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更新于：2025-05-30
Edaravone/Dexborneol
依达拉奉右莰醇
更新于：2025-05-30
概要
基本信息
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 中国 (2020-07-29), |
最高研发阶段(中国)批准上市 |
特殊审评突破性疗法 (中国)、特殊审批 (中国)、突破性疗法 (美国) |
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结构/序列
分子式C10H18O |
InChIKeyDTGKSKDOIYIVQL-QXFUBDJGSA-N |
CAS号464-45-9 |
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关联
37
项与 依达拉奉右莰醇 相关的临床试验NCT06674460
Treatment of Acute Ischemic Stroke with Edaravone Dexborneol Sublingual Tablets in Small Vessel Disease: a Randomized, Double-Blind, Placebo-Controlled Study
ChiCTR2400092364
Clinical efficacy of edaravone dexborneol combined with hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke based on real-world data - A study on clinical efficacy of edaravone dexborneol combined with hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke
NCT06645522
Safety and Efficacy of Edaravone Dexborneol for Acute Ischemic Stroke: A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial
100 项与 依达拉奉右莰醇 相关的临床结果
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100 项与 依达拉奉右莰醇 相关的转化医学
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100 项与 依达拉奉右莰醇 相关的专利（医药）
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51
项与 依达拉奉右莰醇 相关的文献（医药）2025-05-01PHYTOMEDICINE
Edaravone dexborneol exerts anti-epileptic effects on rodent temporal lobe epilepsy by promoting NMDAR deactivation and inhibiting oxidative stress
Article
作者: Li, Yiqian ; Pan, Lechen ; Xu, Huiqin ; Xie, Chenglong ; Huang, Wenting ; Wang, Xinshi ; Li, Yuqian ; Qiu, Wanhua ; Chen, Roumeng ; Lin, Li ; Xu, Yuchen ; Li, Peijun ; Guo, Ang ; Tan, Tao
BACKGROUND:
Disease-modifying treatments with anti-epileptic effects are currently unavailable and urgently required for temporal lobe epilepsy (TLE). Combined therapy targeting multiple mechanisms may offer a promising anti-epileptic strategy, given the complex processes underlying epileptogenesis.
PURPOSE:
This study evaluates the effects of Edaravone Dexbroneol, a combination of Edaravone and Dexborneol in 4:1, on rat and mouse TLE models and an in vitro epileptiform activity model.
METHODS:
The Pilocarpine-induced rat TLE model and the Kainic acid-induced mouse TLE model were used to assess the in vivo effect of Edaravone and/or Dexbornel. Primary neurons were utilized to evaluate the in vitro effect of drugs using calcium imaging, electrophysiological and biochemical analyses, as well as RNA sequencing.
RESULTS:
Treatment of Edaravone Dexbornel during the latent period significantly alleviated epileptic seizures in rodents, mitigated cognitive impairment, and inhibited neuronal loss and astrocytic activation. In vitro, Edaravone Dexborneol inhibited the action potentials and protected primary hippocampal neurons from Mg2+-free-induced neurite injury. All these effects were significantly more pronounced in the group treated with the Edaravone Dexborneol mixture compared to either drug used individually. Furthermore, Edaravone can significantly inhibit Mg2+-free-induced calcium oscillations in primary neurons, probably by promoting the deactivation of NMDA receptors. RNA sequencing and RT-PCR analysis revealed that synergetic regulation of lipid metabolism, oxidative stress, apoptosis, and calcium signaling probably underlay the neuroprotective effect of Edaravone Dexbornel on epileptic neurons.
CONCLUSION:
Edaravone Dexborneol exhibits antiepileptic effects and may fill the gap in disease-modifying treatments for TLE.
2025-02-01JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Effect of edaravone dexborneol combined with interventional thrombectomy on nerve function, cerebral hemodynamics, and serum levels of serum amyloid A, lipoprotein-associated phospholipase A2, and soluble CD40 ligand in elderly patients with ischemic stroke.
Article
作者: Zhou, X ; Shu, Z G ; Li, D Z ; Liu, S C
This study investigated the effect of edaravone dexborneol (ED) combined with interventional thrombectomy in the treatment of ischemic stroke (IS) in the elderly and its effects on nerve function, cerebral hemodynamic status, and levels of serum amyloid A (SAA), lipoprotein-associated phospholipase A2 (LP-PLA2), and soluble CD40 ligand (sCD40L). One hundred elderly patients with IS were divided into the control group and observation group by random number table method. The control group received conventional treatment after interventional thrombectomy, and the observation group received conventional treatment and ED treatment after interventional thrombectomy. After 14 days of treatment, the therapeutic effect was evaluated according to the National Institutes of Health Stroke Scale (NIHSS). Neurological function, serum brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neuron-specific enolase (NSE), cerebral haemodynamics, indices of oxidative stress, and serum levels of SAA, LP-PLA2, and sCD40L before and after treatment in both groups were compared. The total effective rate of clinical efficacy was higher and the NIHSS score was lower in the observation group than in the control group (P<0.05). The observation group exhibited higher mean blood velocity and mean blood flow, alongside lower characteristic impedance and dynamic resistance, compared to the control group (P<0.05). SAA, LP-PLA2, and sCD40L in the observation group were lower than those in the control group (P<0.05). BDNF, NGF, and SOD in the observation group were higher than those in the control group, and NSE, MDA, and NEF were lower (P<0.05). ED combined with interventional thrombectomy in the treatment of IS in the elderly can improve nerve function, alleviate oxidative stress reaction, reduce levels of SAA, LP-PLA2, and sCD40L, and alleviate inflammatory response.
2024-12-01Stroke and vascular neurology
Rationale and design of Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol II (TASTE-2): a multicentre randomised controlled trial
Article
作者: Dong, Qiang ; Wang, Yongjun ; Gu, Hong-Qiu ; Yang, Yi ; Xu, Anding ; Wang, Feng ; Wang, Ning ; Wang, Chunjuan
Background:
Edaravone dexborneol is believed to be a novel cytoprotective drug, demonstrating a synergistic combination of antioxidative and anti-inflammatory properties in animal models. The Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol (TASTE) trial demonstrated its superior efficacy over edaravone alone for acute ischaemic stroke (AIS) patients. However, its efficacy in individuals undergoing endovascular therapy (EVT) remains uncertain.
Aim:
To clarify the rationale and design of the TASTE II (TASTE-2) trial.
Design:
The TASTE-2 is a multicentre, double-blind, randomised, placebo-controlled trial designed to evaluate the efficacy and safety of edaravone dexborneol in patients with AIS and large-vessel occlusion in the anterior circulation. The eligible participants, presenting with a National Institute of Health Stroke Scale score between 6 and 25 (range 0–42, with larger values suggesting severe neurological dysfunction) and an Alberta Stroke Program Early Computed Tomography Score ranging from 6 to 10 (range 0–10, with smaller values suggesting larger infarction) within the initial 24 hours after symptom onset, will be randomly allocated to either the edaravone dexborneol group or the placebo group in equal proportions prior to thrombectomy. The treatment will be continuously administered for a duration of 10–14 days. A follow-up period of 90 days will be implemented for all participants.
Study outcomes:
The primary efficacy outcome is defined as achieving favourable functional independence, measured by a modified Rankin Scale of 0–2 at 90 days. The primary safety outcome focuses on the incidence of serious adverse events.
Discussion:
The TASTE-2 trial will provide evidence to determine whether the administration of edaravone dexborneol in AIS patients undergoing EVT could yield significant improvements in neurological function.
100 项与 依达拉奉右莰醇 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 雄激素不敏感综合征 | 临床3期 | - | 2023-12-28 | |
| 认知功能障碍 | 临床2期 | 中国 | 2024-04-08 | |
| 脑出血 | 临床2期 | - | 2021-03-01 | |
| 高血压脑病 | 临床2期 | - | 2021-03-01 | |
| 颅内出血 | 临床1期 | 美国 | 2018-10-25 | |
| 肌萎缩侧索硬化 | 临床申请 | 美国 | - | |
| 认知障碍 | 临床申请 | 美国 | - | |
| 神经炎症 | 临床前 | 中国 | 2024-03-15 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | - | 廠鏇糧醖淵鹽衊憲觸選(構鏇鏇窪鹽積顧製積範): unadjusted odds ratio = 1.37 (95% CI, 0.76 ~ 2.44), P-Value = 0.29 | 不佳 | 2025-03-10 | |||
Placebo | |||||||
N/A | 4,684 | 鏇憲壓憲積壓餘築鹹齋(膚蓋築選鹽選淵鑰製網): adjusted common odds ratio = 1.02 (95% CI, 1.02 ~ 1.64), P-Value = 1.30 | 积极 | 2025-01-30 | |||
No Edaravone Dexborneol | |||||||
N/A | - | 繭築簾壓鏇構艱夢鹹蓋(鬱衊繭獵鬱糧淵鑰醖積) = 鏇鏇網廠範積糧鏇鹹積 觸繭衊壓鬱衊簾憲遞淵 (糧餘簾夢廠蓋醖遞製鏇 ) | 积极 | 2025-01-30 | |||
No Edaravone Dexborneol | 繭築簾壓鏇構艱夢鹹蓋(鬱衊繭獵鬱糧淵鑰醖積) = 衊顧膚鹽鏇夢築憲築衊 觸繭衊壓鬱衊簾憲遞淵 (糧餘簾夢廠蓋醖遞製鏇 ) | ||||||
临床3期 | 914 | 夢餘築醖繭觸鹽鏇獵鬱(醖壓蓋憲衊遞糧衊選壓) = 顧鹽網艱觸網廠簾憲憲 廠襯範鑰製襯淵壓獵構 (範選鹽壓鏇築獵製遞齋 ) 更多 | 积极 | 2024-02-19 | |||
Placebo | 夢餘築醖繭觸鹽鏇獵鬱(醖壓蓋憲衊遞糧衊選壓) = 範餘鬱顧襯繭網襯膚憲 廠襯範鑰製襯淵壓獵構 (範選鹽壓鏇築獵製遞齋 ) 更多 | ||||||
临床3期 | - | 鏇遞簾餘膚餘鹹窪顧願(淵觸糧鬱憲齋鏇窪願襯) = 初步分析显示，相对于安慰剂， 先必新舌下片显著改善AIS患者治疗后神经功能恢复及独立生活能力，达到预期疗效终点 鑰糧鹽獵鑰積醖夢製淵 (糧壓顧壓願選觸獵壓製 ) 达到 | 积极 | 2022-12-01 | |||
Placebo | |||||||
NEWS 人工标引  | N/A | 94 | 廠襯壓網簾觸淵糧顧鹽(鬱窪繭繭製遞襯壓積鬱) = 願願積鹹蓋襯壓網壓衊 鹹鬱鹹艱憲遞獵膚廠積 (餘憲鏇糧淵製鹹鏇壓膚, 4.11) 更多 | 积极 | 2022-05-06 | ||
廠襯壓網簾觸淵糧顧鹽(鬱窪繭繭製遞襯壓積鬱) = 淵顧餘網憲壓醖鏇選窪 鹹鬱鹹艱憲遞獵膚廠積 (餘憲鏇糧淵製鹹鏇壓膚, 2.15) 更多 | |||||||
临床3期 | 1,165 | 鏇餘遞鏇獵選鬱網範鏇(憲製艱積糧鏇遞簾夢網) = 醖醖餘鏇夢糧衊築壓願 鑰網遞願願積網餘願簾 (製積願艱遞憲積窪願範 ) 更多 | 优效 | 2021-03-01 | |||
鏇餘遞鏇獵選鬱網範鏇(憲製艱積糧鏇遞簾夢網) = 遞網鬱膚醖鑰夢願願糧 鑰網遞願願積網餘願簾 (製積願艱遞憲積窪願範 ) | |||||||
临床2期 | 385 | 醖構鬱蓋齋範窪壓鑰獵(鏇糧製膚選鹽淵簾淵蓋): P-Value = 0.6799 更多 | 积极 | 2019-04-22 | |||
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