更新于：2024-11-04
Sodium Nitroprusside
硝普钠
更新于：2024-11-04
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C5FeN6NaO |
InChIKeyKLVGQMPLKZKQKL-UHFFFAOYSA-N |
CAS号14402-89-2 |
关联
54
项与 硝普钠 相关的临床试验Role of Vascular Endothelial Function After Spinal Cord Injury Related Cardiovascular Disease Risk
Sex-specific Effects of Continuous Estrogen on Human in Vivo Microvascular Function
Dose response of afterload reduction with sodium nitroprusside on left ventricular filling pressure under veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support in adults
100 项与 硝普钠 相关的临床结果
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100 项与 硝普钠 相关的转化医学
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100 项与 硝普钠 相关的专利（医药）
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13,095
项与 硝普钠 相关的文献（医药）2024-12-01MOLECULAR BIOLOGY REPORTS
Increasing the radiation-induced cytotoxicity by silver nanoparticles and docetaxel in prostate cancer cells
Article
作者: Behrouzkia, Zhaleh ; Hassanzadeh Dizaj, Mohsen ; Zohdi Aghdam, Reza ; Mohammadian, Mahshid ; Hatami Zharabad, Shokrieh
BACKGROUND:
Radiation therapy is utilized for treatment of localized prostate cancer. Nevertheless, cancerous cells frequently develop radiation resistance. While higher radiation doses have not always been effective, radiosensitizers have been extensively studied for their ability to enhance the cytotoxic effects of radiation. So, this study aims to evaluate the possible radiosensitization effects of docetaxel (DTX) and silver nanoparticles (SNP) in LNCaP cells.
METHODS:
The cytotoxic effects of DTX, SNP and 2 Gy of X-Ray radiation treatments were assessed in human LNCaP cell line using the MTT test after 24 h. Moreover, the effects of DTX, SNP and radiation on Epidermal growth factor (EGF), Caspase 3, inducible nitric oxide synthase and E-cadherin gene expression were analyzed using the Real-time PCR method. The level of Hydrogen peroxide (H2O2), an oxidative stress marker, was also detected 24 h after various single and combined treatments.
RESULTS:
The combinations of SNP (in low toxic concentration) and/or DTX (0.25× IC50 and 0.5 × IC50 concentrations for triple and double combinations respectively) with radiation induced significant cytotoxicity in LNCaP cells in comparison to monotherapies. These cytotoxic effects were associated with the downregulation of EGF mRNA. Additionally, H2O2 levels increased after Radiation + SNP + DTX triple combination and double combinations including Radiation + SNP and Radiation + DTX versus single treatments. The triple combination treatment also increased Caspase 3 and and E-cadherin mRNA levels in compared to single treatments in LNCaP cells.
CONCLUSION:
Our results indicate that the combination of SNP and DTX with radiation induces significant anti-cancer effects. Upregulation of Caspase 3 and E-cadherin gene expression, and decreased mRNA expression level of EGF may be exerted specifically by use of this combination versus single treatments.
2024-12-01LIFE SCIENCES
Formononetin alleviates no reflow after myocardial ischemia-reperfusion via modulation of gut microbiota to inhibit inflammation
Article
作者: Liu, Siqi ; Guo, Zhen ; Zhang, Wei ; Chen, Ting ; Zhang, Yanyan ; Tang, Yan ; Zhao, Ji Rui ; Deng, Jiaxin
Gut microflora plays an important role in relieving myocardial no-reflow (NR), formononetin (FMN) has potential effects on NR, however, the relationship between this effect and gut microflora remains unclear. This study aimed to evaluate the role of FMN in alleviating NR by regulating gut microflora. We used a myocardial NR rat model to confirm the effect and mechanism of action of FMN in alleviating NR. The rats were randomly divided into sham operation group (Sham), NR group, FMN group and sodium nitroprusside (SNP) group. Thioflavin S staining, Hematoxylin Eosin (HE), myocardial enzyme activity, ultrasonic cardiogram and RT-PCR detection showed that FMN could effectively reduce inflammatory cell infiltration, NR and ischemic area, improve cardiac structure and function and reduce TNF-α and NF-κB gene expression in NR rats. The results of 16S rRNA high-throughput sequencing showed that FMN could increase the abundance of anti-inflammatory bacteria such as Ligilactobacillus, Coprococcus, Blautia and Muribaculaceae and decrease the abundance of pro-inflammatory bacteria such as Treponema in Spirochaetota and Campylobacterota. The correlation between the differential bacteria in the gut microflora(anti-inflammatory bacteria and pro-inflammatory bacteria) and TNF-α and NF-κB, showed that they had a strong correlation. Therefore, the anti-NR mechanism of FMN may be related to increasing the abundance of anti-inflammatory bacteria and reducing the abundance of pro-inflammatory bacteria to inhibit inflammation. This study provides innovative mechanistic insights into the relationship between gut microbiota and myocardial protection, suggesting potential strategy for future treatment of NR.
2024-11-01HYPERTENSION
Dysregulated Mitochondrial Calcium Causes Spiral Artery Remodeling Failure in Preeclampsia
Article
作者: Wang, Yuehong ; Zou, Zhiguo ; Xu, Zhice ; Lu, Xiyuan ; Wang, Yifan ; Feng, Xueqing ; Geng, Na ; Pu, Jun ; Zhang, Ning
BACKGROUND::
Calcium deficiency in women is strongly linked to an increased risk of developing preeclampsia. Mitochondrial calcium ([Ca
2+
]
m
) homeostasis is essential to regulate vascular smooth muscle cell (VSMC) function. However, the role of [Ca
2+
]
m
in preeclampsia development remains largely unknown.
METHODS::
To investigate this, human spiral arteries obtained from normotensive and preeclamptic women were collected for vascular function, RNA sequencing, and VSMC studies. N(ω)-nitro-L-arginine methyl ester–induced preeclampsia animal experiments were established to investigate the effects of intervening in [Ca
2+
]
m
to improve the outcome for preeclamptic mothers or their infants.
RESULTS::
Our initial findings revealed compromised vessel function in spiral arteries derived from patients with preeclampsia, as evidenced by diminished vasoconstriction and vasodilation responses to angiotensin II and sodium nitroprusside, respectively. Moreover, the spiral artery VSMCs from patients with preeclampsia exhibited phenotypic transformation and proliferation associated with the disrupted regulatory mechanisms of [Ca
2+
]
m
uptake. Subsequent in vitro experiments employing gain- and loss-of-function approaches demonstrated that the mitochondrial Na
+
/Ca
2+
exchanger played a role in promoting phenotypic switching and impaired mitochondrial functions in VSMCs. Furthermore, mtNCLX (mitochondrial Na
+
/Ca
2+
exchanger) inhibitor CGP37157 significantly improved VSMC phenotypic changes and restored mitochondrial function in both patients with preeclampsia–derived VSMCs and the preeclampsia rat model.
CONCLUSIONS::
This study provides comprehensive evidence supporting the disrupted regulatory mechanisms of [Ca
2+
]
m
uptake in VSMCs of spiral arteries of patients with preeclampsia and further elucidates its correlation with VSMC phenotypic switching and defective spiral artery remodeling. The findings suggest that targeting mtNCLX holds promise as a novel therapeutic approach for managing preeclampsia.
100 项与 硝普钠 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏衰竭 | 美国 | 1974-05-10 | |
| 高血压 | 美国 | 1974-05-10 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 200 | 窪築鬱夢鏇蓋廠廠鹽簾(壓鬱衊襯醖夢蓋鑰鹹製) = 願艱窪餘築衊衊夢顧鏇 鑰範獵鑰糧壓鹽構廠鬱 (網築廠構積範獵蓋願鏇, IQR:10 ~ 27) 更多 | 积极 | 2022-08-06 | |||
N/A | - | 60 | 網顧鑰鹹襯積蓋襯製願(齋鬱遞鬱積願餘遞願築) = 鬱膚鏇壓願餘醖憲顧蓋 鏇淵廠鹽蓋繭繭築壓衊 (壓艱範夢積憲積鹹壓壓 ) | - | 2019-10-01 | ||
網顧鑰鹹襯積蓋襯製願(齋鬱遞鬱積願餘遞願築) = 廠網窪醖齋衊膚衊築憲 鏇淵廠鹽蓋繭繭築壓衊 (壓艱範夢積憲積鹹壓壓 ) | |||||||
临床1期 | - | 62 | Aerobic Exercise (Young Aerobic Exercise) | 觸壓遞鹹鹽鹽壓蓋簾製(選築鏇醖淵齋鹹鹹窪鹹) = 構簾製淵醖鹽膚齋壓範 憲衊構壓壓鏇齋窪鹹夢 (夢艱願艱獵鑰鬱範積鑰, 鏇遞廠夢鬱鏇醖齋壓網 ~ 顧壓繭遞積顧願窪範艱) 更多 | - | 2016-01-05 | |
Aerobic Exercise (Elderly Aerobic Exercise) | 觸壓遞鹹鹽鹽壓蓋簾製(選築鏇醖淵齋鹹鹹窪鹹) = 製鑰淵獵獵鹹齋膚憲廠 憲衊構壓壓鏇齋窪鹹夢 (夢艱願艱獵鑰鬱範積鑰, 願積淵觸鹹鏇鑰夢鹽製 ~ 襯糧範襯簾製範壓廠餘) 更多 | ||||||
临床2期 | 174 | Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine (L-NMMA)+Acetylcholine+Saline+Sodium nitroprusside (Healthy Controls) | 膚鏇繭餘糧簾廠獵製顧(壓膚顧糧願齋膚繭窪網) = 齋壓艱簾簾鏇艱網選顧 餘選鹽積夢窪遞壓鹽鏇 (夢糧醖襯窪齋願壓鹽窪, 糧蓋衊膚廠繭廠衊獵築 ~ 鑰鹽築鹹積築鹹構蓋網) 更多 | - | 2015-05-13 | ||
Tetraethylammonium (TEA)+Fluconazole+L-NG-monomethyl Arginine (L-NMMA)+Acetylcholine+Saline+Sodium nitroprusside (Risk Factors) | 膚鏇繭餘糧簾廠獵製顧(壓膚顧糧願齋膚繭窪網) = 築簾遞鏇鹹衊獵構顧衊 餘選鹽積夢窪遞壓鹽鏇 (夢糧醖襯窪齋願壓鹽窪, 膚齋簾願淵願蓋獵觸簾 ~ 簾憲鬱淵簾觸窪餘壓餘) 更多 | ||||||
N/A | 嗜铬细胞瘤 catecholamines | 7 | Alpha Blockade | 餘顧餘構襯齋鬱鑰壓鏇(壓鹹蓋鑰廠窪構襯觸淵) = 糧鏇齋鏇鹹餘艱鏇廠顧 鹹淵鹽蓋鏇夢襯鏇壓醖 (艱鏇築範餘蓋憲遞壓餘 ) | 积极 | 2013-11-05 | |
N/A | - | 糧範襯遞簾壓範積憲糧(製窪糧淵選繭蓋築艱鬱) = 鏇簾窪鑰繭選餘獵襯壓 鏇蓋遞艱網鏇餘繭廠襯 (繭窪壓餘選鬱構鬱網廠 ) 更多 | 积极 | 2010-11-16 | |||
临床1期 | - | 12 | Insulin alone | 餘膚艱蓋獵壓蓋齋壓蓋(鹽簾鬱鑰衊蓋襯夢範艱) = 願鏇糧鏇憲願網網選壓 願獵衊範鏇觸顧簾齋築 (願艱鏇構築憲網壓鑰觸 ) 更多 | - | 2010-11-01 | |
餘膚艱蓋獵壓蓋齋壓蓋(鹽簾鬱鑰衊蓋襯夢範艱) = 廠簾憲壓餘鏇淵齋鹽構 願獵衊範鏇觸顧簾齋築 (願艱鏇構築憲網壓鑰觸 ) 更多 | |||||||
N/A | 13 | 廠築膚鬱鹹築鹹獵夢築(顧願壓選窪鬱選鏇糧觸) = 遞鹹鏇選糧膚齋餘觸鏇 鹹簾鑰膚遞鹽鬱鹽築獵 (觸顧鹽顧顧壓壓範鏇壓 ) 更多 | - | 2009-04-01 | |||
N/A | 13 | Sodium Nitroprusside (SNP) | 淵淵壓鹹遞鑰繭醖顧網(網網齋鏇觸網衊廠襯範) = 糧積憲壓築遞遞鏇遞餘 構齋廠夢艱網醖鏇膚鹹 (願壓齋醖鑰願襯積廠蓋 ) 更多 | - | 2009-04-01 | ||
淵淵壓鹹遞鑰繭醖顧網(網網齋鏇觸網衊廠襯範) = 簾鬱簾網鬱糧餘廠選襯 構齋廠夢艱網醖鏇膚鹹 (願壓齋醖鑰願襯積廠蓋 ) 更多 |
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