Delving into the Latest Updates on Research Fdn for Microbial Diseases of Osaka University with Synapse

概览

疾病领域	数量

感染	9
神经系统疾病	2

排名前五的药物类型	数量

预防性疫苗	8
联合疫苗	6
类毒素疫苗	3
多价疫苗	2
减毒活疫苗	2

排名前五的靶点	数量

hemagglutinin(血凝素)	1
Tetanus toxin(破伤风毒素)	1

关联

9

项与 Research Fdn for Microbial Diseases of Osaka University 相关的药物

Freeze-dried Live Attenuated Measles, Rubella Combined Vaccine(Research Fdn for Microbial Diseases of Osaka University)

靶点-

作用机制-

在研机构

Research Fdn for Microbial Diseases of Osaka University

原研机构

Research Fdn for Microbial Diseases of Osaka University

在研适应症

麻疹 [+1]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期2025-01-24

Adsorbed Diphtheria-purified Pertussis-tetanus-Acute polio-Haemophilus influenzae type b(Sabin strain)Combined Vaccine(KM Biologics)

白喉/破伤风/百日咳/急性脊髓灰质炎及b 型流感嗜血杆菌疫苗(KM Biologics)

靶点-

作用机制

免疫刺激剂

在研机构

Mitsubishi Tanabe Pharma Corp. [+2]

原研机构

KM Biologics KK

在研适应症

白喉 [+4]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期2020-07-31

Adsorbed Diphtheria-purified Pertussis-tetanus-inactivated polio(Sabin strain)Combined Vaccine(Minimum Requirements for Biological Products)

吸附型四价联合疫苗(Biken Techno Corp.)

靶点-

作用机制

免疫刺激剂

在研机构

Research Fdn for Microbial Diseases of Osaka University

原研机构-

在研适应症

白喉 [+3]

非在研适应症

细菌性脑膜炎

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期2012-07-27

100 项与 Research Fdn for Microbial Diseases of Osaka University 相关的临床结果

登录后查看更多信息

0 项与 Research Fdn for Microbial Diseases of Osaka University 相关的专利（医药）

登录后查看更多信息

27

项与 Research Fdn for Microbial Diseases of Osaka University 相关的文献（医药）

2014-09-01·Vaccine3区 · 医学

A national reference for inactivated polio vaccine derived from Sabin strains in Japan

3区 · 医学

Article

作者: Shirato, Haruko ; Takahashi, Motohide ; Someya, Yuichi ; Ouchi, Yasumitsu ; Horiuchi, Yoshinobu ; Wakita, Takaji ; Takeda, Naokazu ; Ota, Yoshihiro ; Tano, Yoshio ; Wakabayashi, Kengo ; Abe, Shinobu ; Yamazaki, Shudo ; Ochiai, Masaki

As one aspect of its campaign to eradicate poliomyelitis, the World Health Organization (WHO) has encouraged development of the inactivated polio vaccine (IPV) derived from the Sabin strains (sIPV) as an option for an affordable polio vaccine, especially in low-income countries. The Japan Poliomyelitis Research Institute (JPRI) inactivated three serotypes of the Sabin strains and made sIPV preparations, including serotypes 1, 2 and 3 D-antigens in the ratio of 3:100:100. The National Institute of Infectious Diseases, Japan, assessed the immunogenic stability of these sIPV preparations in a rat potency test, according to an evaluation method recommended by the WHO. The immunogenicity of the three serotypes was maintained for at least 4 years when properly stored under -70°C. Based on these data, the sIPV preparations made by JPRI have been approved as national reference vaccines by the Japanese national control authority and used for the quality control of the tetracomponent sIPV-containing diphtheria-tetanus-acellular pertussis combination vaccines that were licensed for a routine polio immunization in Japan.

2013-11-01·Journal of Virology2区 · 医学

A Strain-Specific Epitope of Enterovirus 71 Identified by Cryo-Electron Microscopy of the Complex with Fab from Neutralizing Antibody

2区 · 医学

Article

作者: Nishimura, Yorihiro ; Ashley, Robert E. ; Shimizu, Hiroyuki ; Makhov, Alexander M. ; Conway, James F. ; Tano, Yoshio ; Cifuente, Javier O. ; Hafenstein, Susan ; Lee, Hyunwook

ABSTRACTEnterovirus 71 (EV71) is a picornavirus that causes outbreaks of hand, foot, and mouth disease (HFMD), primarily in the Asia-Pacific area. Unlike coxsackievirus A16, which also causes HFMD, EV71 induces severe neuropathology leading to high fatalities, especially among children under the age of 6 years. Currently, no established vaccines or treatments are available against EV71 infection. The monoclonal antibody MA28-7 neutralizes only specific strains of EV71 that have a conserved glycine at amino acid VP1-145, a surface-exposed residue that maps to the 5-fold vertex and that has been implicated in receptor binding. The cryo-electron microscopy structure of a complex between EV71 and the Fab fragment of MA28-7 shows that only one Fab fragment occupies each 5-fold vertex. A positively charged patch, which has also been implicated in receptor binding, lies within the Fab footprint. We identify the strain-specific epitope of EV71 and discuss the possible neutralization mechanisms of the antibody.

2010-06-15·Journal of Virology2区 · 医学

2A Protease Is Not a Prerequisite for Poliovirus Replication

2区 · 医学

Article

作者: Yoshino, Yasuko ; Horie, Hitoshi ; Miyazawa, Miwako ; Nomoto, Akio ; Igarashi, Hiroko ; Ohka, Seii

ABSTRACT Poliovirus (PV) 2A pro has been considered important for PV replication and is known to be toxic to host cells. A 2A pro -deficient PV would potentially be less toxic and ideal as a vector. To examine whether 2A pro is needed to form progeny virus, a full-length cDNA of dicistronic ( dc ) PV with (pOME) or without (pOMEΔ2A) 2A pro was constructed in the strain PV1(M)OM. RNAs of both pOME and pOMEΔ2A were capable of forming progeny viruses, called OME and OMEΔ2A, respectively. In their ability to induce a cytopathic effect (CPE), the strains ranked as OMEΔ2A < OME ≒ PV1(M)OM. These results suggest that 2A pro is not essential for full-length dc PV to form progeny virus and that it contributes to the efficient viral replication and/or induction of a CPE. To clarify whether 2A pro is essential for P1-null (lacking the entire coding sequence for capsid proteins) PV, the RNA replication activity of P1-null PV (pOMΔP1) or P1-null PV without 2A pro (pOMΔP1Δ2A) or without both 2A pro and 2B (pOMΔP1Δ2AΔ2B) was examined. The RNAs of pOMΔP1 and pOMΔP1Δ2A could replicate and form progeny viruses under a trans supply of P1 protein, whereas the RNA of pOMΔP1Δ2AΔ2B could not. These results suggest that 2A pro is not needed for the replication of P1-null PV, although it is important for PV RNA replication and inducing a CPE. To know whether a 2A pro -deficient PV can be used as a vector, a P1-null PV containing the enhanced green fluorescent protein (EGFP) coding sequence with or without 2A pro was examined. It expressed fluorescent protein. This result suggests that 2A pro -deficient PV can express foreign genes.

100 项与 Research Fdn for Microbial Diseases of Osaka University 相关的药物交易

登录后查看更多信息

100 项与 Research Fdn for Microbial Diseases of Osaka University 相关的转化医学

登录后查看更多信息

组织架构

使用我们的机构树数据加速您的研究。

登录

或

查看完整样例数据

管线布局

2025年05月08日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

批准上市

9

登录后查看更多信息

当前项目

药物(靶点)	适应症	全球最高研发状态

水痘抗原(一般財団法人阪大微生物病研究会)	水痘更多	批准上市
吸附白喉类毒素(财団法人坂大微生物病研究会)	白喉更多	批准上市
四价流感疫苗(Osaka University) ( hemagglutinin )	流感病毒感染更多	批准上市
Adsorbed Diphtheria-tetanus Combined Toxoid(Biken Techno Corp.)	破伤风更多	批准上市
吸附型四价联合疫苗(Biken Techno Corp.)	破伤风更多	批准上市