Approximately 21 subjects with amyotrophic lateral sclerosis (ALS) will be randomized (6 to 1) to receive by mouth seven morning doses of CC100 or placebo for 7 days. Subjects are required to stay in the Clinic for approximately 9 hours following the first and last dose. Subjects will also have a mid-week clinic visit and will be contacted by phone within 3 to 5 days after the last dose.
Funding Source - FDA OOPD

开始日期2017-04-07

申办/合作机构

Chemigen, Inc.

NCT02050334

/ Completed临床1期

Protocol CC100A CC100: Safety and Tolerability of Single Doses

The purpose of this study is to see if CC100, given by mouth, is safe and is tolerated in increasing doses. How long the drug remains in the body will also be calculated.

开始日期2013-11-01

申办/合作机构

Chemigen, Inc.

NCT02744703

/ CompletedN/AIIT

Professor, Ege University Faculty of Dentistry

Matrix metalloproteinases (MMPs); activated by the application of adhesive systems on dentin cause degradation of the collagen proteins and loss of bond strength in adhesive restorations. Caffeic acid phenethyl ester (CAPE) showed inhibitory activities on dentinal MMPs. It is hypothesised that dentin pretreatment with CAPE, as an MMP inhibitor, would be beneficial for the bonding of resin material and tooth substrate over the course of time. This study evaluated the effect of 5 % CAPE pretreatment on the microtensile bond strength of a nanohybrid resin restoration applied with total-etch or self-etch adhesive systems on 10 patients (12-18 yrs). Two standard cavities (3 x 3 x 4 mm) prepared on the occlusal surfaces of one of the two premolar teeth in each patient were randomly assigned into four treatment groups (n=10); 5% CAPE pretreatment and total-etch adhesive (TC), Total-etch adhesive (control) (T), 5% CAPE pretreatment and self-etch adhesive (SC), Self-etch adhesive (control) (S) followed by restoration and 3 months of intra-oral functioning. After teeth extraction, the specimens were stored in distilled water+thymol solution at 4°C to inhibit microbial growth and used in one week period. Dentin-composite sticks were obtained from each restoration for µTBS tests and scanning electron microscopy (SEM) evaluation. Failure mode analysis was performed microscopically. Data were analysed statistically using Repeated Measure ANOVA (p < 0.05). Dentin pretreatment with CAPE solution (5%) for 60 seconds significantly increased the composite resin restorations' bond strengths to dentin applied with either total-etch or self-etch adhesive system. Thus it can be used as an MMP inhibitor prior to the the resin restorations. However further long term clinical studies are needed to support the use of CAPE pretreatment along with self-etch and total-etch adhesive systems.

开始日期2013-04-01

申办/合作机构

Ege Universitesi

100 项与 Caffeic acid phenethyl ester 相关的临床结果

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100 项与 Caffeic acid phenethyl ester 相关的转化医学

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100 项与 Caffeic acid phenethyl ester 相关的专利（医药）

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1,688

项与 Caffeic acid phenethyl ester 相关的文献（医药）

2025-04-01·Aquaculture

Caffeic acid phenethyl ester promotes adipocyte hyperplasia and improves the growth performance, lipid metabolism, and inflammation in grass carp, Ctenopharyngodon idellus fed with high-fat diet

作者: Ji, Shanghong ; Song, Lei ; Ji, Hong ; Li, Handong ; Wei, Mingkui ; Tian, Zhiqi ; Sun, Jian

High-fat diet (HFD) is becoming more prevalent, necessitating the enhancement of fish tolerance and utilization of such diets for efficient use in aquaculture.Our previous research indicated that promoting adipocyte hyperplasia via peroxisome proliferator-activated receptor γ (PPARγ) is considered as a new nutritional strategy to increase HFD tolerance and utilization of grass carp, but feed additives with this effect has not been reported in fish.Caffeic acid phenethyl ester (CAPE), a phenolic compound extracted from honeybee hives, has the function of activating PPARγ.To investigate the effect of CAPE on adipocyte hyperplasia and HFD tolerance and utilization in fish, this study added different levels of CAPE (0, 200, 500, and 800 mg/kg) to HFD to prepare five exptl. diets (control, HFD, HFD + C200, HFD + 500, HFD + C800). 270 grass carp (initial weight: 13.98 ± 0.22 g) were divided into 5 groups and fed for 8 wk.HFD reduced final body weight, weight gain rate, specific growth rate, protein deposition rate and crude protein of grass carp, while the addition of CAPE significantly mitigated these adverse effects.CAPE also significantly reduced the HFD-induced increase in feed conversion ratio.As expected, CAPE promoted adipocyte hyperplasia, leading to healthy adipose tissue remodeling, including decreased immune cell infiltration and promoted the ability of adipose tissue to handle fat as well as reduced lipid accumulation.Addnl., CAPE supplementation alleviated hepatopancreas steatosis by reducing hepatopancreas lipid absorption and synthesis, while also improving the protein sparing of lipid in muscle.Furthermore, CAPE significantly decreased the expression of pro-inflammatory factors in adipose tissue, hepatopancreas and muscle, as well as lowered levels of serum lactic dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and low-d. lipoprotein cholesterol (LDL), thereby indicating a pos. impact on inflammatory response.In conclusion, our study systematically evaluated the effects of CAPE on growth, metabolism and inflammation of grass carp fed with HFD, and found that CAPE can promote adipocyte hyperplasia and improve the adverse effects of HFD on grass carp, providing valuable insights for developing effective feed additives to improve the tolerance and utilization of fish to HFD.

2025-03-03·Acta Oto-Laryngologica

The effect of caffeic acid phenethyl ester on facial nerve regeneration

Article

作者: Şeneldir, Lütfü ; Gölcük, Veysel Alparslan

BACKGROUNDCaffeic acid phenethyl ester (CAPE), an active component of honey bee propolis, has been demonstrated in animal models and studies to have anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, and cytoprotective properties.OBJECTIVEWe investigated the efficacy of CAPE, which we believe may be therapeutically useful in facial nerve restoration due to its neuroprotective and antioxidant properties.MATERIAL AND METHODS20 Sprague Dawley rats were divided randomly into 4 primary and 2 secondary groups and assigned as control, methylprednisolone, CAPE, CAPE+methylprednisolone groups and the sham and the trauma groups. Except for the sham group, all groups had the left facial nerve crushed. Three weeks after surgery, prospective functional, electrophysiologic, and histologic recovery was assessed.RESULTSThe CAPE and CAPE+methylprednisolone group had similar and more significant recovery at Nerve Excitability Thresholds and achieved a significantly faster improvement in histopathological evaluation at the end of three weeks.CONCLUSIONS AND SIGNIFICANCEThe combination of CAPE and methylprednisolone was found to be efficient in nerve regeneration in an experimental rat facial nerve crush model. Given the strong systemic adverse effects of methylprednisolone, the combination of CAPE may be a good alternative for lowering the dose of methylprednisolone and thereby reducing its negative effects.

2025-03-01·Animal Bioscience

Cupric citrate supplementation improves growth performance, nutrient utilization, antioxidant capacity, and intestinal microbiota of broilers

Article

作者: Zhang, Tietao ; Lu, Zhentao ; Wu, Xuezhuang ; Jiang, Qingkui ; Zhou, Yahao ; Zhang, Yunting

Objective: This study aimed to examine the impact of cupric citrate on broilers and compare it with the copper sulfate groups and a control group.Methods: A total of 360 1-day-old Ross 308 broilers were randomly assigned into 5 groups, each with 6 replicates of 12 broilers per treatment. The control group was fed a basal diet without any copper supplementation. In contrast, the other groups received basal diets supplemented with either 50 mg/kg (CS-50) or 100 mg/kg (CS-100) of copper in the form of copper sulfate, or 50 mg/kg (CC-50) or 100 mg/kg (CC-100) of copper in the form of cupric citrate, for a period of 42 days.Results: The results showed that copper supplementation affected the average daily gain (ADG) from day 1 to 21 (p = 0.026) and day 1 to 42 (p = 0.025) in a source-dependent manner. Copper source also influenced the energy digestibility (p = 0.004), with the CC-100 being the most effective treatment. Notably, birds in the CC-100 groups had significantly reduced concentrations of Escherichia coli (p<0.05) in the cecum, and the Lactobacillus in the ileum, compared to the control group. Dietary copper supplementation also increased the pH in the duodenum (p<0.05) irrespective of the sources and levels. In addition, the source of copper affected the activities of ceruloplasmin (p = 0.014) and CuZn superoxide dismutase (p = 0.025) in the serum, with the CC-100 group showing the highest levels of both enzymes.Conclusion: Copper supplementation generally improves the growth, nutrient utilization, intestinal microflora, gastrointestinal pH, and antioxidant defences of broilers. Moreover, cupric citrate is as effective as copper sulfate even at equal or lower concentrations.

项与 Caffeic acid phenethyl ester 相关的新闻（医药）

2023-02-27

·PRNewswire

Cymbiotika Announces Launch of New Supplement, ParaX ™

This all-natural formula supports overall whole-body wellness SAN DIEGO, Feb. 27, 2023 /PRNewswire/ -- Cymbiotika, the leading supplement brand known for creating clean, science-backed supplements, announced its newest product, ParaX™. ParaX is a comprehensive approach to balancing the gut microbiome, enhancing detox pathways, fortifying the immune system, and providing whole-body wellness. ParaX utilizes vitamins, minerals, standardized herbal extracts, fatty acids, and phenols encapsulated within powerful ozonated, oxygen-infused oils. What makes ParaX unique is that it was designed inside a gel capsule with suspended ParaX-Spheres. The formula also contains a powerful blend of ozonated oils made of monolaurin, coconut, thyme, clove, olive, and oregano. This combination provides a wide range of antimicrobial and antiseptic agents. The formula also contains CAPE (Caffeic Acid Phenethyl Ester), a highly bioactive compound found in bee propolis and utilized for its extraordinary antioxidant and immune properties, and Andrographolide, which is shown to support the immune system, promote a healthy inflammatory response and support the body during bacterial and viral infections. "We designed this formula to offer a proactive approach to combating the overgrowth of bacteria, microbes, and other foreign invaders in our microbiome that can cause many diverse health issues. ParaX is a daily supplement intentionally formulated for overall wellness and immune support rather than act as a harsh, one-time cleanse," said Dr. Pejman Taghavi, a Cymbiotika's Board of Advisors member. Cymbiotika's ParaX is a powerful supplement that provides an extra line of defense against bacteria, microbes, and foreign invaders that the body is exposed to. ParaX retails for $92 and is available for purchase through the Cymbiotika website. Customers over the age of 18 should take three capsules daily, with water or juice, as directed by a qualified healthcare practitioner. The formula was designed for individuals to take three weeks on and one week off. ParaX can be taken any time of the day, but it is crucial to be consistent with the time it is taken. For increased effectiveness, take alongside Cymbiotika's Liposomal Vitamin C. About Cymbiotika Cymbiotika is an innovative wellness brand based in San Diego. With the motto, "Your mind and body deserve the best," Cymbiotika is driven by the higher purpose of inspiring everyday people to achieve their optimal health. Founded in 2018, Cymbiotika uses the most advanced bioavailable absorption technology and sources only the highest quality plant-based nutrients to resolve specific nutritional deficiencies and support healthy aging, detoxification, and longevity. Cymbiotika never uses synthetics, GMOs, fillers, chemicals, preservatives, or additives in its products. For more information, visit . SOURCE Cymbiotika

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适应症	最高研发状态	国家/地区	公司	日期
肌萎缩侧索硬化	临床3期	美国	Chemigen, Inc.	2017-04-07
口腔鳞状细胞癌	临床前	中国台湾	Mackay Medical College	2017-09-01
结直肠癌	临床前	韩国	Andong National University	2007-05-01
结直肠癌	临床前	美国	University of Tennessee	2007-05-01
结直肠癌	临床前	美国	The National Institute of Environmental Health Sciences	2007-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02050334 (CC100A, CTgov)	临床1期	-	18	CC100 (CC100 (3 Single Doses))	廠窪構鬱範窪壓鬱襯憲(鏇積簾夢繭夢簾網觸獵) = 製觸憲廠衊壓簾觸窪獵襯構繭鹽襯繭鑰鑰窪襯 (衊範鏇範顧積鹹鑰顧夢, 襯窪鏇製餘窪艱構艱蓋 ~ 選襯簾顧範餘糧繭獵範) 更多	-	2015-04-29
				Placebo+CC100 (CC100 (2 Single Doses) & Placebo(1 Dose))	廠窪構鬱範窪壓鬱襯憲(鏇積簾夢繭夢簾網觸獵) = 鑰糧窪遞顧鏇餘鬱鹹艱襯構繭鹽襯繭鑰鑰窪襯 (衊範鏇範顧積鹹鑰顧夢, 鬱鏇艱夢壓糧襯構繭觸 ~ 遞製願窪淵齋憲繭鏇鬱) 更多