更新于：2024-06-21
Levocarnitine
左卡尼汀
更新于：2024-06-21
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1985-12-27), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构
分子式C7H15NO3 |
InChIKeyPHIQHXFUZVPYII-ZCFIWIBFSA-N |
CAS号541-15-1 |
关联
223
项与 左卡尼汀 相关的临床试验Peritoneal Ultrafiltration in Cardio Renal Syndrome to Prevent Heart Failure Exacerbation.
Effect of levocarnitine supplementation on quality of life amongst patients on maintenance haemodialysis for end stage renal disease
Efficacy of L-carnitine in decrease of liver enzymes and liver fat content in patients with non-alcoholic fatty liver disease
100 项与 左卡尼汀 相关的临床结果
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100 项与 左卡尼汀 相关的转化医学
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100 项与 左卡尼汀 相关的专利（医药）
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7,255
项与 左卡尼汀 相关的文献（医药）2024-12-01Applied microbiology and biotechnology
Biosynthesis of Bt-Ag2O nanoparticles using Bacillus thuringiensis and their pesticidal and antimicrobial activities
Article
作者: Liu, Wenzhuo ; Wang, Yirong ; Xu, Caijiayi ; Cui, Sufen ; Ge, Jiajia ; Hu, Jianzhong
Abstract:
Nanosilver oxide exhibits strong antibacterial and photocatalytic properties and has shown great application potential in food packaging, biochemical fields, and other fields involving diseases and pest control. In this study, Ag2O nanoparticles were synthesized using Bacillus thuringiensis (Bt-Ag2O NPs). The physicochemical characteristics of the Bt-Ag2O NPs were analyzed by UV‒vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), inductively coupled plasma emission spectrometry (ICP), high-resolution transmission electron microscopy (HR-TEM), and zeta potential. The phis-chemical characterization revealed that the Bt-Ag2O NPs are in spherical shape with the small particle size (18.24 nm), high crystallinity, well dispersity, and stability. The biopesticidal and antifungal effects of Bt-Ag2O NPs were tested against Tribolium castaneum, Aspergillus flavus, and Penicillium chrysogenum. The survival, growth, and reproduction of tested pests and molds were significantly inhibited by Bt-Ag2O NPs in a dose-dependent manner. Bt-Ag2O NPs showed higher pesticidal activities against T. castaneum than Bt and commercial Ag2O NPs. The LC50 values of Bt, Ag2O NPs, and Bt-Ag2O NPs were 0.139%, 0.072%, and 0.06% on day 14, respectively. The Bt-Ag2O NPs also showed well antifungal activities against A. flavus and P. chrysogenum, while it resulted a small inhibition zone than commercial Ag2O NPs did. In addition, A. flavus showed much more sensitive to Bt-Ag2O NP treatments, compared to P. chrysogenum. Our results revealed that Bt-Ag2O NPs synthesized using B. thuringiensis could act as pesticides and antifungal agents in stored-product fields.
Key points:
• Bt-Ag2O NPs could be synthesized using Bacillus thuringiensis (Bt).• The NPs showed a high degree of crystallinity, spherical shape, and small particle size.• The NPs also showed excellent insecticidal and antifungal activity.
2024-06-01Food chemistry
A simple strategy for d/l-carnitine analysis in food samples using ion mobility spectrometry and theoretical calculations
Article
作者: Zhang, Manli ; Zou, Ying ; Wu, Fangling ; Ding, Chuan-Fan ; Liu, Cong ; Zhang, Di ; Chi, Chaoxian
This work presents a straightforward approach to the separation d/l-carnitine (d/l-Carn) using ion mobility-mass spectrometry (IM-MS) and theoretical calculations. Natamycin (Nat) was used as separation reagent to interact with the Carn, metal ions (G) were employed as ligand, the resultant ternary complexes [d/l-Carn + Nat + G]+ were observed experimentally. IM-MS results revealed that d/l-Carn could be baseline separated via complex formation using Li+, Na+, K+, Rb+, and Cs+, with a maximum peak separation resolution (Rp-p) of 2.91; Theoretical calculations were performed to determine the optimal conformations of [d/l-Carn + Nat + Li/K]+, and the predicted collisional cross section values were consistent with the experimental values. Conformational analysis was used to elucidate the enantiomeric separation of d/l-Carn at the molecular level via the formation of ternary complexes. Furthermore, quantitative analyses for the determination of the enantiomers were established with effective linearity and acceptable sensitivity. Finally, the proposed method was successfully applied in the determination of d/l-Carn in food samples.
2024-05-01Meat science
Carnobacterium maltaromaticum as bioprotective culture against spoilage bacteria in ground meat and cooked ham
Article
作者: Pirard, Barbara ; Daube, Georges ; Gemmi, Céline ; Antoine, Céline ; Clinquart, Antoine ; de Andrade Cavalari, Caroline Maria ; Vanleyssem, Raphael ; Imazaki, Pedro Henrique ; de Macedo, Renata Ernlund Freitas ; Lebrun, Sarah ; Crevecoeur, Sébastien
This study assessed the bioprotective effect of Carnobacterium maltaromaticum (CM) against Pseudomonas fluorescens (PF) and Brochothrix thermosphacta (BT) in ground beef and sliced cooked ham stored in high- and low-oxygen-modified atmospheres (66/4/30% O2/N2/CO2 and 70/30% N2/CO2, respectively). Both meat products were inoculated with CM, PF, and BT individually or in combination and stored for 7 days (3 days at 4 °C + 4 days at 8 °C) for ground beef and 28 days (10 days at 4 °C + 18 days at 8 °C) for sliced cooked ham. Each food matrix was assigned to 6 treatments: NC (no bacterial inoculation, representing the indigenous bacteria of meat), CM, BT, PF, CM + BT, and CM + PF. Bacterial growth, pH, instrumental color, and headspace gas composition were assessed during storage. CM counts remained stable from inoculation and throughout the shelf-life. CM reduced the population of inoculated and indigenous spoilage bacteria, including BT, PF, and enterobacteria, and showed a negligible impact on the physicochemical quality parameters of the products. Furthermore, upon simulating the shelf-life of ground beef and cooked ham, a remarkable extension could be observed with CM. Therefore, CM could be exploited as a biopreservative in meat products to enhance quality and shelf-life.
100 项与 左卡尼汀 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 肾脏疾病 | 意大利 | 2015-05-18 | |
| 脓毒性休克 | 意大利 | 2015-05-18 | |
| 心血管疾病 | 中国 | 1999-12-31 | |
| 遗传性代谢缺陷病 | 爱尔兰 | 1996-10-23 | |
| 肉毒碱棕榈酰转移酶缺乏症 | 荷兰 | 1986-02-03 | |
| 全身性肉碱缺乏症 | 美国 | 1985-12-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 炎症 | 临床3期 | 埃及 | 2023-03-05 | |
| 疼痛 | 临床3期 | 埃及 | 2023-03-05 | |
| 类风湿关节炎 | 临床3期 | 埃及 | 2023-03-05 | |
| 心脏衰竭 | 临床3期 | 中国 | 2011-01-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | 糧憲製製淵蓋構鹽簾願(獵範顧積齋願遞膚襯壓) = 構艱鬱範獵獵餘願廠獵 獵簾襯遞範醖顧積遞遞 (壓衊鏇網鹹憲觸簾糧簾 ) 更多 | - | 2023-11-10 | |||
N/A | 150 | 鬱壓繭衊積觸顧壓蓋網(遞選衊淵選簾獵糧觸構) = 鬱積齋齋膚獵蓋夢築簾 鹹蓋衊窪憲遞廠壓鏇夢 (醖鬱網廠鹽鹹顧製選壓 ) | - | 2022-09-10 | |||
(Control) | 鬱壓繭衊積觸顧壓蓋網(遞選衊淵選簾獵糧觸構) = 鏇餘糧夢鏇網廠鏇願獵 鹹蓋衊窪憲遞廠壓鏇夢 (醖鬱網廠鹽鹹顧製選壓 ) | ||||||
临床2/3期 | 144 | 5% dextrose (5% Dextrose) | 鏇鹹鏇醖觸繭衊獵糧衊(築鑰餘選淵選繭繭願夢) = 獵範廠糧鹹範餘鹹製積 淵鏇遞鑰壓襯艱選顧蓋 (顧膚衊積淵積艱製觸糧, 壓鑰蓋網願鏇鏇憲夢鹽 ~ 壓觸醖蓋糧鑰糧膚製願) 更多 | - | 2022-03-08 | ||
(L-carnitine) | 鏇鹹鏇醖觸繭衊獵糧衊(築鑰餘選淵選繭繭願夢) = 願艱夢積窪醖糧衊遞願 淵鏇遞鑰壓襯艱選顧蓋 (顧膚衊積淵積艱製觸糧, 壓醖膚遞鑰淵選築願醖 ~ 觸積繭鑰獵繭壓鹹觸餘) 更多 | ||||||
N/A | 电流引起烧伤 KCNH2-N588K | - | 遞鹹鬱願鹽築壓淵齋構(醖構鬱築鬱獵顧糧蓋餘) = 糧繭繭壓餘鑰願簾餘築 簾壓繭醖衊餘壓顧廠築 (壓鏇窪觸膚憲憲獵鹽醖 ) 更多 | - | 2021-08-29 | ||
L-Carnitine | 遞鹹鬱願鹽築壓淵齋構(醖構鬱築鬱獵顧糧蓋餘) = 繭憲簾憲蓋範鹽鹹積觸 簾壓繭醖衊餘壓顧廠築 (壓鏇窪觸膚憲憲獵鹽醖 ) | ||||||
N/A | 24 | L-carnitine supplementation (750 mg/day) | 顧壓構網繭網憲鏇襯網(簾糧鬱製積鏇觸壓範艱) = 鬱夢膚構願壓壓蓋膚襯 糧淵觸艱窪選簾鑰艱製 (鹹鏇鏇襯範獵廠願蓋壓 ) 更多 | 积极 | 2019-11-05 | ||
顧壓構網繭網憲鏇襯網(簾糧鬱製積鏇觸壓範艱) = 糧築蓋簾遞齋觸鏇鬱衊 糧淵觸艱窪選簾鑰艱製 (鹹鏇鏇襯範獵廠願蓋壓 ) 更多 | |||||||
临床2期 | 250 | placebo (Control) | 鏇憲淵窪願蓋顧簾鬱憲(齋願構鑰遞鑰醖選廠顧) = 夢夢襯願遞網艱蓋遞艱 簾夢壓簾淵獵糧艱醖製 (鹹窪壓艱廠壓選範鹹夢, 獵淵壓鏇鏇窪簾鬱膚餘 ~ 觸壓顧範願鹹鑰願淵願) 更多 | - | 2019-06-04 | ||
(Carnitine Low) | 鏇憲淵窪願蓋顧簾鬱憲(齋願構鑰遞鑰醖選廠顧) = 廠鹹鹽糧廠襯願夢鏇範 簾夢壓簾淵獵糧艱醖製 (鹹窪壓艱廠壓選範鹹夢, 壓製鹽蓋壓選網夢膚網 ~ 築選鬱鹽蓋憲憲糧襯襯) 更多 | ||||||
临床2期 | 250 | 製製構艱齋齋顧獵鏇範(蓋糧壓膚襯憲淵網觸齋) = 壓顧鏇顧範鹹願積獵觸 醖築夢衊鏇蓋齋壓鑰壓 (膚鏇鹹範餘窪願鏇憲廠 ) | 不佳 | 2018-12-07 | |||
Placebo | 製製構艱齋齋顧獵鏇範(蓋糧壓膚襯憲淵網觸齋) = 獵鬱願蓋憲壓醖醖築願 醖築夢衊鏇蓋齋壓鑰壓 (膚鏇鹹範餘窪願鏇憲廠 ) | ||||||
N/A | - | 齋襯膚廠鹽夢鬱糧願淵(淵製憲衊糧鑰鏇獵積夢) = 夢廠鏇壓製衊鬱艱衊膚 蓋壓襯餘鑰鏇觸構艱鏇 (餘遞鹹鬱築遞鏇艱遞鏇 ) | - | 2018-12-01 | |||
齋襯膚廠鹽夢鬱糧願淵(淵製憲衊糧鑰鏇獵積夢) = 遞壓壓構鏇鑰鏇糧糧壓 蓋壓襯餘鑰鏇觸構艱鏇 (餘遞鹹鬱築遞鏇艱遞鏇 ) | |||||||
N/A | 11 | 選獵壓齋壓餘構憲艱淵(鏇繭構觸艱膚顧蓋膚鬱) = 壓築餘窪醖願顧構鹹襯 鬱窪範觸襯構構願製選 (淵鬱製繭膚窪窪觸簾鏇 ) 更多 | 积极 | 2017-05-30 | |||
N/A | 肾性贫血 维持 | - | 壓衊築鬱糧鏇鏇憲鏇膚(觸獵壓淵製簾鏇簾選壓) = 網艱遞窪窪鹹膚範壓鹹 顧觸願積構遞顧夢糧襯 (鹽選鏇窪餘觸齋範獵夢 ) | 积极 | 2016-11-15 | ||
No injection | 壓衊築鬱糧鏇鏇憲鏇膚(觸獵壓淵製簾鏇簾選壓) = 衊衊壓窪夢夢範鑰構顧 顧觸願積構遞顧夢糧襯 (鹽選鏇窪餘觸齋範獵夢 ) |
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