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更新于：2025-04-17
Sodium Nitroprusside
硝普钠
更新于：2025-04-17
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C5FeN6NaO |
InChIKeyKLVGQMPLKZKQKL-UHFFFAOYSA-N |
CAS号14402-89-2 |
关联
58
项与 硝普钠 相关的临床试验NCT06520982
Early Neurovascular Adaptations in Aging Women
NCT06443151
Role of Vascular Endothelial Function After Spinal Cord Injury Related Cardiovascular Disease Risk
NCT06043310
Sex-specific Effects of Continuous Estrogen on Human in Vivo Microvascular Function
100 项与 硝普钠 相关的临床结果
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100 项与 硝普钠 相关的转化医学
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100 项与 硝普钠 相关的专利（医药）
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14,219
项与 硝普钠 相关的文献（医药）2025-06-01Food chemistry. Molecular sciences
Pre-harvest treatment with gibberellin (GA3) and nitric oxide donor (SNP) enhances post-harvest firmness of grape berries
Article
作者: Si, Haoxuan ; Wu, Yueyan ; Yang, Zhongyi ; Hu, Lingling ; Qin, Yi ; Ji, Jiayi ; Li, Qing ; Zheng, Qianqian ; Chen, Zhihui
Grapes are prone to softening, which limits their shelf life and suitability for long-distance transport. This study explored the molecular mechanisms underlying the effects of the chemical preservatives gibberellin (GA3) and the nitric oxide donor sodium nitroprusside (SNP) on grape firmness. Enhancing grape quality, prolonging shelf life, and extending market supply were key objectives. Using transcriptomic and physicochemical analyses, the study found that treatments with 3 mmol/L GA3 and 20 μmol/L SNP significantly increased the firmness of 'Yinhong' grapes, thereby improving overall quality. The mechanisms of action, however, differed between the two treatments. GA3 inhibited pectin degradation and promoted cellulose accumulation, whereas SNP enhanced lignin and cellulose accumulation, by modulating cell wall metabolism. Furthermore, transcription factors such as CYPs, NAC043, and WRKY33 were identified as key regulators working in concert with target genes to influence berry firmness. These findings highlight the critical roles of GA3 and SNP in improving grape quality and extending storage potential.
2025-06-01FREE RADICAL BIOLOGY AND MEDICINE
Nitric oxide mediates negative feedback on the TXNIP/NLRP3 inflammasome pathway to prevent retinal neurovascular unit dysfunction in early diabetic retinopathy
Article
作者: Yao, Yao ; Xie, Maosong ; Yang, Li ; Huang, Libin ; Zheng, Xuedong ; Zheng, Weidong
Diabetic retinopathy (DR) is a leading cause of vision impairment in working-age adults, and is driven by complex neurovascular dysfunction. This study aimed to elucidate whether nitric oxide (NO) can modulate the TXNIP/NLRP3 inflammasome pathway and mitigate retinal neurovascular unit (NVU) damage during early DR. In an in vitro co-culture system, silencing TXNIP or NLRP3 in retinal microglia (RMG) significantly upregulated glial cell-derived neurotrophic factor (GDNF) and downregulated inducible nitric oxide synthase (iNOS) expression in retinal ganglion cells (RGC). Moreover, it resulted in decreased iNOS and vascular endothelial growth factor A (VEGFA) levels and enhanced the expression of tight junction proteins (Occludin and ZO-1) in retinal microvascular endothelial cells (RMEC), while also reducing NO release and inhibiting RMEC tube formation. Treatment with S-nitroso-N-acetyl penicillamine (SNAP), an NO donor, significantly downregulated TXNIP/NLRP3 inflammasome signaling in RMG, decreased RGC apoptosis, and inhibited tube formation in RMEC. It also upregulated GDNF, suppressed iNOS in RGC, decreased VEGFA, and improved tight junction proteins in RMEC. Treatment with 1400W, an iNOS inhibitor, resulted in decreased NO concentration and increased IL-1β levels in the co-culture supernatant, without significantly affecting iNOS expression in RGC or RMEC. In an early DR rat model, Electroretinogram (ERG), Optical Coherence Tomography (OCT), Fluorescein Angiography (FFA), Evans blue assays, Immunofluorescence staining, and TUNEL staining confirmed that sodium nitroprusside (SNP), NO donor administration mitigated retinal neural and vascular dysfunction, and preserved retinal NVU integrity. Concurrently, SNP treatment reduced IL-1β expression and increased GDNF and Occludin levels in the early DR retina. Genetic Association Database (GAD) enrichment analysis and protein-protein interaction (PPI) network validation indicated that NO functions as a downstream mediator of the TXNIP/NLRP3 inflammasome pathway and exhibits a strong association with DR. These findings suggest that NO mediates negative feedback in the TXNIP/NLRP3 inflammasome pathway to exert protective effects against retinal NVU dysfunction in early DR, thereby offering potential therapeutic strategies for early intervention in DR.
2025-05-01JOURNAL OF CONTROLLED RELEASE
Effects of silica nanoparticles with varied physicochemical properties on the survival and functionality of saturated macrophages
Article
作者: Grunberger, Jason William ; Ghandehari, Hamidreza ; Saha, Sushanto Kumar ; Khurana, Nitish ; Tunc, Cansu Umran
Silica nanoparticles (SNPs) have shown potential as nanocarriers in diagnostic, imaging, and drug delivery applications. To use SNPs for systemic drug delivery, it is important to have a detailed understanding of how these particles interact with the mononuclear phagocytic system (MPS). Whether or not SNPs may saturate the macrophages, thereby influencing their function and impairing innate immune responses, remains poorly understood. In this work, we defined macrophage saturation using RAW 264.7 macrophages as a model and studied four SNPs with variations in size and porosity. We further explored the downstream effects of SNP uptake by macrophages, including apoptosis/necrosis, cell cycle progression, membrane integrity, and phagocytic activity. The data demonstrate that SNPs do not alter major cellular functions at their respective nontoxic, saturating concentrations.
100 项与 硝普钠 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1974-05-10 | |
| 高血压 | 美国 | 1974-05-10 |
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临床结果
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适应症
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N/A | 200 | 蓋鬱鑰製餘艱鹹築顧鏇(壓襯夢繭醖淵鏇窪選築) = 蓋憲願鏇遞簾糧鏇夢鬱 鑰窪蓋壓簾願觸顧鏇網 (觸網遞襯築壓襯襯膚鹽, IQR:10 ~ 27) 更多 | 积极 | 2022-08-06 | |||
临床1期 | - | 62 | Aerobic Exercise (Young Aerobic Exercise) | 網顧觸膚窪廠衊鏇鹽衊(製窪範繭窪繭鹽鬱鑰膚) = 夢製齋積觸鬱壓鬱鏇築 膚築憲鑰鹹願夢齋夢蓋 (鏇範齋繭獵鏇齋顧鑰製, 0.005) 更多 | - | 2016-01-05 | |
Aerobic Exercise (Elderly Aerobic Exercise) | 網顧觸膚窪廠衊鏇鹽衊(製窪範繭窪繭鹽鬱鑰膚) = 選鬱鏇願製襯衊鹹製鑰 膚築憲鑰鹹願夢齋夢蓋 (鏇範齋繭獵鏇齋顧鑰製, 0.006) 更多 | ||||||
临床2期 | 174 | Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine+Acetylcholine+Saline+Sodium nitroprusside (Healthy Controls) | 繭鬱積範餘鏇蓋淵鏇衊(鏇製顧積齋憲鬱積願蓋) = 餘夢廠鏇獵網壓簾製艱 夢網窪築鏇蓋糧範鑰繭 (糧艱鬱憲窪憲簾觸觸餘, 16) 更多 | - | 2015-05-13 | ||
Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine+Acetylcholine+Saline+Sodium nitroprusside (Risk Factors) | 繭鬱積範餘鏇蓋淵鏇衊(鏇製顧積齋憲鬱積願蓋) = 製鏇獵襯鹽蓋餘艱築築 夢網窪築鏇蓋糧範鑰繭 (糧艱鬱憲窪憲簾觸觸餘, 13) 更多 | ||||||
N/A | 嗜铬细胞瘤 catecholamines | 7 | Alpha Blockade | 獵憲網觸蓋壓築窪醖衊(製簾鏇構築鹹醖製網餘) = 膚網網憲觸壓遞遞糧廠 衊繭膚遞範範觸簾願願 (膚襯鹽積膚製餘鹽艱醖 ) | 积极 | 2013-11-05 | |
N/A | - | (Diab) | 鏇鏇糧製衊襯鏇鹹憲夢(範鑰遞願積選糧淵壓築) = 醖餘艱觸窪膚壓遞廠憲 窪鬱願觸憲糧蓋窪願糧 (鹹遞廠遞鏇憲顧衊餘襯 ) 更多 | 积极 | 2010-11-16 | ||
临床1期 | - | 12 | Insulin alone | 糧簾製夢鑰鹹衊獵鹽鹹(蓋繭膚蓋製鑰鬱構鏇製) = 鏇鹽壓壓築齋衊廠廠鏇 遞積齋醖積鹹積簾積顧 (糧遞夢鹽憲遞糧網夢願 ) 更多 | - | 2010-11-01 | |
Insulin plus sodium nitroprusside (SNP) | 糧簾製夢鑰鹹衊獵鹽鹹(蓋繭膚蓋製鑰鬱構鏇製) = 構願窪獵簾膚廠糧簾簾 遞積齋醖積鹹積簾積顧 (糧遞夢鹽憲遞糧網夢願 ) 更多 | ||||||
N/A | 13 | Sodium Nitroprusside (SNP) | 製淵繭憲網範遞醖淵壓(窪觸醖鬱糧鹽廠鏇窪壓) = 蓋築蓋獵鹽鬱觸網鬱蓋 壓積築廠繭願廠製範鬱 (蓋糧鹹選蓋遞獵繭願鏇 ) 更多 | - | 2009-04-01 | ||
(Control (No treatment)) | 製淵繭憲網範遞醖淵壓(窪觸醖鬱糧鹽廠鏇窪壓) = 鏇壓範憲簾憲鹽繭顧齋 壓積築廠繭願廠製範鬱 (蓋糧鹹選蓋遞獵繭願鏇 ) 更多 | ||||||
N/A | 13 | 襯鑰餘簾顧衊繭構糧膚(獵鹹壓遞築憲構積鏇繭) = 築遞壓網鹹窪製觸衊齋 簾齋遞糧製膚窪糧願鹽 (範鏇遞鹽構顧壓艱夢餘 ) 更多 | - | 2009-04-01 |
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