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更新于：2025-03-25
Sodium Thiosulfate
硫代硫酸钠
更新于：2025-03-25
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1984-05-11), |
最高研发阶段(中国)批准上市 |
特殊审评突破性疗法 (美国)、快速通道 (美国)、孤儿药 (美国)、孤儿药 (欧盟)、优先审评 (中国) |
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结构/序列
分子式H12Na2O8S2 |
InChIKeyJIWXHKJJHDWKGC-UHFFFAOYSA-N |
CAS号10102-17-7 |
关联
65
项与 硫代硫酸钠 相关的临床试验NCT06672822
An Open Label Evaluation of Intralesional Injection of Sodium Thiosulfate in the Treatment of Cutaneous or Tendon Calcinosis in Connective Tissue Disease
CTIS2023-510255-34-00
A prospective, multi-centre, open-label, investigator-initiated randomised controlled study investigating calcinosis cutis in patients with systemic sclerosis undergoing treatment with sodium thiosulfate assessed by novel biomarkers and diagnostic imaging
TCTR20240520004
Efficacy of intratympanic sodium thiosulfate gel injection to preventisplatin-induced ototoxicity: a randomized controlled trial
100 项与 硫代硫酸钠 相关的临床结果
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100 项与 硫代硫酸钠 相关的转化医学
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100 项与 硫代硫酸钠 相关的专利（医药）
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3,113
项与 硫代硫酸钠 相关的文献（医药）2025-06-01SEPARATION AND PURIFICATION TECHNOLOGY
Quercetin enhanced the phenanthrene degradation in Fe(III)/H2O2 system: Role of quercetin and fate of reactive oxygen species under different initial pH values
作者: Ma, Li-Bang ; Ren, Xue-Chang ; Ma, Xiao-Hong ; Wu, Ying-ying ; Cao, Shi-Qing ; Li, Shao-Fei
Polycyclic aromatic hydrocarbons (PAHs) are widely present in air, soil, sediment, and water, posing carcinogenic and mutagenic risks to human health.Although Fenton processes are widely employed for organic wastewater treatment, they exhibit limitations such as a narrow operational pH range, low H2O2 utilization, and limited Fe(III)/Fe(II) cycling efficiency.To overcome these limitations, a novel method for enhancing the Fenton-like degradation of phenanthrene (PHE) in water by complexing quercetin (QC) with Fe(III) was proposed.The Fe(III)/QC/H2O2 system degraded 93.64% of PHE within 60 min at initial pH = 5.0.D. functional theory (DFT) calculations confirmed the exptl. findings, demonstrating that the 3-hydroxychromone site is the most preferred site for complexation with Fe(III).The addition of QC inhibits Fe(III) precipitation, slows the ineffective decomposition of H2O2, and promotes Fe(III)/Fe(II) cycling.ESR, quenching and probe experiments revealed the presence of three ROS, hydroxyl radicals (•OH), superoxide anion radicals (O•-2), and Fe(IV) in Fe(III)/QC/H2O2 system, which play crucial roles in PHE degradationO•-2 does not directly degrade PHE; instead, it promotes the generation of •OH by reducing Fe(III).Pathways for Fe(IV) formation under pH 3.0 and 5.0 were proposed.The role of QC and the fate of ROS vary with different initial pH values.The intermediates of PHE and QC were determined by mass spectrometry, and possible degradation pathways were suggested.This study demonstrates that the QC enhanced Fe(III)/H2O2 Fenton-like system holds significant potential for the remediation of PAH contamination.
2025-06-01SEPARATION AND PURIFICATION TECHNOLOGY
Adsorption-catalytic synergistic Fenton degradation of potassium butyl xanthate in flotation tailing wastewater by renewable iron-loaded sludge: Performance, kinetics and mechanism
作者: Hursthouse, Andrew ; Deng, Renjian ; Li, Zhi ; Hou, Baolin ; Wang, Zhenghua ; Shu, Jinkai ; Liu, Jinyue ; Ren, Bozhi ; Kuang, Yu ; Tang, Jiping ; Wang, Chuang
The renewable iron-loaded residual sludge heterogeneous catalyst (RLS-Fe) was prepared by impregnation-pyrolysis method and applied to the heterogeneous Fenton for the degradation of potassium Bu xanthate (BX-K) in flotation tailing wastewater.The rich pore structure and uniformly distributed iron oxides endowed the catalyst with excellent adsorption and catalytic capabilities.RLS-Fe exhibited maximum adsorption capacity of 86.47 mg/g, with surface concentration (Cs) of 2.88 mg/cm2 and surface coverage (θ) exceeding 80%.The interaction of monolayer-adsorbed BX-K with catalytically generated .OH facilitated the Fenton reaction and enhanced the adsorption process, making the degradation and mineralization of BX-K more efficient, with the removal rate of 99.82% in 80 min.Through the synergistic effects of adsorption and catalytic processes, H2O2 was efficiently decomposed and effectively utilized.The .OH generated in the initial stage rapidly degraded the adsorbed BX-K and released the adsorption sites, while the .O-2 produced subsequently targeted the catalytic sites and restored their activity.The Langmuir-Hinshelwood (L-H) kinetic model confirmed that the mutual promotion of adsorption and catalysis elevated the apparent reaction rate constant and accelerated the mineralization of BX-K.Addnl., d. functional theory (DFT), Fukui indexes and Gibbs free energy calculations were employed to analyze the intermediates and degradation pathways of BX-K.The -C=S- bond was identified as the primary target for .OH attack.The RLS-Fe catalyst prepared in this study presented excellent stability and renewability, offering new insights for the streamlined preparation of renewable catalysts and efficient treatment of tailings wastewater.
2025-06-01APPLIED CATALYSIS B-ENVIRONMENTAL
Efficient photo-Fenton degradation of water pollutants via peracetic acid activation over sulfur vacancies-rich metal sulfides/MXenes
作者: Li, Wen-Wei ; Zheng, Heshan ; Zhang, Tianqi ; Ma, Jun ; Niu, Junfeng ; Zhang, Wen ; Li, Shuo
Photo-Fenton processes promise removal of various recalcitrant organic pollutants from water in a low-carbon manner, but the low reactivity and inadequate stability of the existing photocatalytic systems remain key barriers to their practical application.Here, we constructed a heterojunction catalyst, consisting of titanium carbide (Ti3C2 MXene) and cobalt-doped zinc sulfide (ZnS), for efficient photocatalytic activation of peracetic acid (PAA) and pollutants degradationThe system exhibited 10 times faster kinetics for tetracycline hydrochloride (TCH) degradation than that of the ZnCoS/PAA group, and far outperformed most of the existing photocatalytic systems.The abundantly-formed sulfur vacancy (SVs), induced by the Ti3C2 introduction into ZnCoS, played a key role in the activity augmentation through simultaneously promoting the process of light adsorption, photocharge separation, and PAA activation.The nonradical-dominated pathway also endowed the system superior environmental robustness and stability.Its feasibility for treating real river water and tap water under sunlight was also demonstrated, implying a great potential for practical water treatment.Our work may inspire new development of photocatalytic decontamination technologies towards sustainable environmental remediation applications and beyond.
100 项与 硫代硫酸钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 耳毒性 | 美国 | 2022-09-20 | |
| 消毒剂 | 日本 | 2013-11-12 | |
| 氰化物中毒 | 澳大利亚 | 2007-08-30 | |
| 中毒 | 日本 | 1984-05-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 钙化防御 | 临床3期 | 美国 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 加拿大 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 英国 | 2017-05-24 | |
| 眼部疾病 | 临床2期 | 比利时 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 法国 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 西班牙 | 2022-01-10 | |
| 听力损失 | 临床1期 | 美国 | 2020-02-21 | |
| 听力损失 | 临床1期 | 澳大利亚 | 2020-02-21 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 16 | 艱鑰獵遞窪觸構積簾築 = 窪觸簾憲襯範遞積憲遞 繭醖鏇膚襯憲憲觸鹽製 (餘鏇遞憲獵鹽選獵憲衊, 膚蓋醖鹹遞築艱顧鹽蓋 ~ 鑰鑰製餘簾築衊獵觸築) 更多 | - | 2024-06-28 | |||
N/A | - | 鹹鏇觸膚製夢淵淵築鏇(構襯憲糧遞襯築鬱網廠) = 簾築淵遞夢觸鏇積鑰淵 願襯遞憲襯願範鬱衊膚 (積積艱鬱餘簾衊繭鹽願 ) | - | 2024-04-01 | |||
临床2/3期 | 15 | 遞觸遞簾餘膚壓獵網範(齋願壓鏇淵淵夢簾餘鏇) = 選觸醖糧繭蓋築鹹糧鏇 繭膚餘鬱蓋鬱選鏇壓製 (製夢夢繭願蓋淵獵獵築, 0.89) 更多 | - | 2024-02-26 | |||
N/A | 钙化防御 辅助 | - | 窪壓鏇齋顧積遞鏇願繭(醖壓鏇顧淵齋鏇鬱積顧) = 壓鏇襯襯願醖衊糧鹹顧 齋衊醖餘顧廠艱製築遞 (構選壓構選願鑰憲範構 ) 更多 | - | 2023-07-07 | ||
EMA 人工标引  | N/A | 109 | (with hepatoblastoma) | 蓋齋繭醖製構糧獵廠鹹(簾構鬱淵遞鑰鏇窪壓鏇) = 製蓋憲願艱鹹鑰鹹網獵 淵遞鏇鹽鏇膚繭淵衊積 (願鏇願選遞艱鹹壓鏇獵 ) 更多 | 积极 | 2023-06-02 | |
(with hepatoblastoma) | 蓋齋繭醖製構糧獵廠鹹(簾構鬱淵遞鑰鏇窪壓鏇) = 願獵遞鹽醖憲廠鏇壓築 淵遞鏇鹽鏇膚繭淵衊積 (願鏇願選遞艱鹹壓鏇獵 ) 更多 | ||||||
EMA 人工标引 | N/A | 104 | (with different types of cancer) | 襯淵製淵鹽壓膚襯範繭(夢遞廠襯醖顧構鬱膚夢) = The risk of having hearing loss was statistically significantly lower in the CIS+STS arm compared with the CIS Alone arm, corresponding to a clinically meaningful 48% lower risk after STS treatment. 網顧鏇繭鏇憲簾鏇鹹製 (膚願壓鬱構夢壓鹽齋積 ) 更多 | 积极 | 2023-06-02 | |
(with different types of cancer) | |||||||
临床1期 | 19 | 艱簾網膚壓繭構淵網繭(選鏇積糧觸襯鹽衊廠鏇) = Ear pain (15/19 subjects, 78.9%) and tinnitus (8/19 subjects, 42.1%) were common. Ear pain was more common in DB-020 treated ears, and tinnitus was more common in placebo treated ears. 糧淵積遞築衊獵構鬱網 (構鬱艱鬱顧簾積齋壓製 ) 更多 | 积极 | 2023-05-26 | |||
Placebo | |||||||
N/A | - | Sodium Thiosulfate (STS) | 窪顧壓製蓋壓淵簾醖範(獵憲襯鹹窪蓋衊鏇網淵) = the patient's severe pain persisted despite escalation of analgesic therapy prompting consideration of hospice 遞憲觸獵簾餘齋衊製醖 (衊餘獵鑰願觸齋糧選鏇 ) | - | 2022-11-06 | ||
Bicarbonate therapy | |||||||
临床1期 | 19 | 夢觸廠餘範製簾獵獵積(膚築齋製憲網齋鹽夢鹹) = 鏇餘願襯艱鬱構鑰衊網 壓壓繭觸齋蓋鑰膚齋糧 (製簾鑰鬱鏇壓繭憲積鹹 ) | 积极 | 2022-06-28 | |||
Placebo | 夢觸廠餘範製簾獵獵積(膚築齋製憲網齋鹽夢鹹) = 憲獵範構繭選選遞鏇簾 壓壓繭觸齋蓋鑰膚齋糧 (製簾鑰鬱鏇壓繭憲積鹹 ) | ||||||
N/A | 钙化防御 维持 | - | Optimized Sodium Thiosulfate Therapy | 範鏇構願鏇觸顧積夢糧(夢鏇範鹹襯積鹹餘選艱) = most adverse events appeared in the course of increasing the STS dose and would be relieved when we stopped adding it or decreased to the day-before dose 遞壓餘遞網選選淵壓廠 (繭願顧鏇網齋鏇簾獵齋 ) | 积极 | 2022-05-03 |
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