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更新于：2025-08-16
Dequalinium Chloride
地喹氯铵
更新于：2025-08-16
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 中国 (1996-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C30H40Cl2N4 |
InChIKeyLTNZEXKYNRNOGT-UHFFFAOYSA-N |
CAS号522-51-0 |
关联
8
项与 地喹氯铵 相关的临床试验CTR20240880
地喹氯铵含片人体生物等效性研究（预试验）
NCT05788991
Comparative Study of the Efficacy and Safety of Vaginally Applied Dequalinium Chloride (10 mg) and Orally Applied Metronidazole (2 x 500 mg) in the Treatment of Bacterial Vaginosis
NCT04057482
Treatment of Bacterial Vaginosis With Dequalinium Chloride Vaginal Tablets and a Test of Cure Using a New Molecular Diagnostic Test for the Diagnosis of Bacterial Vaginosis
100 项与 地喹氯铵 相关的临床结果
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100 项与 地喹氯铵 相关的转化医学
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100 项与 地喹氯铵 相关的专利（医药）
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356
项与 地喹氯铵 相关的文献（医药）2025-07-01COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Unveiling the role of hydrophobicity and foam property in froth flotation of lepidolite with decamine, dodecylamine, tetradecylamine, hexadecylamine and MIBC
作者: Li, Fangxu ; Liu, Shuo
In order to overcome the limitations of fatty amines (FAS) and reduce consumption and costs, this study developed a high-efficiency flotation system that FAS with Me iso-Bu methanol (MIBC).Single mineral flotation results showed that MIBC enhanced the collecting ability of decamine (DCA), dodecylamine (DDA), tetradecylamine (TDA), and hexadecylamine (HCA) while reducing their dosage.At pH 3, recoveries for DCA, DDA, TDA, and HCA were 63.22 ± 1.34%, 86.284 ± 4.33%, 72.30 ± 3.34%, and 40.02 ± 2.27%, resp.With MIBC added, these increased to 89.43 ± 1.87%, 89.58 ± 2.66%, 73.38 ± 4.27%, and 79.60 ± 2.23%.Batch flotation experiments also demonstrated that lepidolite recovery by DDA and HCA rose from 96.64% and 36.47-96.70% and 98.29%, resp.Surface tension and viscosity detection revealed that the addition of MIBC to FAS resulted in a decrease in surface tension and an increase in solution viscosity.The adsorption, zeta potential, contact angle and foaming property tests indicated that MIBC can enhanced the recovery of lepidolite by adjusting the adsorption densities of DCA and DDA, as well as modifying the bubble properties of TDA and HDA in the flotation pulp.These findings highlighted the critical role of bubble properties in lepidolite flotation systems, going beyond mere hydrophobicity effects.
2025-01-01Research in Pharmaceutical Sciences
The development of mitochondria-targeted quercetin for rescuing Sertoli cells from oxidative stress
Article
作者: Satrialdi ; Pratiwi, Cellina ; Mudhakir, Diky ; Khaeranny, Ryan Novia
Background and purpose::
The imbalance between reactive oxygen species (ROS) production and endogenous antioxidant capacity leads to oxidative stress, which may damage several cellular functions, particularly spermatogenesis. This condition is a leading cause of male infertility, so controlling ROS levels is crucial. The ROS level can be controlled by supporting the endogenous antioxidant system through antioxidant therapy. Mitochondria are the prime target for antioxidant therapy due to the majority of endogenous ROS produced in mitochondria and their critical role in providing energy during fertilization. This research aimed to develop mitochondria-targeted hybrid nanoplatforms by combining liposomes with dequalinium’s mitochondriotropic agent (DQ) to deliver quercetin for targeted antioxidant therapy to mitochondria.
Experimental approach::
The quercetin-loaded nanocarrier was constructed using the hydration method. We varied the concentration of DQ to investigate its impact on physical characteristics, encapsulation efficiency, intracellular trafficking, and in vitro antioxidant activity.
Findings/Results::
The impact of different DQ densities on particle size, encapsulation efficiency, and mitochondria targeting was insignificant. However, lowering the DQ density reduced the zeta potential. Minimizing oxidative stress on TM4 cells was only achieved with low-density DQ (Q-LipoDQ LD), while high-density DQ (Q-LipoDQ HD) failed to mitigate the negative impact.
Conclusion and implications::
According to the findings, LipoDQ LD preserves a promising potential as mitochondria-targeted nanoplatforms and validates the importance of mitochondria as a target for antioxidant therapy.
2024-11-01AMERICAN FAMILY PHYSICIAN
Dequalinium Is Noninferior to Metronidazole for Bacterial Vaginosis.
Article
作者: Slawson, David C
100 项与 地喹氯铵 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 外阴阴道念珠菌病 | 瑞士 | 2007-05-29 | |
| 细菌性阴道炎 | 瑞士 | 2007-05-07 | |
| 口腔炎 | 中国 | 1996-01-01 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 151 | (Dequalinium Chloride) | 積齋鹹範鹽壓鑰選膚遞 = 膚獵蓋憲網憲築範廠觸 襯鹹構醖鑰夢憲範築襯 (糧廠獵襯遞鹽糧觸衊鑰, 蓋夢網醖淵範遞鏇築醖 ~ 廠衊積鹹蓋鬱繭簾憲願) 更多 | - | 2024-10-16 | ||
(Metronidazole) | 積齋鹹範鹽壓鑰選膚遞 = 壓網選衊鏇積獵選憲範 襯鹹構醖鑰夢憲範築襯 (糧廠獵襯遞鹽糧觸衊鑰, 蓋膚繭廠遞糧鬱顧繭膚 ~ 顧遞築願築糧選網範繭) 更多 | ||||||
临床4期 | 147 | 選艱繭範獵構壓廠鹽鬱(顧鹹築壓獵糧網鏇獵鹹) = Three patients in the metronidazole group suspended treatment due to an adverse event 淵遞襯襯繭襯繭夢鬱網 (憲獵艱憲艱糧顧願鹹獵 ) | 积极 | 2024-05-02 | |||
临床4期 | 150 | 鑰壓遞遞齋夢餘廠範憲(繭觸糧膚鬱願製網窪壓): OR = 0.79 (95% CI, 0.56 ~ 1.1), P-Value = 0.197 | - | 2021-01-01 | |||
临床3期 | 321 | Dequalinium Chloride Vaginal Tablets (Fluomizin) | 蓋糧醖窪夢夢願壓鹽願(憲窪遞範壓簾餘觸積醖) = 築襯醖餘夢憲衊衊鑰廠 襯顧鏇簾觸糧顧糧積遞 (淵憲鹽鑰蓋鬱壓獵窪鹹 ) 更多 | 积极 | 2012-01-01 | ||
Clindamycin Vaginal Cream | 蓋糧醖窪夢夢願壓鹽願(憲窪遞範壓簾餘觸積醖) = 範糧製築壓觸積壓選淵 襯顧鏇簾觸糧顧糧積遞 (淵憲鹽鑰蓋鬱壓獵窪鹹 ) 更多 |
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