预约演示
更新于：2025-07-15
Luliconazole
卢立康唑
更新于：2025-07-15
概要
基本信息
药物类型 小分子化药 |
别名 Luconac Solution、Luliconazole (JAN/USAN/INN)、Lulifin + [12] |
作用方式 抑制剂 |
作用机制 fungal CYP51A1抑制剂(真菌细胞色素P450家族成员51抑制剂) |
非在研适应症 |
权益机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H9Cl2N3S2 |
InChIKeyYTAOBBFIOAEMLL-REQDGWNSSA-N |
CAS号187164-19-8 |
关联
20
项与 卢立康唑 相关的临床试验IRCT20240711062393N1
Efficacy Evaluation of Loaded Nanostructured Lipid Carriers (NLC) with Luliconazole in Treatment-Resistant Dermatophytosis
CTRI/2024/03/063613
A Comparative study to evaluate the efficacy and safety of topical Luliconazole versus topical Ciclopirox olamine among patients with Tinea corporis/cruris - NIL
CTRI/2024/03/063840
A Single Center, Randomized, Open-Label, Prospective, Parallel Group Study to Evaluate antifungal and biofilm inhibition activity of formulation containing Lactoferrin cream + Luliconazole cream against Luliconazole Cream in the Treatment of Patients with cutaneous Candidiasis and Dermatophytosis - Nill
100 项与 卢立康唑 相关的临床结果
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100 项与 卢立康唑 相关的转化医学
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100 项与 卢立康唑 相关的专利（医药）
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383
项与 卢立康唑 相关的文献（医药）2025-10-01DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Concurrent chromoblastomycosis and subcutaneous phaeohyphomycosis by different pathogens in a renal transplant recipient
Article
作者: Rudramurthy, Shivaprakash M ; Sharma, Ashish ; Agnihotri, Sourav ; Kaur, Harsimran ; Narang, Tarun ; Sethi, Jasmine ; Gupta, Charvi ; Srinivasan, Radhika ; Kumar, Karthick ; Ahmad, Haseen ; Gupta, Nalini
Chromoblastomycosis and subcutaneous phaeohyphomycosis are implantation mycoses caused by melanized fungi. We present a unique case of concurrent chromoblastomycosis by Fonsecaea monophora and phaeohyphomycosis by Medicopsis romeroi presenting as polypoidal wrist lesion and painless cystic toe lesion respectively in a renal transplant recipient. The diagnosis was confirmed by microbiological (including molecular identification by sequencing of ITS region of rDNA) and histopathological examination. The wrist lesion was surgically excised. Oral itraconazole and topical luliconazole led to healing of both lesions within six months of therapy. This case highlights the emergence of rare opportunistic fungal pathogens causing concurrent skin infections in an immunocompromised patient. This warrants investigation of their epidemiology and virulence to implement preventive measures in renal transplant recipients.
2025-07-01JOURNAL OF DERMATOLOGY
Widespread Majocchi's Granuloma Caused by Multidrug‐Resistant Trichophyton rubrum Successfully Treated With Amphotericin B and Posaconazole
Article
作者: Noguchi, Hiromitsu ; Hiruma, Masataro ; Takamori, Kenji ; Kano, Rui ; Suga, Yasushi ; Matsumoto, Tadahiko ; Kimura, Utako
ABSTRACT:
We encountered a 60‐year‐old Japanese female patient with disseminated dermatophytosis caused by terbinafine‐resistant Trichophyton rubrum with mutant SQLE (Leu393Phe substitution). Histopathology showed fungus in the dermis, indicating Majocchi granuloma. Oral fosravuconazole and topical luliconazole were administered for 18 months, resulting in invasive dermatophytosis with a high β‐d‐glucan level of 7320 pg/mL. The MICs of amphotericin B, posaconazole, griseofulvin, itraconazole, voriconazole, ravuconazole, and terbinafine were 0.5, 0.5, 8, 16, 8, 16, and 32 μg/mL, respectively. Amphotericin B for 6 months followed by oral posaconazole for another 6 months cured the disease. Posaconazole may be a promising agent for the treatment of multidrug‐resistant dermatophytes. We present the first reported case of multiazole‐resistant T. rubrum resulting from prolonged fosravuconazole treatment.
2025-05-14Cureus Journal of Medical Science
Dermatophytosis in a Healthy Adolescent: A Report of Terbinafine-Resistant Trichophyton indotineae Infection in Kuwait
Article
作者: AlFadhel, Noria ; Abdulwahab, Hanan ; AlQusaimi, Reem ; Al Otaibi, Mohammad F ; AlHashel, Maryam ; Alajmi, Hanan ; AlSharhan, Fahad ; Alkhaleefa, Ayaa ; AlRujaib, Fawziah
Dermatophytosis caused by Trichophyton species is a common fungal infection of the skin, hair, and nails. However, the emergence of antifungal-resistant Trichophyton strains has become an increasing challenge, leading to persistent and recurrent infections that are recalcitrant to treatment. We present the case of a 19-year-old Yemeni male patient with a dermatophyte infection caused by a terbinafine-resistant Trichophyton species. The patient experienced symptoms for two weeks despite standard antifungal treatment. Fungal culture results showed the growth of Trichophyton indotineae. The patient was subsequently treated with topical clotrimazole 1% twice daily and luliconazole 1% cream at night, which led to the significant clinical improvement and complete resolution of the rash within two weeks. This case highlights the growing concern of antifungal resistance in dermatophyte infections, particularly against terbinafine, one of the most commonly prescribed treatments. The increasing prevalence of resistant Trichophyton strains underscores the need for antifungal susceptibility testing in refractory cases and the consideration of alternative treatment strategies.
100 项与 卢立康唑 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 手癣 | 美国 | 2018-02-20 | |
| 甲癣 | 日本 | 2016-01-22 | |
| 皮肤念珠菌病 | 中国 | 2012-06-27 | |
| 真菌病 | 韩国 | 2010-02-01 | |
| 体癣 | 日本 | 2005-07-31 | |
| 股癣 | 日本 | 2005-07-31 | |
| 足癣 | 日本 | 2005-07-31 | |
| 念珠菌病 | 日本 | 2005-04-11 | |
| 癣 | 日本 | 2005-04-11 | |
| 花斑癣 | 日本 | 2005-04-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性皮肤黏膜念珠菌病 | 药物发现 | 美国 | 2011-01-11 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 75 | (Luliconazole Cream 1%) | 願簾製簾衊齋顧鹽糧醖(淵顧蓋觸鑰鬱膚餘艱膚) = 鬱鑰顧鏇繭鑰網遞鹽衊 遞鹹餘顧鑰構餘製鹽鹹 (糧顧壓醖範壓網觸選簾, 2.93) 更多 | - | 2019-11-27 | ||
Vehicle Cream (Vehicle Cream) | 願簾製簾衊齋顧鹽糧醖(淵顧蓋觸鑰鬱膚餘艱膚) = 壓壓顧壓襯淵製膚製襯 遞鹹餘顧鑰構餘製鹽鹹 (糧顧壓醖範壓網觸選簾, NA) 更多 | ||||||
临床4期 | 20 | Omeprazole 40 mg+Luliconazole Cream 1% | 憲遞夢構鹽糧願遞窪餘(選餘襯蓋鑰蓋襯製壓鹽) = 網範築積淵網範醖夢窪 餘鹹蓋夢鬱願鹽網艱積 (淵觸齋網構願選築顧壓, 0) 更多 | - | 2019-11-27 | ||
临床4期 | 30 | (Tinea Pedis) | 憲繭齋網壓繭製淵製艱(網鬱築構積製繭簾簾積) = 鬱觸憲窪餘廠獵鹹齋壓 膚醖鹹鏇窪齋鹹襯構積 (廠選獵襯廠襯獵蓋鬱壓, 1.71) 更多 | - | 2019-11-27 | ||
(Tinea Cruris) | 選齋鏇醖鑰繭鹹簾獵夢(網憲衊遞夢鹽願夢憲構) = 製範醖構遞膚淵鹹齋遞 齋網顧鏇襯夢齋網積餘 (簾鬱範壓製壓網壓積廠, 13.62) 更多 |
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