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更新于：2025-06-25
Sodium Thiosulfate
硫代硫酸钠
更新于：2025-06-25
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1984-05-11), |
最高研发阶段(中国)批准上市 |
特殊审评突破性疗法 (美国)、快速通道 (美国)、孤儿药 (美国)、孤儿药 (欧盟)、优先审评 (中国) |
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结构/序列
分子式H12Na2O8S2 |
InChIKeyJIWXHKJJHDWKGC-UHFFFAOYSA-N |
CAS号10102-17-7 |
关联
66
项与 硫代硫酸钠 相关的临床试验NCT06672822
An Open Label Evaluation of Intralesional Injection of Sodium Thiosulfate in the Treatment of Cutaneous or Tendon Calcinosis in Connective Tissue Disease
CTIS2023-510255-34-00
A prospective, multi-centre, open-label, investigator-initiated randomised controlled study investigating calcinosis cutis in patients with systemic sclerosis undergoing treatment with sodium thiosulfate assessed by novel biomarkers and diagnostic imaging
TCTR20240520004
Efficacy of intratympanic sodium thiosulfate gel injection to preventisplatin-induced ototoxicity: a randomized controlled trial
100 项与 硫代硫酸钠 相关的临床结果
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100 项与 硫代硫酸钠 相关的转化医学
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100 项与 硫代硫酸钠 相关的专利（医药）
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3,154
项与 硫代硫酸钠 相关的文献（医药）2025-09-01FOOD CHEMISTRY
Optimization and characterization of a novel oleofoam using mixed structuring agents based on sheep tail stearin, glycerol monostearate, and sorbitan monostearate
Article
作者: Calligaris, Sonia ; Basso, Federico ; Goli, Sayed Amir Hossein ; Soltanizadeh, Nafiseh ; Abdollahi, Maryam
Oleofoam is an innovative aerated system for designing low-fat lipid-based food products. This study optimized oleofoam formulation by adjusting sheep tail stearin (STS; 15-35 wt%), glycerol monostearate (GMS; 0-10 wt%), and sorbitan monostearate (SMS; 0-10 wt%) proportions using an optimal mixture design. The best formulations giving oleogels with maximum oil binding capacity (>93.4 %) and intermediate hardness (3.0-9.4 N), and oleofoams with high overrun (56.7-92.4 %) and stability after 7 days (95.5-99.4 %) resulted from those containing 27 wt% STS and 8 wt% GMS/SMS was selected for further analysis. Mixed oleogels exhibited two crystallization peaks, with GMS/SMS as nuclei for more crystal formation, leading to greater G'LVR than STS-based control sample. After whipping, STS-GMS-based oleofoam displayed uniformly smaller air bubbles (30.42 μm) within oil network, stable against heating up to 50 °C. It also maintained ultrastability (>97 %) during 40 days, with air incorporation not affecting oxidative stability.
2025-08-01TOXICOLOGY
High-content screening morphological analysis to evaluate hepatic apoptosis induced by plant alkaloids in a Chang cell model
Article
作者: Choi, Hwa Young ; Jang, Sihyeon ; Park, Young Eun ; Chun, Hyang Sook ; Park, Su Been
As interest in plant-derived compounds and their application in the pharmaceutical and functional food industries has increased, the rapid detection of chemical toxicity has become increasingly important for developing safe products. High-content screening (HCS) can quantify cellular and organelle morphological changes through image analysis; however, most HCS studies on apoptosis, a key toxicological event, have focused on the expression of apoptosis-related genes or proteins. In this study, we aimed to verify whether apoptosis can be detected solely based on cellular morphological changes. Chang cells were treated with staurosporine (STS), a well-known apoptosis inducer, and the morphological changes in the cells were quantified using HCS assays. The correlation between these HCS morphological descriptors and apoptosis rates measured using flow cytometry was determined. Chang cells were also treated with several plant-derived alkaloids known to induce apoptosis, and the same process was performed. The correlation coefficients, which were used to evaluate the correlation between HCS descriptors and apoptosis rates after STS treatment, ranged from 0.64 to 0.98, with 13 descriptors showing significant correlations. In contrast, the highest correlation coefficients between HCS descriptors and apoptosis rates after treatment with 1 of the 12 alkaloids investigated were determined to be 0.75 (at 10 μg/ml) and 0.49 (at 100 μg/ml). The apoptosis-related morphological changes induced by STS and alkaloids were observed using confocal microscopy. The present study demonstrates that HCS assays can detect apoptosis solely based on cellular morphological changes, providing a potential tool for rapid toxicity screening in early product development.
2025-08-01APPLIED CATALYSIS B-ENVIRONMENTAL
Modulation of sulfur vacancies in MoS2/Fe3P enhancing non-radical pathway of the Fenton-like reaction for complex real water
作者: Li, Zhenghao ; Yang, Liwei ; Wang, Junfeng ; Zhong, Chao ; Xu, Xing ; Liu, Yongjia ; Liu, Zhen ; Zhao, Chuanliang ; Zhang, Changzhi
The modulation activity and mechanism of the sulfur vacancies (Svs) in MoS2/Fe3P to peroxymonosulfate (PMS) based Fenton-like reaction were investigated in this study.A series of MoS2/Fe3P catalysts with distinct Svs contents were synthesized using hydrothermal method.The highest Svs content contributed to improving the pollutant degradation rates to 1.1-13.3 times higher due to greater involvement of electron transfer process (ETP), 1O2 and FeIV=O.The decontamination contribution of non-radical pathway was efficiently raised from 38.20% to 48.02%.D. functional theory (DFT) calculations reaffirmed that Svs bolstered PMS adsorption and reduced the energy barrier for electron transfer.These findings demonstrated the significance of Svs for the enhancement of catalytic efficiency, material stability and recyclability, which were further verified in continuous flow systems.This work highlights the potential of vacancy engineering in designing efficient catalysts for practical environmental applications, and offers a promising solution for sustainable wastewater treatment.
100 项与 硫代硫酸钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 耳毒性 | 美国 | 2022-09-20 | |
| 消毒剂 | 日本 | 2013-11-12 | |
| 氰化物中毒 | 澳大利亚 | 2007-08-30 | |
| 中毒 | 日本 | 1984-05-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 钙化防御 | 临床3期 | 美国 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 加拿大 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 英国 | 2017-05-24 | |
| 眼部疾病 | 临床2期 | 比利时 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 法国 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 西班牙 | 2022-01-10 | |
| 听力损失 | 临床1期 | 美国 | 2020-02-21 | |
| 听力损失 | 临床1期 | 澳大利亚 | 2020-02-21 |
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临床结果
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适应症
分期
评价
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临床2期 | 16 | 齋齋淵憲網範鹹網顧選 = 築製獵鬱糧廠蓋簾簾鬱 醖艱獵範選鏇艱膚鑰觸 (艱膚鑰淵簾鏇衊蓋鹹顧, 膚築願衊顧選繭窪構壓 ~ 築築壓選淵鹽夢鑰夢淵) 更多 | - | 2024-06-28 | |||
N/A | - | 襯衊窪餘遞網製積憲夢(網衊觸鏇夢鹹窪壓齋艱) = 鬱壓淵鬱窪繭淵顧範醖 齋艱鹽簾襯選鑰糧膚選 (糧選壓壓窪構積遞襯艱 ) | - | 2024-04-01 | |||
临床2/3期 | 15 | 壓繭願願膚襯醖鹽夢網(蓋鹹壓鑰願蓋遞齋網蓋) = 築獵襯鏇觸壓顧繭鹹襯 網網簾蓋鹽廠壓鹽鑰鏇 (觸範繭衊積顧鏇衊蓋膚, 0.89) 更多 | - | 2024-02-26 | |||
N/A | 钙化防御 辅助 | - | 淵窪積鬱簾製壓製選醖(膚築鬱襯築膚膚糧觸膚) = 醖構遞構醖憲製餘醖蓋 鹹網糧衊鹽蓋膚鑰糧積 (顧選蓋醖壓鏇觸繭獵廠 ) 更多 | - | 2023-07-07 | ||
EMA 人工标引  | N/A | 109 | (with hepatoblastoma) | 憲製製齋鏇製廠鬱鏇願(範積窪願鑰簾鬱襯積遞) = 齋築鹹鬱製鬱艱糧鬱獵 積簾壓衊製選鹽艱鹹蓋 (獵鏇鬱製製觸憲簾淵憲 ) 更多 | 积极 | 2023-06-02 | |
(with hepatoblastoma) | 憲製製齋鏇製廠鬱鏇願(範積窪願鑰簾鬱襯積遞) = 積蓋齋選憲網獵積鏇選 積簾壓衊製選鹽艱鹹蓋 (獵鏇鬱製製觸憲簾淵憲 ) 更多 | ||||||
EMA 人工标引 | N/A | 104 | (with different types of cancer) | 糧鏇廠鹽鬱積膚築範壓(醖遞憲蓋簾鬱醖蓋觸膚) = The risk of having hearing loss was statistically significantly lower in the CIS+STS arm compared with the CIS Alone arm, corresponding to a clinically meaningful 48% lower risk after STS treatment. 構範餘糧繭鏇築蓋願襯 (獵獵衊艱願襯鬱憲鹽膚 ) 更多 | 积极 | 2023-06-02 | |
(with different types of cancer) | |||||||
临床1期 | 19 | 襯鬱窪憲獵積淵鹽製衊(網壓膚餘憲衊鏇觸繭簾) = Ear pain (15/19 subjects, 78.9%) and tinnitus (8/19 subjects, 42.1%) were common. Ear pain was more common in DB-020 treated ears, and tinnitus was more common in placebo treated ears. 鑰範窪觸繭窪糧觸構築 (鑰窪築衊製醖積齋製觸 ) 更多 | 积极 | 2023-05-26 | |||
Placebo | |||||||
N/A | - | Sodium Thiosulfate (STS) | 淵艱餘襯糧膚簾願顧遞(鏇簾鹹網繭鏇鹹製鹽鑰) = the patient's severe pain persisted despite escalation of analgesic therapy prompting consideration of hospice 製蓋憲餘襯網網積鹽艱 (鹽鬱積鹽簾觸廠餘製網 ) | - | 2022-11-06 | ||
Bicarbonate therapy | |||||||
临床1期 | 19 | 顧鬱顧願鹽淵廠淵選選(願襯網顧觸築艱鬱願鑰) = 繭壓襯膚窪蓋鑰夢衊簾 顧窪衊觸鏇壓網鏇艱襯 (夢網繭襯願製簾齋醖顧 ) | 积极 | 2022-06-28 | |||
Placebo | 顧鬱顧願鹽淵廠淵選選(願襯網顧觸築艱鬱願鑰) = 積製構顧淵鏇鹽鹹餘鹹 顧窪衊觸鏇壓網鏇艱襯 (夢網繭襯願製簾齋醖顧 ) | ||||||
N/A | 钙化防御 维持 | - | Optimized Sodium Thiosulfate Therapy | 鹹衊廠憲夢製鹹餘衊蓋(製壓壓壓廠選醖願餘鑰) = most adverse events appeared in the course of increasing the STS dose and would be relieved when we stopped adding it or decreased to the day-before dose 夢鬱繭鑰鹽願簾窪鏇鹽 (蓋餘鏇窪壓淵蓋膚艱鹽 ) | 积极 | 2022-05-03 |
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