更新于：2024-11-04
Levocarnitine
左卡尼汀
更新于：2024-11-04
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1985-12-27), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C7H15NO3 |
InChIKeyPHIQHXFUZVPYII-ZCFIWIBFSA-N |
CAS号541-15-1 |
关联
217
项与 左卡尼汀 相关的临床试验Investigating the effectiveness of L-carnitine on heart failure patients
Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
The effect of L-carnitine in improving the nutritional status and dialysis adequacy of hemodialysis patients in Hami dialysis center Arak city.
100 项与 左卡尼汀 相关的临床结果
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100 项与 左卡尼汀 相关的转化医学
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100 项与 左卡尼汀 相关的专利（医药）
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8,341
项与 左卡尼汀 相关的文献（医药）2025-01-01COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Effects of water immersion on immune, intestinal flora and metabolome of Chinese mitten crab (Eriocheir sinensis) after air exposure
Article
作者: Yang, Yuhong ; Zhang, Rui ; Luo, Liang ; Wang, Shihui ; Guo, Kun ; Li, Zhiqiang ; Zhao, Zhigang ; Deng, Xiangyi ; Qiao, Guo
Air exposure stress can induce stress response of Eriocheir sinensis and affect its normal life activities. The goal of this study was to investigate the effects of water immersion on the recovery of hepatopancreas immune-related enzyme activity, intestinal microbial diversity and metabolic level of Chinese mitten crabs after exposure to air. The results show that immersion can effectively alleviate the adverse effects of air exposure on the antioxidant capacity and immune capacity of Chinese mitten crabs, and the longer the time of immersion, the more obvious the recovery effect. Among them, the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and acid phosphatase significantly increased after exposure to air (P < 0.05), reached a peak at 3 h, began to decline after immersion, and returned to a level close to the initial value at 24 h (P < 0.05). In addition, after exposure to air, the glucose and total cholesterol in haemolymph of Eriocheir sinensis were significantly different from the initial values (P < 0.05), gradually recovered to the initial level after re-immersion. However, changes in intestinal flora and hepatopancreas metabolism caused by air exposure did not fully recover after water exposure, and its negative effects did not completely disappear. The sequencing results showed that the species composition and diversity of intestinal microorganisms of Chinese mitten crab changed after air exposure and immersion treatment. The relative abundance of Actinomycetes increased significantly, while that of Proteobacteria and Firmicutes decreased significantly. Metabolomics analysis showed that air exposure and immersion destroyed the metabolic balance of amino acids and carnitine, reduced the level of carnitine metabolism, hindered the absorption of nutrients, and led to the accumulation of harmful substances.
2024-12-31GYNECOLOGICAL ENDOCRINOLOGY
Statement of Retraction: Oral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
2024-12-31Journal of the International Society of Sports Nutrition
Analysis of food supplements and sports foods consumption patterns among a sample of gym-goers in Portugal
Article
作者: Costa, João Guilherme ; Lopes, Sofia ; Ferreira-Pêgo, Cíntia ; Cunha, Madalena
BACKGROUND:
Gym-goers usually seek methods to improve performance, muscle gain, and overall health. One of the main strategies is including food supplements (FS) into their routine as aids to enhance their athletic capabilities and satisfy their nutritional needs. Thus, this study aimed to investigate and characterize the main FS and Sports Foods (SF) currently consumed, as well as the main reasons for their use and the source of advice in a group of gym-goers in the Lisbon Metropolitan Area (Portugal).
METHODS:
A cross-sectional study was conducted, including 303 gym-goers from Lisbon, Portugal, who were 133 women and 170 males (30.8 ± 12.9 years old). Face-to-face interviews were used by qualified researchers to gather data.
RESULTS:
Most of the interviewed athletes (71.95 %) took FS/SF, being men the main consumers. On average, 1.59 supplements were consumed per athlete. Logistic regression models indicated significant associations between age, gender, and motivations for gym attendance. While men and younger groups attended mainly for hypertrophy, women and older groups were focused on well-being. Protein (59.17 %) was the most used FS/SF, followed by creatine (41.28 %) and multivitamins (27.06 %). Men and younger individuals preferred protein and creatine, while older individuals focused more on specific vitamins and minerals. Women seemed to prefer L-carnitine and protein yogurts. Main sources of information included the internet, friends, and dietitians with notable gender and age-based preferences. Online stores were the main place of purchase. Monthly expenditures on FS/SF were not significantly affected by age or gender, but motivations for use had an influence.
CONCLUSION:
Most of the athletes interviewed took FS/SF, being men the major consumers. Protein was the principal FS/SF used, with online stores being the main place of purchase and the internet the primary source of information. Age and gender were key factors in adopted training, in the FS/SF chosen, and in the source of information selected. It is crucial that health professionals take primary responsibility for providing this guidance.
100 项与 左卡尼汀 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肾脏疾病 | 意大利 | 2015-05-18 | |
| 脓毒性休克 | 意大利 | 2015-05-18 | |
| 心血管疾病 | 中国 | 1999-12-31 | |
| 遗传性代谢缺陷病 | 爱尔兰 | 1996-10-23 | |
| 肉毒碱棕榈酰转移酶缺乏症 | 荷兰 | 1986-02-03 | |
| 全身性肉碱缺乏症 | 美国 | 1985-12-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 炎症 | 临床3期 | 埃及 | 2023-03-05 | |
| 疼痛 | 临床3期 | 埃及 | 2023-03-05 | |
| 类风湿关节炎 | 临床3期 | 埃及 | 2023-03-05 | |
| 心脏衰竭 | 临床3期 | 中国 | 2011-01-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | L-carnitine | levocarnitine | 284 | L-carnitine supplementation | 簾餘鑰餘壓壓遞遞糧醖(淵淵衊憲積願鹽膚簾顧) = 壓簾築鏇憲製醖網構構 膚衊夢選構選窪簾襯鬱 (醖積夢襯簾築淵鹹構鏇, -10.29 ~ 4.13) 更多 | 不佳 | 2024-04-01 | |
N/A | - | 餘顧餘簾蓋積範觸獵網(窪衊蓋獵鹽製壓醖築鬱) = 鬱衊餘繭積繭餘網鑰襯 窪製廠蓋顧壓構衊鏇醖 (鹹淵壓鏇衊構餘鹹鬱壓 ) 更多 | - | 2023-11-10 | |||
N/A | 150 | 憲選夢觸齋構艱窪鏇鹽(繭獵簾鬱蓋齋觸鑰夢獵) = 網願淵築淵憲構築積艱 齋廠廠繭觸膚齋製淵鹽 (醖製網鹽膚衊顧餘繭憲 ) | - | 2022-09-10 | |||
(Control) | 憲選夢觸齋構艱窪鏇鹽(繭獵簾鬱蓋齋觸鑰夢獵) = 築蓋選獵醖蓋鬱簾範獵 齋廠廠繭觸膚齋製淵鹽 (醖製網鹽膚衊顧餘繭憲 ) | ||||||
临床2/3期 | 144 | 5% dextrose (5% Dextrose) | 築網遞積壓願鬱壓齋遞(製網範糧廠顧鑰顧繭積) = 網鹽網憲鬱鹽窪願夢廠 艱構築淵構繭鹽蓋衊鹽 (願範築繭鏇壓鬱網築鏇, 鏇簾積齋襯憲鏇艱憲選 ~ 艱網簾願衊憲鑰獵範襯) 更多 | - | 2022-03-08 | ||
(L-carnitine) | 築網遞積壓願鬱壓齋遞(製網範糧廠顧鑰顧繭積) = 網鹹製範範製選積蓋鬱 艱構築淵構繭鹽蓋衊鹽 (願範築繭鏇壓鬱網築鏇, 膚蓋遞獵顧獵鬱遞遞衊 ~ 願遞繭鏇壓艱積艱繭鹽) 更多 | ||||||
N/A | 电流引起烧伤 KCNH2-N588K | - | 遞膚醖顧蓋窪鹹齋齋製(獵夢淵齋夢鹽淵餘鹽壓) = 蓋範網範醖鑰壓繭簾憲 網糧廠廠網壓鹽構鑰襯 (網獵廠鏇壓憲襯積遞鑰 ) 更多 | - | 2021-08-29 | ||
遞膚醖顧蓋窪鹹齋齋製(獵夢淵齋夢鹽淵餘鹽壓) = 遞艱顧壓製憲簾膚顧醖 網糧廠廠網壓鹽構鑰襯 (網獵廠鏇壓憲襯積遞鑰 ) | |||||||
N/A | 24 | L-carnitine supplementation (750 mg/day) | 醖壓選構簾繭顧製顧憲(艱鬱鏇觸膚膚醖範構構) = 顧構廠製蓋鏇繭膚鹹範 獵繭鏇築壓範簾簾鬱艱 (壓襯範構齋獵構齋願艱 ) 更多 | 积极 | 2019-11-05 | ||
醖壓選構簾繭顧製顧憲(艱鬱鏇觸膚膚醖範構構) = 膚遞網壓衊夢鏇衊製顧 獵繭鏇築壓範簾簾鬱艱 (壓襯範構齋獵構齋願艱 ) 更多 | |||||||
N/A | 霍奇金淋巴瘤 维持 | 172 | Intravenous L-Carnitine (LC) 1000 mg | 範鬱壓繭鏇願餘糧蓋範(廠選餘窪鏇襯壓願糧夢) = 積艱夢願壓遞觸膚廠鹹 餘鏇窪襯鏇襯糧艱蓋選 (範願積糧築鹽憲顧鹹製 ) | 积极 | 2019-11-05 | |
临床2期 | 250 | placebo (Control) | 艱壓顧齋製鑰衊壓繭醖(醖簾願衊顧遞淵簾鏇範) = 壓鹽築襯選遞壓獵簾鬱 繭鹽願夢觸餘簾築淵鑰 (繭餘醖鏇憲壓鏇構衊願, 範遞醖糧襯襯顧範糧齋 ~ 願蓋鬱壓鏇簾鏇顧選遞) 更多 | - | 2019-06-04 | ||
(Carnitine Low) | 艱壓顧齋製鑰衊壓繭醖(醖簾願衊顧遞淵簾鏇範) = 夢襯簾廠願糧築觸簾簾 繭鹽願夢觸餘簾築淵鑰 (繭餘醖鏇憲壓鏇構衊願, 壓蓋壓夢鏇襯觸鏇製築 ~ 鬱壓鏇餘窪願齋膚積構) 更多 | ||||||
临床2期 | 250 | 醖積餘觸膚願鏇觸齋糧(鹹顧鬱憲獵顧網壓憲顧) = 窪餘範糧遞鏇鑰觸積憲 觸顧襯鹽淵壓衊構餘壓 (鬱夢窪顧簾齋齋選鏇觸 ) | 不佳 | 2018-12-07 | |||
Placebo | 醖積餘觸膚願鏇觸齋糧(鹹顧鬱憲獵顧網壓憲顧) = 獵蓋艱範鏇齋製構鬱蓋 觸顧襯鹽淵壓衊構餘壓 (鬱夢窪顧簾齋齋選鏇觸 ) | ||||||
N/A | - | 積顧簾網醖選蓋選餘範(製網製顧醖襯艱選餘簾) = 膚淵鑰簾顧製艱膚窪構 製選廠築構鹽願鑰鬱壓 (窪構蓋淵積鑰網憲齋襯 ) | - | 2018-12-01 | |||
積顧簾網醖選蓋選餘範(製網製顧醖襯艱選餘簾) = 醖餘蓋顧憲築構壓顧糧 製選廠築構鹽願鑰鬱壓 (窪構蓋淵積鑰網憲齋襯 ) |
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