Carfilzomib

Samir R. Patel, M.D., appointed as Chief Executive Officer Abizer Gaslightwala appointed to Board of Directors BOSTON and LONDON, Dec. 18, 2024 (GLOBE NEWSWIRE) -- Akari Therapeutics, Plc (Nasdaq: AKTX) today announced the appointment of Samir R. Patel, M.D., as Chief Executive Officer, effective December 16, 2024. Dr. Patel has served as interim Chief Executive Officer since May 2024. Additionally, the Company announced it has appointed Abizer Gaslightwala to its Board of Directors, effective December 16, 2024. Michael Grissinger, a member of the Board of Directors, provided notice of his resignation on December 16, 2024. “Since beginning my role as interim CEO in May 2024, we have worked diligently to close the merger with Peak Bio, which we accomplished in November, and position Akari for continued growth and value creation. Looking ahead, we are focusing our efforts and resources to streamline operations and execute on our portfolio prioritization – our potentially best-in-class ADC platform. I am pleased to solidify my role with the Akari team and look forward to building momentum and driving shareholder value in the near and long term,” commented Dr. Patel, Chief Executive Officer of Akari. About Samir R. Patel, M.D. Dr. Patel currently serves as founder and principal of PranaBio Investments, LLC, a firm providing consulting, strategic advisory, and investment services for small cap biotechnology companies. He is also a consultant to GE Global Research, GE’s innovation engine that is creating novel products and solutions across several sectors including biomanufacturing and biotechnology. He has more than 20 years of experience in life sciences including founding SPEC Pharma, LLC, a company that develops and manufactures injectables used in human and veterinary applications. Previously, Dr. Patel held multiple roles in Medical Affairs with Centocor, Inc. (now Johnson & Johnson Innovative Medicine, part of Johnson & Johnson). He holds multiple patents, has been an author on several publications and has been an investigator in numerous clinical research studies. He has served on the boards of several public companies, including Rezolute Bio. Dr. Patel received his medical degree from the Medical College of Ohio and completed his internal medicine internship, residency, and rheumatology fellowship at The University of New Mexico School of Medicine Affiliated Hospitals. About Abizer Gaslightwala Mr. Gaslightwala is a well-established biotechnology / pharmaceutical industry leader with a demonstrated track record of success spanning over 25 years in the development and commercialization of novel medicines across a range of companies and therapeutic areas. Mr. Gaslightwala currently serves as the Senior Vice President and Franchise Head for Oncology at Jazz Pharmaceuticals, where he has full responsibility for a portfolio of products spanning both solid and hematological malignancies that have total annual sales of $1B. These brands include ZIIHERA® for HER2+ cancers, ZEPZELCA® for small cell lung cancer, and RYLAZE®, DEFITELIO®, and VYXEOS® for a range of hematological malignancies. “We are pleased to welcome Abizer to our Board of Directors. We believe the depth and breadth of his development and commercialization leadership and expertise amassed over the course of his career will provide valuable insight as we work to propel Akari to its next phase of growth. Additionally, we would like to thank Michael for his years of service on our board. His perspective and guidance have played a key role in getting the Company to where we are today,” added Dr. Patel. Mr. Gaslightwala added, “I'm thrilled to join the Akari board and have been extremely compelled by the Company’s unique ADC platform targeting the spliceosome, that has the potential to set a new standard of care for cancer patients. I look forward to working closely with the management team and other members of the board to advance this platform forward and potentially address areas of significant unmet need for cancer patients.” Prior to his current position at Jazz Pharmaceuticals, Mr. Gaslightwala has led and driven growth in several leadership roles at Amgen, Pfizer, and Johnson & Johnson across multiple brands including Kyprolis®, Vectibix®, Neulasta®, XGEVAf®, Repatha®, and ELIQUIS®. His experience spans business unit leadership, brand marketing, sales leadership, commercial pipeline planning, advanced analytics and insights, and business development. Mr. Gaslightwala also helped lead R&D strategic planning within the autoimmune/inflammation portfolio at Johnson & Johnson, as well as lead commercial planning for Remicade® and several novel pipeline molecules focused on rheumatoid arthritis, inflammatory bowel disease, psoriasis, and atopic dermatitis. Additionally, Mr. Gaslightwala advised several life science companies through his time at the Boston Consulting Group (BCG). Mr. Gaslightwala holds a BS in Chemical Engineering from Cornell University, and an MBA from the Sloan School of Management, and a MS in Chemical Engineering from MIT. About Akari Therapeutics Akari Therapeutics, Plc (Nasdaq: AKTX) is a biotechnology company developing advanced therapies for autoimmune, oncology and inflammatory diseases. Akari has two lead assets, investigational nomacopan and an antibody drug conjugate (ADC) platform. Nomacopan is a bispecific recombinant inhibitor of complement C5 activation and leukotriene B4 (LTB4) activity. The Company’s ADC platform includes novel toxins and linkers coupled with important cancer antibody targets. For more information about Akari, please visit akaritx.com. Cautionary Note Regarding Forward-Looking Statements This press release includes express or implied forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended (the Exchange Act), about the Company that involve risks and uncertainties relating to future events and the future performance of the Company. Actual events or results may differ materially from these forward-looking statements. Words such as “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “future,” “opportunity” “will likely result,” “target,” variations of such words, and similar expressions or negatives of these words are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of such forward-looking statements include, but are not limited to, express or implied statements regarding: the business combination and related matters, including, but not limited to, post-closing operations and the outlook for the Company’s business; the Company’s targets, plans, objectives or goals for future operations, including those related to its product candidates; financial projections; future economic performance,; and the assumptions underlying or relating to such statements. These statements are based on the Company’s current plans, estimates and projections. By their very nature, forward-looking statements involve inherent risks and uncertainties, both general and specific. A number of important factors, including those described in this communication, could cause actual results to differ materially from those contemplated in any forward-looking statements. Factors that may affect future results and may cause these forward-looking statements to be inaccurate include, without limitation: the risk that Akari and Peak Bio may not realize the anticipated benefits of the Merger in the time frame expected, or at all; the ability to retain and hire key personnel; potential adverse reactions or changes to business relationships resulting from the Merger; the potential impact of unforeseen liabilities, future capital expenditures, revenues, costs, expenses, earnings, synergies, economic performance, indebtedness, financial condition and losses on the future prospects, business and management strategies for the management, expansion and growth of the combined business; uncertainties as to the long-term value of Akari’s American Depositary Shares (and the ordinary shares represented thereby), including the dilution caused by Akari’s issuance of additional American Depositary Shares (and the ordinary shares represented thereby) in connection with the Merger; risks related to global as well as local political and economic conditions, including interest rate and currency exchange rate fluctuations; potential delays or failures related to research and/or development of the Company’s programs or product candidates; risks related to any loss of the Company’s patents or other intellectual property rights; any interruptions of the supply chain for raw materials or manufacturing for the Company’s product candidates, the nature, timing, cost and possible success and therapeutic applications of product candidates being developed by the Company and/or its collaborators or licensees; the extent to which the results from the research and development programs conducted by the Company, and/or its collaborators or licensees may be replicated in other studies and/or lead to advancement of product candidates to clinical trials, therapeutic applications, or regulatory approval; uncertainty of the utilization, market acceptance, and commercial success of the Company’s product candidates; unexpected breaches or terminations with respect to the Company’s material contracts or arrangements; risks related to competition for the Company’s product candidates; the Company’s ability to successfully develop or commercialize its product candidates; potential exposure to legal proceedings and investigations; risks related to changes in governmental laws and related interpretation thereof, including on reimbursement, intellectual property protection and regulatory controls on testing, approval, manufacturing, development or commercialization of any of the Company’s product candidates; the Company’s ability to maintain listing of its ADSs on the Nasdaq Capital Market. While the foregoing list of factors presented here is considered representative, no list should be considered to be a complete statement of all potential risks and uncertainties. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company's filings with the SEC, copies of which may be obtained from the SEC's website at www.sec.gov. The Company assumes no, and hereby disclaims any, obligation to update the forward-looking statements contained in this press release. Investor Contact: JTC Team, LLCJenene Thomas908.824.0775AKTX@jtcir.com A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/110aebf9-2683-41c9-ba9d-bf06f7e42054

注：本文不构成任何投资意见和建议，以官方/公司公告为准；本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及），不代表平台立场。任何文章转载需要得到授权。 在全球范围内，多发性骨髓瘤（MM）作为一种血液系统常见的恶性浆细胞肿瘤，以其高度异质性、高复发率给医疗健康带来了严峻挑战。摩熵咨询最新发布的《市场研究专题报告—多发性骨髓瘤药物》报告，深入剖析了多发性骨髓瘤的流行病学数据、诊疗指南、药物市场竞争格局以及治疗药物的市场趋势，为业界揭示了该领域的发展前景与潜在机遇。 本文聚焦于该报告的部分核心内容，着重剖析了多发性骨髓瘤的流行病学特征与治疗领域的最新进展。为行业相关从业者深入了解这一疾病及其治疗现状提供了详实且极具价值的参考信息，更好地把握其整体态势。 01 多发性骨髓瘤全球每年 新发患者30万例，中国新发约3万例 多发性骨髓瘤（MM）作为一种不可治愈的浆细胞恶性肿瘤，具备高度异质性且患者复发率高的特点，主要症状体现为骨质流失，白细胞数量减少，红细胞生成减少等造血抑制，以及肾功能损坏等。 据世界卫生组织（WHO）数据统计，2022年全球新发多发性骨髓瘤患者约30万例，死亡患者达18.5万例。而在不同国家和地区，其发病及死亡情况存在差异。 其中，2022年我国新发患者3万例，发病率为2.1人/10万人；死亡患者1.9万例，死亡率为1.3人/10万人；美国新发患者3.2万例，发病率为9.7人/10万人；死亡患者1.3万例，死亡率为3.9人/10万人；欧洲新发患者5万例，发病率为11.2人/10万人；死亡患者3.2万例，欧洲死亡率为7.1人/10万人。 02 不同阶段多发性骨髓瘤 的治疗目标及创新药影响 不同阶段多发性骨髓瘤的治疗目标各异，各种创新药的上市有望延长患者生存期。 对于新诊断的多发性骨髓瘤患者而言，自体造血干细胞移植是适合移植患者的一线选择，并且无论是否进行移植，诱导治疗都是必不可少的环节。诱导治疗的目的是快速减少肿瘤细胞数量，降低肿瘤负荷，进而控制症状。 当患者在诱导治疗后达到深度缓解时，则需要开展维持治疗，其目的在于延缓复发时间，且维持治疗会一直持续到患者首次复发。首次复发阶段的治疗目标是获得最大程度的缓解，尽可能延长无进展生存期。 而针对多线复发的患者，治疗目标转变为在提高患者生活质量的基础上，尽力获得最大程度缓解，此时治疗过程更加注重安全性。 值得一提的是，随着 BCMA CD3 双抗与 BCMA CAR-T 等创新药的上市，复发/难治性骨髓瘤（R/R MM）患者有望获得更长期的生存期，为改善这部分患者的预后带来了新的希望。 03 多发性骨髓瘤的治疗方式演变 多发性骨髓瘤的治疗方式演变，从仅有的干细胞移植到目前CAR-T，双抗等联合疗法。针对多发性骨髓瘤的治疗药物在不断升级进化，CD38抗体、CD3 双抗、CAR-T等创新药层出不穷，多药联合治疗方式目前已成为指南的I 级推荐疗法。 在过去的半个世纪里，多发性骨髓瘤的治疗取得了长足进步。从20世纪60年代中期开始，马法兰或环磷酰胺等烷化剂联合皮质类固醇被认为是MM的标准疗法。上世纪90年代，自体造血干细胞移植（ASCT）的应用进一步延长了患者生存，且至今仍为MM治疗的重要组成部分。 90年代末，第一代免疫调节剂沙利度胺问世，使MM的治疗模式发生了巨大转变。自2000年代初以来，蛋白酶体抑制剂（硼替佐米、伊沙佐米、卡非佐米）和新型免疫调节剂（来那度胺、泊马度胺）的应用逐渐改善了患者临床结局，并成为MM治疗的基石。 然而，多发性骨髓瘤仍然无法治愈，大多数患者最终会发展为以免疫逃逸和对标准治疗耐药为特征的复发性疾病，迫切需要具有良好耐受性以及可提供深度持久缓解的新型治疗方式。 多发性骨髓瘤在研药物进度及详情查询（部分）图片来源：摩熵医药全球药物研发数据库 近年来，免疫疗法用于新诊断MM（NDMM）和复发/难治性MM（RRMM）的治疗取得了显著进展，被认为是克服免疫抑制性微环境并促进抗肿瘤免疫反应的有力工具，具有诱导免疫记忆以降低复发风险的独特潜力。直接靶向肿瘤细胞表面抗原的免疫疗法是当前MM治疗的快速发展领域，CD38、CD47、CD138、SLAMF7、GPRC5D、FcRH5和BCMA等在恶性浆细胞表面高表达，成为了MM免疫治疗的热门靶点。 随后，又出现了各种新的免疫治疗方法，它们以不同的机制发挥作用，在多发性骨髓瘤中实现深度和高度持久的反应，包括双特异性或三特异性T细胞接合物(BiTEs)，ADCs ，CAR-T细胞或CAR-NK细胞疗法。未来这些新型疗法的有效性将被验证，有望改变MM的现有治疗模式。 结语 多发性骨髓瘤作为一种严重的浆细胞恶性肿瘤，其全球及中国的流行病学数据揭示了该疾病的广泛影响。随着医学研究的不断深入和新型治疗药物的快速发展，多发性骨髓瘤的治疗策略正在不断优化，为患者提供了更多的生存机会和生活质量改善的可能性。随着更多创新药物的研发和应用，以及精准医疗和个体化治疗理念的推广，多发性骨髓瘤的治疗前景将更加光明。 END 本文为原创文章，转载请留言获取授权  摩熵咨询市场研究专题报告三 多发性骨髓瘤药物，下期内容预告 目录 一、破100亿美元大关！多发性骨髓瘤药物市场，强生、赛诺菲...狭路相逢 二、多发性骨髓瘤治疗药物市场趋势：从双抗到CAR-T，辉瑞、强生领跑！ 近期将持续更新，敬请期待 近期热门资源获取 【摩熵咨询】以终为始 ，数据助力高质量立项-2024.05.27  【摩熵咨询】市场洞察，精准决策，医疗大数据赋能药企市场准入-2024.5.23 【摩熵咨询】CGT产业现状与未来趋势蓝皮书-2024.05.30  【摩熵咨询】2024年十大重磅小分子药物-2024.05.30  【摩熵咨询】-吸入制剂壁垒高玩家少，国产替代空间广阔-2024.06.04  【摩熵咨询】中药行业现状与未来趋势白皮书-2024.7.8  【摩熵咨询】2023年医药企业综合实力排行榜-2024.07.23  【摩熵咨询】跨越国界，引领创新：中国药企出海的布局实践-2024.08 【摩熵咨询】2023年医药企业综合实力排行榜-2024.11.24 更多摩熵咨询热门报告，识别下方二维码领取 联系我们，体验摩熵医药更多专业服务 会议 合作 园区 服务 数据库 咨询 定制 服务 媒体 合作 👆👆👆点击上方图片，即可开启摩熵化学数据查询 点击阅读原文，申请摩熵医药企业版免费试用！