇淵糧襯範築網餘 ~ 齋憲淵齋蓋顧窪憲觸鹹) 更多 | - | 2018-12-24 | ||
(Mirabegron + Propiverine) | 顧艱齋餘鹽廠觸顧製糧(構築網網遞糧壓鏇遞醖) = 衊壓糧鹽鑰鹽顧窪淵餘 選繭築膚鑰遞襯積鑰築 (網觸願積範積繭淵遞鑰, 蓋蓋鹽醖願網簾築膚衊 ~ 範製醖構蓋築鹹襯膚廠) 更多 | ||||||
N/A | 308 | 遞夢窪範憲糧積願製簾(襯鹽夢艱範築壓觸製獵) = 遞襯衊遞蓋觸觸壓選鬱 鑰鏇選憲壓餘積鹹醖艱 (憲積糧憲蓋範顧艱簾獵, 1.47 ~ 2.74) 更多 | 积极 | 2013-10-01 |
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