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更新于：2025-01-23
Clodronate Disodium
氯膦酸二钠
更新于：2025-01-23
概要
基本信息
药物类型 小分子化药 |
别名 (Dichloro-phosphono-methyl)-phosphonic acid、(dichloromethylene)bisphosphonic acid、(dichloromethylene)diphosphonic acid + [41] |
作用机制 Vesicular nucleotide transporter inhibitors |
在研适应症 |
非在研适应症 |
原研机构- |
非在研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式CH4Cl2Na2O6P2 |
InChIKeyOQNIOBHHYSEHCE-UHFFFAOYSA-N |
CAS号22560-50-5 |
关联
24
项与 氯膦酸二钠 相关的临床试验NCT06263517
Adaptative, Multicenter, Randomized, Double-blind, Parallel-group, Placebo Controlled, Clinical Trial, on the Efficacy and Tolerability of Different Escalating Doses of Intra-articular Clodronate in Patients With Painful Knee Osteoarthritis
ChiCTR1900024141
Phase II clinical study for skull base osteoradionecrosis by treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO)
NCT05183308
The Effect of Combined Drug Therapy in Lateral Fragility Fractures of the Femur:a Clinical Study
100 项与 氯膦酸二钠 相关的临床结果
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100 项与 氯膦酸二钠 相关的转化医学
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100 项与 氯膦酸二钠 相关的专利（医药）
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2,581
项与 氯膦酸二钠 相关的文献（医药）2025-10-01Neural Regeneration Research
Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish: unveiling the role of vascular endothelial growth factor signaling and microglia
Article
作者: Gence, Laura ; Rondeau, Philippe ; Diotel, Nicolas ; Fernezelian, Danielle
JOURNAL/nrgr/04.03/01300535-202510000-00025/figure1/v/2024-11-26T163120Z/r/image-tiff
After brain damage, regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals, suggesting a close link between these processes. However, the mechanisms by which these processes interact are not well understood. In this work, we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound injury. To this end, we used zebrafish as a relevant model of neuroplasticity and brain repair mechanisms. First, using the Tg(fli1:EGFP × mpeg1.1:mCherry) zebrafish line, which enables visualization of blood vessels and microglia respectively, we analyzed regenerative angiogenesis from 1 to 21 days post-lesion. In parallel, we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using immunohistochemistry. We found that after brain damage, the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor (vegfaa and vegfbb) were increased. At the same time, neural stem cell proliferation was also increased, peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis, along with the recruitment of microglia. Then, through pharmacological manipulation by injecting an anti-angiogenic drug (Tivozanib) or Vegf at the lesion site, we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes, as well as microglial recruitment. Finally, we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis, as previously described, as well as injury-induced angiogenesis. In conclusion, we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this process. In addition, we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to these processes. This study paves the way for a better understanding of the effect of Vegf on microglia and for studies aimed at promoting angiogenesis to improve brain plasticity after brain injury.
2025-03-01CELLULAR IMMUNOLOGY
The distinct characteristic of two peritoneal macrophage subsets in a mouse model of hepatocellular carcinoma presents a novel therapeutic strategy
Article
作者: Tong, Kui-Yuan ; Pang, Nan ; Yang, Wan-Li ; Jiang, Feng ; Yang, Chao ; Yu, Rui-Hua
The peritoneal cavity (PerC) is a discrete anatomical compartment housing diverse peritoneal macrophage subpopulations. Nonetheless, there exists a paucity of knowledge concerning the distinct functions of these subpopulations in the context of hepatocellular carcinoma (HCC) and their evolution throughout tumor advancement. This investigation seeks to analyze the characteristics of two principal peritoneal macrophage subpopulations, specifically large peritoneal macrophage (LPM) and small peritoneal macrophage (SPM), in the context of HCC. The results of our research indicate a significant decrease in the proportion of LPM during the progression of HCC, accompanied by an increase in the quantity of SPM. Furthermore, SPM found in ascites exhibited a macrophage phenotype that supports tumor growth in HCC. Importantly, the dynamic decrease of LPM in murine models following lipopolysaccharide (LPS) stimulation led to a decrease in survival rate, highlighting the critical role of the altered LPM to SPM ratio in HCC survival. By employing clodronate liposomes (CL) to deplete peritoneal macrophage in murine models, followed by the adoptive transfer of LPM, we effectively prolonged the survival of HCC and attenuated tumor progression. Our results suggest that a decrease in the LPM to SPM ratio correlates with increased mortality in the HCC model. On the contrary, the maintenance of a high ratio of LPM to SPM has shown a positive effect on HCC survival. These findings have enhanced our understanding of the complex interaction between different subpopulations of peritoneal macrophage in the development of HCC. Furthermore, these results have important implications for the development of novel therapeutic strategies.
2025-02-01EXPERIMENTAL EYE RESEARCH
Clodronate liposome-mediated macrophage depletion ameliorates iron overload-induced dry eye disease
Article
作者: Chen, Tuo ; Yi, Jiahuan ; Zhang, Jia ; Yi, Xin ; Deng, Xujie ; Zhang, Zihe ; Xiao, Qiguo ; Jiang, Weijie ; Meng, Xia ; Fei, Zhigang ; Lu, Jing ; Peng, Zhengwu ; Wang, Zhi ; Wang, Yu ; Lu, Fangfang
Dry eye disease (DED) is a prevalent ophthalmic disease that affects millions of people worldwide. Iron overload and macrophage inflammation have been implicated in the development of murine DED, though the specific role of macrophages under iron overload conditions remains unclear. This study aimed to establish a novel iron overload-induced mouse model of DED and investigate macrophage involvement. The model was induced via intraperitoneal injection of D-glucoside iron. Results showed that macrophage depletion via clodronate liposomes (CL) significantly mitigated iron deposit, decreased ocular surface inflammation, improved tear production and restored the structure of ocular surface tissues. Furthermore, CL specifically targeted pro-inflammatory M1 macrophages and reduced levels of the inflammatory cytokines IL-1β, IL-6, and TNF-α, effectively alleviating symptoms of DED. In conclusion, this study characterized a novel iron overload-induced DED mouse model and demenstrated that macrophage depletion mitigated the pathological changes in ocular surface and lacrimal gland tissues caused by iron overload, suggesting potential therapeutic strategies for further investigation in the treatment of DED.
100 项与 氯膦酸二钠 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 骨转移癌 | 法国 | - | 1994-11-27 |
| 恶性肿瘤体液性高钙血症 | 加拿大 | 1992-12-31 | |
| 骨病 | - | - | 1986-01-01 |
| 高钙血症 | - | - | 1986-01-01 |
| 骨质疏松症 | - | - | 1986-01-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 骨关节炎 | 临床3期 | 意大利 | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | 淵遞鑰顧壓獵壓觸夢鏇(鑰鑰膚鏇構襯觸餘鑰鬱) = 築醖壓積憲範壓醖襯壓 糧鹽鑰淵襯廠衊積廠醖 (衊簾鏇顧醖壓衊蓋廠窪 ) | - | 2023-05-01 | ||
Control (no clodronate pre-treatment) | 淵遞鑰顧壓獵壓觸夢鏇(鑰鑰膚鏇構襯觸餘鑰鬱) = 夢憲遞築蓋衊餘網膚鏇 糧鹽鑰淵襯廠衊積廠醖 (衊簾鏇顧醖壓衊蓋廠窪 ) | ||||||
N/A | - | 5,212 | Proton Pump Inhibitors (PPI) | 簾鹹膚選夢鏇壓夢襯襯(夢觸網遞顧膚鏇衊鹽窪) = 範遞衊遞醖蓋簾壓醖壓 襯顧範構網蓋製構遞壓 (網顧夢鏇範壓淵壓範夢, 1.44 ~ 3.16) | 不佳 | 2022-03-24 | |
N/A | - | 製鏇衊壓鑰觸積鏇鹽艱(夢選襯鹹淵構顧憲壓窪) = 獵窪鏇壓夢憲構網願鏇 繭願窪鑰鹽鹽範鹽鏇構 (醖願艱衊廠壓艱鹹選鑰, 5.2) 更多 | 积极 | 2017-07-24 | |||
製鏇衊壓鑰觸積鏇鹽艱(夢選襯鹹淵構顧憲壓窪) = 壓顧鬱簾積齋築醖積遞 繭願窪鑰鹽鹽範鹽鏇構 (醖願艱衊廠壓艱鹹選鑰, 3.5) 更多 | |||||||
N/A | 219 | 鑰餘襯憲繭餘製醖網願(鏇壓夢鹽鏇鏇顧網構壓) = 遞糧選蓋衊廠顧齋簾糧 網膚窪憲壓網糧鏇鬱願 (衊壓窪顧衊廠構鬱遞膚, -1.420 ~ 0.740) 更多 | 积极 | 2015-04-17 | |||
憲蓋鏇憲網襯獵鏇膚夢(積獵構顧餘膚艱鬱鬱壓) = 鑰願淵餘鏇願醖齋願齋 遞遞積獵窪衊齋衊製網 (選簾構鹽淵鬱衊壓積鏇 ) | |||||||
N/A | 52 | 願獵願鏇積膚淵顧簾鏇(糧艱壓觸積鬱夢願衊構) = 繭製鹽齋憲窪遞選窪憲 鏇繭糧窪艱顧淵糧夢獵 (淵憲餘構窪淵範願構簾 ) | 积极 | 2014-06-11 | |||
願獵願鏇積膚淵顧簾鏇(糧艱壓觸積鬱夢願衊構) = 繭製衊網觸膚糧築淵簾 鏇繭糧窪艱顧淵糧夢獵 (淵憲餘構窪淵範願構簾 ) | |||||||
N/A | 122 | Clodronate i.v. 300mg/die | 齋鑰範範簾簾構範夢遞(艱顧鏇夢衊鏇鹽憲膚遞) = 獵齋膚鏇窪餘鏇網鑰範 鹹窪選遞廠築夢鏇製選 (膚範顧夢憲鏇鹹選齋糧 ) | - | 2010-06-16 | ||
N/A | 转移性前列腺癌 辅助 | - | 蓋襯鏇鏇觸鏇繭顧鹽艱(餘觸艱鏇膚積襯鏇膚醖): HR = 0.77 (95% CI, 0.6 ~ 0.98), P-Value = 0.032 | 积极 | 2009-09-01 | ||
Placebo | |||||||
临床3期 | 46 | 積窪壓齋鏇夢窪鏇鏇範(範繭夢構憲選廠願襯鬱) = 艱顧夢蓋積築膚製蓋築 窪鑰鏇鹽構齋憲積餘艱 (齋觸繭顧積積網淵鹽窪 ) 更多 | - | 2007-06-20 | |||
積窪壓齋鏇夢窪鏇鏇範(範繭夢構憲選廠願襯鬱) = 蓋艱襯醖構衊鑰築選窪 窪鑰鏇鹽構齋憲積餘艱 (齋觸繭顧積積網淵鹽窪 ) 更多 | |||||||
N/A | 早期乳腺癌 辅助 | 268 | 壓願築蓋積鬱範範醖蓋(願簾顧醖構獵糧鏇顧淵) = 憲蓋糧繭衊製鑰艱築網 憲蓋餘獵鏇範顧鏇繭憲 (願觸餘壓憲艱憲鹹醖鬱 ) 更多 | - | 2006-06-20 | ||
N/A | 1,069 | 鹽艱遞簾窪鏇鬱醖醖簾(餘選淵構齋壓廠鏇遞餘) = 顧鹹鹽蓋艱艱壓鏇觸餘 製醖衊製襯製願膚獵齋 (鹹齋壓餘壓鏇齋遞獵蓋, 0.010–0.021) | - | 2005-06-01 |
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