A Phase 2 Randomized, Double-blind and Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of SR750 in Patients With Trigeminal Neuralgia

The goal of this clinical trial is to evaluate the efficacy，safety and tolerability of SR750 in patients with trigeminal neuralgia (TN). Patients will receive SR750 (study drug) or placebo for 6 weeks and keep a diary of daily pain. The study duration for each patient is up to 11 weeks.

开始日期2024-08-01

申办/合作机构

上海赛默罗生物科技有限公司

ACTRN12623000035628 / Not yet recruiting临床2期

A Phase 2, Double Blind Placebo-Controlled Study of BIT225, an Orally Administered SARS-CoV-2 Viroporin Inhibitor, to Evaluate Antiviral Activity, Safety, and Immune Biomarkers in Non-Hospitalised Vaccinated and Unvaccinated Adults with COVID-19.

开始日期2023-05-08

申办/合作机构

Biotron Ltd.

100 项与 Ion channels 相关的临床结果

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100 项与 Ion channels 相关的转化医学

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0 项与 Ion channels 相关的专利（医药）

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项与 Ion channels 相关的文献（医药）

2021-04-30·Science1区 · 综合性期刊

Engineering small-ion transporter channels

1区 · 综合性期刊

Article

作者: Hinds, Bruce J.

Voltage-gated channels microfabricated in graphene sheets act as ion-selective transistors

2005-01-01·No to shinkei = Brain and nerve

[Channelopathy update].

Review

作者: Kobayashi, Takayoshi

2003-04-01·The Journal of Neuroscience1区 · 医学

Exocytosis at the Ribbon Synapse of Retinal Bipolar Cells Studied in Patches of Presynaptic Membrane

1区 · 医学

Article

作者: Leon Lagnado ; Artur Llobet ; Anne Cooke

The distribution of exocytic sites and ion channels in the synaptic terminal of retinal bipolar cells was investigated by measuring capacitance and conductance changes in cell-attached patches of presynaptic membrane. Patch depolarization evoked capacitance and conductance increases that were inhibited by blocking Ca2+influx or loading the terminal with EGTA. The increase in capacitance declined as the depolarization approached the reversal potential for Ca2+, indicating that it was a result of Ca2+-dependent exocytosis. The conductance increase was caused by KCachannels that were also activated by Ca2+influx. Two observations indicated that sites of exocytosis and endocytosis colocalized with clusters of Ca2+channels and KCachannels; the initial rate of exocytosis was correlated with the activation of KCachannels, and exocytosis did not occur in the 41% of patches lacking this conductance. Electron microscopy demonstrated that there were ∼16 vesicles docked to the plasma membrane at each active zone marked by a ribbon, but vesicles were also attached to the rest of the membrane at a density of 1.5/μm2. The density of ribbons was 0.10 ± 0.02/μm2, predicting that ∼43% of cell-attached patches would lack an active zone. The density of Ca2+channel clusters assayed by capacitance and conductance responses was therefore similar to the density of ribbons. These results are consistent with the idea that Ca2+channel clusters were colocalized with ribbons but do not exclude the possibility that calcium channels also occurred at other sites. The wide distribution of vesicles docked to the plasma membrane suggests that exocytosis might also be triggered by the spread of Ca2+from Ca2+channel clusters.