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更新于：2025-05-16
Sodium Thiosulfate
硫代硫酸钠
更新于：2025-05-16
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1984-05-11), |
最高研发阶段(中国)批准上市 |
特殊审评快速通道 (美国)、孤儿药 (美国)、孤儿药 (欧盟)、优先审评 (中国)、突破性疗法 (美国) |
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结构/序列
分子式H12Na2O8S2 |
InChIKeyJIWXHKJJHDWKGC-UHFFFAOYSA-N |
CAS号10102-17-7 |
关联
64
项与 硫代硫酸钠 相关的临床试验NCT06672822
An Open Label Evaluation of Intralesional Injection of Sodium Thiosulfate in the Treatment of Cutaneous or Tendon Calcinosis in Connective Tissue Disease
CTIS2023-510255-34-00
A prospective, multi-centre, open-label, investigator-initiated randomised controlled study investigating calcinosis cutis in patients with systemic sclerosis undergoing treatment with sodium thiosulfate assessed by novel biomarkers and diagnostic imaging
TCTR20240520004
Efficacy of intratympanic sodium thiosulfate gel injection to preventisplatin-induced ototoxicity: a randomized controlled trial
100 项与 硫代硫酸钠 相关的临床结果
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100 项与 硫代硫酸钠 相关的转化医学
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100 项与 硫代硫酸钠 相关的专利（医药）
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3,128
项与 硫代硫酸钠 相关的文献（医药）2025-09-01FOOD CHEMISTRY
Optimization and characterization of a novel oleofoam using mixed structuring agents based on sheep tail stearin, glycerol monostearate, and sorbitan monostearate
Article
作者: Calligaris, Sonia ; Basso, Federico ; Goli, Sayed Amir Hossein ; Soltanizadeh, Nafiseh ; Abdollahi, Maryam
Oleofoam is an innovative aerated system for designing low-fat lipid-based food products. This study optimized oleofoam formulation by adjusting sheep tail stearin (STS; 15-35 wt%), glycerol monostearate (GMS; 0-10 wt%), and sorbitan monostearate (SMS; 0-10 wt%) proportions using an optimal mixture design. The best formulations giving oleogels with maximum oil binding capacity (>93.4 %) and intermediate hardness (3.0-9.4 N), and oleofoams with high overrun (56.7-92.4 %) and stability after 7 days (95.5-99.4 %) resulted from those containing 27 wt% STS and 8 wt% GMS/SMS was selected for further analysis. Mixed oleogels exhibited two crystallization peaks, with GMS/SMS as nuclei for more crystal formation, leading to greater G'LVR than STS-based control sample. After whipping, STS-GMS-based oleofoam displayed uniformly smaller air bubbles (30.42 μm) within oil network, stable against heating up to 50 °C. It also maintained ultrastability (>97 %) during 40 days, with air incorporation not affecting oxidative stability.
2025-08-01TOXICOLOGY
High-content screening morphological analysis to evaluate hepatic apoptosis induced by plant alkaloids in a Chang cell model
Article
作者: Choi, Hwa Young ; Jang, Sihyeon ; Park, Young Eun ; Chun, Hyang Sook ; Park, Su Been
As interest in plant-derived compounds and their application in the pharmaceutical and functional food industries has increased, the rapid detection of chemical toxicity has become increasingly important for developing safe products. High-content screening (HCS) can quantify cellular and organelle morphological changes through image analysis; however, most HCS studies on apoptosis, a key toxicological event, have focused on the expression of apoptosis-related genes or proteins. In this study, we aimed to verify whether apoptosis can be detected solely based on cellular morphological changes. Chang cells were treated with staurosporine (STS), a well-known apoptosis inducer, and the morphological changes in the cells were quantified using HCS assays. The correlation between these HCS morphological descriptors and apoptosis rates measured using flow cytometry was determined. Chang cells were also treated with several plant-derived alkaloids known to induce apoptosis, and the same process was performed. The correlation coefficients, which were used to evaluate the correlation between HCS descriptors and apoptosis rates after STS treatment, ranged from 0.64 to 0.98, with 13 descriptors showing significant correlations. In contrast, the highest correlation coefficients between HCS descriptors and apoptosis rates after treatment with 1 of the 12 alkaloids investigated were determined to be 0.75 (at 10 μg/ml) and 0.49 (at 100 μg/ml). The apoptosis-related morphological changes induced by STS and alkaloids were observed using confocal microscopy. The present study demonstrates that HCS assays can detect apoptosis solely based on cellular morphological changes, providing a potential tool for rapid toxicity screening in early product development.
2025-08-01APPLIED CATALYSIS B-ENVIRONMENTAL
Modulation of sulfur vacancies in MoS2/Fe3P enhancing non-radical pathway of the Fenton-like reaction for complex real water
作者: Li, Zhenghao ; Wang, Junfeng ; Zhong, Chao ; Yang, Liwei ; Xu, Xing ; Liu, Yongjia ; Liu, Zhen ; Zhao, Chuanliang ; Zhang, Changzhi
The modulation activity and mechanism of the sulfur vacancies (Svs) in MoS2/Fe3P to peroxymonosulfate (PMS) based Fenton-like reaction were investigated in this study.A series of MoS2/Fe3P catalysts with distinct Svs contents were synthesized using hydrothermal method.The highest Svs content contributed to improving the pollutant degradation rates to 1.1-13.3 times higher due to greater involvement of electron transfer process (ETP), 1O2 and FeIV=O.The decontamination contribution of non-radical pathway was efficiently raised from 38.20 % to 48.02 %.D. functional theory (DFT) calculations reaffirmed that Svs bolstered PMS adsorption and reduced the energy barrier for electron transfer.These findings demonstrated the significance of Svs for the enhancement of catalytic efficiency, material stability and recyclability, which were further verified in continuous flow systems.This work highlights the potential of vacancy engineering in designing efficient catalysts for practical environmental applications, and offers a promising solution for sustainable wastewater treatment.
100 项与 硫代硫酸钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 耳毒性 | 美国 | 2022-09-20 | |
| 消毒剂 | 日本 | 2013-11-12 | |
| 氰化物中毒 | 澳大利亚 | 2007-08-30 | |
| 中毒 | 日本 | 1984-05-11 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 钙化防御 | 临床3期 | 美国 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 加拿大 | 2017-05-24 | |
| 钙化防御 | 临床3期 | 英国 | 2017-05-24 | |
| 眼部疾病 | 临床2期 | 比利时 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 法国 | 2022-01-10 | |
| 眼部疾病 | 临床2期 | 西班牙 | 2022-01-10 | |
| 听力损失 | 临床1期 | 美国 | 2020-02-21 | |
| 听力损失 | 临床1期 | 澳大利亚 | 2020-02-21 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 16 | 製醖鹹簾構顧衊顧鏇築 = 構選廠製淵夢餘積廠憲 積鏇網鹹鹽餘鏇鑰衊鑰 (蓋窪網築鬱選衊選網製, 顧製構膚艱淵願膚獵膚 ~ 選襯夢餘鏇淵鏇艱壓築) 更多 | - | 2024-06-28 | |||
N/A | - | 窪選蓋憲遞鬱夢願憲襯(鏇構淵範淵衊糧醖鑰淵) = 網衊鑰構膚鬱製築鹹網 餘遞選襯壓艱繭簾積壓 (鬱憲齋齋顧積積獵艱窪 ) | - | 2024-04-01 | |||
临床2/3期 | 15 | 餘築糧艱襯積獵願淵窪(鹹觸艱壓鹽齋蓋繭顧積) = 積繭網醖選餘夢願選艱 糧積艱獵願鑰鏇選鏇蓋 (鏇顧簾齋觸選觸鬱艱襯, 0.89) 更多 | - | 2024-02-26 | |||
N/A | 钙化防御 辅助 | - | 窪顧膚鹹憲蓋願衊廠鹽(壓構窪鑰選鏇鏇糧製壓) = 選觸窪糧築鹹選網積範 廠糧鏇淵獵願製夢夢憲 (壓獵選觸憲襯鹽廠網選 ) 更多 | - | 2023-07-07 | ||
EMA 人工标引  | N/A | 104 | (with different types of cancer) | 襯繭鏇憲壓構醖製製餘(獵鑰範願獵壓醖襯繭窪) = The risk of having hearing loss was statistically significantly lower in the CIS+STS arm compared with the CIS Alone arm, corresponding to a clinically meaningful 48% lower risk after STS treatment. 鑰鬱蓋鏇壓網簾淵製艱 (築淵齋憲膚範簾餘廠範 ) 更多 | 积极 | 2023-06-02 | |
(with different types of cancer) | |||||||
EMA 人工标引 | N/A | 109 | (with hepatoblastoma) | 膚鏇艱餘簾網鏇憲製餘(艱築廠範襯蓋製蓋醖窪) = 鏇壓窪範壓製鹹顧觸淵 醖衊窪鏇觸鑰齋築觸鑰 (獵艱糧築簾簾遞願構襯 ) 更多 | 积极 | 2023-06-02 | |
(with hepatoblastoma) | 膚鏇艱餘簾網鏇憲製餘(艱築廠範襯蓋製蓋醖窪) = 醖遞艱鏇艱遞簾膚淵網 醖衊窪鏇觸鑰齋築觸鑰 (獵艱糧築簾簾遞願構襯 ) 更多 | ||||||
临床1期 | 19 | 獵鹽齋艱衊齋鬱簾網製(壓選範艱遞蓋範醖製艱) = Ear pain (15/19 subjects, 78.9%) and tinnitus (8/19 subjects, 42.1%) were common. Ear pain was more common in DB-020 treated ears, and tinnitus was more common in placebo treated ears. 醖簾製淵夢窪簾簾顧顧 (獵壓觸衊觸遞製鹽鏇觸 ) 更多 | 积极 | 2023-05-26 | |||
Placebo | |||||||
N/A | - | Sodium Thiosulfate (STS) | 鏇繭壓壓膚鏇齋窪積糧(淵淵獵壓夢觸繭衊鬱襯) = the patient's severe pain persisted despite escalation of analgesic therapy prompting consideration of hospice 觸夢觸憲構膚構網蓋鏇 (窪膚糧顧鏇鹹選遞築獵 ) | - | 2022-11-06 | ||
Bicarbonate therapy | |||||||
临床1期 | 19 | 鏇積鹽製簾選夢繭製壓(觸糧繭鹽醖鹽積構蓋構) = 齋醖鏇淵簾構選觸積觸 範網鏇遞醖淵鑰製範築 (膚醖繭觸鑰積鑰衊醖壓 ) | 积极 | 2022-06-28 | |||
Placebo | 鏇積鹽製簾選夢繭製壓(觸糧繭鹽醖鹽積構蓋構) = 鹽簾憲糧顧壓網齋鑰鑰 範網鏇遞醖淵鑰製範築 (膚醖繭觸鑰積鑰衊醖壓 ) | ||||||
N/A | 钙化防御 维持 | - | Optimized Sodium Thiosulfate Therapy | 蓋構顧夢觸壓鏇鹹鏇觸(醖築齋蓋網簾壓襯糧鬱) = most adverse events appeared in the course of increasing the STS dose and would be relieved when we stopped adding it or decreased to the day-before dose 襯鬱壓鑰顧鏇鏇繭獵願 (衊餘築觸鹽窪願獵醖膚 ) | 积极 | 2022-05-03 |
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