Delving into the Latest Updates on Innophore GmbH with Synapse

概览

疾病领域	数量

感染	1

排名前五的药物类型	数量

重组蛋白	1

排名前五的靶点	数量

ACE2(血清血管紧张素转化酶2)	1

关联

1

项与 Innophore GmbH 相关的药物

ACE2 Mutant(SignalChem Lifesciences)

靶点

ACE2

作用机制

ACE2抑制剂

在研机构

Innophore GmbH初创企业 [+1]

原研机构

SignalChem Lifesciences Corp [+1]

在研适应症

新型冠状病毒感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Innophore GmbH 相关的临床结果

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0 项与 Innophore GmbH 相关的专利（医药）

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21

项与 Innophore GmbH 相关的文献（医药）

2025-01-13·ACS Sustainable Chemistry & Engineering

Substrate-Binding Cavity Engineering of the Lipoxygenase from Pseudomonas aeruginosa to Produce 8S- and 11S-Hydroxyeicosatetraenoic Acids

作者: Oh, Deok-Kun ; Hwang, Se-Yeun ; Köchl, Katharina ; Lee, Hyo-Ran ; Bornscheuer, Uwe T. ; Kwon, Yong-Uk ; Nestl, Bettina ; Seo, Eun-Ji ; Park, Jin-Byung

Lipoxygenases catalyze the dioxygenation of polyunsaturated fatty acids.Notably, most microbial lipoxygenases including the lipoxygenase from Pseudomonas aeruginosa (Pa-LOX) catalyze oxygenation of linoleic acid and arachidonic acid into 13S-hydroperoxyoctadecenoic acid (13S-HPODE) and 15S-hydroperoxyeicosatetraenoic acid (15S-HPETE), resp.Therefore, this study has focused on modification of positional specificity or regioselectivity of Pa-LOX.The linoleic acid oxygenations and substrate-docking simulations suggested that the regioselectivity of Pa-LOX might depend on the geometry of the hydrocarbon tail-binding cavity.Therefore, the interior end of the substrate-binding cavity was enlarged to make C10 instead of C13 face the iron active site.Remarkably, the M434G mutation led to alteration of the oxygenation products from 15S-hydroxyeicosatetraenoic acid (15S-HPETE) to 11S-HPETE as the major product from arachidonic acid.On the other hand, the Y609G substitution allowed the formation of 8S-HPETE from arachidonic acid. 8S-HPETE was recovered after reduction by tris(2-carboxyethyl)phosphine hydrochloride with an isolated yield of 62% with a purity of 94% via Escherichia coli-based whole-cell biocatalysis, solvent extraction, and silica gel chromatog.This is the first report of the production of 11S-HPETE and 8S-HPETE from arachidonic acid at high conversions.Therefore, this study contributes to the preparation of biol. active oxylipins from renewable fatty acids in a sustainable way.

2024-07-02·ChemBioChem

The Development and Opportunities of Predictive Biotechnology

Review

作者: Schürmann, Martin ; Nebel, Bernd A ; Nestl, Bettina M ; Resch, Verena ; Tischler, Dirk

AbstractRecent advances in bioeconomy allow a holistic view of existing and new process chains and enable novel production routines continuously advanced by academia and industry. All this progress benefits from a growing number of prediction tools that have found their way into the field. For example, automated genome annotations, tools for building model structures of proteins, and structural protein prediction methods such as AlphaFold2TM or RoseTTAFold have gained popularity in recent years. Recently, it has become apparent that more and more AI‐based tools are being developed and used for biocatalysis and biotechnology. This is an excellent opportunity for academia and industry to accelerate advancements in the field further. Biotechnology, as a rapidly growing interdisciplinary field, stands to benefit greatly from these developments.

2023-07-07·ACS Catalysis

A Career in Catalysis: Bernhard Hauer

作者: Syrén, Per-Olof ; Aberle, Benjamin ; Weissenborn, Martin J. ; Breuer, Michael ; Schneider, Andreas ; Nestl, Bettina M. ; Nebel, Bernd A. ; Hammer, Stephan C.

100 项与 Innophore GmbH 相关的药物交易

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100 项与 Innophore GmbH 相关的转化医学

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