Ivabradine Hydrochloride

THOUSAND OAKS, Calif. , Oct. 30, 2024 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced financial results for the third quarter of 2024. "Strong growth in sales and earnings this quarter reflects the momentum we're building throughout our business. We continue to invest heavily in our rapidly advancing pipeline, with a focus on delivering innovative therapies across our core therapeutic areas," said Robert A. Bradway , chairman and chief executive officer. Key results include: References in this release to "non-GAAP" measures, measures presented "on a non-GAAP basis" and "free cash flow" (computed by subtracting capital expenditures from operating cash flow) refer to non-GAAP financial measures. Adjustments to the most directly comparable GAAP financial measures and other items are presented on the attached reconciliations. Refer to Non-GAAP Financial Measures below for further discussion. Product Sales Performance General Medicine Oncology Inflammation Rare Disease Except for TAVNEOS ® , the products listed below were added through the acquisition of Horizon on Oct. 6, 2023 . Established Products Product Sales Detail by Product and Geographic Region $Millions, except percentages Q3 '24 Q3 '23 YOY Δ U.S. ROW TOTAL TOTAL TOTAL Repatha ® $         281 $         286 $         567 $         406 40 % EVENITY ® 289 110 399 307 30 % Prolia ® 683 362 1,045 986 6 % BLINCYTO ® 237 90 327 220 49 % Vectibix ® 132 150 282 252 12 % KYPROLIS ® 238 140 378 349 8 % LUMAKRAS ® /LUMYKRAS ™ 53 45 98 52 88 % XGEVA ® 373 168 541 519 4 % Nplate ® 345 111 456 419 9 % IMDELLTRA ™ 36 — 36 — N/A MVASI ® 136 59 195 213 (8 %) TEZSPIRE ® 269 — 269 161 67 % Otezla ® 460 104 564 567 (1 %) Enbrel ® 817 8 825 1,035 (20 %) AMJEVITA ® /AMGEVITA ™ 28 138 166 152 9 % TEPEZZA ®(1) 482 6 488 — N/A KRYSTEXXA ®(1) 310 — 310 — N/A UPLIZNA ®(1) 74 32 106 — N/A TAVNEOS ® 74 6 80 37 * Ultra-Rare products (1) 180 8 188 — N/A EPOGEN ® 33 — 33 50 (34 %) Aranesp ® 105 232 337 323 4 % Parsabiv ® 32 38 70 95 (26 %) Neulasta ® 84 26 110 124 (11 %) Other products (2) 228 53 281 281 — % Total product sales $      5,979 $      2,172 $      8,151 $      6,548 24 % N/A = not applicable *Change in excess of 100% (1) Horizon-acquired products, and the Ultra-Rare products consist of RAVICTI ® , PROCYSBI ® , ACTIMMUNE ® , QUINSAIR ® and BUPHENYL ® (2) Consists of (i) Aimovig ® , RIABNI ® , KANJINTI ® , AVSOLA ® , NEUPOGEN ® , IMLYGIC ® , BEKEMV ™ , Corlanor ® , WEZLANA ™ /WEZENLA ™ and Sensipar ® /Mimpara ™ , where Biosimilars total $148 million in Q3 '24 and $104 million in Q3 '23; and (ii) Horizon-acquired products including RAYOS ® and PENNSAID ® Operating Expense, Operating Margin and Tax Rate Analysis On a GAAP basis for the third quarter: On a non-GAAP basis for the third quarter: $Millions, except percentages GAAP Non-GAAP Q3 '24 Q3 '23 YOY Δ Q3 '24 Q3 '23 YOY Δ Cost of Sales $   3,310 $   1,806 83 % $   1,454 $   1,137 28 % % of product sales 40.6 % 27.6 % 13.0 pts 17.8 % 17.4 % 0.4 pts Research & Development $   1,450 $   1,079 34 % $   1,440 $   1,070 35 % % of product sales 17.8 % 16.5 % 1.3 pts 17.7 % 16.3 % 1.4 pts Selling, General & Administrative $   1,625 $   1,353 20 % $   1,565 $   1,293 21 % % of product sales 19.9 % 20.7 % (0.8) pts 19.2 % 19.7 % (0.5) pts Other $        71 $      644 (89 %) $        — $        — N/A Total Operating Expenses $   6,456 $   4,882 32 % $   4,459 $   3,500 27 % Operating Margin operating income as % of product sales 25.1 % 30.9 % (5.8) pts 49.6 % 52.0 % (2.4) pts Tax Rate 8.7 % 11.1 % (2.4) pts 13.4 % 16.1 % (2.7) pts pts: percentage points N/A = not applicable Cash Flow and Balance Sheet $Billions, except shares Q3 '24 Q3 '23 YOYΔ Operating Cash Flow $         3.6 $         2.8 $         0.8 Capital Expenditures $         0.3 $         0.2 $         0.0 Free Cash Flow $         3.3 $         2.5 $         0.8 Dividends Paid $         1.2 $         1.1 $         0.1 Share Repurchases $         0.0 $          — $         0.0 Average Diluted Shares (millions) 542 538 4 Note: Numbers may not add due to rounding $Billions 9/30/24 12/31/23 YTD Δ Cash and Investments $         9.0 $       10.9 $        (1.9) Debt Outstanding $       60.4 $       64.6 $        (4.2) Note: Numbers may not add due to rounding 2024 Guidance For the full year 2024, the Company now expects: Third Quarter Product and Pipeline Update The Company provided the following updates on selected product and pipeline programs: General Medicine MariTide (maridebart cafraglutide, AMG 133) AMG 513 Olpasiran (AMG 890) Repatha Oncology IMDELLTRA BLINCYTO Xaluritamig (AMG 509) AMG 193 Bemarituzumab Nplate LUMAKRAS/LUMYKRAS Inflammation TEZSPIRE Rocatinlimab (AMG 451/KHK4083) Otezla Blinatumomab Inebilizumab Efavaleukin alfa (AMG 592) Ordesekimab (AMG 714/PRV-015) AMG 104 (AZD8630) Rare Disease TAVNEOS TEPEZZA KRYSTEXXA UPLIZNA Dazodalibep Daxdilimab Fipaxalparant Biosimilars TEZSPIRE is being developed in collaboration with AstraZeneca. AMG 104 is being developed in collaboration with AstraZeneca. Rocatinlimab, formerly AMG 451/KHK4083, is being developed in collaboration with Kyowa Kirin. Ordesekimab, formerly AMG 714 and also known as PRV-015, is being developed in collaboration with Provention Bio , a Sanofi Company . For the purposes of the collaboration, Provention Bio conducts a clinical trial and leads certain development and regulatory activities for the program. Xaluritamig, formerly AMG 509, is being developed pursuant to a research collaboration with Xencor, Inc. IDE397 is an investigational MAT2A inhibitor from IDEAYA Biosciences. EYLEA is a registered trademark of Regeneron Pharmaceuticals, Inc. OPDIVO is a registered trademark of Bristol-Myers Squibb Company. KEYTRUDA is a registered trademark of Merck & Co., Inc. Non-GAAP Financial Measures In this news release, management has presented its operating results for the third quarters of 2024 and 2023, in accordance with U.S. Generally Accepted Accounting Principles (GAAP) and on a non-GAAP basis. In addition, management has presented its full year 2024 EPS and tax guidance in accordance with GAAP and on a non-GAAP basis. These non-GAAP financial measures are computed by excluding certain items related to acquisitions, divestitures, restructuring and certain other items from the related GAAP financial measures. Management has presented Free Cash Flow (FCF), which is a non-GAAP financial measure, for the third quarters of 2024 and 2023. FCF is computed by subtracting capital expenditures from operating cash flow, each as determined in accordance with GAAP. The Company believes that its presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. The Company uses certain non-GAAP financial measures to enhance an investor's overall understanding of the financial performance and prospects for the future of the Company's normal and recurring business activities by facilitating comparisons of results of normal and recurring business operations among current, past and future periods. The Company believes that FCF provides a further measure of the Company's liquidity. The Company uses the non-GAAP financial measures set forth in the news release in connection with its own budgeting and financial planning internally to evaluate the performance of the business, including to allocate resources and to evaluate results relative to incentive compensation targets. The non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP. About Amgen Amgen discovers, develops, manufactures and delivers innovative medicines to help millions of patients in their fight against some of the world's toughest diseases. More than 40 years ago, Amgen helped to establish the biotechnology industry and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what's known today. Amgen is advancing a broad and deep pipeline that builds on its existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. In 2024, Amgen was named one of the "World's Most Innovative Companies" by Fast Company and one of "America's Best Large Employers" by Forbes, among other external recognitions . Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average ® , and it is also part of the Nasdaq-100 Index ® , which includes the largest and most innovative non-financial companies listed on the Nasdaq Stock Market based on market capitalization. For more information, visit Amgen.com and follow Amgen on X , LinkedIn , Instagram , TikTok , YouTube and Threads . Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen . All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd. or Kyowa Kirin Co., Ltd.), the performance of Otezla ® (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), our acquisitions of Teneobio, Inc. , ChemoCentryx, Inc. , or Horizon (including the prospective performance and outlook of Horizon's business, performance and opportunities and any potential strategic benefits, synergies or opportunities expected as a result of such acquisition, and any projected impacts from the Horizon acquisition on our acquisition-related expenses going forward), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems on our business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen , including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico , and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. There can be no guarantee that we will be able to realize any of the strategic benefits, synergies or opportunities arising from the Horizon acquisition, and such benefits, synergies or opportunities may take longer to realize than expected. We may not be able to successfully integrate Horizon, and such integration may take longer, be more difficult or cost more than expected. A breakdown, cyberattack or information security breach of our information technology systems could compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Our business and operations may be negatively affected by the failure, or perceived failure, of achieving our environmental, social and governance objectives. The effects of global climate change and related natural disasters could negatively affect our business and operations. Global economic conditions may magnify certain risks that affect our business. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. CONTACT: Amgen , Thousand Oaks Elissa Snook , 609-251-1407 (media) Justin Claeys , 805-313-9775 (investors) Amgen Inc. Consolidated Statements of Income - GAAP (In millions, except per-share data) (Unaudited) Three months ended September 30 , Nine months ended September 30 , 2024 2023 2024 2023 Revenues: Product sales $    8,151 $    6,548 $  23,310 $  19,077 Other revenues 352 355 1,028 917 Total revenues 8,503 6,903 24,338 19,994 Operating expenses: Cost of sales 3,310 1,806 9,746 5,339 Research and development 1,450 1,079 4,240 3,250 Selling, general and administrative 1,625 1,353 5,218 3,905 Other 71 644 187 874 Total operating expenses 6,456 4,882 19,391 13,368 Operating income 2,047 2,021 4,947 6,626 Other income (expense): Interest expense, net (776) (759) (2,408) (2,054) Other income, net 1,830 685 1,288 2,431 Income before income taxes 3,101 1,947 3,827 7,003 Provision for income taxes 271 217 364 1,053 Net income $    2,830 $    1,730 $    3,463 $    5,950 Earnings per share: Basic $      5.27 $      3.23 $      6.45 $    11.12 Diluted $      5.22 $      3.22 $      6.40 $    11.06 Weighted-average shares used in calculation of earnings per share: Basic 537 535 537 535 Diluted 542 538 541 538 Amgen Inc. Consolidated Balance Sheets - GAAP (In millions) September 30 , December 31 , 2024 2023 (Unaudited) Assets Current assets: Cash and cash equivalents $                9,011 $              10,944 Trade receivables, net 7,317 7,268 Inventories 7,362 9,518 Other current assets 3,076 2,602 Total current assets 26,766 30,332 Property, plant and equipment, net 6,156 5,941 Intangible assets, net 28,920 32,641 Goodwill 18,658 18,629 Other noncurrent assets 10,383 9,611 Total assets $              90,883 $              97,154 Liabilities and Stockholders' Equity Current liabilities: Accounts payable and accrued liabilities $              16,768 $              16,949 Current portion of long-term debt 3,544 1,443 Total current liabilities 20,312 18,392 Long-term debt 56,854 63,170 Long-term deferred tax liabilities 1,711 2,354 Long-term tax liabilities 2,280 4,680 Other noncurrent liabilities 2,199 2,326 Total stockholders' equity 7,527 6,232 Total liabilities and stockholders' equity $              90,883 $              97,154 Shares outstanding 538 535 Amgen Inc. GAAP to Non-GAAP Reconciliations (Dollars in millions) (Unaudited) Three months ended September 30 , Nine months ended September 30 , 2024 2023 2024 2023 GAAP cost of sales $       3,310 $       1,806 $       9,746 $       5,339 Adjustments to cost of sales: Acquisition-related expenses (a) (1,856) (668) (5,546) (2,008) Certain net charges pursuant to our restructuring and cost-savings initiatives — (1) — (36) Total adjustments to cost of sales (1,856) (669) (5,546) (2,044) Non-GAAP cost of sales $       1,454 $       1,137 $       4,200 $       3,295 GAAP cost of sales as a percentage of product sales 40.6 % 27.6 % 41.8 % 28.0 % Acquisition-related expenses (a) (22.8) (10.2) (23.8) (10.5) Certain net charges pursuant to our restructuring and cost-savings initiatives 0.0 0.0 0.0 (0.2) Non-GAAP cost of sales as a percentage of product sales 17.8 % 17.4 % 18.0 % 17.3 % GAAP research and development expenses $       1,450 $       1,079 $       4,240 $       3,250 Adjustments to research and development expenses: Acquisition-related expenses (b) (10) (9) (60) (27) Certain net charges pursuant to our restructuring and cost-savings initiatives — — — (17) Total adjustments to research and development expenses (10) (9) (60) (44) Non-GAAP research and development expenses $       1,440 $       1,070 $       4,180 $       3,206 GAAP research and development expenses as a percentage of product sales 17.8 % 16.5 % 18.2 % 17.0 % Acquisition-related expenses (b) (0.1) (0.2) (0.3) (0.1) Certain net charges pursuant to our restructuring and cost-savings initiatives 0.0 0.0 0.0 (0.1) Non-GAAP research and development expenses as a percentage of product sales 17.7 % 16.3 % 17.9 % 16.8 % GAAP selling, general and administrative expenses $       1,625 $       1,353 $       5,218 $       3,905 Adjustments to selling, general and administrative expenses: Acquisition-related expenses (c) (60) (47) (255) (138) Certain net charges pursuant to our restructuring and cost-savings initiatives — (13) — (13) Total adjustments to selling, general and administrative expenses (60) (60) (255) (151) Non-GAAP selling, general and administrative expenses $       1,565 $       1,293 $       4,963 $       3,754 GAAP selling, general and administrative expenses as a percentage of product sales 19.9 % 20.7 % 22.4 % 20.5 % Acquisition-related expenses (c) (0.7) (0.8) (1.1) (0.7) Certain net charges pursuant to our restructuring and cost-savings initiatives 0.0 (0.2) 0.0 (0.1) Non-GAAP selling, general and administrative expenses as a percentage of product sales 19.2 % 19.7 % 21.3 % 19.7 % GAAP operating expenses $       6,456 $       4,882 $      19,391 $      13,368 Adjustments to operating expenses: Adjustments to cost of sales (1,856) (669) (5,546) (2,044) Adjustments to research and development expenses (10) (9) (60) (44) Adjustments to selling, general and administrative expenses (60) (60) (255) (151) Certain net charges pursuant to our restructuring and cost-savings initiatives (d) — (16) 4 (183) Certain other expenses (e) (71) (628) (191) (691) Total adjustments to operating expenses (1,997) (1,382) (6,048) (3,113) Non-GAAP operating expenses $       4,459 $       3,500 $      13,343 $      10,255 Three months ended September 30 , Nine months ended September 30 , 2024 2023 2024 2023 GAAP operating income $       2,047 $       2,021 $       4,947 $       6,626 Adjustments to operating expenses 1,997 1,382 6,048 3,113 Non-GAAP operating income $       4,044 $       3,403 $      10,995 $       9,739 GAAP operating income as a percentage of product sales 25.1 % 30.9 % 21.2 % 34.7 % Adjustments to cost of sales 22.8 10.2 23.8 10.7 Adjustments to research and development expenses 0.1 0.2 0.3 0.2 Adjustments to selling, general and administrative expenses 0.7 1.0 1.1 0.8 Certain net charges pursuant to our restructuring and cost-savings initiatives (d) 0.0 0.2 0.0 1.0 Certain other expenses (e) 0.9 9.5 0.8 3.7 Non-GAAP operating income as a percentage of product sales 49.6 % 52.0 % 47.2 % 51.1 % GAAP interest expense, net $        (776) $        (759) $      (2,408) $      (2,054) Adjustments to interest expense, net: Interest expense on acquisition-related debt (f) — 332 — 788 Non-GAAP interest expense, net $        (776) $        (427) $      (2,408) $      (1,266) GAAP other income, net $       1,830 $          685 $       1,288 $       2,431 Adjustments to other income, net Interest income and other expenses on acquisition-related debt (f) — (313) — (607) Net gains from equity investments (g) (1,608) (170) (693) (1,305) Total adjustments to other income, net (1,608) (483) (693) (1,912) Non-GAAP other income, net $          222 $          202 $          595 $          519 GAAP income before income taxes $       3,101 $       1,947 $       3,827 $       7,003 Adjustments to income before income taxes: Adjustments to operating expenses 1,997 1,382 6,048 3,113 Adjustments to interest expense, net — 332 — 788 Adjustments to other income, net (1,608) (483) (693) (1,912) Total adjustments to income before income taxes 389 1,231 5,355 1,989 Non-GAAP income before income taxes $       3,490 $       3,178 $       9,182 $       8,992 GAAP provision for income taxes $          271 $          217 $          364 $       1,053 Adjustments to provision for income taxes: Income tax effect of the above adjustments (h) 228 271 1,007 442 Other income tax adjustments (i) (33) 23 (44) 6 Total adjustments to provision for income taxes 195 294 963 448 Non-GAAP provision for income taxes $          466 $          511 $       1,327 $       1,501 GAAP tax as a percentage of income before taxes 8.7 % 11.1 % 9.5 % 15.0 % Adjustments to provision for income taxes: Income tax effect of the above adjustments (h) 5.6 4.2 5.4 1.6 Other income tax adjustments (i) (0.9) 0.8 (0.4) 0.1 Total adjustments to provision for income taxes 4.7 5.0 5.0 1.7 Non-GAAP tax as a percentage of income before taxes 13.4 % 16.1 % 14.5 % 16.7 % GAAP net income $       2,830 $       1,730 $       3,463 $       5,950 Adjustments to net income: Adjustments to income before income taxes, net of the income tax effect 161 960 4,348 1,547 Other income tax adjustments (i) 33 (23) 44 (6) Total adjustments to net income 194 937 4,392 1,541 Non-GAAP net income $       3,024 $       2,667 $       7,855 $       7,491 Note: Numbers may not add due to rounding Amgen Inc. GAAP to Non-GAAP Reconciliations (In millions, except per-share data) (Unaudited) The following table presents the computations for GAAP and non-GAAP diluted earnings per share: Three months ended September 30, 2024 Three months ended September 30, 2023 GAAP Non-GAAP GAAP Non-GAAP Net income $        2,830 $        3,024 $        1,730 $        2,667 Weighted-average shares for diluted EPS 542 542 538 538 Diluted EPS $          5.22 $          5.58 $          3.22 $          4.96 Nine months ended September 30, 2024 Nine months ended September 30, 2023 GAAP Non-GAAP GAAP Non-GAAP Net income $        3,463 $        7,855 $        5,950 $        7,491 Weighted-average shares for diluted EPS 541 541 538 538 Diluted EPS $          6.40 $        14.52 $        11.06 $        13.92 (a) The adjustments related primarily to noncash amortization of intangible assets and fair value step-up of inventory acquired from business acquisitions. (b) For the three months ended September 30, 2024 , the adjustments related primarily to noncash amortization of intangible assets from business acquisitions. For the nine months ended September 30, 2024 , the adjustments related primarily to acquisition-related costs related to our Horizon acquisition. For the three and nine months ended September 30, 2023 , the adjustments related primarily to noncash amortization of intangible assets from business acquisitions. (c) For the three and nine months ended September 30, 2024 and 2023, the adjustments related primarily to acquisition-related costs related to our Horizon acquisition. (d) For the three and nine months ended September 30, 2023 , the adjustments related primarily to separation costs associated with our restructuring plan initiated in early 2023. (e) For the three and nine months ended September 30, 2024 , the adjustments related primarily to impairment charges for in-process R&D assets and changes in the fair values of contingent consideration liabilities, both related to our Teneobio, Inc. acquisition from 2021. For the three and nine months ended September 30, 2023 , the adjustments related primarily to a net impairment charge for AMG 340. (f) For the three and nine months ended September 30, 2023 , the adjustments included (i) interest expense and income on senior notes issued in March 2023 and (ii) debt issuance costs and other fees related to our bridge credit and term loan credit agreements, incurred prior to the closing of our acquisition of Horizon. (g) For the three and nine months ended September 30, 2024 , the adjustments related primarily to our BeiGene equity fair value adjustment. For the three and nine months ended September 30, 2023 , the adjustments related primarily to our Neumora Therapeutics, Inc. and BeiGene equity fair value adjustments, respectively. (h) The tax effect of the adjustments between our GAAP and non-GAAP results takes into account the tax treatment and related tax rate(s) that apply to each adjustment in the applicable tax jurisdiction(s). Generally, the tax impact of adjustments, including the amortization of intangible assets and acquired inventory, gains and losses on our investments in equity securities and expenses related to restructuring and cost-savings initiatives, depends on whether the amounts are deductible in the respective tax jurisdictions and the applicable tax rate(s) in those jurisdictions. Due to these factors, the effective tax rate for the adjustments to our GAAP income before income taxes for the three and nine months ended September 30, 2024 , was 58.6% and 18.8%, respectively, compared to 22.0% and 22.2% for the corresponding periods of the prior year. (i) The adjustments related to certain acquisition items, prior period and other items excluded from GAAP earnings. Amgen Inc. Reconciliations of Cash Flows (In millions) (Unaudited) Three months ended September 30 , Nine months ended September 30 , 2024 2023 2024 2023 Net cash provided by operating activities $    3,571 $    2,760 $      6,719 $      7,933 Net cash (used in) provided by investing activities (210) (262) (644) 885 Net cash (used in) provided by financing activities (3,651) (2,005) (8,008) 18,294 (Decrease) increase in cash and cash equivalents (290) 493 (1,933) 27,112 Cash and cash equivalents at beginning of period 9,301 34,248 10,944 7,629 Cash and cash equivalents at end of period $    9,011 $   34,741 $      9,011 $    34,741 Three months ended September 30 , Nine months ended September 30 , 2024 2023 2024 2023 Net cash provided by operating activities $    3,571 $    2,760 $      6,719 $      7,933 Capital expenditures (257) (248) (725) (863) Free cash flow $    3,314 $    2,512 $      5,994 $      7,070 Amgen Inc. Reconciliation of GAAP EPS Guidance to Non-GAAP EPS Guidance for the Year Ending December 31, 2024 (Unaudited) GAAP diluted EPS guidance $   8.71 — $   9.56 Known adjustments to arrive at non-GAAP*: Acquisition-related expenses (a) 11.33 — 11.38 Net gains from equity investments (1.01) Other 0.12 Non-GAAP diluted EPS guidance $ 19.20 — $ 20.00 * The known adjustments are presented net of their related tax impact, which amount to approximately $2.39 per share. (a) The adjustments primarily include noncash amortization of intangible assets and fair value step-up of inventory acquired in business acquisitions. Our GAAP diluted EPS guidance does not include the effect of GAAP adjustments triggered by events that may occur subsequent to this press release such as acquisitions, asset impairments, litigation, changes in fair value of our contingent consideration obligations and changes in fair value of our equity investments. Reconciliation of GAAP Tax Rate Guidance to Non-GAAP Tax Rate Guidance for the Year Ending December 31, 2024 (Unaudited) GAAP tax rate guidance 9.0 % — 10.5 % Tax rate of known adjustments discussed above 4.5 % — 5.0 % Non-GAAP tax rate guidance 14.0 % — 15.0 % View original content to download multimedia: https://www.prnewswire.com/news-releases/amgen-reports-third-quarter-2024-financial-results-302291966.html SOURCE Amgen

✦ ✦ ✦ 随着中国经济的快速增长和科技实力的提升，国内新药研发蓬勃发展，为出海打下良好基础。一直以来，中国医药、原料药出口贸易在东南亚市场占有举足轻重的份额。其中，印度尼西亚、泰国、越南、菲律宾和马来西亚五个国家占据了东南亚医药市场的90%以上。未来这些国家将会成为国内企业转战的重要市场，包括投资建厂等深度合作开发。 为助力中国药企加速布局东南亚医药市场，9月11日，东南亚医药市场开拓机遇与挑战主题会议将于CPHI & PMEC 制药工业展（深圳）展会期间在深圳会展中心（福田）举办。会议将从当下市场的最新国际形势出发，结合案例与报告，与上下游企业共同探讨东南亚市场的发展机遇。 ✦ ✦ ✦ 东南亚医药市场开拓机遇与挑战主题会议 会议时间 9月11日 会议地点 深圳会展中心（福田） 论坛区A（展位：9A56） 主办单位 上海博华国际展览有限公司 承办单位 北京东方比特科技有限公司 协办单位 E药经理人 扫描太阳码 0元领票并报名听会 8月30日前完成预登记 现场可领取电子会刊一份 SHENZHEN 会议议程 09:30 主持人致辞 09:40-10:20  东南亚国家医药国际贸易报告 嘉宾介绍 吴惠芳 北京东方比特（健康网）总经理兼首席研究员，北京玉德未来控股有限公司副总裁 吴女士在军事医学科学院药物分析专业获理学硕士学位，1980年起从事药学相关工作，2000年前在部队医疗、科研机构从事临床药学、科研管理等工作，技术职务副主任药师。2000年退役后从事医药信息研究工作，专注于医药行业研究、市场研究、产业链结构研究等领域。在医药原料药、医药商品进出口、医药产业数据等信息方面有发布了大量文献资料和报告发表。为国内外企业、政府和科研机构提供咨询服务。连续多年为“中国化学制药工业协会”所著《医药发展蓝皮书》、《中国医药手册》作者之一；是《中国医药报》、《医药经济报》的特约撰稿人，在国内重要医药报刊发表大量文章。多次被邀请在中国医药行业大型会议和展览上做有关中国医药市场专题演讲。她的演讲以实际数据和案例阐明问题、总结变化规律，在中国制药企业中广为流传，受到医药界的好评。 ☝🏿☝🏿上下滑动了解嘉宾完整简介 10:20-10:50  中国制药企业出海东南亚国家的案例分享 嘉宾介绍 王亚锋 上海医药国际业务事业部东南亚区域负责人、上药泰国总经理 中国药科大学本科，中欧国际工商学院Global EMBA。 从事医药国际营销工作十余年，深厚的医药行业知识和专业能力。拥有丰富的海外子公司运营和营销团队管理经验。深度参与海外工厂立项，写字楼，仓库等绿地项目建设。 海外常驻包括非洲加纳，尼日利亚，乌干达，科特迪瓦，东南亚泰国，菲律宾等多个国家。熟悉多个市场药政法规以及行业准入要求。多次在海外国家从零开始设立全资公司、合资公司，组建销售团队，实现业绩从零突破，运作药品进入国家用药指南和国家医保。所在团队曾实现单品种中国制剂出口第一。 历任复星医药集团桂林南药国际商务代表，销售经理，海外国家经理，大区经理等，现任上海医药国际业务事业部东南亚区域负责人，上药泰国总经理。 ☝🏿☝🏿上下滑动了解嘉宾完整简介 10:50-11:20  印度尼西亚制药业的机遇和市场开拓实践 嘉宾介绍 张君丽 成都市一诺医药化工有限公司总经理采购总监 公司团队深耕印尼市场十年，专注医药API等产品出口； 聘请多名印尼本地员工，长期穿梭在印尼各个制剂工厂，拜访客户，与当地前十大药企均有超级深度的合作与链接！ 11:20-11:45  印尼清真医药产品市场情况更新 嘉宾介绍 Dr. Ir. Muslich, M.Si Halal Partnership  and Audit Services Director, LPPOM 获得IPB大学学士(S1)、研究生(S2)和博士(S3)学位;此前曾在多家私营公司工作(1991年至1993年)，PT TELKOM WITEL IX Jayapura农业和农用工业发展中心经理(1993年至1994年)，LPPOM MUI清真保证体系负责人(2010年至2015年)，QA和LPPOM MUI标准负责人(2015年至2019年)，LPPOM MUI高级顾问(2020年)，MUI清真认证要求开发团队负责人(2010年至2011年);现为IPB大学农业技术学院农业工业工程系讲师(自1994年起)，清真审核员(自1995年起)，清真管理体系标准制定技术委员会(SNI 99 001)成员，清真家禽屠宰场(SNI 99 002)，家庭切清真反刍(SNI 99 003)，清真食品(SNI 99 004)国家标准化机构(自2015年起)，SKKNI主管能力测试设备开发团队负责人Halal & SKKNI清真审核员(自2017年起)，国家认证机构能力评估员职业(BNSP)(自2015年起)，食品安全能力评估员，机构专业认证(LSP)食品质量保证与安全(JMKP)(自2015年起);于2020-2022年被任命为LPPOM MUI清真合作与审计服务总监。 ☝🏿☝🏿上下滑动了解嘉宾完整简介 11:20-12:00  圆桌讨论：寻找东南亚市场的机会 讨论嘉宾 深圳市远邦医药有限公司 湖南尔康制药股份有限公司 成都倍特药业有限公司 广州康臣药业有限公司 ...... 扫描太阳码 0元领票并报名听会 8月30日前完成预登记 现场可领取电子会刊一份 把握东南亚市场发展机遇 加速融入全球制药供应链 随着东南亚医药市场的发展潜能进一步释放，中国医药企业将迎来更多发展机遇。作为中国药企链接国际市场的重要纽带，CPHI & PMEC 制药工业展（深圳）将携手400余家优质展商，共同探索企业在东南亚乃至全球市场的发展路径。 下面就请跟随小编的步伐，一起走近本期的优选展商吧！ 浙江瑞邦药业股份有限公司 展位：9F08 浙江瑞邦药业股份有限公司成立于1956年，具有60多年生产医药原料药和食品添加剂的生产经验。公司以药品生产质量管理规范（GMP) 标准组织生产和销售。本公司的产品获得了美国FDA，欧洲CEP和中国GMP的认证。主要产品有葡萄糖酸盐系列，莫匹罗星，莫匹罗星钙，环孢菌素，夫西地酸等。浙江瑞邦药业股份有限公司在国内外都享有良好的声誉。产品远销美国，欧洲，日本，印度及其他南美和东南亚地区。 主推产品 环孢菌素、莫匹罗星、莫匹罗星钙、葡萄糖酸钙、葡萄糖酸锌、葡萄糖酸钾、葡萄糖酸镁、葡萄糖酸亚铁、葡萄糖酸铜、葡萄糖酸锰、葡萄糖酸钠、多粘菌素B、夫西地酸、夫西地酸钠、米尔贝肟、葡萄糖酸内酯、非达霉素、甘草次酸、原儿茶酸。 ☝🏿☝🏿上下滑动查看完整展商介绍 河北华晨药业集团有限公司 展位：9D46 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