地塞米松/聚维酮碘(Dexamethasone/Povidone Iodine) - 药物靶点：GR_在研适应症：结膜炎_专利_临床

概要

基本信息

药物类型

小分子化药

别名

PVP-I/dexamethasone、Povidone iodine/dexamethasone

+ [2]

靶点

GR

作用方式

激动剂

作用机制

GR激动剂(糖皮质激素受体激动剂)

治疗领域

眼部疾病

在研适应症

结膜炎

非在研适应症

腺病毒性结膜炎腺病毒科感染细菌性结膜炎+ [1]

原研机构

CLS Pharma SAS

在研机构

CLS Pharma SAS

非在研机构

Shire Plc

权益机构

Shire Pharmaceuticals LLC

Foresight Biotherapeutics, Inc.

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C6H9I2NO

InChIKeyCPKVUHPKYQGHMW-UHFFFAOYSA-N

CAS号25655-41-8

关联

8

项与地塞米松/聚维酮碘相关的临床试验

CTRI/2019/04/018758

/ Terminated临床3期

A Phase 3, Multi-center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of SHP640 (PVP-Iodine 0.6% and Dexamethasone 0.1%) Ophthalmic Suspension Compared to Placebo in the Treatment of Adenoviral Conjunctivitis

开始日期2019-04-30

申办/合作机构

Shire Human Genetic Therapies, Inc.

[+1]

NCT03004924

/ Completed临床3期

A Phase 3, Multi-center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of SHP640 (PVP-Iodine 0.6% and Dexamethasone 0.1%) Ophthalmic Suspension Compared to Placebo in the Treatment of Bacterial Conjunctivitis

The purpose of this study is to determine if an investigational treatment is effective compared with placebo and PVP-Iodine in the treatment of adults and children with bacterial conjunctivitis.

开始日期2017-03-29

申办/合作机构

Shire Plc

NCT02998554

/ Terminated临床3期

A Phase 3, Multi-center, Randomized, Double-Masked Study to Evaluate the Clinical Efficacy and Safety of SHP640 (PVP-Iodine 0.6% and Dexamethasone 0.1%) Ophthalmic Suspension Compared to Placebo in the Treatment of Adenoviral Conjunctivitis

The purpose of this study is to determine if an investigational treatment is effective compared with placebo in the treatment of adults and children with adenoviral conjunctivitis.

开始日期2017-03-28

申办/合作机构

Shire Plc

100 项与地塞米松/聚维酮碘相关的临床结果

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100 项与地塞米松/聚维酮碘相关的转化医学

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100 项与地塞米松/聚维酮碘相关的专利（医药）

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1

项与地塞米松/聚维酮碘相关的文献（医药）

2011-01-21·Investigative Opthalmology & Visual Science2区 · 医学

Clinical and Antiviral Efficacy of an Ophthalmic Formulation of Dexamethasone Povidone-Iodine in a Rabbit Model of Adenoviral Keratoconjunctivitis

2区 · 医学

ArticleOA

作者: Bhattacharjee, Partha S. ; Liang, Bo ; Capriotti, Joseph A. ; Clement, Christian ; Foster, Timothy P. ; Hill, James M. ; Hobden, Jeffery A. ; Thompson, Hilary W. ; Mahmud, Rashed ; Kumar, Manish

PURPOSETo determine the efficacy of a new formulation of topical dexamethasone 0.1%/povidone-iodine 0.4% (FST-100) in reducing clinical symptoms and infectious viral titers in a rabbit model of adenoviral keratoconjunctivitis.METHODSRabbit corneas were inoculated bilaterally with 2×10(6) plaque-forming-units (PFU) of adenovirus type 5 (Ad5) after corneal scarification. Animals were randomized 1:1:1:1 (five rabbits per group) to FST-100, 0.5% cidofovir, tobramycin/dexamethasone (Tobradex; Alcon Laboratories, Fort Worth, TX) ophthalmic suspension, and balanced salt solution (BSS; Alcon Laboratories). Treatment began 12 hours after viral inoculation and continued for 7 consecutive days. The eyes were clinically scored daily for scleral inflammation (injection), ocular neovascularization, eyelid inflammation (redness), friability of vasculature, inflammatory discharge (pus), and epiphora (excessive tearing). Eye swabs were collected daily before treatment for the duration of the study. Virus was eluted from the swabs and PFU determined by titration on human A549 cells, according to standard procedures.RESULTSThe FST-100 treatment resulted in significantly lower clinical scores (P<0.05) than did the other treatments. The 0.5% cidofovir exhibited the most ocular toxicity compared with FST-100, tobramycin/dexamethasone, and balanced salt solution treatments. FST-100 and 0.5% cidofovir significantly (P<0.05) reduced viral titers compared with tobramycin/dexamethasone or balanced salt solution.CONCLUSIONSFST-100 was the most efficacious in minimizing the clinical symptoms of adenovirus infection in rabbit eyes. FST-100 and 0.5% cidofovir were both equally effective in reducing viral titers and decreasing the duration of viral shedding. By providing symptomatic relief in addition to reducing infectious virus titers, FST-100 should be a valuable addition to treatment of epidemic adenoviral keratoconjunctivitis.

100 项与地塞米松/聚维酮碘相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
结膜炎	临床3期	-	CLS Pharma SAS	-
腺病毒性结膜炎	药物发现	意大利	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	波兰	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	英国	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	以色列	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	匈牙利	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	西班牙	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	德国	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	爱沙尼亚	Shire Plc	2017-03-27
腺病毒性结膜炎	药物发现	秘鲁	Shire Plc	2017-03-27

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02998554 (CTgov)	临床3期	腺病毒性结膜炎	156	SHP640 (SHP640)	醖構網鹹鹽繭膚蓋繭網(遞蓋構選蓋網簾艱鹽觸) = 醖獵鬱窪願繭鏇襯齋艱積窪窪範窪觸窪齋蓋簾 (淵夢鹽願膚齋積繭廠艱, 壓鹽憲簾願鹹鏇積顧襯 ~ 積願淵夢鹹構襯鑰艱夢) 更多	-	2020-05-29
				Placebo (Placebo)	醖構網鹹鹽繭膚蓋繭網(遞蓋構選蓋網簾艱鹽觸) = 構艱製積鑰繭艱齋淵製積窪窪範窪觸窪齋蓋簾 (淵夢鹽願膚齋積繭廠艱, 鏇衊壓選膚簾遞積齋淵 ~ 艱簾積憲願蓋獵壓簾壓) 更多
NCT02998541 (CTgov)	临床3期	腺病毒性结膜炎	219	SHP640 (SHP640)	艱鏇鏇廠糧製夢夢網簾(簾獵顧構積繭夢憲願繭) = 窪築構糧願範蓋願構衊憲顧鏇糧築鹹網糧選積 (選艱膚窪夢築艱製遞憲, 積願夢製積憲廠襯觸蓋 ~ 餘選構積窪餘窪遞鹹鹽) 更多	-	2020-05-27
				PVP-I 0.6% (PVP-I 0.6%)	艱鏇鏇廠糧製夢夢網簾(簾獵顧構積繭夢憲願繭) = 願網夢鹹壓築繭選網齋憲顧鏇糧築鹹網糧選積 (選艱膚窪夢築艱製遞憲, 鑰繭餘襯遞夢衊蓋衊襯 ~ 築獵繭衊鏇夢糧膚廠憲) 更多
NCT03004924 (CTgov)	临床3期	细菌性结膜炎	753	SHP640 (SHP640)	齋淵衊窪壓鑰繭願窪艱(醖選蓋蓋鹽獵鹹願鹹網) = 襯膚構顧構齋鑰網選鹹遞鬱構鑰積築齋遞繭淵 (壓簾鏇糧膚鬱膚獵壓淵, 襯積淵築遞廠構鑰繭蓋 ~ 範築窪網簾繭醖鹽夢醖) 更多	-	2019-10-28
				PVP-I 0.6% (PVP-I 0.6%)	齋淵衊窪壓鑰繭願窪艱(醖選蓋蓋鹽獵鹹願鹹網) = 膚廠夢鬱壓鹽觸憲壓艱遞鬱構鑰積築齋遞繭淵 (壓簾鏇糧膚鬱膚獵壓淵, 衊構積繭窪獵鑰憲窪鏇 ~ 願壓廠築襯廠網鏇構齋) 更多