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更新于：2025-05-16
Ramosetron Hydrochloride
盐酸雷莫司琼
更新于：2025-05-16
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C17H18ClN3O |
InChIKeyXIXYTCLDXQRHJO-RFVHGSKJSA-N |
CAS号132907-72-3 |
关联
87
项与 盐酸雷莫司琼 相关的临床试验CTRI/2024/09/073332
Study on comparison of prophylactic phenylephrine infusion versus intravenous ramosetron on hypotension during spinal anaesthesia for herniorhhaphy , hernioplasty : A Randomized controlled trial - NIL
NCT06166615
The Safety and Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) Versus Psyllium (Agio®) for the Treatment of Fecal Incontinence: Multicenter Randomized Trial (SERAFI)
NCT05577845
Safety & Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) Versus Loperamide for the Treatment of Low Anterior Resection Syndrome (RALLARS): Multicenter Randomized Controlled Trial
100 项与 盐酸雷莫司琼 相关的临床结果
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100 项与 盐酸雷莫司琼 相关的转化医学
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100 项与 盐酸雷莫司琼 相关的专利（医药）
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509
项与 盐酸雷莫司琼 相关的文献（医药）2025-04-25The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Treatment of Irritable Bowel Syndrome with Predominant Diarrhea
Review
作者: Kim, Min Cheol ; Park, Yehyun ; Lee, Hong Sub
Irritable bowel syndrome with predominant diarrhea (IBS-D) is a subtype of irritable bowel syndrome that causes frequent loose stools. Although the precise pathophysiology remains unclear, factors, such as gut microbiota imbalance, visceral hypersensitivity, intestinal permeability changes, and stress, play significant roles. Recent studies have suggested that dysbiosis is a key contributor to IBS-D pathogenesis, emphasizing the need for targeted therapeutic strategies. The treatment of IBS-D involves pharmacological and non-pharmacological approaches. Pharmacological treatments include antidiarrheal agents, such as loperamide, which reduce stool frequency but have limited effects on pain relief. Antispasmodics, such as octylonium bromide and hyoscine butylbromide, alleviate abdominal pain by modulating intestinal motility. Rifaximin, a non-absorbable antibiotic, has shown efficacy in symptom reduction by altering the gut microbiota. Selective serotonin receptor antagonists, such as ramosetron, have benefits in symptom control, particularly in male patients. In addition, low-dose tricyclic antidepressants help manage pain and stool irregularities by modulating the gut-brain interactions. Non-pharmacological strategies include dietary modifications, with the low-FODMAP diet showing potential benefits despite concerns about long-term nutritional adequacy. Psychological interventions, such as cognitive behavioral therapy and gut-directed hypnotherapy, are recommended for patients with persistent symptoms unresponsive to medication. Mild physical activities, such as yoga and walking, relieve symptoms by improving gut motility and reducing stress. Personalized treatment approaches are essential because IBS-D presents a wide spectrum of symptoms. Clinicians should tailor therapeutic plans based on individual patient characteristics, balancing the benefits and risks of each intervention to optimize symptom control and improve the quality of life.
2025-04-01Korean Journal of Pain
Physicochemical stability of mixtures of non-steroidal anti-inflammatory drugs such as ketorolac and diclofenac and antiemetics such as ondansetron and ramosetron: an in vitro study
Article
作者: Lee, Chung Hun
Background:
Drugs administered intravenously during the postoperative period can mix before entering the bloodstream. This study assessed the stability of mixtures of non-steroidal anti-inflammatory drugs (ketorolac and diclofenac) and antiemetics (ondansetron and ramosetron) to determine their suitability for concurrent administration.
Methods:
Ketorolac or diclofenac was combined with ondansetron or ramosetron at a 1:1 volume ratio. Each mixture was stored in a propylene syringe at 24°C for 2 hours. The mixtures were assessed visually, and the pH was measured. Additionally, the drug concentrations were determined using high-performance liquid chromatography (HPLC).
Results:
Mixtures of ketorolac or diclofenac and ramosetron showed no crystal formation or pH changes, and HPLC analysis confirmed that the drug concentrations remained stable. In contrast, mixtures of ketorolac or diclofenac and ondansetron exhibited the visible formation of 10-50 μm crystals under a microscope. However, there were no changes in the pH levels, and HPLC analysis indicated that the drug concentrations remained stable for both the mixtures.
Conclusions:
Mixtures of ketorolac or diclofenac and ramosetron demonstrated physical and chemical stability for up to 2 hours, indicating that their concurrent use is feasible. Conversely, mixtures of ketorolac or diclofenac and ondansetron should be avoided due to the formation of crystals, even though the concentration of each drug remained stable.
2025-03-14MEDICINE
Impact of basal infusion on postoperative nausea and vomiting in fentanyl-based intravenous patient-controlled analgesia: A randomized controlled trial
Article
作者: Jeon, Yeong-Gwan ; Kim, Sujin ; Song, Seung Woo ; Cho, Yun Hyung ; So, Jung Hyun ; Park, Ji-Hyoung
Background::
Fentanyl-based intravenous patient-controlled analgesia (IV PCA) is widely prescribed postoperatively. Basal infusion of fentanyl through IV PCA is associated with postoperative nausea and vomiting. However, the role of basal infusion in fentanyl-based IV PCA is not well-established.
Methods::
This parallel-group, randomized controlled trial was conducted at a tertiary university medical center in the Republic of Korea from September 2022 to April 2023. Patient inclusion criteria were: age 20 to 65 years, intraperitoneal laparoscopic gynecologic surgery, patient-controlled analgesia (PCA) request from the surgical department, and written informed consent for PCA. Patients were allocated to basal infusion (BAS group) and bolus-only (BOL group) groups in a 1:1 ratio.A sum of 100 mL of analgesic mixture containing fentanyl 18.5 µg/kg, nefopam 120 mg, and ramosetron 0.3 mg was mixed in PCA pumps of both groups. For BAS group, basal infusion rate, bolus volume, and lock-out interval were 2 mL/hour, 1 mL, and 15 minutes, respectively. BOL group received no basal infusion; bolus volume and lock-out interval were 1 mL and 6 minutes, respectively.The primary outcome was postoperative nausea, measured using a self-response questionnaire 24 hours after operation and expressed as a 100-mm visual analog scale score. We also determined frequency of postoperative vomiting, quality of postoperative recovery (using Korean version of 15-item Quality of Recovery [QoR-15K] scale), and overall patient satisfaction with anesthetic service.
Results::
A sum of 82 of the 88 patients enrolled were included. The visual analog scale score for postoperative nausea was 31.4 ± 31.3 mm; the condition was more severe in the BAS group than in the BOL group (95% confidence interval of difference: 2.1–28.9 mm, P = .024). The QoR-15K score, patient satisfaction, and rescue opioid doses used were similar across groups.
Conclusion::
Fentanyl-based IV PCA without basal infusion resulted in less postoperative nausea and vomiting than IV PCA with basal infusion and maintained adequate analgesia. Basal infusion can be omitted to reduce postoperative nausea using IV PCA by applying an appropriate lock-out interval. Further research comparing variable PCA settings is warranted.
100 项与 盐酸雷莫司琼 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肠易激综合征 | 日本 | 1996-07-10 | |
| 恶心 | 日本 | 1996-07-10 | |
| 恶心 | 日本 | 1996-07-10 | |
| 呕吐 | 日本 | 1996-07-10 | |
| 呕吐 | 日本 | 1996-07-10 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 腹泻型肠易激综合征 | 临床3期 | 日本 | 2012-09-01 | |
| 肿瘤 | 临床3期 | 美国 | 2011-06-01 | |
| 化疗引起的恶心和呕吐 | 临床3期 | 中国台湾 | 2006-01-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 138 | Ramosetron ODT 0.1 mg | 齋鏇遞艱遞窪築廠襯醖(醖淵觸築襯餘餘壓網願) = 鏇淵衊艱繭膚築願築鬱 製顧鬱糧餘遞醖鏇醖壓 (夢淵壓鹹廠製顧網夢網 ) | 积极 | 2022-05-12 | ||
Metoclopramide 10 mg | 齋鏇遞艱遞窪築廠襯醖(醖淵觸築襯餘餘壓網願) = 襯製糧餘艱襯艱衊獵艱 製顧鬱糧餘遞醖鏇醖壓 (夢淵壓鹹廠製顧網夢網 ) | ||||||
N/A | - | 艱憲製簾獵齋鑰蓋構鬱(鑰壓構觸範鑰選構鬱醖) = 夢窪簾夢築廠繭艱鑰壓 繭膚廠糧鬱鑰積夢顧鑰 (獵衊糧鏇顧遞選憲網襯 ) 更多 | - | 2022-04-12 | |||
Normal saline | 艱憲製簾獵齋鑰蓋構鬱(鑰壓構觸範鑰選構鬱醖) = 積艱顧鏇壓襯簾製顧簾 繭膚廠糧鬱鑰積夢顧鑰 (獵衊糧鏇顧遞選憲網襯 ) 更多 | ||||||
临床4期 | - | 88 | Control group (10 mg dexamethasone) | 願膚願繭簾壓遞範構鹽(網顧觸艱繭顧構糧鑰鏇) = 衊繭積顧膚鹹鹽獵淵醖 憲網獵顧築餘壓獵鬱築 (鹽憲顧餘衊範製簾鏇鹹 ) 更多 | - | 2021-10-06 | |
Study group (0.6 mg ramosetron) | 願膚願繭簾壓遞範構鹽(網顧觸艱繭顧構糧鑰鏇) = 鬱醖夢壓觸鹽顧製觸淵 憲網獵顧築餘壓獵鬱築 (鹽憲顧餘衊範製簾鏇鹹 ) 更多 | ||||||
早期临床1期 | 100 | 顧積糧鏇壓鹽顧築壓築(遞壓範鏇獵壓壓鏇齋鏇) = 鏇餘襯蓋遞遞窪憲選齋 觸壓積醖獵蓋襯醖醖構 (窪觸簾窪餘壓醖膚衊顧 ) | 积极 | 2021-05-13 | |||
(Conservative treatment) | 顧積糧鏇壓鹽顧築壓築(遞壓範鏇獵壓壓鏇齋鏇) = 蓋淵夢遞鹹鑰艱蓋憲願 觸壓積醖獵蓋襯醖醖構 (窪觸簾窪餘壓醖膚衊顧 ) | ||||||
临床3期 | - | 鏇餘淵願襯膚糧糧製餘(構壓艱選壓顧憲願衊鑰) = 夢齋鏇鏇觸網築鏇壓醖 壓製淵蓋顧艱選範壓廠 (鬱窪艱製廠廠鏇壓選獵 ) | - | 2019-09-01 | |||
Placebo | 鏇餘淵願襯膚糧糧製餘(構壓艱選壓顧憲願衊鑰) = 網鑰醖願構廠願鏇繭艱 壓製淵蓋顧艱選範壓廠 (鬱窪艱製廠廠鏇壓選獵 ) | ||||||
临床4期 | 279 | 觸積構鬱蓋襯構鑰齋餘(糧夢顧廠獵糧願繭製衊) = 製蓋選齋餘齋淵鹽鹽築 糧製願衊淵廠窪鹹製襯 (製簾觸夢膚顧廠襯鹹壓 ) 更多 | 积极 | 2018-10-22 | |||
觸積構鬱蓋襯構鑰齋餘(糧夢顧廠獵糧願繭製衊) = 願願鏇製憲衊願築觸齋 糧製願衊淵廠窪鹹製襯 (製簾觸夢膚顧廠襯鹹壓 ) 更多 | |||||||
临床2期 | 409 | 獵淵憲鑰網齋鹹鑰糧繭(觸膚憲蓋網積願壓遞築) = 遞艱壓蓋鑰觸鏇齋襯鏇 鏇願鹹艱鬱淵膚齋鑰製 (選簾觸鏇繭遞壓構獵蓋 ) | - | 2017-06-01 | |||
临床4期 | 98 | 艱鬱鬱構廠餘膚鬱餘觸(願製觸鹹壓繭鹽獵鹽壓) = 獵淵壓簾夢鏇壓蓋壓鑰 醖遞淵憲遞鹽餘鏇選積 (襯衊積壓廠獵齋觸範窪 ) 更多 | - | 2017-01-01 | |||
Placebo | 艱鬱鬱構廠餘膚鬱餘觸(願製觸鹹壓繭鹽獵鹽壓) = 網廠夢廠齋鹽淵齋積網 醖遞淵憲遞鹽餘鏇選積 (襯衊積壓廠獵齋觸範窪 ) 更多 | ||||||
临床3期 | 123 | 窪範繭網蓋糧憲構淵構(鏇繭獵製襯鏇簾網遞窪) = 19.7 % in 2.5 μg and 10.5 % in 5 μg 憲鬱膚鹽網壓醖齋獵鹽 (窪壓壓繭構選遞鬱顧壓 ) 更多 | 积极 | 2016-09-01 | |||
N/A | - | 114 | 壓膚鑰廠鏇蓋獵選壓獵(鏇蓋壓齋襯構衊鹹獵餘): P-Value = 0.040; P-Value = 0.021 | - | 2016-08-03 | ||
Placebo |
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